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임신 중기 양수천자 3,503예에 대한 세포 유전학적 분석: CUMC 경험 (2)
박인양 ( Park In Yang ),신종철 ( Sin Jong Cheol ),김석찬 ( Kim Seog Chan ),안현영 ( An Hyeon Yeong ),문희봉 ( Mun Hui Bong ),박철훈 ( Park Cheol Hun ),이희중 ( Lee Hui Jung ),이영 ( Lee Yeong ),나종구 ( Na Jong Gu ),김수평 ( Kim 대한산부인과학회 2004 Obstetrics & Gynecology Science Vol.47 No.1
목적 : 산전 유전진단을 위해 시행된 양수천자술을 이용한 염색체 분석의 검사 이유와 결과를 분석하여 임신 중기 양수천자술의 효용성과 적절한 검사 조건을 알아보고자 하였다. 연구 방법 : 가톨릭대학교 의과대학부속 강남성모병원 세포유전연구실에서 1997년 11월부터 2002년 11월까지 산전유전진단의 적응증이 있거나 유전상담 및 본인이 원하여 양수천자술에 의한 염색체 검사를 시행 받은 3,503예를 대상으로 하였다. 결과 : 총 대상 임신부 3,503예 중 Objective : To analyze chromosomal abnormalities according to patient`s age and indications of patients in midtrimester amniocentesis for prenatal genetic diagnosis. Methods : We retrospectively analyzed 3,503 cases of midtrimester prenatal genetic amnioc
다발성 골수종이 동반된 정상 지질단백혈증을 보인 광범위 편평 황색종
박현영 ( Hyeon Young Park ),이제중 ( Je Jung Lee ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ),윤숙정 ( Sook Jung Yun ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.6
Diffuse plane xanthoma (DPX) is a rare variant of plane xanthoma and DPX appears as yellow flat patches or slightly elevated plaques on the eyelids, neck, upper trunk and flexural areas. Lynch and Winkelmann divided it into two groups according to the presence of hyperlipidemia. Diffuse normolipemic plane xanthoma is often associated with reticuloendothelial proliferative disease such as multiple myeloma and monoclonal gammopathy with unknown significance (MGUS). We report here on a case of diffuse normolipemic plane xanthoma associated with multiple myeloma in a 59 year-old man. (Korean J Dermatol 2011;49(6):516∼519)
박현영 ( Hyeon Young Park ),윤숙정 ( Sook Jung Yun ),이지범 ( Jee Bum Lee ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.10
Lymphomatoid papulosis is a lymphoproliferative disorder which is characterized by chronic recurrent self-healing papules or nodules with histologic features suggestive of a malignant lymphoma. An association of lymphomatoid papulosis with other lymphomas including mycosis fungoides, Hodgkin`s disease and anaplastic large cell lymphoma is present in approximately 10 to 20% of cases. We herein report a case of lymphomatoid papulosis developed after remission of Hodgkin`s disease. (Korean J Dermatol 2011;49(10):927∼930)
편마비 환자의 양측 상완에 발생한 국소형 물집유사천포창
박현영 ( Hyeon Young Park ),윤숙정 ( Sook Jung Yun ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ),이지범 ( Jee Bum Lee ) 대한피부과학회 2011 대한피부과학회지 Vol.49 No.5
Bullous pemphigoid is a chronic autoimmune blistering disease characterized clinically by tense bullae that develop on normal or erythematous skin. Bullous pemphigoid is associated with autoantibodies to two hemidesmosomal proteins, BPAG1 (230 kD) and BPAG2 (180 kD). The localized form of BP is an unusual variant that occurs in 5∼30% of the patients. A 58-year-old man who had been suffering from right hemiplegia since 2006, presented with multiple tense bullae localized on both arms and hands. Direct immunofluorescence test showed linear deposition of IgG and C3 along the basement membrane zone. The antibodies against the recombinant NC16a-domain of BP180 were positive by ELISA and immunoblotting using epidermal extract of normal human foreskin demonstrated that the patient`s serum reacted with only BP180 antigen. Here, we report a case of localized bullous pemphigoid on both upper extremities in a hemiplegic patient predominantly on the opposite side to the hemiplegia. (Korean J Dermatol 2011;49(5):444∼447)
여드름의 광선역학요법에서 적색광과 청색광의 광원에 따른 효과 비교 연구
박현영 ( Hyeon Young Park ),윤숙정 ( Sook Jung Yun ),김성진 ( Seong Jin Kim ),이승철 ( Seung Chul Lee ),원영호 ( Young Ho Won ),이지범 ( Jee Bum Lee ) 대한피부과학회 2010 대한피부과학회지 Vol.48 No.12
Background: Acne vulgaris is a very common inflammatory disease, particularly in adolescents and young adults. Problems such as the inconvenience of long term treatment, the resistance of Propionibacterium acnes to antibiotics and the side effects of isotretinoin have led to investigate photodynamic therapy for the treatment of acne vulgaris. Objective: We wanted to evaluate of the efficacy and safety of topical methyl aminolevulinate-photodynamic therapy (MAL-PDT) using red and blue light emitting diode (LED) lights on acne vulgaris. Methods: Thirty two patients with inflammatory facial acne were treated with topical MAL-PDT with red LED light on the right side and blue LED light on the left side at 2-week intervals for three sessions. MAL was applied to the acne lesions on the entire face with a 45-minutes incubation time. Evaluation was performed by counting the acne lesions at baseline, 2, 4, 6, 8 and 12 weeks after the beginning of the treatment. Results: After 12 weeks of PDT, we found a statistically significant reduction of the inflammatory and non- inflammatory acne lesions from baseline using both red and blue LED lights. Yet there was no significant difference in effectiveness between the two treatments on the inflammatory and non-inflammatory acne lesions. Some of the patients experienced transient erythema, stinging, pain and hyperpigmentation with both treatments. Conclusion: Photodynamic therapy with red and blue LED lights appeared to be an effective and safe therapeutic modality for the inflammatory and non-inflammatory acne lesions of mild to moderate acne vulgaris, although there was no significant difference in the efficacy between the two kinds of lights. (Korean J Dermatol 2010;48(12): 1060∼1067)
The physical characteristics of corneocyte: different patterns from face and arm
박현영 ( Hyeon Young Park ),Min Youl Chang,Cheon Koo Lee,Seong Jin Kim 한국피부장벽학회 2009 한국피부장벽학회지 Vol.11 No.2
Stratum corneum is the most outer part of the skin reflecting the pathophysiology of the skin, thus either the structure or morphology pattern of corneocyte could be a good parameter of skin status. In present study, we evaluated the differences in structure or morphology of corneocyte from face skin and forearm skin. When the elasticity of face and arm skin was measured by cutometer, the elastic properties of the facial skin were rather less than those of the forearm skin. At a given hydrating condition, the facial skin seems to be more affected in its elastic parameters than forearm skin. Interestingly, the surface roughness of corneocyte from face skin under atomic force microscope showed less roughness on its surface than that of forearm skin. These results suggested that each individual areas of the body surface have some different physical characteristics, even in the uppermost skin layer as corneocyte.