Cleidocranial dysostosis 1例 報告

朴辰河,文命相 최신의학사 1971 最新醫學 Vol.14 No.9

A Case of cleidocranial dysostosis in a 3 months old infant was presented with review of the literature.

아세토니트릴-물 혼합용매중에서 브롬화파라즈로모펜아실과 아닐린과의 반응속도론적 연구

박진하,신철호 全北大學校 基礎科學硏究所 1985 基礎科學 Vol.8 No.1

The rate constants, thermodynamic parameters and isokinetic temperature for the reaction of p-bromophenacyl bromide with aniline in acetonitrile-water was studied by conductometry. The pseudo-first-order rate constants were calculated by Guggenheim equation, and then the second-order rate constants were determined. In result, it was found that rate constants, the values of enthalpies of activation and those of entropies of activation increased in proportion as the dielectric constants increased. The values of ehthalpies of activation were comparatively low and those of entropies of activation were quite negative, and both increased in proportion as water content increased. It, therefore, may be concluded that the reaction was to be S_N2 mechanism. The isokinetic temperature was 227K(-46℃) and this temperature was lower than experimental one, so this reaction was entropy controlled.

아세토니트릴 물 혼합용매중의 브롬화 페나실과 파라톨루이딘과의 반응속도 연구

朴鎭夏,韓光來 全北大學校 基礎科學硏究所 1979 基礎科學 Vol.2 No.1

The reactions of phenacyl bromide with p-toluidine have been studied in acetonitrilewater by conductometrically. The rate constants were calculated by Guggenheim equation and the activation thermodynamic parameters were also evaluated. In results, the rate constants were increased with water content and the reaction was the second-order. The values of the enthalpy of activation were comparatively low and those of the entropy of activation were quite negative. It, therefore, may be concluded that the reaction was to be S_N2 mechanism. It is also found that the change of activation entropy was important in the rate of reaction. Some effects of protic-dipolar aprotic solvent were considered and discussed.

아세톤 및 아세토니트릴 용매중에서 브롬화페나실과 나프틸아민과의 반응속도

박진하 全北大學校 1982 論文集 Vol.24 No.-

The observed pseudo-first order rate constants k_obs for the reactions of phenacyl bromide with 1-and 2-naphthylamine in acetone and acetonitrile were determined by conductometry using the Guggenheim method, and then the second order rate constants k_2 and the third order catalytic rate constants k_3 were calculated from k_obs. The order of magnitude of k_2 was 2-naphthylamine-acetonitrile>2-naphthylamine-acetone>1-naphthylamine-acetonitrile>1-naphthylamine-acetone. k_3 obtained were negative and they are largely due to the formations of charge transfer complexes. Peri-hydrogen effect was observed for 1-naphthylamine. Taking the k_2, the values of entropy of activation were quite negative and those of enthalpy of activation were comparatively low. It, therefore, is concluded that the reaction were to be S_N2 mechanism.

아세톤중 브롬화페나실과 메타 및 파라니트로 아닐린과의 친핵반응속도

朴鎭夏 全北大學校 文理科大學 1976 論文集 Vol.4 No.-

The rate constants for nucleophilic substitution ractions of phenacyl bromide with m- and p-nitroaniline in anhydrous acetone were determined, and the activation parameters were also evaluated. In the result, the reactions were first-order with respect to each reactant and the rate constant of the reaction with m-nitroaniline was larger by about eight times than that of the reaction with p-nitroaniline at 35℃. This is interpreted as meaning that the electron-withdrawing effect of p-nitro group is larger than that of m-nitro group, and that the softness on nitrogen atom of p-nitroaniline is smaller than that of m-nitroaniline. The values of the enthalpy of activation were comperatively low and those of the entropy of activation were quite negative. It is, therefore, concluded that the reactions were to be S_N2 mechanism.

아세톤-물 혼합용매중에서 브롬화파라브로모펜아실과 아닐린과의 반응속도

박진하,오병용 全北大學校 基礎科學硏究所 1984 基礎科學 Vol.7 No.1

The reaction of p-bromophenacyl bromide with aniline in acetone-water have been studied by conductometric method. The observed pseudo-order rate constants were determined by Guggenheim method, and then the second-order rate constants were determined and the activation themodynamic parameters were evaluated. In result, the reaction was second-order and the rate constants were increased as water content and temperature had been increased. The values of enthalpies of activation were comparatively low and those of entropies of activation were quite negative. It, therefore, may be concluded that the reaction was S_N2 mechanism. It was also found that the reaction is entropy controlled.

아세톤 용매중에서 브롬화파라브로모펜아실과 파라톨루아딘과의 반응속도

박진하,이재존 全北大學校 基礎科學硏究所 1983 基礎科學 Vol.6 No.1

The reaction of p-bromophencyl bromide with p-toluidine have been studied in aceton conductomerically. The observed pseudo-first order rate constants were calculates by Guggenheim eguation and the activation thermodymamic parameters were also evaluated. In result, the reaction rate constant was increased at higher temperature, and was second-order. The value of the enthalpy of activation was comparatively low and that of the entropy of activation was quite negative. It, therefore, may be concluded that the reaction is to be S_N2 mechanism.

銅의 Tiron에 依한 吸光光度定量法

朴鎭夏 全北大學校 1970 論文集 Vol.12 No.-

Tiron reacts with copper to form a water soluble copper(11)-tiron complex. The optimum conditions of determination of copper in acidic solution with tiron were examined. The absorbance of copper (11)-tiron complex solution in pH 0f 4.7-5.1 buffered with Clark-Lubs buffer solution were measured at the wave length of 430m_μ. Beer's law obeyed up to 178㎍/ml of copper in the presence of 2.03×10^-2 M of tiron and the apparent molar absorptivity was 93.64±0.34. The composition of copper (11)-tiron complex were investigated by mole ratio method and the result was 1 : 1-2. The effects of temperature, standing time and some foreign ions were also investigated.

Tiron溶液中 銅(Ⅱ)의 Polarography

朴鎭夏,高錫梵 全北大學校 1971 論文集 Vol.13 No.-

Polarographic behaviors of copper (11) in the tiron solution were investigated. Copper(11) in 4.56 mM tiron solution showed a wave, of which half-wave potential was -0.03(V vs. SCE) at the pH of 4.7. The diffusion current varied irregularly with increase of pH. The half-wave potential was constant when the pH was less than 4.1, and increased gradually when the pH was in excess of that, consequently, the number of proton participated in electrode reaction was two. As the result of wave analysis, the number of electron participated in electrode reaction was two, therefore, the wave was reversible. However, the diffusion was not rate-determining process. The relation between the concentration of copper(11) and the diffusion current was satisfactorily linear. The effects of temperature, standing time and some foreign ions were also studied.

아세톤-물 混合溶媒中의 브롬化페나실과 파라클로아닐린과의 反應速度硏究

朴鎭夏,洪性完 全北大學校 基礎科學硏究所 1982 基礎科學 Vol.5 No.1

The rate constants of the reactions of phenacyl bromide with p-chloroaniline in acetone-water at 30, 35 and 40℃ were determined by means of electric conductivity method and some activation parameters were also calculated. In the results, the rate constants were first order with respect to each reactant and increased with water content and the values of entropy of activation were quite negative and those of enthalpy of activation were comparatively low. Therefore, it is concluded that the reactions were to be S_N2 mechanism.