아름다운 사람-2004년 신지식인 선정, 전북시각장애인도서관 송경태 관장

박지혜,Park, Ji-Hye 한국사회복지사협회 2005 Social workers Vol.2 No.-

희귀난치성질환자들의 징검다리 '여울돌'

박지혜,Park, Ji-Hye 한국사회복지사협회 2005 Social workers Vol.6 No.-

가와사키병 환아에서 면역글로불린 투여 전후의 혈중 Nitric Oxide와 Tumor Necrosis Factor-α에 대한 연구

박지혜,신지선,홍영미,Park, Ji Hye,Shin, Jee Seon,Hong, Young Mi 대한소아청소년과학회 2005 Clinical and Experimental Pediatrics (CEP) Vol.48 No.7

목 적 : 가와사키병은 면역 조절 인자의 이상을 동반하는 전신적 혈관염으로 관상동맥질환을 초래한다. NO는 혈관내 평활근의 granulocyte cyclase의 기전에 영향을 미쳐 혈관의 이완을 유발하는 역할을 하며 과다하게 분비될 경우 혈관의 변성을 초래하는 것으로 알려져 있다. 본 저자들은 가와사키병에서 NO와 $TNF-{\alpha}$의 혈중 농도를 측정하여 관상동맥질환 발생과 연관이 있는지 알아보기 위해 본 연구를 실시하였다. 방 법 : 가와사키병 환아 24명을 관상동맥 확장이 없는 군(1군)과 관상동맥 확장이 있는 군(2군)으로 분류하여 각 군의 임상 양상과 면역글로불린 투여 전과 후, 회복기에서의 NO, $TNF-{\alpha}$의 혈중 농도를 면역효소법(ELISA)으로 측정하여 비교하였다. 대조군으로는 같은 시기에 내원한 열이 없는 정상 대조군(3군) 13명과 열이 있는 대조군(4군) 10명으로 하였다. 결 과 : 면역글로불린 투여 전의 혈중 NO는 1군($13.2{\pm}5.7{\mu}mol/L$), 2군($20.4{\pm}10.7{\mu}mol/L$)과 4군($12.4{\pm}8.9{\mu}mol/L$)이 3군($3.1{\pm}1.4{\mu}mol/L$)보다 높았고 2군이 1군과 4군에 비해 유의하게 높았다(P<0.05). $TNF-{\alpha}$는 2군($858.4{\pm}934.0pg/mL$)에서 3군($8.7{\pm}2.3pg/mL$)과 4군($226.7{\pm}647.2pg/mL$)에 비해 유의하게 높았으며 1군($522.4{\pm}859.6pg/mL$)도 3군에 비해 높았다(P<0.05). 면역글로불린 투여 후 NO는 1군, 2군과 4군이 3군에 비해 유의하게 높았으며 $TNF-{\alpha}$는 각 군별로 유의한 차이가 없었다. 가와사키병 관상동맥 확장군과 비확장군 모두에 있어 NO와 $TNF-{\alpha}$의 혈중 농도가 면역글로불린 투여 전에 가장 높았고 면역글로불린 투여 후와 회복기로 갈수록 감소하였다. 또한 관상동맥 확장군에서 백혈구 수치와 혈청 NO는 유의한 양의 상관관계가 있었다(r=0.430). 결 론 : 가와사키병 환자에 있어 NO, $TNF-{\alpha}$의 혈중 농도가 유의하게 높았으며 NO의 농도가 관상동맥이 확장된 환자에서 비 확장군보다 의미있게 높은 것으로 보아 NO가 관상동맥질환에 관여할 것으로 생각한다. Purpose : Kawasaki disease(KD) is a systemic panvasculitis that causes coronary artery lesions. KD is accompanied by immunoregulatory abnormalities. Nitric oxide(NO) can induce relaxation of blood vessels by activating guanylate cyclase in smooth muscle cells and high levels of NO may result in coronary artery lesions. We investigated tumor necrosis factor$(TNF)-{\alpha}$ and NO production before and after intravenous immunoglobulin(IVIG) therapy to study the roles of NO and $TNF-{\alpha}$ in KD with coronary artery lesions. Methods : Serum levels of NO and $TNF-{\alpha}$ were measured in 24 patients with KD(group I, eight patients with normal coronary artery; group II, 16 patients with coronary artery lesions) and 23 controls(group III, 13 afebrile controls; group IV, 10 febrile controls). Blood samples from each subject were drawn before and after IVIG therapy and in the convalescent stage. Serum concentrations of NO and $TNF-{\alpha}$ were measured by enzyme linked immuno sorbent assay. Results : The NO levels before IVIG therapy were significantly higher in group II than in group I, group III and group IV. After IVIG therapy the levels of NO were significantly higher in group I and group II than in group III. The $TNF-{\alpha}$ levels before IVIG therapy were significantly higher in group I and group II than in group III. The serum $TNF-{\alpha}$ and NO levels were higher before IVIG therapy and decreased through the convalescent stage in KD patients. In the acute stage of KD patients with coronary artery lesions, serum NO levels significantly correlated with white blood cells (r=0.43, P<0.05). Conclusion : The serum concentration levels of $TNF-{\alpha}$ and NO were abnormally high in KD patients and NO concentrations were statistically higher in the KD patients with coronary artery abnormalities than those without coronary abnormality during the early stage of the KD. These results suggest NO may be involved in the development of coronary artery lesions.

염소의 표면처리에 따른 IR 및 CR Blend의 특성 연구

박지혜,이창섭,박현호,Park, Ji-Hye,Lee, Chang-Seop,Park, Hyun-Ho 대한화학회 2010 대한화학회지 Vol.54 No.6

본 연구에서는 IR과 CR의 블렌딩을 통하여 물성 개선 및 내구 성능 개선을 목적으로 IR/CR의 비율을 다양하게 블렌딩하여 제조한 고무시료의 가교 특성, 물성 변화, Morphology의 변화 및 화학적 특성을 조사하였다. 한편으로 블렌딩 된 고무에 다양한 조건으로 염소 표면처리를 하였을 때 고무시료의 Morphology를 관찰하고 마찰 시험을 통해 염소의 표면처리가 마찰계수에 미치는 영향을 조사하였다. 고무의 가교특성에서는 CR의 함량이 증가할수록 가교 속도가 감소하였으나 가교밀도는 일정하였고,경도, 모듈러스가 증가하였는데 이것은 가교특성의 변화와 밀접한 관계가 있으며, 가교 반응의 활성화에 의한 결정화 영향으로 기계적 강도가 증가하는 것으로 나타났다. 노화 후 물성 변화는 IR/CR Blend가 상호 기계적 물성의 단점을 보완하여 노화에 의한 물성 변화를 감소시키는 역할을 하는 것으로 나타났다. 염소 표면처리 한 시료의 노화 전, 후 상태물성의 변화는 감소하였다. 현미경 사진 관찰 결과 CR 함량 증가에 따라 표면 분산도가 증가함을 알 수 있었다. 염소 표면처리된 고무의 표면은 일정한 방향으로 균일하게 표면처리되었고 매끄러움과 광택이 증가하였다. 고무 표면의 개질 정도는 표면염소잔류량으로 확인할 수 있었으며, 마찰계수는 고무와 결합된 염소함량에 의존하는 것으로 나타났다. CR 함량이 10 - 40 phr까지는 표면처리 초기단계에서 마찰계수가 급격히 감소하였으나, 처리용액의 염소농도가 증가할수록 마찰계수의 감소는 둔화되었고, CR 함량이 50 phr에서는 처리용액의 염소농도 변화에 따라 마찰계수의 감소가 둔화되었다. In this study, rubber vulcanization property, change in physical property, morphology and chemical characteristics of blended rubber depending on various IR/CR ratio were investigated for the purpose of the improvement of material property and durability. The effect of surface treatment by chlorine on the friction coefficient was also studied with various conditions of surface treatment. In terms of vulcanization property, as the amount of CR content increased, the speed of cure was decreased, while the density of crosslinking stayed constant. It means hardness and modulus were increased as the CR content increased. It is related to change in cure property and mechanical strength was improved by the effect of crystallization reaction. In the aging property, as the CR content increases, the changed amount of basic properties were decreased, which acts as a reducing factor in change of aged property by complementing weak point in mechanical property. It was found that the degree of property change for surface treated samples were reduced. According to the microscopic result, the degree of surface dispersion on rubber blends was increased by increasing CR content. Rubber surface showed uniform direction in pattern with increased smoothness and luster by treatment with chlorine. The degree of rubber reforming was measured by the remaining amount of chlorine and the friction coefficient was dependent on the amount of chlorine combined with rubber. In the initial stage of surface treatment, from 10 to 40 phr, the friction coefficient of specimen was rapidly reduced. However, as the concentration of chlorine solution increased, the change in friction coefficient was decreased.

결혼 이주여성을 위한 멘토링 프로그램

박지혜,Park, Ji-Hye 한국사회복지사협회 2006 Social workers Vol.10 No.-

중심시야 결손 여부에 따른 녹내장시야지표의 유용성

박지혜,유정권,김용연,Ji-Hye Park,Chung Kwon Yoo,Yong Yeon Kim 대한안과학회 2011 대한안과학회지 Vol.52 No.6

Purpose: To evaluate the glaucoma discrimination ability of visual field index (VFI), a new perimetric index of Humphrey field analyzer II, in glaucoma patients with central and peripheral visual field defects (VFD). Methods: Humphrey visual field test and OCT were performed in 204 glaucomatous eyes and 70 healthy eyes. The associations of VFI with mean deviation (MD), pattern standard deviation (PSD), and average retinal nerve fiber layer thickness (RNFLT) were analyzed using Pearson’s correlation. The diagnostic abilities of the parameters were analyzed using the areas under the receiver operating characteristic curves (AUROC). The AUROC were compared between MD-matched patients with central VFD (at least one point with p < 1% within the central most 16 points of 30-2 SITA standard automated visual field) and peripheral VFD (VFD beyond the central most 16 points of 30-2 SITA standard automated visual field). Results: The associations between analyzed parameters and VFI were statistically significant. The MD, RNFLT, age, intraocular pressure, and central cornea thickness were not different between the two groups (p > 0.05). The AUROC value of VFI was greater than those of the MD and average RNFLT but was not different from that of PSD (p = 0.332) in the central VFD group. However, there were no significant differences between AUROC value of VFI and those of other parameters in the peripheral VFD group (all, p > 0.05). Conclusions: The results from the present study suggest that VFI may be more useful than MD in diagnosing glaucoma, especially in patients with central VFD. J Korean Ophthalmol Soc 2011;52(6):709-715

매체순환연소를 위한 Ni계열 산소전달입자의 반응 특성 및 반응 모델

박지혜,황라현,백점인,류호정,이광복,PARK, JI HYE,HWANG, RA HYUN,BAEK, JEOM-IN,RYU, HO-JUNG,YI, KWANG BOK 한국수소및신에너지학회 2018 한국수소 및 신에너지학회논문집 Vol.29 No.1

Reaction characteristics and kinetics of a oxygen carrier (OCN717-R1SU) for chemical looping combustion (CLC) have been investigated using TGA by changing gas concentration (10-30 vol.% $CH_4$) and reaction temperature ($825-900^{\circ}C$). Reaction rate of OCN717-R1SU increased as temperature increased and it was found that reaction is delayed at the initial reaction regime. Johnson-Mehl-Avrami (JMA) model was adopted to explain the reaction phenomenon. The activation energy (E) determined by JMA model in reduction reaction of OCN717-R1SU is $151.7{\pm}2.03kJ/mol$ and pre-exponential factor and JMA exponent were also obtained. The parameters calculated in this study will be applied in design of the reactor and operation conditions for CLC process.

한국장애인재활협회 장애청년 헤드헌팅대회

박지혜,Park, Ji-Hye 한국사회복지사협회 2006 Social workers Vol.8 No.-

채혈 시간에 따른 부신피질 자극 호르몬 검사의 참고치 설정에 관한 고찰

박지혜,최진주,임수연,유선희,이선호,Ji-Hye Park,Jin-Ju Choi,Soo-Yeon Lim,Seon-Hee Yoo,Sun-Ho Lee 대한핵의학기술학회 2023 핵의학 기술 Vol.27 No.1

Purpose The reference range described in Adrenocorticotropic Hormone reagent used in our laboratory is 10-60 pg/mL at 8 a.m. to 10 a.m., and 6-30 pg/mL at 8 p.m. to 10 p.m. However, in the case of outpatients, blood is mainly collected between 10 a.m. and 6 p.m., accounting for 57.8% of the total. Therefore, This study is intended to help make a more accurate diagnosis by reevaluating the reference range provided by the manufacturer of the Adrenocorticotropic Hormone reagent and setting split-timed reference range. Materials and Methods The patients collected blood before 10 a.m. were group A (68 people), and the patients collected blood after 10 a.m. were set to group B (80 people). A T-test was performed between groups to test their significance. And it was confirmed whether it was necessary to set the gender classification as a subgroup. The method of setting the reference range was calculated by the Bayesian's method and the Hoffmann's method. Results The reference range of Group A was 8.6 to 60.6 pg/mL by the Bayesian's method, and the Hoffmann's method was 3.6 to 61.3 pg/mL. The reference range of Group B was 6.9 to 50.5 pg/mL when applying the Bayesian's method, and the Hoffmann method's was 2.3 to 48.9 pg/mL. Conclusion This study was concluded that it was necessary to set the split-timed reference range. Through this study, the later the blood collection time, the lower the level of Adrenocorticotropic Hormone, indicating that blood collection time is important for patients with clinical significance. If a large number of subjects are selected and supplemented in the future, it is believed that systematic and accurate reference range can be set.

3차원 공간정보 오픈 플랫폼을 활용한 일조 시간 산정

박지혜,서용철,PARK, Ji-Hye,SUH, Yong-Cheol 한국지리정보학회 2017 한국지리정보학회지 Vol.20 No.3

오늘날 도시성장과 인구밀집으로 인해 많은 대도시에서 빌딩숲이 생겨나고, 그로인한 쾌적한 거주환경에 대한 요구가 커지면서 일조권 침해에 대한 관심이 증가하고 있다. 이와 관련한 법규 및 관련분야의 연구가 수행되기 시작하였으나, 특정 전문기관에 의뢰 없이 일반인이 쉽게 건물 층별 일조권을 파악하는 데에 한계가 있다. 따라서 본 연구에서는 공간정보 오픈 플랫폼을 이용하여 도시음영지역 분석 시뮬레이션을 통한 건물 객체별 일조량을 산정하였다. 연구 대상지는 부산광역시에 위치하고 있는 해운대구 신도시를 대상으로 하였다. 이를 위하여, 해운대구 신도시지역에 대한 공간정보를 구축하기 위해 기 구축된 건축물 3차원 공간정보 데이터에서 건물높이를 추출하고, 태양의 고도와 방위각을 이용하여 3차원 도시 공간 음영분석 시뮬레이션을 수행하였다. 건물의 각 객체별 일조권을 연속 일조시간과 총 일조시간으로 구분해 정량적으로 분석함으로서 일조권 침해 여부를 보다 정밀하게 간편하게 판단할 수 있는 방법을 제시하였다. Due to urban growth and increasing population density, many large cities contain building forests. Moreover, due to increasing demands for pleasant residential environments, there is growing concern over the encroachment of sunshine. Although research on related laws and other related fields is emerging, there is a limit to the extent to which the public can easily determine the amount of sunshine per building without referral to specialized agencies. Therefore, in this study, the duration of sunshine per building object was calculated via a simulation of urban shaded area using a spatial information open platform application programming interface. The study area was the'L'apartment complex located in the new city, Haeundae, Busan, China. To perform the duration of sunshine simulation for three-dimensional urban spatial objects, the building height was extracted from pre-built three-dimensional spatial information data, and the position of the sun was determined from calculations of the altitude and azimuth of the sun. This study provides a more precise and easier method of judging whether sunshine is impeded from reaching buildings by quantitatively analyzing sunshine and classifying the total duration of sunshine and the continuous duration of sunshine on each object.