사암도인침법의 통증 질환 접근법에 대한 고찰

박지연 ( Ji-yeun Park ),이순호 ( Soon-ho Lee ),김송이 ( Song-yi Kim ),박히준 ( Hi-joon Park ) 대한경락경혈학회 2017 Korean Journal of Acupuncture Vol.34 No.2

Objectives : Saam acupuncture initiated by Saamdoin in 17^th century is one of the most widely adopted acupuncture techniques used by Korean medical doctors in clinic. Our study aimed to analyze the application of the Saam acupuncture method to pain diseases based on the literature data. Methods : Based on the contents described in 『(Do Hae Kyo Kam) Saam`s acupuncture method』, the texts related to pain condition were analyzed. The frequency of prescription of Saam acupuncture method was analyzed, and then the relationships between each acupoint were visualized by network analysis and hierarchical cluster analysis for the quantitative aspect. Results and conclusions: In our study, Lung tonifying and Liver tonifying acupuncture were the most frequently used method for the treatment of pain disease. As the acupoints, BL66 and SI5 were used the most frequently. It was found that visceral pattern identification was considered as the most important factor in the selection of the Saam acupuncture method. Network analysis and hierarchical clustering analysis showed that each acupoint was closely related to other acupoints, and most of them were connected more closely according to the method of Saam acupuncture operation. The experiential prescriptions of Saam acupuncture were classified as an independent group. In the future, fundamental research on the principle of Saam acupuncture method is needed for the various diseases, and research for the clinical efficacy and the mechanism of Saam acupuncture method should be preceded.

한국에서 발생한 침구요법의 이상반응 보고사례에 대한 체계적 분석

박지연(Ji-Yeun Park),김송이(Song-Yi Kim),채윤병(Youn-Byoung Chae),채한(Han Chae),구성태(Sung-Tae Koo),김승태(Seung-Tae Kim),신상우(Sang-Woo Shin),장인수(In-Soo Jang),이상훈(Sang-Hoon Lee),인창식(Chang-Shik Yin),이혜정(Hye-Jung Lee) 대한한의학회 2010 대한한의학회지 Vol.31 No.2

통증과 우울증의 병합 동물모델에 대한 최신 연구 동향 분석

송지혜 ( Ji-hye Song ),국혜정 ( Hye-jung Kook ),박병진 ( Byung-jin Park ),김송이 ( Song-yi Kim ),박지연 ( Ji-yeun Park ) 경락경혈학회 2021 Korean Journal of Acupuncture Vol.38 No.2

Objectives : The purpose of this study is to analyze animal behavioral changes and related neurobiological mechanisms in recent studies using animal models with pain and depression. Methods : We conducted database search in Pubmed, NDSL, and EMBASE up to January 2021. Included studies were classified as depression-like behavior observed in pain model, pain-like behavior observed in depression model, and pain and depression comorbidity model. The results of pain- and depression-like behaviors, the changes of neurobiological mechanisms, and the treatment methods such as drugs, natural substance-derived chemicals, or acupuncture were analyzed. Results : We included 124 studies (81 studies in depression-like behavior observed in pain model, 19 studies in pain-like behavior observed in depression model, and 24 studies in pain and depression comorbidity model). Pain and depression comorbidity animal models were induced using various methods by drugs or surgery. Von frey test, a method for evaluating mechanical allodynia was the most commonly used for measuring pain-like behavior and the forced swimming test was the most commonly used for measuring depression-likes behavior. The changes of neurobiological factors, such as decrease of 5-hydroxytryptamine and increase of oxidative stress and pro-inflammation cytokines were generally changed in the frontal cortex, hippocampus, thalamus, and spinal cord in all types of models. For treating pain and depression-like behaviors, various types of drugs such as antidepressant, tranquilizer, analgesic, and natural substance-derived chemicals were used. Acupuncture treatment was used in 4 studies. Conclusions : In the future, more diverse studies on the combined model of pain and depression need to be conducted. In addition, it is necessary to establish a mechanistic basis for the development of various treatments by identifying the common mechanisms of pain and depression.

국내 한방 패치 특허 현황에 대한 분석연구

박선주,우성천,박지연,Park, Sunju,Woo, Seong-Cheon,Park, Ji-Yeun 대한예방한의학회 2018 대한예방한의학회지 Vol.22 No.1

Objectives : The purpose of this study is to present trends and contents of herbal Korean Medicine patches by analyzing the herbal patches in Korean patents. Methods : Electronic search for herbal patch patents was conducted in KIPRIS (Korea Intellectual Property Rights Information Service). Korean patents that were registered by January 1, 2018 were selected in study. Patents that were not using herbal medicine or not related to patch were excluded in this study. The applicant, application date, International Patent Classification (IPC), contents and adhesive site of patches, target diseases, model of experiment and extraction methods were analyzed. Results : A total of 17 patents were included in this study. In applicant analysis, 61.5% of applicants were corporations. All IPCs in patents were involved in Section A (Human necessities & Agriculture) and 66.7% of IPCs were A61K (Preparations formedical, dental, ortoiletpurposes). In types of patch, 8 patents were hydrogel patches (47.1%), followed by 3 heating patches (17.6%). Skin related symptoms were the most targeted diseases (52.9%), Human was the most used model in experiments. Solvent extraction and hot water extraction were used frequently, and some patents had no limit for extraction were also existed. Conclusions : The study results will be helpful to diversify formulation of herbal medicine, to expand market scale of patent and to develop new application using Korean medicine. In order to establish sufficient data for utilizing patent technologies, more patent studies providing analyzed patent information are needed.

노년기 식생활에 대한 중ㆍ장년 층의 가치관

구난숙(Koo, Nan Sook),박지연(Park, Ji Yeun) 한국생활과학회 2000 한국생활과학회지 Vol.9 No.2

대전지역 성인 남ㆍ녀의 건강보조제 및 건강식품 섭취실태

구난숙(Koo, Nan Sook),박지연(Park, Ji Yeun) 한국생활과학회 2001 한국생활과학회지 Vol.10 No.2

국내분리 오제스키병 바이러스의 게놈 유전자 특성 분석

현방훈,김인중,표현미,차상호,박지연,송재영,조인수,양창범,안수환,이중복,Hyun, Bang-Hun,Kim, In-Joong,Pyo, Hyun-Mi,Cha, Sang-Ho,Park, Ji-Yeun,Song, Jae-Young,Cho, In-Soo,Yang, Chang-Bum,An, Soo-Hwan,Lee, Joong-Bok 대한수의학회 2009 大韓獸醫學會誌 Vol.49 No.1

The molecular genetic characterization of Aujeszky's disease virus (ADV) Yangsan strain (ADVYS), a Korean isolate, was investigated by analyzing the electrophoresis patterns and the physical maps of the viral DNA digested with various endonucleases. To establish DNA library for ADV-YS, twelve major BamHI restricted segments were cloned. Each location of the segments in the ADV genome was determined by sequence comparison with the sequences reported in Genbank and those sequences of the both termini of the segments. Physical maps were constructed based on the electrophoresis patterns of the digested viral DNA by restriction endonuclease and the results of Southern blot analyses with various DIG labeled probes originated from those of enzyme restricted segments of virulent (Shope) and avirulent (Bartha) strain. Comparing ADV-YS with a standard strain of Kaplan in the maps of restriction enzymes, following major respects were identified: (i) disappearance of BamHI restriction site between the first and second BamHI segments, (ii) creation of the BamHI restriction site in the fifth segment, and (iii) generation of the BglII site in the unique short (US) region. The genome of ADV-YS also contains a type 2 herpesvirus DNA molecule (in which the US region only inverts itself relative to the unique longregion) like all other ADV strains except Norden strain(type3), analyzed up to date. The size of the ADV genome estimated from the sizes of the restriction enzyme fragments, was approximately 145.3 kb (BamHI) or 145.4 kb (BglII). BamHI enzyme cleavage patterns were compared among the five Korean ADV isolates: Yangsan, Yongin, Dangjin, Jincheon and Iksan strains. Difference either in the number or in the size of the DNA fragments, suspected regions of termini of IR and TR, could be detected among all five strains.

국내 인ㆍ허가 온열의료기기 기술 현황 조사 및 분석

임수란 ( Su-ran Lim ),박정환 ( Jung-hwan Park ),박지연 ( Ji-yeun Park ),김송이 ( Song-yi Kim ) 경락경혈학회 2023 Korean Journal of Acupuncture Vol.40 No.4

Objectives : This study aimed to determine the status of thermal stimulation devices approved in Korea for medical applications over the past 10 years, and based on this, to obtain insight for future thermal treatment in Korean medical institutions. Methods : We searched the item classification list entitled Regulations on Medical Device Items and Rating by Item” from the Ministry of Food and Drug Safety Notice No. 2021-24, 2021 (Enforced March 19, 2021; www.mfds.go.kr) for individually licensed heaters using the terms heat and heating. Results : We identified 17 items of thermal stimulation product group, of which 1,308 devices were licensed by February 4, 2022, and 53.2% of them (n=696) were devices with valid permits for distribution in Korea. Among the licensed devices, heating pad systems under/overlay (electric, home use) were approved the most, but combinational stimulator (for medical use, home use; Grade 2) accounted for the highest percentage among the current valid permission. Moxibustion apparatuses were licensed separately for electrical use and non-electrical use, and occupied a low percentage of the total devices. We analyzed 307 devices that were accompanied by technical documents and found that the heat sources were wires in 145 (47.2%), infrared rays in 44 (14.3%) and ultrasonic waves in 42 (13.7%) devices. Most (83.1%) devices were used for pain relief, while other applications included beauty, cancer treatment, maintenance of infant body temperature, and healing fractures. Conclusions : Thermal stimulation devices accounted for about 0.9% of all medical devices, and among them, combinational stimulators and heating pad systems under/overlay had the most valid permits. Thermal stimulation devices using heating wires and infrared rays were the most prevalent, and most were used to relieve pain. In order to develop a range of thermal stimulation devices that can be utilized in Korean medical institutions, it is imperative that they have potential applications beyond pain management, addressing various medical purposes. To achieve this, foundational research is necessary to effectively apply diverse heat sources based on medical objectives.

한방의료기관의 온열 치료 기기 활용 현황 및 개발 수요에 대한 조사 연구

인소영 ( So-young In ),임수란 ( Su-ran Lim ),박지연 ( Ji-yeun Park ),박정환 ( Jung-hwan Park ),김송이 ( Song-yi Kim ) 경락경혈학회 2023 Korean Journal of Acupuncture Vol.40 No.4

Objectives : This study investigated the current utilization status of thermotherapy devices in Korean medicine (KM) institutions and identified areas for improvement and further development, as perceived by KM doctors (KMDs). Methods : An online survey was conducted, targeting KMDs primarily engaged in clinical patient care. The questionnaire included items about respondents’ clinical practices, the extent of thermotherapy device usage, their opinions on these devices, and perceived improvement needs. The collected data underwent quantitative analysis. Results : From the 1,025 respondents, data from 862 respondents who provided complete responses were analyzed. On average, respondents utilized thermotherapy treatments for 80% of their patients. Infrared (IR) phototherapy unit, electrical moxibustion apparatus, and heater-based thermotherapy devices were predominantly owned by respondents, with IR being the most frequently used. The average satisfaction score for current thermotherapy devices was 79. A significant concern raised was the necessity for improved health insurance coverage and efficacy evaluation. Conclusions : This research has confirmed that the extensive use of thermotherapy devices by KMDs in treating primarily musculoskeletal and gastrointestinal ailments - common conditions among patients in KM institutions. The main areas identified for improvement encompass safety, cost-effectiveness, and device efficacy. Future enhancements in thermotherapy devices should address these crucial aspects.

간정격과 사관혈 침 치료의 우울 행동 개선 효과 및 뇌신경 반응성 분석 연구

엄근향 ( Geun-hyang Eom ),류재상 ( Jae-sang Ryu ),박지연 ( Ji-yeun Park ) 경락경혈학회 2021 Korean Journal of Acupuncture Vol.38 No.3

Objectives : We aimed to identify the antidepressant effect of liver tonification acupuncture treatment (ACU (LT); KI10, LR8, LU8, LR4) and four gate acupuncture treatment (ACU (FG); LI4, LR3) and its brain neural activity in the normal and chronic restraint stress (CRS)-induced mouse model. Methods : Firstly, normal mice were given ACU (LT) or ACU (FG) and the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Secondly, CRS was administered to mice for 4 weeks, then ACU (LT) or ACU (FG) was performed for 2 weeks. The depression-like behavior was evaluated using open field test (OFT) before and after acupuncture treatment. Then, the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Results : In normal mice, ACU (FG) regulated brain neural activities in the hypothalamus, hippocampus, and periaqueductal gray. ACU (LT) changed more brain regions in the prefrontal cortex, insular cortex, striatum, and hippocampus, including those altered by ACU (FG). In CRS-induced model, ACU (LT) alleviated depression-like behavior more than ACU (FG). Also, brain neural activities in the motor cortex area 2 (M2), agranular ventral part and piriform of insular cortex (AIV and Pir), and cornu ammonis (CA) 1 and CA3 of hippocampus were changed by ACU (LT), and those of AIV and CA3 were also changed by ACU (FG). As in normal mice, ACU (LT) resulted in changes in more brain regions, including those altered by ACU (FG) in CRS model. M2, Pir, and CA1 were only changed by ACU (LT) in depression model, suggesting that these brain regions reflect the specific effect of ACU (LT). Conclusions : ACU (LT) relieved depression-like behavior more than ACU (FG), and this acupuncture effect was associated with modulation of brain neural activities in the motor cortex, insular cortex, and hippocampus.