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제올라이트 Beta, USY, Mordenite 촉매를 이용한 Methylnaphthalene의 트랜스메틸화 반응
박중남 ( Jung Nam Park ),박용기 ( Yong Ki Park ),백진욱 ( Jin Ook Baeg ),홍석인 ( Suk In Hong ),이철위 ( Chul Wee Lee ) 한국화학공학회 2005 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.43 No.5
1-methylnaphthalene(1-MN)과 2-methylnaphthalene(2-MN) 사이에서의 트랜스메틸화 반응을 제올라이트, H-mordenite (HM), H-Beta(Hb), H-USY(HUSY) 촉매를 이용한 고정층 반응기에서 수행하였다. Hb25(SiO2/Al2O3=25) 촉매는 다음과 같은 조건, 반응온도 350˚C, 반응압력 1.5Mpa, 전체 액상 반응물의 WHSV 2.7gfeed/gcat · h, 반응물 1-MN과 2-MN의 몰비 1:1, 반응 1시간에서 2-MN/1-MN 비=2.3와 2,6-DMN/2,7-DMN 비=1.3을 보이면서 다른 촉매보다 높은 전환율과 안정성을 나타내었다. 촉매의 세공구조, 산성도와 관련하여 촉매성능을 해석하였다. Catalytic performances of zeolite catalysts such as H-mordenite (HM), H-Beta (Hb), H-USY (HUSY) for the transmethylation between 1-methylnaphthalene (1-MN) and 2-methylnaphthalene (2-MN) were investigated in a fixed-bed flow reactor. Hb showed higher and more stable conversion than others to exhibit a high and stable 2-MN/1-MN ratio of 2.3 and 2,6-DMN/2,7-DMN ratio of 1.3 at the 1st hour of time on stream under the reaction conditions as follows: reaction temperature of 350˚C, reaction pressure of 1.5 MPa, WHSV of 2.7gfeed/gcat·h and the molar ratio of 1-MN and 2-MN of 1:1. The catalytic behavior has been discussed in relation with the catalyst pore structure and acidity.
최적화에 의한 Ketoconazole Solid Dispersion System 의 약물 속도론적 연구
신영희,박중남,이치호 慶星大學校 1991 論文集 Vol.12 No.3
Ketoconazole was manufactured as solid dispersion system(SDS)by computer optimization technique and pharmacokientic properties were investigated in vivo by animal study using rabbits. Following results, doses (25,50 and 100mg/kg)and AUC?? had both a good relationship between them administered by SDS as well as ketoconazole only. AUC?? obtained by administration of ketoconazole only, physical mixture and SDS was occurred SDS>physical mixture>ketoconazole only in turn and plasma comcentration was increased about 2.3 fold by SDS administration than ketoconazole only. The results obtained by in vivo absorption test of SDS that made maximum dissolution in the artificial intestinal juice revealed a good relationship between in vitro and in vivo test.