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Lactobacillus plantarum 첨가 고추장의 C57BL/6 마우스에서 대장염 예방 증진효과
박의성,허주희,임양이,주재현,박건영 한국식품저장유통학회 2017 한국식품저장유통학회지 Vol.24 No.8
Gochujang, a traditional Korean food, is fermented by mixing red pepper powder, various grain, meju and salt. Changes in the kind of ingredients and fermentation method could increase health functionalities. In this study, in vivo anti-colitis effects of gochujang prepared with mixed grains, bamboo salt baked 3 times and meju starters on DSS-induced colitis in C57BL/6 mice were studied. We prepared gochujang prepared with mixed grains (MG), bamboo salt, and Aspergillus oryzae (A) and Baccillus subtilis (B) mixed starters (MG-AB) and gochujang prepared with MG, bamboo salt and A, B and Lactobacillus plantarum (L) mixed starters (MG-ABL). MG-AB and MG-ABL significantly increased body weight and colon length compared to the control (p<0.05). MG-ABL showed significantly decreased interleukin-6 (IL-6) expression in serum compared to the control and MG-AB group (p<0.05). MG-ABL also regulated mRNA and protein levels of pro-apoptotic Bcl-2-associated X protein (Bax) and anti-apoptotic B-cell lymphoma-2 (Bcl-2) in the mice colon tissue (p<0.05). Therefore, MG-ABL exhibited the increased anticolitis effects by inhibiting damage of colon tissue, probably by regulating a pro-inflammatory cytokine of IL-6 and regulated apoptosis related genes. These results indicated that gochujang changed with good ingredients and starters had colitis preventive effects and might be due to active compounds in mixed grain and bamboo salt, and produced by L during the fermentation of gochujang.
박의성,유정,이혜진,임양이,이승민,박건영 한국식품영양과학회 2021 Journal of medicinal food Vol.24 No.4
The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied. We prepared three types of sea salt: generally manufactured sea salt (GS), generally manufactured after filtering seawater (FS), and manufactured with only new seawater (NS). Sea salt intake increased colon length and reduced colon length/weight ratio, tumor number, and progression of colon cancer in colon tissue. The differently prepared sea salts also ameliorated liver injury. In addition, the mineral composition of each salt was different. Moreover, the sea salts enhanced activation of natural killer cell (CD56) expression in colon and spleen tissues. However, the mineral compositions of sea salts were not simply associated with anticancer effects in AOM/DSS+HFD induced mice. Thus, the anticolorectal cancer effects of sea salts may be mediated by different factors, which remain to be identified.
박의성,박은정,Jia-Le Song,김인석,박건영 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.10
We investigated the preventive effects of Ramyeon made from brown rice–sorghum noodles and doenjang–bamboo salt soup (BS+DB) on colitis induced by dextran sulfate sodium (DSS) in C57BL/6 mice. Noodles were prepared with 10% brown rice and 10% sorghum powders added to wheat flour and potato powder, and soup was made using starter fermented (SF) doenjang powder (32%) and bamboo salt (13.5%). The experimental animals were divided into five groups: Normal, Control, BS (brown rice and sorghum noodles)+DB (doenjang and bamboo salt soup) (BS+DB Ramyeon), W (white flour noodles, commercial one)+DB, W+dC (W+doenjang commercial soup), and W + D (W+SF doenjang powder [100%]). The BS+DB and W + D groups showed significant reduction of DSS-induced colitis symptoms (P < .05). Doenjang soup (100%) (W+D) also showed a strong anticolitic effect even though the noodles were prepared with W. Histological observation of the colon revealed that BS+DB Ramyeon markedly alleviated colitis development in mice. Serum protein and mRNA levels of proinflammatory cytokines (TNF-α, IL-1β, and IL-6) were significantly suppressed in colon tissue of the BS+DB group compared with those of the W+DB and W+dC groups. BS+DB Ramyeon also reduced colon mRNA levels of inducible nitric oxide synthase and cyclooxygenase-2 compared with those of other groups (P < .05). Our results show that modification of noodle ingredients using brown rice and sorghum as well as alteration of soup composition using doenjang and bamboo salt improved the health benefits of Ramyeon.
청소년의 가정폭력 경험이 학교폭력 가해행동에 미치는 영향 - 발달자산의 매개효과를 중심으로
박성숙,박성옥,손의성 한국상담학회 2015 상담학연구 Vol.16 No.1
This study aims to verify that the developmental assets mediate the relationships between domestic violence experienced by adolescents and school violence action, and also this study has been carried out to identify that there is a double mediating effect provided by external assets and internal assets. In order to get the answers, a survey of 1,330 male and female adolescents was carried out. And the relations among variables have been analyzed by using the SEM(structural equation modeling), and the medium effects have been verified by applying the phantom model-based bootstrapping as well. According to the study results, it has been verified that the internal and external developmental assets partially mediated the relationship between domestic violence against adolescents and school violence action, also it has turned out that the dual mediating effects of internal developmental assets through external developmental assets are bigger than the direct effects of domestic violence experience on school violence action. It suggests that the increase in the level of external assets is related to the increase in the level of internal assets, which results in reduction of school violence actions, so that the authors have concluded that the school violence actions can be reduced by building up external and internal developmental assets. According to the study results, it is required to intervene in the lives of adolescent, as well as to build programs for promotion of developmental assets in connection with families, schools, neighbors and schools, so that youth violence and delinquency can be reduced and successful growth can be maintained as well. 본 연구는 발달자산이 청소년의 가정폭력경험과 학교폭력 가해행동 간의 관계를 매개하는지, 그리고 외적발달자산과 내적발달자산의 이중매개효과가 있는지를 검증하기 위해 수행되었다. 이를 위해 중. 고등학교 남․녀 재학생 1,330명을 대상으로 설문을 실시하고, 구조방정식모형(structural equation modeling, SEM)으로 변수 간 인과관계를 분석하고, 팬텀모형(phantom model)에 의한 Bootstrapping 방법을 적용하여, 매개효과를 검증하였다. 연구 결과, 청소년의 가정폭력경험이 학교폭력가해행동에 영향을 미치는 관계에서 외적발달자산과 내적발달자산의 부분매개효과가 검증되었고, 가정폭력경험이 학교폭력 가해행동에 직접 작용하는 것보다는 외적발달자산을 통한 내적 발달자산의 이중매개효과가 더 큰 것으로 파악되었다. 외적발달자산 수준의 증가는 내적발달자산 수준의 증가와 관련되고 내적발달자산 수준의 증가는 학교폭력 가해행동의 감소와 관련되는 것으로 나타나, 외적․내적 발달자산의 조성을 통해 학교폭력 가해행동 감소에 영향을 줄 수 있음을 시사하였다. 따라서 가정폭력을 경험한 청소년의 폭력비행 감소와 성공적인 성장발달을 위해 가족, 학교, 이웃, 지역사회 등이 관련된 발달자산 증진 프로그램의 구축과 개입이 필요함을 보여주었다.