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돌연변이 p53 단백질의 Silencing에 의한 사람유방암세포의 in vivo 항종양 효과
박원익(Won Ick Park),박세라(Se-Ra Park),박현주(Hyun-Joo Park),배윤희(Yun-Hee Bae),유현수(Hyun Su Ryu),장혜옥(Hye-Ock Jang),배문경(Moon-Kyoung Bae),배수경(Soo-Kyung Bae) 한국생물공학회 2016 KSBB Journal Vol.31 No.1
Mutant p53 (R280K) is highly expressed in MDAMB-231 triple-negative human breast cancer cells. Currently, we reported the role of mutant p53-R280K in mediating the survival of MDA-MB-231 cells in vitro. The present study was undertaken to determine whether mutant p53-R280K affects breast cancer cell growth in vivo. To this end, we used small interfering RNA to knockdown the level of mutant p53- R280K in MDA-MB-231 cells. Silencing of mutant p53- R280K in MDA-MB-231 cells causes substantial tumor regression of established xenografts in vivo. In xenograft model for breast cancer, silencing of mutant p53-R280K in MDAMB-231 cells significantly inhibited the tumor growth. Moreover, TUNEL assay showed more occurrence of apoptotic cells in mutant p53-R280K silenced tumors compared to control. Our data indicate that mutant p53-R280K has an important role in mediating tumor growth of MDA-MB-231 cells in vivo. Taken together, this study suggests that endogenous mutant p53-R280K could be used as a therapeutic target for breast cancer cells harboring this TP53 missense mutation.
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'Long Days's Journey Into Night'의 劇構成上의 特徵考察
박원익 단국대학교 대학원 1989 學術論叢 Vol.13 No.-
The purpose of this thesis is to study all the characteristics of dramatic structure in LDJ. This play is said to be O'Neill's autobiographical work written in tears and blood, and with deep pity and understanding and forgiveness. In terms of two sides : outward and inward, this play has many features. First, in the external phase, rhythm and repetition, description of characters, and treatment of time are a most remarkable. Secondly, in the internal phase, understanding and forgiveness, and transcendental spirit are noticeable as well. More than anything else, this play is characterized by its setting, its symbolic words and its souds : fog, foghorn, ships'bell, ominous coughing, and movement in the upstairs room. All the characters can blame one another, but their basic relationship tied on hate-love, anger-regret, and harshiness-pity rhythms remains uninfluenced because of love. Edmund's compromise with his brother and father can be thought to be the play's climax. This compromise derives from understanding and forgiveness, and develops into trascendence : the Eastern Nirvana.
ScienceON
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