포스펜 안압계와 골드만 안압계에 의한 안압측정치의 비교와 상관관계 분석

박운철,박기호.Un Chul Park. M.D.. Ki Ho Park. M.D.. Ph.D.. 대한안과학회 2005 대한안과학회지 Vol.46 No.1

Purpose: To compare the intraocular pressure (IOP) measured by the pressure phosphene tonometer (PPT) and the Goldmann applanation tonometer (GAT) according to the feedback of the IOP measured by GAT and the use of the dominant hand during the measurement. Methods: In a group of 40 eyes of 40 normal subjects in their twenties and thirties without diagnostic specificity, IOP was measured with PPT three times by themselves and with the GAT by one examiner on 3 different days. In 20 eyes of the feedback group, the subjects were informed of their IOP measured by GAT and were allowed to measure with PPT again. In each group, half of the eyes (20 eyes) were assigned to use the dominant hand to measure the IOP (dominant group) and the other half (20 eyes) were assigned in the other way (nondominant group). Results: In feedback, nonfeedback and dominant groups, comparison of the first day showed statistically significant differences of mean IOP. But on the third day, there were no significant differences among all 4 groups and there were significant correlations. There was a stronger correlation between the two methods in the feedback group (r=0.721) than in the nonfeedback group. The correlation coefficient of all 40 eyes was 0.605 (p<0.001). Conclusions: PPT has a strong correlation with GAT in the range of normal IOP and is thought to be more useful as a self tonometer for the measurement of both eyes with the periodical measurement of IOP by GAT in clinics.

특발성 황반원공의 내경계막 제거 시 트리암시놀론 아세토나이드와 인도사이아닌그린의 비교

박운철,박규형,유영석,정흠,Un-Chul Park,Kyu-Hyung Park,Young-Suk Yu,Hum Chung 대한안과학회 2005 대한안과학회지 Vol.46 No.12

Purpose: To compare the surgical outcomes and complications of triamcinolone acetonide (TA) with those of indocyanine green (ICG) staining of the internal limiting membrane (ILM) during idiopathic macular hole surgery. Methods: Twenty-four eyes of 23 consecutive patients with an idiopathic macular hole underwent vitrectomy, ILM peeling, and intravitreal gas injection. For enhanced visualization of ILM, ICG was used in 13 eyes and TA in the remaining 11 eyes. Functional and anatomical success rates and surgical complications were compared between the groups. Results: The mean follow-up periods were 10.8 months (ICG group) and 7.5 months (TA group). Best corrected visual acuity increased by two or more lines in 10 eyes (76.9%) of the ICG group and in eight eyes (72.7%) of the TA group (P=1.000). Anatomical closure after the first surgery was achieved in 10 eyes (76.9%) of the ICG group and in all 11 eyes of the TA group (100%) (P=0.223). Postoperative atrophic changes in the retinal pigment epithelium (RPE) in the macular hole bed was found in two eyes of the ICG group and in three eyes of the TA group. All of these (5 eyes) showed the photoreceptor outer segment defect in the closed macular areas by optical coherence tomography and had a postoperative best corrected visual acuity of 0.3 or less. Conclusions: In view of the potential toxicities of ICG, TA appears to be a promising alternative adjuvant for ILM peeling during macular hole surgery. However, postoperative RPE atrophy was detected as a postoperative complication in both the ICG and TA groups. Further study is needed to evaluate the TA toxicity in macular hole surgery.

심한 고도근시 교정 목적의 투명수정체적출술 시행 7년 후의 임상결과

박운철,이진학,Un-Chul Park,Jin-Hak Lee 대한안과학회 2005 대한안과학회지 Vol.46 No.4

Purpose: To evaluate the postoperative outcomes and complications 7 years after clear lens extraction (CLE) for the correction of high myopia. Methods: The medical records of 23 eyes of 15 patients who had undergone CLE to correct myopia higher than -12 diopter and who could be followed up for more than 7 years were reviewed. A scleral tunnel incision and continuous curvilinear capsulorhexis were made, followed by phacoemulsification and posterior chamber intraocular lens implantation. Refractive error, visual acuity and postoperative complications were recorded. Results: Mean follow-up was 98.2 (84~118) months. Posterior capsular opacification developed in 12 eyes (52.2%) and neodymium : YAG laser posterior capsulotomy was performed in 7 eyes. Retinal detachment developed in 3 eyes of 2 patients at 6 months, 34 months, and 9 years after CLE. At 7 years after CLE, the spherical equivalent (SE) of 14 (60.9%) of 20 eyes was within ±2 diopter of targeted refractive error. Shift to myopia occurred by 1 diopter compared to SE at 1 year after CLE. Best corrected visual acuity improved by 2 lines in 14 eyes (60.9%) and was 0.5 or better in 17 eyes (73.9%). Conclusions: CLE for correction of high myopia had good visual outcomes with acceptable predictability. However, long term follow-up revealed gradual increase of serious complications like retinal detachment, posterior capsular opacification, and myopic shift by 1 diopter between 1 year and 7 years after CLE.

수정체유화술 초심자의 첫 1000예에서 발생한 후낭 파열의 임상양상

박운철,권지원,한영근,Un-Chul Park,Ji-Won Kwon,Young-Keun Han 대한안과학회 2005 대한안과학회지 Vol.46 No.8

Purpose: To analyze the results of posterior capsule rupture (PCR) that occurred in the first 1000 cases performed by a newly trained phacoemulsification surgeon. Methods: The medical records of 47 eyes of 45 patients who suffered PCR among the first 1000 cases of cataract surgery performed by one newly trained surgeon were reviewed. All surgeries started with the plan of phacoemulsification and there was no supervision by any experienced surgeon. Results: Over the course of the series of 1000 cases, the PCR incidence rate steadily fell from 12% in the first 100 cases to 4.7% (47 cases) for all 1000 cases as the operator gained experience with the techniques. However, after the change of phaco machine and the technique of nucleus removal, the incidence increased abruptly to 11% and then decreased again. There was no significant difference in PCR incidence between surgeries of the first eye and the second eye of the 335 patients who underwent cataract surgery in both eyes by the surgeon (p=0.534). PCR occurred most commonly in the course of phacoemulsification (83.0%) and mainly in the eyes with severe nucleus sclerosis. Conclusions: In the early stages of the career of a phacoemulsification surgeon, the PCR incidence showed a learning curve that decreased with increasing experiences, then it increased again after the change of operational procedure before finally decreasing once more. In the surgery of the second eye, poor patient cooperation could be overcome with a careful approach, and PCR occurred most commonly in the course of phacoemulsification (83.0%).

후천성 3, 4, 6번 뇌신경마비의 임상 양상과 자연 경과

박운철,김성준,유영석,Un-Chul Park,M,D,Seong-Joon Kim,M,D,Young-Suk Yu,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.9

Purpose: To analyze the clinical features and natural history of acquired third, fourth, and sixth cranial nerve palsy. Methods: We reviewed the medical records of 89 patients who were diagnosed with acquired third, fourth, and sixth nerve palsy from January 2003 to March 2005. The natural course of the disease and the factors affecting recovery were analyzed for the 66 patients who had their first ocular examination within 3 months from onset and were followed up for at least 6 months. Results: The average age of onset was 50.1 years. The sixth cranial nerve was affected most frequently (n=43, 48.3%). Vascular disease (n=27, 30.3%) was most common etiology of cranial nerve palsy, followed by an undetermined cause (n=19, 21.3%). Of the 66 patients who had their first ocular examination within 3 months from onset and were followed up for at least 6 months, 40 (60.6%) patients showed a decrease in the angle of deviation by more than 10 prism diopters, and of these, 32 (48.5%) patients made a complete recovery from pareses. The recovery rates for patients with vascular disease or undetermined etiology (p=0.001), milder initial eyeball deviation and ocular motor restriction (p<0.001) were higher. Conclusions: In the natural course of the disease, the recovery rate of acquired third, fourth, and sixth nerve palsy was 60.6%. The most favorable prognosis occurred with vascular disease, undetermined etiology, and less severe paralysis on onset.

전기자극을 이용한 토끼 외안근 수축

박운철(Un Chul Park),서종모(Jong-Mo Seo),김성준(Seong Joon Kim),유형곤(Hyeong Gon Yu),유영석(Young Suk Yu),정흠(Hum Chung) 대한검안학회 2007 Annals of optometry and contact lens Vol.6 No.1

목적: 전기 자극으로 토끼 외안근의 수축을 확인하고, 수축을 유발하는 최적의 자극 조건을 알아보았다. 대상과 방법: 토끼를 전신 마취하고 윗눈꺼풀을 제거하여 상직근을 최대한 노출시켰다. 서로 다른 4가지 재질과 모양의 전극을 사용하여 다양한 전기 자극 조건에 따른 상직근 반응을 관찰하였다. 백금봉 전극을 이용한 전기자극에서 자극 전압의 변화와 전극 사이 거리에 따른 길이방향 근육 수축량도 분석하였다. 결과: 백금 봉 전극을 사용한 전기적 근육자극에서는 산화 반응이나 근육 손상 등의 합병증 없이 상직근 전폭에 걸친 길이방향 수축이 관찰되었으며, 자극 지속시간, 자극 빈도, 자극사이 간격에 관계없이 전기자극이 가해지는 동안 수축이 지속되었다. 2.0 V 이상의 전압에서 뚜렷한 길이방향 근수축이 나타났으나, 그 수축량은 최대 1 mm 정도였으며, 근육 수축에 따른 안구 회전은 미약하였다. 길이 방향 근수축량은 자극 전압의 크기에 비례하였고, 전극사이의 거리에 반비례하였다. 결론: 전기자극을 이용하여 토끼 외안근의 수축을 유발하고, 자극 조건에 따라 길이 방향 수축 길이를 조절할 수 있었다. 하지만, 안구 회전을 일으키는 효율적인 외안근 수축 유발을 위한 추가 연구가 필요하다. Purpose: To verify the contraction of extraocular muscle by electrical stimulation and to investigate the appropriate stimulation parameters for muscle contraction. Methods: Under the general anesthesia, anterior part of superior rectus was maximally exposed after removal of upper lid in the rabbit eye. Using four different electrodes made of various materials and shapes, electrical stimuli with various stimulation parameters were delivered and the responses of the superior rectus muscle were observed. Under the electrical stimulation with the platinum rod electrode, longitudinal contraction length according to the stimulation voltage level and the distance between electrodes was analyzed. Results: Under the electrical stimulation with the platinum rod electrode, longitudinal contraction over full width of superior rectus muscle was observed without muscle injury or oxidative reaction on the surface of the electrode, and the muscle contraction was maintained during the stimulation independent of pulse duration, frequency or interval. Definite longitudinal contraction was observed over 2.0 V of voltage stimulus, but the length of maximal contraction was about 1.0 mm, which was not enough to rotate the eyeball. The length of longitudinal contraction was proportionally increased according to the stimulation voltage level, but showed inverse correlation with the distance between the electrodes. Conclusions: The electrically-evoked extraocular muscle contraction in rabbit was verified, and the length of the longitudinal contraction could be controlled by the stimulation parameters. However, further investigation is needed to provoke efficient extraocular muscle contraction for the rotation of the eyeball.

보존제가 없는 분말 형태의 트리암시놀론 아세토나이드를 이용한 내경계막의 시각화

강경태,박운철,유형곤 대한안과학회 2020 대한안과학회지 Vol.61 No.5

Purpose: To evaluate and compare the degree of visualization of the vitreous and internal limiting membrane (ILM) during pars plana vitrectomy (PPV) using preservative-free triamcinolone acetonide (PF-TA) or triamcinolone acetonide suspension (TAS). Methods: We retrospectively analyzed the medical records of 61 eyes of 61 patients who underwent 25-gauge PPV and ILM peeling for various macular diseases. We assigned the patients to PF-TA and TAS groups, i.e., according to the type of triamcinolone acetonide used. The degree of visualization of the vitreous and ILM was classified into four different categories. The number of dye injections during PPV, need for indocyanine green (ICG), time elapsed before ILM peeling, and intraocular pressure (IOP) before surgery, 1 day and 1 month after surgery were determined. Results: The degree of visualization of the vitreous and ILM was significantly better in the PF-TA group compared with the TAS group. Although the number of dye injections during PPV was not different between the PF-TA and TAS groups (2.56 ± 0.07 and 2.37 ± 1.08, respectively, p = 0.06), the need for ICG was significantly different (6 and 22 eyes, respectively, p < 0.01). The time elapsed before ILM peeling was 185.68 ± 130.02 s in the PF-TA group and 411.15 ± 267.38 s in the TAS group (p < 0.01). The IOP was not different before or 1 day after surgery between the PF-TA and TAS groups, but was significantly different 1 month after surgery (12.88 ± 3.10 and 14.41 ± 2.91 mmHg, respectively, p = 0.03). Conclusions: Visualization of the vitreous and ILM was better when using PF-TA compared to TAS. PF-TA-assisted PPV could reduce the usage of ICG and was associated with a reduced latency to ILM peeling. Because this was in turn associated with a lower IOP at postoperative 1 month, PF-TA was safer and more effective than TAS. 목적: 보존제가 없는 분말 형태 트리암시놀론 아세토나이드(triamcinolone acetonide, TA)와 현탁액 형태 TA의 내경계막의 시각화 정도를 비교하고자 하였다. 대상과 방법: 유리체절제술 및 내경계막 제거를 시행 받은 61명에 대한 후향적 분석을 실시하였다. 사용한 TA의 종류로 환자군을 두 군으로 나누고, 유리체 및 내경계막 가시화 정도를 각각 4단계로 나누어 평가하였다. 염료의 유리체강내 주입 횟수, indocyanine green (ICG)의 추가 사용 여부, 내경계막제거술에 걸린 시간 및 수술 전후의 안압을 분석하였다. 결과: 분말 형태 TA를 이용한 경우, 유리체 및 내경계막의 가시화 정도가 현탁액 형태 TA를 이용한 경우에 비하여 우수하였다(p<0.01). 염료의 유리체강내 주입 횟수는 분말 형태 TA군에서 평균 2.65회 ± 0.07회, 현탁액 형태 TA군에서 2.37 ± 1.08회로 차이는 없었으나(p=0.06), ICG를 이용한 염색법이 필요한 경우는 각각 6안과 22안으로 차이를 보였고(p<0.01), 내경계막제거술에 걸리는 평균 시간도 각각 185.68 ± 130.02초, 411.15 ± 267.38초로 차이를 보였다(p<0.01). 수술 1개월 후 안압은 각각 12.88 ± 3.10 및 14.41 ± 2.91 mmHg로 차이를 보였다(p=0.03). 결론: 가시화를 위하여 분말 형태 TA를 이용하는 경우 유리체와 내경계막의 시각화가 보다 용이하였고, ICG 사용의 필요성을 줄이고, 내경계막 제거에 걸리는 시간을 줄이는 데 도움이 되었으며, 수술 1개월 후 안압상승도 비교적 적었기 때문에 보다 안전하고 효과적인 방법인 것으로 생각된다.

단안 특발망막전막 환자에서의 융합과 억제

조인환,박운철,김성준,유나경,유형곤 대한안과학회 2020 대한안과학회지 Vol.61 No.7

Purpose: To investigate the presence of fusion and suppression in patients with unilateral idiopathic epiretinal membrane (ERM). Methods: Thirty-five patients with unilateral idiopathic ERM received a full ophthalmologic exam including best corrected visual acuity (BCVA). Patients were divided into suppression and non-suppression groups according to the results of 4 Prism Dioptre Base-out Test and Worth 4 Dot test. Age, symptoms, duration of ERM, BCVA, average M-chart score, results of Titmus test and optical coherence tomography parameters were compared between the two groups. Factors associated with suppression were also evaluated. Results: Eleven (31%) of 35 patients had suppression. The BCVA (0.18 ± 0.12 vs. 0.29 ± 0.12 p = 0.019) and stereopsis (2.25 ± 0.27 vs. 2.66 ± 0.62, p = 0.009) were significantly lower in the suppression group than the non-suppression group. Median age was older (63.21 ± 9.64 vs. 70.82 ± 6.80, p = 0.013) and duration of ERM (7.86 ± 3.69 vs. 18.54 ± 14.92 months, p = 0.004) was longer in the suppression group than the non-suppression group. Average M-chart score was higher in the suppression group. However, not all the patients suffered from metamorphopsia, including the suppression group when using binocular vision. Conclusions: Unilateral suppression is common in unilateral idiopathic ERM and influences the patient’s stereopsis. Suppression was significantly correlated with age, duration of symptoms and metamorphopsia. 목적: 단안 특발망막전막 환자에서 융합과 억제가 발생하는지 알아보았다. 대상과 방법: 단안 특발망막전막 환자 35명 35안을 대상으로 최대교정시력을 포함한 안과 검사를 시행하였다. 감각 융합 상태를 평가하기 위해 4프리즘바닥가쪽검사와 워스4등검사를 시행하고 억제가 있는 군(억제군)과 없는 군(비억제군)으로 나누어 각 군에서 나이, 증상, 기간, 최대교정시력, 평균 M-chart 점수, 티트무스검사와 빛간섭단층촬영 결과를 비교하였고 억제와 연관이 있는 인자를 찾아보았다. 결과: 35안 중 11안(31%)에서 망막전막이 있는 눈에 억제가 발생하였다. 억제군에서는 비억제군에 비해 교정시력(0.18 ± 0.12 vs. 0.29 ± 0.12, p=0.019)과 입체시(2.25 ± 0.27 vs. 2.66 ± 0.62, p=0.009)가 유의하게 더 낮았다. 또한 억제군의 평균 나이가 더 많았고(63.21 ± 9.64 vs. 70.82 ± 6.80세, p=0.013), 유병 기간이 더 길었다(7.86 ± 3.69 vs. 18.54 ± 14.92개월, p=0.004). 한편, 억제군의 단안 변형시 정도는 비억제군에 비해 유의하게 심했지만(0.43 ± 0.38 vs. 0.85 ± 0.56, p=0.020), 양안으로 M-chart 검사를 시행했을 경우는 억제가 있는 11안(31%) 모두에서 변형시를 느끼지 못했다. 결론: 이러한 결과는 단안 망막전막 환자에서 망막전막이 있는 눈에 억제가 흔하게 발생하고, 입체시에 영향을 미치며, 환자의 나이와 유병 기간, 변형시가 억제에 영향을 미침을 보여준다.

전방 내로 이동한 덱사메타손 삽입물의 임상양상과 위험인자 분석

이혁준,박운철,유형곤,이은경 대한안과학회 2020 대한안과학회지 Vol.61 No.10

Purpose: To investigate the clinical features, risk factors, and treatment outcomes for anterior chamber migration of an intravitreal dexamethasone implant (Ozurdex®; Allergan Inc., Irvine, CA, USA). Methods: We retrospectively reviewed the medical records of patients who were diagnosed with anterior chamber Ozurdex® migration. Prior surgical histories were obtained and comprehensive ophthalmic examinations were conducted for all eyes. Treatment strategies and outcomes were also analyzed. Results: Among 1,276 intravitreal Ozurdex® injections, anterior migration occurred in six eyes of six patients (0.47%). All six eyes were pseudophakic, and they had undergone prior vitrectomies. The vitrectomized pseudophakic eyes, in contrast to the nonvitrectomized pseudophakic eyes, were significantly associated with an increased risk of anterior chamber migration (odds ratio [OR] = 19.2, p = 0.009). Moreover, the vitrectomized eyes with reduced zonular/capsular bag complex integrity, in contrast to the vitrectomized eyes with intact zonular/capsular bag complex integrity, were significantly associated with an increased risk of anterior chamber migration (OR = 50.2, p < 0.001). All six eyes underwent surgical intervention: one eye with a repositioning procedure, and the other five eyes with surgical removal of the implant. Corneal edema was resolved within two months after surgery; however, one patient eventually developed corneal endothelial dysfunction. Conclusions: Prior vitrectomy and a defective lens capsule or weak zonules/zonular dehiscence are risk factors for anterior chamber Ozurdex® migration; thus, caution is recommended in these patients. Urgent removal of the implant should be considered when anterior migration of the implant is diagnosed with corneal edema. 목적: 유리체강내 덱사메타손 삽입물(Ozurdex [오저덱스]®; Allergan Inc., Irvine, CA, USA)이 전방 내로 이동한 환자의 임상양상과 위험 인자, 치료 결과에 대해 분석하고자 한다. 대상과 방법: 전방 내로 오저덱스®가 이동한 환자를 대상으로 후향적 의무기록 조사를 시행하였다. 이전 수술 병력과 오저덱스® 이동의 위험 인자에 대해 조사하였고, 치료 방법과 치료 이후 임상 경과에 대해 분석하였다. 결과: 총 1,276건의 오저덱스® 주입술 중, 오저덱스®의 전방 내 이동이 확인된 환자는 총 6명 6안으로 유병률은 0.47%였다. 6안 모두 인공수정체안이었으며, 이전에 유리체절제술의 병력이 있었다. 유리체절제술을 시행 받은 인공수정체안 환자들이 그렇지 않은 환자들에 비해 전방 내 이동 위험이 더 높았다(odds ratio [OR]=19.2, p=0.009). 또한 유리체절제술을 시행 받은 환자 중 섬모체 소대나수정체낭 복합체의 결손이 관찰된 환자들이 그렇지 않은 환자들에 비해 전방 내 이동 위험이 더 높았다(OR=50.2, p<0.001). 6안 중 1안은 오저덱스® 재배치를, 5안은 수술적 제거를 시행하였다. 수술적 치료를 시행한 이후 각막부종이 있던 3안 모두에서 2달 안에 각막부종이 호전되었으나, 이 중 1명에서는 결국 각막내피세포부전으로 진행하였다. 결론: 유리체절제술을 시행 받은 병력과 수정체낭의 결손 또는 섬모체소대의 약화 및 해리가 있는 경우 오저덱스®의 전방 내 이동에 위험 인자가 되며, 이러한 환자들에게는 오저덱스® 주입에 주의가 필요하다. 오저덱스®의 전방 내 이동이 각막부종과 함께 진단될 경우 가능한 한 빨리 수술적 제거를 고려해야 할 것이다.

분자유전검사로 확진된 상염색체 우성 드루젠

송재신,오백록,박운철,유형곤,이은경 대한안과학회 2021 대한안과학회지 Vol.62 No.1

Purpose: To report a case of autosomal dominant drusen confirmed by molecular genetic testing and the clinical features and findings of a multimodal diagnostic imaging study. Case summary: A 32-year-old male presented with decreased visual acuity in his right eye from 1 year prior to his first visit. On the first visit, his visual acuities were 0.3 in the right eye and 1.2 in the left eye. A fundus examination showed numerous drusen of various sizes widely distributed on the posterior pole of both eyes, as well as subretinal fibrotic change with pigmentation in the right eye. Optical coherence tomography showed extensive hyperreflective deposits beneath the retinal pigment epithelium in both eyes and small amounts of cystic intraretinal fluid in the right eye. Fluorescein angiography and fundus autofluorescence showed the drusen as multiple hyperfluorescent spots, while indocyanine green angiography indicated hypofluorescence corresponding to the drusen. Genetic sequence analysis revealed a pathogenic variant of the EFEMP1 gene, heterozygous c.1033C>T (p.Arg345Trp), which accords with the diagnosis of autosomal dominant drusen. Intravitreal bevacizumab injection was given in the right eye; however, there was no improvement in the amount of intraretinal fluid nor visual acuity. Conclusions: Autosomal dominant drusen is a very rare disease. It is necessary to distinguish it from age-related macular degeneration, as the affected age and clinical features of drusen are different, including the response to anti-vascular endothelial growth factor treatment. 목적: 분자유전검사로 확진된 상염색체 우성 드루젠 1예를 경험하여 이의 임상적 특징 및 여러 진단적 이미지 검사 소견들을 보고하고자 한다. 증례요약: 32세 남성이 1년 전부터 시작된 우안 시력저하를 주소로 내원하였다. 나안시력 우안 0.3, 좌안 1.2였고, 안저검사상 양안 후극부에 광범위하게 분포한 다양한 크기의 수많은 드루젠 및 우안 황반부의 망막하 섬유화 변화와 색소침착이 관찰되었다. 빛간섭단층촬영상 양안 망막색소상피층하 광범위한 고반사 물질의 침착과 우안 소량의 망막내액이 관찰되었다. 이 침착물은 형광안저혈관조영술상 과형광, 인도시아닌그린혈관조영술상 저형광, 안저자가형광검사상 과형광 반점 소견으로 관찰되었다. 분자유전검사 결과 EFEMP1 유전자의 병원성 변이인 이형 접합 c.1033C>T p.Arg345Trp이 검출되어 상염색체 우성 드루젠으로 확진할 수 있었다. 우안 아바스틴 주입술을 시행하였으나, 주사 후 망막내액 및 시력의 호전은 없었다. 결론: 상염색체 우성 드루젠은 매우 드문 질환이나, 일반적인 나이관련황반변성과는 호발 연령 및 드루젠의 임상 양상이 다르고, 항혈관내피성장인자 치료의 반응 또한 차이를 보일 수 있어 감별이 필요하다.