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박영배(Yong Bae Park),한기훈(Ki Hoon Han),최영진(Young Jin Choi),최성주(Sung Joo Choi),손대원(Dae Won Sohn),오병희(Byung Hee Oh),이명묵(Myong Mook Lee),최윤식(Yun Shik Choi),서정돈(Jung Don Seo),이영우(Young Woo Lee) 대한내과학회 1994 대한내과학회지 Vol.47 No.1
N/A Background: Familial hypercholesterolemia (FH) is a frequent dyslipemic disorder (one in 500 in Caucasian) inherited by autosomal dominant trait and constitutes about 59 of all cases who have myocardial infarction. While this disorder is of clinical importance, little is reported about familial hypercholesterolemia in Korea. Method: We analysed the lipid profiles, Achilles tendon thickness, body mass index, lipoprotein levels and lipoprotein (a)(Lp(a)) in patients (N=26) with FH and their first degree relatives (N = 92) who visited the Seoul National University Hospital between January 1991 and August 1992. Clnical characteristics and coronary angio-graphic findings were also analysed in probands and their first degree relatives affected with familial hypercholesterolemia. 1) Twenty seven out of 92 first degree relatives were affected with familial hypercholesterolemia, The overall morbidity was 42.39(53 out of 118) and both sexes were equally affected (male: female=26:27), suggesting that familial hypercholesterolemia is autosomally inherited disorder. 2) The mean cholesterol level of the affected was abnormally very high (mean 345. 6 mg/dl) and was similar to that of Japanese studies on familial hypercholesterolemia. Lp (a), another risk factor of coronary artery disease, was higher (mean 24, 5 mg/dl) in the affected than in normal controls. 3) Achilles tendon thickness was significantly increased in all the cases with familial hypercholesterolemia (N =30, mean l3.7 mm, mean age 46.2 years: 23~75 years), compared with that of those who were not affected with familial hypercholesteolemia (N =20 mena 6. 9 mm, mean age 46 8 years), suggesting that thickening of Achilles tendon is a specific clinical finding of familial hypercholesterolemia (FH). 4) Patients with FH and coronary artery disease (CAD) were significantly older than FH patients without CAD (p<0,01). The coronary atherosclerosis score (CAS: Jenkins 1978) was positively correlate with age (R=0.91), which suggested that developement of CAD and the degree of coronary atherosclerosis was associated with the duration of exposure to, hypercholesterolemia. 5) The significant stenosis of coronary artery develped on proximal segments (14 out of 28 lesions N = 1) according to the findings of coronary arteriography, suggesting that CAD in FH can produee more fatal outcomes. Conclusion: Familial hypercholesterolemia is autosomal dominant inherited disorder of lipid mctabolism and is closely associated with coronary artery disease. The affected are almost totally asymptomatic until they experience angina or myocardial infarction, To prevent the fatal outcome due to coronary artery disease, more intense clinical attention sould be paid to detect familial hypercholesterolemia proband and its affected asymptomatic first degree relatives through pedigree study.
박재성 ( Jae-sung Park ),박영재 ( Young-jae Park ),민재영 ( Jae-young Min ),신용섭 ( Yong-sup Shin ),이상철 ( Sang-chul Lee ),박영배 ( Young-bae Park ),김민용 ( Min-yong Kim ) 대한한의진단학회 2007 大韓韓醫診斷學會誌 Vol.11 No.1
Background and purpose: The purpose of this study is to search recognition patients in Eight constitution Oriental Medical Clinic. And we compare Eight constitution acupuncture methods with the another acupuncture methods. Methods: The subjects were comprised of 200 volunteers. In 3 Eight constitution Oriental Medical Clinic participants were chosen through questionnaire. Finishing answer participants put in their lacked name questionnaire to gathering box. DecisionTree (AnswerTree 3.0 Ver.) statistical software was used for statistical analysis. Results and Conclusion: As a result of the analysis of cognition to Eight constitution acupuncture methods was influenced to patients health, dietetic therapy is best influenced. Next influenced acupuncture reflex degree, age, job, constitution, cure periods, sex distinction, cure degree, diagnosed participant`s Constitution by pulse diagnosis in 8 Constitution Medicine.
나노영가철의 산화,환원에 의한 트리클로로에틸렌 처리특성
박영배 ( Young Bae Park ),정용준 ( Yong Jun Jung ),최정학 ( Jeong Hak Cho ),문병현 ( Boung Hyun Moo ) 한국환경과학회 2014 한국환경과학회지 Vol.23 No.5
This study examined the treatment characteristics of hard-to-degrade pollutants such as TCE which are found in organic solvent and cleaning wastewater by nZVI that have excellent oxidation and reduction characteristics. In addition, this study tried to find out the degradation characteristics of TCE by Fenton-like process, in which H2O2 is dosed additionally. In this study, different ratios of nZVI and H2O2, such as 1.0 mM : 0.5 mM, 1.0 mM : 1.0 mM, and 1.0 mM : 2.0 mM were used. When 1.0 mM of nZVI was dosed with 1.0 mM of H2O2, the removal efficiency of TOC was the highest and the first order rate constant was also the highest. When 1mM of nZVI was dosed with 0.5 mM of H2O2, the first order rate constant and removal efficiency were the lowest. The size of first order rate constant and removal efficiency was in the order of nZVI 1.0 mM : H2O2 1.0 mM > nZVI 1.0 mM : H2O2 2.0 mM > nZVI 1.0 mM : H2O2 0.5 mM > H2O2 1.0 mM > nZVI 1.0 mM. It is estimated that when 1.0 mM of nZVI is dosed with 1.0 mM of H2O2, Fe2+ ion generated by nZVI and H2O2 react in the stoichiometric molar ratio of 1:1, thus the first order rate constant and removal efficiency are the highest. And when 1.0 mM of nZVI is dosed with 2.0 mM of H2O2, excessive H2O2 work as a scavenger of OH radicals and excessive H2O2 reduce Fe3+ into Fe2+. As for the removal efficiency of TOC in TCE by simultaneous dose and sequential dose of nZVI and H2O2, sequential dose showed higher first order reaction rate and removal efficiency than simultaneous dose. It is estimated that when nZVI is dosed 30 minutes in advance, pre-treatment occurs and nanoscale Fe0 is oxidized to Fe2+ and TCE is pre-reduced and becomes easier to degrade. When H2O2 is dosed at this time, OH radicals are generated and degrade TCE actively.
8체질(體質) 진단(診斷) 전문가(專門家) 시스템 개발을 위한 기초연구(基礎硏究)
신용섭 ( Yong-sup Shin ),박영배 ( Young-bae Park ),박영재 ( Young-jae Park ),김민용 ( Min-yong Kim ),이상철 ( Sang-chul Lee ),오환섭 ( Hwan-sup Oh ) 대한한의진단학회 2007 大韓韓醫診斷學會誌 Vol.11 No.1
Background and Purpose: There was seldom study about method that diagnose 8 Constitution beside method of pulse diagnosis in 8 Constitution Medicine Objectives: This study is to make out check list for 8 Constitution Medicine Diagnosis Expert System Development used CBR(Case based Reasoning). Methods: Review of literatures about special quality element of 8 Constitution and supplement learning advice of 8 Constitution Medicine Experts constructed knowledge base. And then, knowledge base divided through AHP(Analytic Hierarchy Process), and made out check list with this. Results: Knowledge base based on special quality element of 8 Constitution was divided by 5 greate classification and 25 bisection kind, and check list consisted of 251 item was made out through this. Conclusion: Based on this research, cases necessary to make 8 Constitution Medicine Diagnosis Expert System can be gathered through check list, and further study for 8 Constitution Medicine Diagnosis Expert System Development used CBR(Case based Reasoning) is needed to supplement this research.
8체질함(體質緘) 자극(刺戟)이 심박변이도(心博變移度)에 미치는 영향
신용섭 ( Yong-sup Shin ),박영재 ( Young-jae Park ),오환섭 ( Hwan-sup Oh ),이상철 ( Sang-chul Lee ),박영배 ( Young-bae Park ) 대한한의진단학회 2005 大韓韓醫診斷學會誌 Vol.9 No.2
Objectives: This paper investigated the effects of 8 Constitution Acupuncture on Heart Rate Variability(HRV) and is intended to find out 8 Constitutional difference on Autonomous Function after 8 Constitution Acupuncture stimulation. Methods: The subjects were comprised of 42 volunteers(11 men and 31 women). The volunteers had acupunctured by 8 Constitution Acupuncture Therapy. HRV and Mean Heart Rate(MHR) were measured by TAS9v2.0(IEMBIO & Saerom, Korea) on two times: before and immediately after acupuncture stimulation. The SPSS 13.0 for windows was used for statistical analysis: Mann-Whitney U-test, Paired Samples T -test and Wilcoxon signed rank test were used to verify the results. Results: 1. There was no statistically significant difference on HRV and MHR between Sympathicotonia and Vagotonia before acupuncture. 2. In the whole subject, immediately after acupuncture stimulation, MHR showed a significant decrease(p<0.01) and Ln(TP), Ln(LF) and Ln(HF) showed a significant increase(p<0.05). But there was no significant difference in LHR. 3. Immediately after acupuncture stimulation, MHR showed a significant decrease and Ln(TP), Ln(HF), showed a significant increase in Pulmotonia(p<0.05), Ln(TP) showed a significant increase in Pancretonia(p<0.05),MHR showed a significant decrease and Ln(TP) showed a significant increase in Hepatonia(p<0.05), and MHR showed a significant decrease and Ln(TP), Ln(HF), showed a significant increase in cholecystonia(p<0.05). But there were no significant difference on HRV and MHR in Colonotonia and vesicotonia. Conclusion: The results suggest that 8 Constitution Acupuncture is associated with changed activity in sympathetic and parasympathetic nervous system. Further study is needed for investigating the effects of 8 Constitution Acupuncture on HRV and autonomic nervous system.
8체질맥진(體質脈診) 숙련도(熟練度) 평가방법(評價方法)에 관(關)한 연구(硏究)
신용섭 ( Yong-sup Shin ),박영재 ( Young-jae Park ),박영배 ( Young-bae Park ),오환섭 ( Hwan-sup Oh ) 대한한의진단학회 2006 大韓韓醫診斷學會誌 Vol.10 No.1
Background: There was seldom study about method that estimate expertness of pulse diagnosis in 8 Constitution Medicine in spite of the diagnostician importance in 8 Constitution Medicine Objectives: This study is to evaluate diagnostician`s consistency and accuracy about pulse diagnosis in 8 Constitution Medicine using Gage R&R study. Methods: The subjects were comprised of 28 volunteers. Among theme, 3 diagnosticians and 10 participants were chosen through questionnaire. Diagnosticians diagnosed participant`s Constitution by pulse diagnosis in 8 Constitution Medicine with hiding their eyes by eyepatch. MINITAB statistical software(ver. 13.20) was used for statistical analysis: Attribute Gage R&R study was used to verify the results. Results: 1. In the measurements of consistency, diagnostician b(agreement=80%, Value of k=0.8276) was very good, diagnostician a(agreement=70%, Value of k=0.7465) was good, and diagnostician c(agreement=50%, Value of k=0.5365) was moderate. 2. In the measurements of accuracy, diagnostician b(agreement =70%, Value of k=0.6812) was good, diagnostician a(agreement=60%, Value of k=0.6414) was good, and diagno-stician c(agreement=0%, Value of k=-0.1000) was poor. 3. In confidence of diagnosis, diagnostician c was 75%, diagnostician a was 70%, and diagno-stician b was 64%. Conclusion: The results suggest that diagnostician`s consistency and accuracy about pulse diagnosis in 8 Constitution Medicine can be evaluated by Gage R&R study. Further study is needed for estimation method of pulse diagnosis in 8 Constitution Medicine.