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박석찬,이상목,김영준,구윤모 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.1
Precipitation and reactive distillation were used to isolate lactic acid from fermentation broth. Lime and ethanol were added to fermentation broth in order to convert soluble lactic acid to insolublecalcium lactate form. In ideal solution of organic acids and fermentation broth, precipitation experiments were performed with varying amount of ethanol. Futhermore, the supernatant after filtration was recycled and reprecipitated adding some amounts of ethanol and lime in order to increase the amount of precipitated calcium lactate.Precipitation process was followed by reactive distillation. Reactive distillation was performed for conversion of carboxylate salts made in previous precipitation process into their corresponding acids. Carboxylate salts were mixed with carbon dioxide, triethylamine to precipitate as calcium carbonate. The remaining liquor was distilled at 150℃ for 1hr. Triethylamine and water and other organic acids were recovered from the top of the distiller, while lactic acid was remained in feeding bottle. The yield of recovered lactic acid was 87.1% with the purity of 99.3%. The main impurities were other organic acids.
박석찬,박준영,최진영,이성근,어성국,엄재구,탁동섭,유명조,유도현,채준석,김범석 한국실험동물학회 2020 Laboratory Animal Research Vol.36 No.4
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging zoonotic disease, which causes high fever, thrombocytopenia, and death in humans and animals in East Asian countries. The pathogenicity of SFTS virus (SFTSV) remains unclear. We intraperitoneally infected three groups of mice: wild-type (WT), mice treated with blocking anti-type I interferon (IFN)-α receptor antibody (IFNAR Ab), and IFNAR knockout (IFNAR −/− ) mice, with four doses of SFTSV (KH1, 5 × 10 5 to 5 × 10 2 FAID 50 ). The WT mice survived all SFTSV infective doses. The IFNAR Ab mice died within 7 days post-infection (dpi) with all doses of SFTSV except that the mice were infected with 5 × 10 2 FAID 50 SFTSV. The IFNAR −/− mice died after infection with all doses of SFTSV within four dpi. No SFTSV infection caused hyperthermia in any mice, whereas all the dead mice showed hypothermia and weight loss. In the WT mice, SFTSV RNA was detected in the eyes, oral swabs, urine, and feces at 5 dpi. Similar patterns were observed in the IFNAR Ab and IFNAR −/− mice after 3 dpi, but not in feces. The IFNAR Ab mice showed viral shedding until 7 dpi. The SFTSV RNA loads were higher in organs of the IFNAR −/− mice compared to the other groups. Histopathologically, coagulation necrosis and mononuclear inflammatory cell infiltration in the liver and white pulp atrophy in the spleen were seen as the main lesions in the IFN signaling lacking mice. Immunohistochemically, SFTSV antigens were mainly detected in the marginal zone of the white pulp of the spleen in all groups of mice, but more viral antigens were observed in the spleen of the IFNAR −/− mice. Collectively, the IFN signaling-deficient mice were highly susceptible to SFTSV and more viral burden could be demonstrated in various excreta and organs of the mice when IFN signaling was inhibited.
박석찬,송병민,이유나,이은경,허경범,계수정,이경현,배유찬,이윤정,김범석 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.3
In 2016, novel H5N6 highly pathogenic avian influenza virus emerged in Korea. During the outbreak, the virus caused the largest culling, especially in brown chicken lines. Wedetermined the pathogenicity and transmissibility of the virus in 2 white chicken lines of the specific pathogen-free chickens, broilers and brown chicken line of Korean native chicken (KNC). A KNC had a longer virus shedding period and longer mean death time than others. Our study showed that this characteristic in the KNC might have contributed to a farm-to- farm transmission of the brown chicken farms.
박석찬(Suk Chan Park),김형근(Hyung Keun Kim),노승한(Seung Han Ro) 한국주택학회 2016 주택연구 Vol.24 No.3
본 연구는 공동주택관리정보시스템(K-apt)을 통해 공개하는 관리비 항목 중 투명성이 다소 낮은 항목인 장기수선충당금의 결정요인을 분석하였다. 특히 관리비와의 관계를 중점적으로 분석한 연구로서 강남구, 양천구 206개 단지의 관리비자료를 이용하여 2014년 1월부터 2014년 12월까지의 12개월의 자료를 분석대상으로 선정하였다. 다중회귀분석을 통해 분석한 결과 주상복합단지가 아파트 단지보다, 그리고 복도식 아파트가 다른 복도유형보다 높은 장기수선충당금을 책정하는 것으로 나타났다. 경과연수는 양의 관계를 형성하여 증가하다가 그 상승 폭이 줄어드는 결과를 얻는데 이는 재건축에 대한 기대감 등으로 대수선에 대한 수요가 낮아지는 것으로 판단된다. 가장 일반적인 관리방식인 위탁관리는 양의 영향을 미치는 것으로 나타났다. 수선유지비는 양의 영향을 미치는 결과로 나타났는데, 이는 평상시 시설물 관리 인식이 높은 단지가 수선비 지출을 많이 하고, 높은 관리 인식수준이 장기수선충당금에도 반영되었다고 해석된다. Although long-term repair reserve should be established on the basis of this long-term management plan, information of long-term repair plan is not disclosed in low transparency. This study analyzes factors that determine the long-term repair reserve for apartment complex in South Korea. We focus its relationship with management fee using 206 apartment complexes in Gangnam-gu and Yangcheon-gu, Seoul, during 12 months, January ~ December in 2014. When regression analysis was conducted using a linear model, we find that types of complex, types of corridor, elapsed years, square of elapsed years, management methods, general management fees and repair and management fees significantly influence the amount of long-term repair reserve for sample apartment complexes. Especially, the maintenance fee has a significantly positive relationship and it implies that the apartment complexes with great maintenance management would tend to reserve more for the long-term repair.
박석찬(Suk Chan Park),김형근(Hyung Keun Kim),노승한(Seung Han Ro) 한국주택학회 2016 한국주택학회 학술대회 발표논문집 Vol.2016 No.1
본 연구는 공개하는 관리비 항목 중 장기수선계획 미공개에 따라 투명성이 다소 낮은 항목인 장기수선충당금과 관리비의 관계에 관해 연구를 하였다. 연구를 위해 공동주택관리정보시스템의 공개자료를 이용하였으며 강남구, 양천구의 206개 단지의 2014년 1월부터 2014년 12월까지의 12개월 월 평균 관리비를 분석대상으로 선정하였다. 다중회귀분석을 통해 분석한 결과 주상복합단지가 아파트 단지에 비해 장기수선충당금에 영향을 미쳤으며, 복도유형에서 복도식 유형이 미치는 영향이 높게 나타났다. 경과연수와 위탁관리방식도 관리비에 영향을 미쳤으며, 일반관리비는 위탁관리형식이 81.8%를 차지함에 영향을 받아 영향을 미치는 것으로 판단되며, 수선유지비가 양(+)의 영향을 미치는 것으로 보아 평상시 시설물 관리에 인식이 높은 단지가 수선비 사용이 많게 되며, 높은 관리 인식수준이 장기수선충당금에도 반영되었다고 보인다.