Phosphatidylserine receptor-targeting therapies for the treatment of cancer

박미소,Keon Wook Kang 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.7

Asymmetric distribution of phospholipids acrossthe plasma membrane is a unique characteristic ofeukaryotic cells. Phosphatidylcholine and sphingomyelinare exposed in the outer leaflet, and phosphatidylserine(PS) is predominantly located in the inner leaflet. Redistributionof PS to the cell surface can be observed in severalphysiological conditions, such as apoptosis and plateletactivation, or in pathological conditions, such as the releaseof microvesicles/exosomes from tumor tissues. PS bindingto the phosphatidylserine receptor (PSR) on immune cellsinitiates immunosuppressive pathways that can lead toimmune evasion by cancer cells. Conversely, PSR activationof cancer cells plays an important role in their survival,proliferation and metastasis. Herein, we briefly summarizeboth recent advances in our understanding of the pathologicalroles of PS and its receptor in cancer biology, aswell as relevant pharmacological approaches.

한라일보_당선소감

박미소 고요아침 2018 시조시학 Vol.66 No.-

운전행동 결정요인분석을 통한 운전행동 재설계에 관한 연구

박미소,윤효진 경기대학교 산업기술종합연구소 2006 산업기술종합연구소 논문집 Vol.31 No.-

일반적으로 교통사고의 원인을 자동차, 운전자, 도로교통환경등의 세 가지 삼각구도로 규명하지만, 교통사고의 직접적인 원인은 교통행동에 의해 결정되어진다고 할 수 있다. 따라서 본 논문에서는 사고원인의 물리적 요소 외에도 인간행동을 결정짓는 요인들을 통해 행동결함들을 분석하여 결함에 대한 대책을 세울 수 있는 방법을 제시하고자 하는 것이다. 결함요인들에 대한 분석을 통해서 특히, 지각·운동요인과 성격요인의 요소들을 통해 결함의 순위를 결정해 보고자 한다. 그리고 이러한 결함을 어떻게 대처해야 할지 운전 재설계의 원칙을 제고해 보는데 그 의의를 두고 있다. 교통과 관련된 일을 하고 있는 일반인들보다는 다소 많은 지식, 정보 그리고 경험을 가지고 있는 전문가들을 대상으로 여러 가지 상세한 설문을 통해서 결함요소와 교통사고, 결함요소간의 상관관계를 분석하여 각 요소에 대한 가중치를 결정하고 다시 이것을 주관성의 일정 부분 배제를 위해 일반화 시켜 그 가중치에 따른 결함 점수의 합계를 구해 어떤 결함이 얼마나 많은 문제점이 있는지 분석하였다. 그리고 최종 결함 점수가 가장 높은 결함을 선정하여 제시된 재설계 원칙에 따라서 운전 행동결함을 수정할 수 있는 정보를 얻고 스스로의 운전 단점을 보완하는데 필요한 자료의 가이드라인으로 활용할 수 있다.

대한민국 이민정책의 역사와 방향에 관한 연구:캐나다 다문화주의와 이민정책을 중심으로

박미소,전일욱 한국행정사학회 2023 韓國行政史學誌 Vol.59 No.-

본 논문은 대한민국의 이민정책의 역사에 캐나다의 이민정책 사례를 살펴보고 방향을 제시하는데 목적이 있다. 그 결과 대한민국 이민정책의 방향으로는 첫 번째, 이민정책을 전담하는 중앙행정기관 설치가 필요하다는 것이다. 이는 이민정책을 총괄하여 추진할 수 있는 ‘이민청’과 같은 컨트롤 타워의 존재가 필요하다는 뜻이다. 두 번째, 이민자 차별금지법 강화이다. 이민자와 현지인 간의 평등을 구현하는 차별금지법은 이민자로 인한 사회통합을 위해서도 필요하다고 본다. 이는 동화주의적 시각으로도 보더라도 장기적으로 사회통합을 하려면 차별금지를 강화하는 제도를 보완해야 한다. 세 번째, 문화・인종 다양성을 이해하고 인정할 수 있는 다양한 프로그램을 개발해야 한다. 이제 대한민국은 단일민족국가에서 국제결혼이나 재한외국인 정책으로 이미 일정 수준의 다문화주의가 정착되는 시점이기에 지금보다 다양한 프로그램 개발은 필수다. 위와 같이 이민정책을 지속 실천한다면 현재 대한민국 사회의 저출산 문제와 고령화로 인한 경제활동 인구문제가 해결의 실마리를 찾을 수 있으며, 나아가 다문화주의의 정착으로 대한민국 사회의 통합이 가능하다고 본다. The purpose of this paper is to examine Canada’s immigration policy cases in the history of Korea’s immigration policy and suggest direction. As a result, the first direction of Korea’s immigration policy is the need to establish a central administrative agency dedicated to immigration policy. This means that there is a need for the existence of a control tower such as the ‘Immigration Office’ that can comprehensively promote immigration policy. Second, the anti-discrimination law against immigrants is strengthened. An anti-discrimination law that realizes equality between immigrants and locals is also considered necessary for the social integration of immigrants. Even from an assimilationist perspective, in order to achieve long-term social integration, the system that strengthens prohibition of discrimination must be supplemented. Third, we must develop various programs that can understand and acknowledge cultural and racial diversity. Now that Korea is a single-ethnic country, a certain level of multiculturalism has already been established through international marriage and policies for foreigners residing in Korea, so the development of more diverse programs is essential. If we continue to implement the immigration policy as above, we can find a solution to the problem of low birth rate and economically active population due to aging in Korean society, and furthermore, it is believed that integration of Korean society is possible through the establishment of multiculturalism.

[한라일보_신작] 먼, 길

박미소 고요아침 2018 시조시학 Vol.66 No.-

UAV와 딥러닝을 활용한 야적퇴비 탐지 및 관리등급 산정

박미소,김흥민,김영민,박수호,김탁영,장선웅 대한원격탐사학회 2024 大韓遠隔探査學會誌 Vol.40 No.1

This research assessed the applicability of the You Only Look Once (YOLO)v8 and DeepLabv3+models for the effective detection of compost heaps, identified as a significant source of non-pointsource pollution. Utilizing high-resolution imagery acquired through Unmanned Aerial Vehicles (UAVs),the study conducted a comprehensive comparison and analysis of the quantitative and qualitativeperformances. In the quantitative evaluation, the YOLOv8 model demonstrated superior performanceacross various metrics, particularly in its ability to accurately distinguish the presence or absence of coverson compost heaps. These outcomes imply that the YOLOv8 model is highly effective in the precisedetection and classification of compost heaps, thereby providing a novel approach for assessing themanagement grades of compost heaps and contributing to non-point source pollution management. Thisstudy suggests that utilizing UAVs and deep learning technologies for detecting and managing compostheaps can address the constraints linked to traditional field survey methods, thereby facilitating theestablishment of accurate and effective non-point source pollution management strategies, and contributingto the safeguarding of aquatic environments.

구기지황탕 투여 후 호전된 경도인지장애 환자 1례에 대한 증례보고

박미소,강석만,유대원,채인철,김경순,성현주,정광렬,유호룡,Park, Mi-so,Kang, Seock-man,Yoo, Dai-won,Chae, In-cheol,Kim, Gyeong-soon,Seong, Hyun-joo,Chung, Kwang-yeol,Yoo, Ho-ryong 대한한방내과학회 2021 大韓韓方內科學會誌 Vol.42 No.5

Objective: Alzheimer's disease is characterized by progressive, irreversible brain damage and cognitive decline. Although the diagnosis and treatment of the prodromal symptoms of dementia are important, no treatment for mild cognitive impairment has been currently established. Herein, we report the case of an 80-year-old female patient with memory complaints treated with Gugijihwang-tang, a traditional Korean medicine herbal formula, as an add-on medication. Case Presentation: The patient was diagnosed with mild cognitive impairment based on clinical examinations using the Mini-Mental State Examination (MMSE), the Consortium to Establish a Registry for Alzheimer's Disease (CERAD), Activities of Daily Living (ADL) Scale, Global Deterioration (GDR) Scale, and Clinical Dementia Rating (CDR) Scale. She was treated with Gugijihwang-tang bis in die for 12 months while continuing her original medications, including 5-mg donepezil and 590-mg acetyl-l-carnitine. The MMSE score in the Korean Version of the CERAD Assessment Packet increased from 21 to 27 during the 12-month treatment period, and the CERAD 2 score increased from 33 to 62. The instrumental ADL scale score improved from 11 to 5. Other clinical examination results also showed improvement. The patient was satisfied and experienced no significant adverse events related to the Gugijihwang-tang treatment. Conclusion: This case suggests that Gugijihwang-tang could be considered as a treatment method for patients with mild cognitive impairment.

차량속도 결정요인에 관한 운전자의 행태분석 및 심리학적 특성에 관한 연구

박미소,윤효진 경기대학교 산업기술종합연구소 2008 산업기술종합연구소 논문집 Vol.33 No.-

침 및 운동 치료로 호전된 파킨슨병 환자 1례에 대한 증례보고

박미소,박상수,이승현,허왕정,유호룡 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.5

Objectives: Parkinson’s disease is characterized by progressive, irreversible damage to dopamine neurons in the substantia nigra pars compacta, as well as motor and non-motor symptoms. This disease currently has no dependable disease-modifying treatment. In this paper, we describe the treatment of a 67-year-old female with Parkinson’s disease using acupuncture and exercise therapy. Case Presentation: Clinical symptoms and the United Kingdom Parkinson’s Disease Society Brain Bank Diagnostic Criteria were used to diagnose the patient with Parkinson’s disease. Over a 12-week period, the patient visited a Korean medicine hospital 18 times and was treated with acupuncture and exercise therapy in addition to anti-Parkinson’s drugs. Before and after treatment, clinical examinations were performed using tools such as the Unified Parkinson’s Disease Rating Scale, Fall Efficacy Scale, Parkinson’s Disease Questionnaire, Berg Balance Scale, and Non-Motor Symptoms Scale. Furthermore, functional near-infrared spectroscopy was used to assess cortical hemodynamics. All clinical examination results improved after 12 weeks of intervention. In particular, improvements on the Total Unified Parkinson’s Disease Rating Scale and Part III of this scale demonstrated large, clinically important differences. Conclusion: This case suggests that combining acupuncture and exercise therapy could produce an effective treatment for Parkinson’s disease patients.

특발성 부종의 중의치료에 대한 임상연구 동향 - CNKI검색을 중심으로

박미소,김수덕,공건식,최요섭,배지은,백혜경,김영준,신동국 대한한방내과학회 2022 大韓韓方內科學會誌 Vol.43 No.4

Objectives: This study investigated the latest clinical studies on Korean medicine treatment of idiopathic edema in the Chinese National Knowledge Infrastructure Database (CNKI). Methods: We searched the last 9 years of clinical studies discussing Oriental medicine-based treatments for idiopathic edema in the CNKI database. The search focused on the authors, publication year, type of study, purposes of study, method and duration of treatment, evaluation criteria, and results of the selected articles. Results: The search identified 7 randomized controlled trials (RCTs) and 9 others. All studies used oral herbal medicine for treatment. The most commonly used herbs were Poria Sclerotium (茯苓), Atractylodis Rhizoma Alba (白朮), and Alismatis Rhizoma (澤瀉), which are the constituent herbs of Oryeong-san (五苓散). All 16 studies confirmed the efficacy of Oriental medicine treatments. Conclusion: More varied and scientifically designed clinical studies are required to develop treatments for idiopathic edema. The results of this study could be used as basic data for further studies on idiopathic edema.