음양조화원리(陰陽調和原理)를 통한 동서의학(東西醫學) 회통(會通)

박기수,이시형,Park, Ki-Soo,Lee, Si-Hyeong 대한한의정보학회 2012 大韓韓醫情報學會誌 Vol.18 No.1

The topic of this study is to ask and answer about 'What matters most in medicine'. And the purpose of this study is to establish paradigm which guarantee 'the original principles of science in medicine' and 'the safety of human life in medicine'. The organized characteristics of this study is as follows. 1. 'The harmony of nature (heaven, earth and human)' is the base of medicine. Because medicine control life directly and all life is 'the son of nature'. 2. 'The harmony of Eum and Yang' is the essential power of universe and the key of metabolism of all life including human, animals and plants. Because 'the nature of universe' and all 'Life field' is 'electro-magnetic field'. 3. The Convergence of Oriental medicine and Western medicine orients 'the harmony of Eum and Yang'.

Zygotic Expression of c-myc Gene in Mouse Early Embryos: Functional Role of c-myc Promoter

박기수,강해묵,심찬섭,선웅,김재만,이영기,김경진,Park, Ki-Soo,Kang, Hae-Mook,Shim, Chan-seob,Sun, Woong,Kim, Jae-man,Lee, Young-Ki,Kim, Kyung-jin The Korean Society for Integrative Biology 1995 동물학회지 Vol.38 No.4

c-myc proto-oncogene은 여러 세포들의 분화와 형질전화에 뿐만 아니라 정상세포의 분열조절에도 관여한다고 알려져왔다. 특히 생쥐의 초기배아에서 c-myc mRNA가 발현되고 antisense c-myc oligomer의 미세주입에 의해 배발생이 억제된다는 연구결과는 c-myc이 초기배아의 발생 및 분열에 관여하는 것을 시사한다. 그러나 최근까지 초기배아에 존재하는 c-myc promoter의 기능적 활성화에 관한 연구는 미진하였다. 이를 위하여, c-myc promoter와 대장균의 lacZ 유전자를 결합시킨 두 종류의 vector(pcmyc-Gall, pcmyc-Ga12)를 만들어 수정란의 전핵에 미세주입한 후, 배 발생에 따른 c-myc promoter의 활성화를 lacZ 유전자의 산물인 $\beta$-galactosidase 에 의한 X-gal 염색으로 조사하였다. 미세주입된 초기 배아는 2세포기 배아를 포함하는 여러 발생단계에서 $\beta$-galactosidase 의 활성을 보였다. 이는 c-myc 유전자가 배아의 게놈유전자로부터 발현되며, 또한 궁극적으로 초기 배아의 발생과정에 중요한 역할을 하고 있음을 시사하고 있다. The c-myc proto-oncogene is Involved In the control of normal cell proliferation and differentiation of many cell lineages. Although it has heen suggested that c-myc may play an important role in the mammalian early development, it Is unclear whether the embryonic c-myc mRNA is originated from zygotic gene expression or stored maternal message. Thus, we have construded expression vectors, In which the 5, flanking sequences including c-myc promoter region and a large non-coding exon I are fused 'sith E. coli lacZ gene that encedes $\beta$-galactosldase as a reporter. As c-myc exon I contains a modulatory sequence, we designed t, vo types of vectors (pcmyc.Gall and pcmyc-Ga12) to examine the role of exon I in c-myc expression. The former contains the complete exon I and the later has a deletion in 40 bp of modulator sequence located In the exon I of c-myc These vectors were microInjected into fertilized one-cell embryos and $\beta$-galactosidase activity was examined by X-gal staining during early embryogenesis. $\beta$-galactosidase activity derived from c-myc promoter was decreased at two-cell stage. The expression level directed by pcmyc- Ga12 was similar to that of pcmyc-Gal1, indicating that the medulatory sequence in exon I may not be Involved at least In the regulation of embryonic c-myc expression. In summary, the present study indicates that the c-myc promoter is functional at the early stage embryo, and the regulation of c-myc expression is under the control of "zygotic" clock of preimplantation mouse embryos.e embryos.

의료협력과 국제 의료관광 네트워크에 관한 연구 - 센텀 메디컬 파트너스를 중심으로 -

박기수,배종철,최봉준,Park, Ki-Soo,Bae, Jong-Cheol,Choi, Bong-Joon 한국임상보건과학회 2014 한국임상보건과학회지 Vol.2 No.1

Purpose. Medical tourism is recently becoming a new industry with great growth potential. The South Korean government is shifting medical tourism from simple cultural tourism to a high value-added industry with a new paradigm. Methods. The government has been providing positive support and marketing policies since the introduction of the article concerning foreign patient attraction to the medical law in 2009, and various types of medical institutions around the country has participated actively in medical tourism by themselves or in cooperation of government bodies and made increasingly greater performance. Results. This study obtained the following results. The medical institutions in Korea have been making efforts to see more development and profitability in diverse ways, including medical tourism for foreign patients and the advance of the Korean medical institutions into foreign markets. However, many local governing bodies and medical institutions participating in medical tourism around the country have primarily focused on examination and treatment on the basis of foreign patients' visit to South Korea and rarely built a medical network with other countries directly for medical tourism. This study presents a case of building a local medical network and a network for international medical tourism successfully on the basis of the local medical association, CMP, which has been formed naturally in Busan. The success factors for CMP included 1) enthusiasm of the official in charge; 2) the medical level, the service level, and open-mindedness of participant medical institutions; 3) cost efficiency due to executive office management with no costs, no conflicts, and constant partnership; 4) security of non-competitive expertise for participants; 5) local factors of CMP; 6) participation of good agencies; 7) reinforcement of participation networks; and 8) post facto management and local doctor management. Conclusions. Its positive effects included patient introduction and greater profitability on an internal basis as well as construction of the collaboration system with the institutions related to medical tourism and confidence. However, there are some limitations: it is still difficult to predict performance due to the short period of their activities, and it is necessary to continue to observe their constant activities since a single medical association was involved.

DFT방법을 이용한 Bis(μ-oxo)dicopper-enzyme의 수소이동반응 연구

박기수,김용호,Park, Ki-soo,Kim, Yong-Ho 대한화학회 2009 대한화학회지 Vol.53 No.5

금속은 생명현상에 필수적인 효소반응에서 핵심적인 역할을 수행한다. 따라서 금속효소 안에서 일어나는 반응에 대한 구체적인 메커니즘은 많은 과학자의 오랜 관심사였다. Methane MonoOxygenase (MMO)는 메탄을 메탄올로 산화시키는 반응을 일으키는 효소이며 최근 Tolman등은 MMO의 모델로서 Bis(μ-oxo)dicopper Complexes의 Hydroxide Transfer 반응에 대한 몇 가지 가능한 메커니즘을 제시하였다. 이후 Hydrogen Transfer와 Hydroxide Rebound의 2단계로 이루어지는 메커니즘이 이론적으로 제시 되었다. 본 연구에서는 Bis($\mu$-oxo)dicopper Complexes 의 반응단계 중 첫 번째 단계인 Hydrogen Transfer 반응과정의 반응물과 전이상태, 생성물의 구조를 최근에 개발된 M06계열의 M06, M06L, M06-2X를 비롯한 여러 가지 DFT방법을 이용하여 계산하였다. M06/6-31G(d,p)/LANL2DZ방법을 사용하여 계산된 반응물의 구조가 실험에서 얻은 XRD구조와 가장 잘 일치했으며 기저함수의 크기에 따라 전이상태의 구조, 활성화 에너지 및 반응에너지에 큰 차이를 보였다. Metals have often played important roles to some enzymatic reactions that are essential to biological processes. Therefore many scientists have studied the reaction mechanisms of catalytic reactions in metaloenzymes for many years. Methane MonoOxygenase (MMO) is an enzyme that oxidize methane to methyl alcohol. Recently Tolman et al. studied a model reaction for MMO, which is a hydroxide transfer reaction in Bis-($\mu$-oxo)-dicopper complex, and suggested several possible mechanisms. Later a two-step mechanism, which is hydrogen transfer followed by hydroxide rebound, was proposed from theoretical studies. In this study we calculated the reactant, product, and the transition state structures, and energetics of the first hydrogen transfer reaction using various DFT methods including recently developed the MO6 family of DFT, namely, MO6, MO6L, and MO6-2X. We found that the M06/6-31G(d,p)/LANL2DZ method reproduce the experimental XRD structure of reactants very well. The TS structures, barrier heights, and reaction energies depend very much on the size of the basis sets.

폐결핵으로 오인된 역형성 거대세포 림프종 1례

현동우,박재용,강태경,박기수,박태인,김창호,손상균,권건영,이규보,정태훈,권삼,Hyun, Dong-Woo,Park, Jae-Yong,Kang, Tae-Kyung,Park, Ki-Soo,Park, Tae-In,Kim, Chang-Ho,Sohn, Sang-Kyun,Kwon, Kun-Young,Lee, Kyu-Bo,Jung, Tae-Hoon,Kweon, Sam 대한결핵및호흡기학회 1998 Tuberculosis and Respiratory Diseases Vol.45 No.1

저자들은 발열, 체중감소 등의 증상과 흉부 X-선 사진상 폐경화의 소견이 있었던 환자에서 폐의 병변이 역형성 거대세포 림프종으로 추측되는 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Anaplastic large cell lymphoma(ALCL) is a recently recognized large cell lymphoma characterized by large pleomorphic cells, with prominent nucleoli, expressing the CD30(Ki-1) antigen. It is often misdiagnosed as metastatic carcinoma, malignant histiocytosis or Hodgkin's disease. Primary pulmonary ALCL is extremely rare although it frequently involves extranodal sites, e.g. skin, bone, gastrointestinal tract, soft tissue and lung. We report a case of ALCL suspected as primarily involving lung.

입소장정에 대한 인성검사 설문지에 고찰

박기수 ( Park Ki-soo ) 국군의무사령부 2003 대한군진의학학술지 Vol.34 No.1

앵커식 및 부착식 도로표지병의 도로포장 형식별 전단강도 평가

박기수 ( Park Ki Soo ),이석기 ( Lee Suk Ki ),박원일 ( Park Won Il ),김용석 ( Kim Yong Seok ) 한국도로교통공단 2022 교통안전연구 Vol.41 No.1

도로표지병은 야간 및 우천 시 차선의 시인성 저하를 보완하기 위해 설치되는 시설물로써 도로환경 변화에 대한 운전자의 주의 환기가 필요한 구간에 우선적으로 설치된다. 본 연구는 표지병 및 접착제 종류, 포장 형식, 환경조건 별 전단시험을 수행하여 도로 포장체와 도로표지병의 부착성능을 평가하였다. 시험결과 앵커식 도로표지병의 경우 건조 시 평균 0.95MPa, 수침 시 평균 0.93MPa의 전단강도를 보였다. 고무변성 에폭시 접착제와 하부형상 개선 표지병을 사용한 경우 건조 시 평균 2.16MPa, 수침 시 2.43MPa로 가장 높은 전단강도를 발현하였으며, 이를 통해 부착식 도로표지병의 성능을 검증하였다. Road Studs play an important role in compensating the visibility reduction of conventional paint-based road markings. This study examined the relative shear performance of anchor- and adhesive-type studs; these comparisons were performed using various adhesives, pavement types, and environmental conditions. Test results showed that anchor-type road studs showed an average shear strength of 0.95 MPa under dry conditions and 0.93 MPa when soaked in water. However, adhesive-type studs that used rubber-modified epoxy showed an average of 2.16 MPa under dry conditions and 2.43 MPa when soaked in water.

〈바람이 분다〉, 풍경과 꿈의 붕괴된 파토스

박기수 ( Ki Soo Park ) 한국언어문화학회 2015 한국언어문화 Vol.0 No.57

<< 신세기 에반게리온 >> 의 서사 특성 연구

박기수(Ki Soo Park) 한국언어문화학회 2001 한국언어문화 Vol.19 No.-

Neon Genesis Evangelion picks up the plot after rhizome that has roots intertwining together rather than a tree-type development that revolves around the central theme. This approach will entice watchers more into the completion of story. The story has the two underlying episodes featuring Oedipus complex at personal and at social level. The most interesting aspect of the story is that it is open-ended to interact with watchers to complete a portfolio of a story. The story is made into a portfolio with the consideration for Otaku to maximize the interaction with watchers and in order to heighten the engaging process.

장정일 시의 서술 특성 연구

박기수(Ki Soo Park) 한국언어문화학회 2000 한국언어문화 Vol.18 No.-

Jung-il is a poet who had appeared late 1980s, did realize the 1980s` deconstruction poems as an advanced guard, also preoccupied the meta-poetical porperties in 1990s at the same time. As he devoted himself to writing novels since 1990s, the estimation on him has come out extremely insignificant allusion and the established consensus on him has been figureded unfairly as well. This study inquired the properties of his poetry as 1) the tendency to metonymic narration and 2) the inclination to self-reflexive narration. And also it examined that the properties was intending the writing for a self-negation (or self-disdain). Due to this study, we might be able to prove his poetry as a part of writing linked continuity with his novels after 1990s.