신종 인플루엔자 A 유행 시 발열 시작과 신속 항원 검사 시행 사이의 시간 간격에 따른 민감도

박근화 ( Geun Hwa Park ),박순빈 ( Sun Bin Park ),김성원 ( Sung Won Kim ) 대한소아알레르기호흡기학회(구 대한소아알레르기 및 호흡기학회) 2012 소아알레르기 및 호흡기학회지 Vol.22 No.1

Purpose: Rapid antigen test (RAT) is used to screen influenza rapidly. The clinical sensitivity of RAT was poor for 2009 H1N1 influenza. The aim of this study was to identify the correlation of time gap (TG) between fever onset and the sensitivity of RAT for 2009 H1N1 influenza. Methods: Data were collected retrospectively during the pandemic H1N1 2009 influenza season between October 2009 and February 2010. The RAT was done by using SD Bioline influenza antigen (Standard Diagnostics Inc.) in nasopharyngeal swab. The 2009 H1N1 influenza was confirmed by real- time reverse transcriptase polymerase chain reaction (rRT-PCR). Specimens were categorized according to the TG between fever onset and performance of RAT. They were classified into <24 hours (TG1), 24 to 48 hours (TG2), 48 to 72 hours (TG3), 72 to 96 hours (TG4), 96 to 120 hours (TG5), >120 hours (TG6). Results: The overall sensitivity of RAT was 69.9%. The TG dependent sensitivity of RAT at TG1, TG2, TG3, TG4, TG5, and TG6 was 64.3%, 73.3%, 61.1%, 88.9%, 83.3%, and 61.1% respectively. The sensitivity of RAT was the highest when the TG was 72 to 96 hours. But this result was not statistically significant. Conclusion: Correlation of TG between fever onset and the sensitivity of RAT for 2009 H1N1 influenza was not statistically significant. But our study suggested that 72 to 96 hours after fever onset is the most sensitive time of RAT. Timely optimal performance of the RAT could have a significant impact on improving results. Further evaluation for better sensitivity would be needed.

SCORing atopic dermatitis index로 평가한 아토피피부염의 중증도와 혈액 검사와의 연관성

박근화 ( Geun Hwa Park ),박종하 ( Jong Ha Park ),황윤하 ( Yoon Ha Hwang ),성명순 ( Myong Sun Sung ),김성원 ( Sung Won Kim ) 대한소아알레르기호흡기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.1

Purpose: SCORing atopic dermatitis (SCORAD) index is the best validated scoring system in atopic dermatitis (AD). But this scoring system has limitation to the interobserver and intraobserver variation. This study was designed to evaluate the correlation between the severity of AD classified by the SCORAD index and the laboratory tests. Methods: We evaluated 67 children admitted in the pediatric allergy and respiratory division of Busan St. Mary’s Medical Center from April 1 to 30, 2011. SCORAD index was measured by one same physician. The patients were classified into mild to moderate and severe groups by SCORAD index. We identified sex, age and family history of allergic disease. We checked laboratory tests including mycoplasma immunoglobulin (Ig) M, total IgE, eosinophil count, eosinophil cationic protein, specific IgE, total protein, albumin, IgG, IgA, IgM, IgD, and inflammatory index (lactate dehydrogenase, C-reactive protein, erythrocyte sedimentation rate) and skin culture. Results: There were no statistically significant differences between two groups in age, sex, parental allergic history, skin culture, mycoplasma IgM, specific IgE, immunoglobulin, and inflammatory index. The SCORAD index has statistically significant positive correlations with serum total eosinophil count, and total IgE, and negative correlations with total protein, and albumin. Conclusion: Our study suggest that serum total eosinophil count, total IgE, total protein, and albumin can be used to evaluate the severity of AD and make up for the SCORAD index. (Allergy Asthma Respir Dis 1(1):79-83, 2013)

아토피피부염 환아의 저단백혈증에 관한 연구

박종하 ( Jong Ha Park ),신영혜 ( Yong Hye Shin ),박근화 ( Geun Hwa Park ),김성원 ( Sung Won Kim ) 대한소아알레르기호흡기학회 1991 소아알레르기 및 호흡기학회지 Vol.1 No.4

Purpose: As a complication of atopic dermatitis (AD), the incidence of hypoproteinemia is increasing among infants with severe AD. It can be a life-threatening condition owing to hypovolemic shock as a result of hypoproteinemia. The aim of this study is to investigate the clinical feature and laboratory findings in pediatric AD patients with hypoproteinemia. Methods: Seventy-five patients who visited pediatric allergy clinic and diagnosed as AD by a physician from January 2005 to January 2012. Patients with low serum protein level were classified as group A (n=27) and those with normal serum protein level were classified as group B (n=48). Age, sex, and parental allergic history were studied. We examined serum protein and albumin, eosinophil count, C-reactive protein (CRP), serum eosinophil cationic protein (ECP), total IgE, specific IgE, skin culture and SCORing Atopic Dermatitis (SCORAD) score. Results: In group A, serum protein and albumin were lower and eosinophil count, CRP, ECP, total IgE and SCORAD score were higher than group B. Group A was sensitized more number of allergens than group B. In parental allergic history, allergic rhinitis was prominent in both group. In skin culture, other species than Staphylococcus aureus were prominent in group A. Egg sensitization was the most common in both group. Serum protein level was positively correlated with serum albumin and negatively correlated with eosinophil count, total IgE, SCORAD score and number of sensitized allergen. Conclusion: Risk factors for hypoproteinemia in pediatric atopic dermatitis are considered infants, severe atopic dermatitis, increased number of sensitized allergens. (Allergy Asthma Respir Dis 2013;1:344-349)

아토피피부염 환아의 저단백혈증에 관한 연구

김성원 ( Sung Won Kim ),박종하 ( Jong Ha Park ),박근화 ( Geun Hwa Park ),신영혜 ( Yonghye Shin ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.4

Purpose: As a complication of atopic dermatitis (AD), the incidence of hypoproteinemia is increasing among infants with severe AD. It can be a life-threatening condition owing to hypovolemic shock as a result of hypoproteinemia. The aim of this study is to investigate the clinical feature and laboratory findings in pediatric AD patients with hypoproteinemia. Methods: Seventy-five patients who visited pediatric allergy clinic and diagnosed as AD by a physician from January 2005 to January 2012. Patients with low serum protein level were classified as group A (n=27) and those with normal serum protein level were classified as group B (n=48). Age, sex, and parental allergic history were studied. We examined serum protein and albumin, eosinophil count, C-reactive protein (CRP), serum eosinophil cationic protein (ECP), total IgE, specific IgE, skin culture and SCORing Atopic Dermatitis (SCORAD) score. Results: In group A, serum protein and albumin were lower and eosinophil count, CRP, ECP, total IgE and SCORAD score were higher than group B. Group A was sensitized more number of allergens than group B. In parental allergic history, allergic rhinitis was prominent in both group. In skin culture, other species than Staphylococcus aureus were prominent in group A. Egg sensitization was the most common in both group. Serum protein level was positively correlated with serum albumin and negatively correlated with eosinophil count, total IgE, SCORAD score and number of sensitized allergen. Conclusion: Risk factors for hypoproteinemia in pediatric atopic dermatitis are considered infants, severe atopic dermatitis, increased number of sensitized allergens.

15년 동안 부산 지역에서 채집된 공중화분 분포 및 알레르기 감작률과의 상관관계

성명순 ( Myong Soon Sung ),박영진 ( Yong Jin Park ),박근화 ( Geun Hwa Park ),오재원 ( Jae Won Oh ),김성원 ( Sung Won Kim ) 대한천식알레르기학회 2014 Allergy Asthma & Respiratory Disease Vol.2 No.1

Purpose: pollen is the most common causative agents of allergic disease. Since 2000, there isn``t no more report about pollen in Busan. This study is that pollen in one area of Busan was collected to investigate species, particle counts, seasonal distribution, and of its correlation with reactivity to skin prick test in children during 1998.2012. Methods: Rotorod sampler was installed on the rooftop of St. Mary Hospital in Busan. A 24-hour sampling of allergens over a fifteen-year period was conducted 6 days/wk from January 1, 1998 to December 31, 2012. After staining they were identified, counted and recorded with the weather in Busan. Results: Major pollens collected were Pine, Alder, Oak, Juniperus, Humulus. The pollen season is relatively short and the pollen dispersed mainly during the period from March to May in case of tree pollen, from April to September in case of grass pollen and from August to October in case of weed pollen. Total annual pollen count ranged from 36,412 grains/m3 (2002) to 1,342 grains/m3 (2006). The peak pollen season was seen for spring and autumn, especially in May and September during 1998.2012. In skin prick tests, birch was the highest sensitization rate (15.1%), followed by alder (14.7%), hazel (14.1%) in the tree for 15 years. And in weed, mugwort and ragweed were the highest sensitization rate (10.6%, 10.3%), followed by humulus (5.5%) for 15 years, but since 2008, was increased. Conclusion: Analysis of pollens sampled in the atmosphere of Busan, Korea, for a 15-year period identified 24 species of pollens with seasonal variation of some clinically important pollen load. Analysis of data, it showed that alder and birch are main allergen in spring for 15 years, and in 1998.2008, ragweed and artemisia was main allergen in fall, since 2009, followed by humulus. (Allergy Asthma Respir Dis 2014;2:38-47)