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뉴로피드백 훈련이 ADHD 아동의 주의력과 문제행동에 미치는 영향
박광제,권순정,김혜란,오영주,최은영,김수경 대한아동·학교작업치료학회 2010 대한아동 ․학교작업치료학회지 Vol.1 No.-
◉ 목적: 본 연구에서는 뉴로피드백 훈련이 ADHD 아동의 문제행동과 주의력에 어떤 영향을 미치는지 알아보고자 하였다. ◉ 연구방법: ADHD로 진단받거나 관련검사에서 ADHD 성향을 보이는 아동 2명을 대상으로 하여 개별실험 연구방법 중 AB 디자인을 적용하였다. 2010년 8월 9일부터 9월 2일까지 기초선 3회기, 중재 12회기를 시행하였다. 평가로는 학습능력검사, 문제행동 관찰, 전산화 신경인지기능 검사를 사용하였고, 중재로는 뉴로피드백 훈련을 12회기 실시하였다. ◉ 결과: 아동 1은 전산화 신경인지 기능 검사 중 시각 조건 연속수행 검사의 반응시간과 색채-단어 간섭 검사의 색단어 단어 읽기 항목에서 T-점수가 증가되었고, 색단어 색채 말하기 항목에서는 중재 전과 후의 변화가 없었다. 아동 2는 전산화 신경인지 기능검사 중 시각 조건 연속수행 검사의 반응시간에서 T-점수가 증가되었고, 색단어 단어 읽기 항목에서는 T-점수 변화가 없었으며 색단어 색채 말하기 항목에서는 감소되었다. 학습능력검사에서 집중력은 아동 1, 아동 2 각각 평균 0.4% 감소, 약 2% 증가를 보였다. 각 아동의 문제행동은 평균 약 2회 감소하거나 변화가 없었다. ◉ 결론: 본 연구에서는 중재 시에 나타난 통제가 불가능한 여러 문제점으로 인해 긍정적인 결과를 얻지 못하였다. 그러나 ADHD 아동의 비약물적 중재 방법인 뉴로피드백 훈련을 적용하여 문제행동과 주의력에 대한 중재를 시도했다는 점에서 의미가 있다. 앞으로 본 연구의 문제점을 보완한 향후 연구가 더 이루어져야 할 것이다. ◉ Objective : This research organized to find what sort of effect on ADHD children’s attention and problem behavior by neurofeedback training. ◉ Methods : The 2 children whose have ADHD or disposition of ADHD had been applied the AB design of single-subject experiment research design. This study enforces 3 times of baseline and 12 times of intervention to Aug, 9th. 2010 until Sep, 2nd. 2010. This investigation had assessed by a Cognitive Functions Assessment, a problem behavior observation, and a Computerized Neuro-cognitive Function Test and then had performed the 12times of neurofeedback training. ◉ Results : The subject 1 revealed increasing T-score on the response time of Visual Controlled Continuous Performance Test in Computerized Neuro-cognitive Function Test and Word Reading of Color Word in Stroop Color-Word interference Test, however he did not reveal any difference before intervention and after intervention at the Color Naming of Color Word. The subject 2 revealed increasing T-score at the Visual Controlled Continuous Performance Test in Computerized Neuro-cognitive Function Test, and then there is a no T-score difference in Word Reading of Color-word item, even decreasing T-score at the Color Naming of Color word item. The subject 1 showed 0.4% decrease and the subject 2 showed about 2% increase in Learning Ability Test. Problem behaviors of each children decreased mean 2 times or did not show difference before and after. ◉ Conclusion : This research could not get positive result by several problems which out of control on the intervention. But this research had a specific meaning ADHD children’s non-medicative intervention method that neurofeedback training applied to try to solve the problem behavior and attention. Hereafter it needs complementary study of the problems of this research.
Melatonin Rescues Human Dental Pulp Cells from Premature Senescence Induced by H2O2
박세라,박광제,옥창엽,박현주,장혜옥,배문경,배문경,배수경 대한구강생물학회 2017 International Journal of Oral Biology Vol.42 No.3
Although anti-aging activities of melatonin, a hormone secreted by the pineal gland, have been reported in senescence-accelerated mouse models and several types of cells, its impact and mechanism on the senescence of human dental pulp cells (HDPCs) remains unknown. In this study, we examined the impact of melatonin on cellular premature senescence of HDPCs. Here, we found that melatonin markedly inhibited senescent characteristics of HDPCs after exposure to hydrogen peroxide (H2O2), including the increase in senescence-associated β-galactosidase (SA-β -gal)-positive HDPCs and the upregulation of p21 protein, an indicator for senescence. In addition, as melatonin attenuated H2O2-stimulated phosphorylation of c-Jun N-terminal kinase (JNK), while selective inhibition of JNK activity with SP600125 significantly attenuated H2O2-induced increase in SA-beta-gal activity. Results reveal that melatonin antagonizes premature senescence of HDPCs via JNK pathway. Thus, melatonin may have therapeutic potential to prevent stress-induced premature senescence, possibly correlated with development of dental pulp diseases, and to maintain oral health across the life span.
유방암세포 성장과 Bmi-1 발현에 대한 레스베라트롤의 억제 효과
박현주(Hyun-Joo Park),박광제(Kwang Je Bak),옥창엽(Chang Youp Ok),장혜옥(Hye-Ock Jang),배문경(Moon-Kyoung Bae),배수경(Soo-Kyung Bae) 한국생물공학회 2017 KSBB Journal Vol.32 No.3
Resveratrol has been actively investigated as an anticancer drug since it induces cell growth inhibition and apoptosis in many cancer cells. Resveratrol acts through modulation of multiple pathways and genes. In this study, we found resveratrol reduced cell growth and mammosphere formation in MDA-MB-231 triple-negative human breast cancer cells. This suppressive effect of resveratrol is accompanied by a reduction in Bmi-1 gene expression. We also observed that knockdown of Bmi-1 gene by small interfering RNA effectively sensitizes breast cancer cells to resveratrol treatment. Our data demonstrate, for the first time, that resveratrol down-regulates Bmi-1 expression in human breast cancer cells and suggest that specific molecular targeting of Bmi-1 can be combined with a chemotherapeutic strategy to improve the response of breast cancer cells to resveratrol.
이경재(Kyung-Jae Lee),문윤근(Yun-Keun Mun),김창용(Chang-Yong Kim),박광제(Kwang-Je Park),김동윤(Dong-Yoon Kim),김영권(Young-Kwon Kim),배재학(Jae-Hak J. Bae) 한국정보과학회 2000 한국정보과학회 학술발표논문집 Vol.27 No.1B
본 논문에서는 학교 본연의 업무인 교수학습 활동을 효과적으로 지원할 수 있는 교육 정보화 방안을 모색하였다. 이를 위해, 기업에서 적용되고 있는 학습조직의 지향점과 제 7차 교육과정의 지향점을 비교하였다. 이를 토대로, 학교의 본원적 활동을 정보기술로써 어떻게 지원할 것인가를 제시하였다.
이성규(Lee, Seong-Gyu),문태헌(Moon, Tae-Heon),박광제(Park, Kwang-Je) 한국주거환경학회 2010 주거환경(한국주거환경학회논문집) Vol.8 No.2
This study aims to analyse the situation of apartment management system and suggest improvement strategies. In Korea, rapid industrialization and economic growth had caused population concentration into urban area, which led to a housing shortage. In order to cope with this problem, government established and promoted housing supply policy like two million housing units plan in 1990's. Though mass supply of apartments could lessen the housing shortage problem, but this proliferation of apartments resulted in management problems. Considering these, this study tried to find several solutions and suggest policy directions for the effective apartment management. As research method, questionnaire survey was conducted in case study city, Jinju City, from Oct. 12th to Nov. 10th, 2009. In order to compare the opinions, the questionnaire was distributed separatedly to apartment managers and residents. According to analysis, apartment management system is not systemized yet and there are still frequent conflicts between apartment managers and residents. Thus many cases in questionnaire pointed out that management system must be flexible to meet the challenges ahead. However, the most important thing is to have good dialogue among residents, management and relevant authorities from local government. Moreover the establishment and amendment of Housing Law and introducing a mediation committee, education and fostering specialized personnels in college program were also suggested.