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분자인식 기법에 의한 키랄 의약품 분리 분석기술 개발동향
박경희(Gyung Hee Park),이요한(Yo-Han Lee),장상목(Sang Mok Chang),김우식(Woo-Sik Kim),김종민(Jong-Min Kim) 한국청정기술학회 2016 청정기술 Vol.22 No.2
문명의 발달과 더불어 경제적으로 생활이 윤택하여지고 산업기술이 고도화 되어감에 따라 평균수명이 급격히 연장되었고, 건강식품과 의약품에 대한 의존도와 수요도 급격하게 증가하는 추세이다. 최근에는 건강식품과 의약품의 부작용이 사회적인 이슈로 등장하고 부작용이 없는 의약품의 개발, 환경과 식품산업의 건전성 향상을 위해 신속 간편하며 정확하게 건강과 환경을 계측할 수 있는 기술의 개발 또한 시급한 과제로 부각되고 있다. 의약품의 생산 공정뿐만 아니라 소비자 스스로 자기건강을 자가 진단하고자 하며, 자기가 먹는 음식의 안전성 여부와 자기가 사는 환경의 안전성 여부를 스스로 확인하고자 하는 욕구 또한 증대되고 있다. 본고에서는 키랄 의약품, 기존의 키랄 의약품 분리기술, 분자자기인식 기법, 그리고 분자자기인식 기법에 의한 키랄 의약품 분리기술 개발동향에 대한 간단한 소개와 분자자기인식 기법에 의한 키랄 의약품 분리 · 분석 기술 개발 현황과 그 시장성에 대해 고찰하고자 한다. As the quality of life has improved, the desire for the safety and quality of the foods and drugs has been gradually increasing. For safety and quality management in foods, drugs, health management, agriculture, environmental conservation, and the industrial fields, the demand for quickly and accurately measuring various chemicals has been increasing. As well, the desire for self-diagnosis of one’s own health state and self-examining the safety of environment has been gradually increasing. Optical Isomers can have very different physiological effects on human beings. One isomer can exhibit desirable pharmacological, pharmacodynamic, pharmacokinetic and physiological properties, while the other isomer can exhibit undesirable and toxic properties toward living organisms, especially human beings. And they can exhibit different activities in chemical and biotechnological processes. Although the majority of commercially available drugs are now both synthetic and chiral materials, a most chiral drugs are still marketed as racemic drugs. Thus, to avoid possible undesirable side effects from chiral drugs, more effective methods for separating and recognizing chiral compounds are urgently needed. In this report, we investigated the overall developing trends of the chiral drug separation and analysis technology by using molecular recognition.
Vero-E6 세포에서 한탄바이러스의 증식에 관한 전자현미경적 연구
박경희(Gyung Hee Park),성인화(In Hwa Sung) 대한바이러스학회 1999 Journal of Bacteriology and Virology Vol.29 No.4
Results of the studies on the morphologic and molecular biologic characteristics of Hantaan virus (HTNV), one of the etiologic agents of Hemorrhagic fever with renal syndrome (HFRS), revealed that HTNV was a member of Family Bunyaviridae and its RNA divided into three segments. And the nucleotide sequences of these segments also were known and the differences in nucleotide sequences of HTNV from other members of genus Hantavirus were clearly evaluated. But the morphorgenesis, pathogenesis of HFRS and the replication time had not been clearly determined, In this study, to estimate the replication time of HTNV in Vero E-6 cells, Vero cells were infected with HTNV 76/118 strain, and cells were harvested from two hours post-infection up to 24 hours at two hours-intervals. Harvested cells were treated with ordinary techniques for electron microscopy and immune-electron microscopy. And then thin sections were observed under transmission electron microscope. HTNV particles were not found in the cytoplasm and in the extracellular space between 2-8 hours after inoculation of virus, but virus particles were observed in extracellular space near the cell membrane of Vero-E6 cells 10 hours after infection. In immune electron microscopy, mature HTNV particles in extracellular spaces and immature virus labelled with gold particles in the cytoplasm of Vero E-6 cell 10 hours after infection of HTNV could be seen. This results suggest that the replication time of HTNV might be about 10 hours.
여성 주체의 변화와 허구 - 목란시와 디즈니의 「뮬란」을 중심으로 -
박경희 ( Gyung Hee Park ) 건국대학교 동화와번역연구소(구 건국대학교 중원인문연구소) 2006 동화와 번역 Vol.12 No.-
Walt Disney`s animation "Mulan" is based on Mu-Lan-Shih, Yue-Fu-Shi of the Bei-Wei period. The particular motive in Mu-Lan-Shih, "going-to-war-in-man`s-clothes", appears in various forms of literary genre from Sui-Tang through Ming-Qing periods to the present days. This paper discusses the relation between ``women`s subjectivity`` in women`s self-realization and that in women`s self-esteem in "Mulan" which employs the motive of Mu-Lan-Shih. Looking into the nature of woman`s subjectivity of the fourth and fifth centuries` Chinese women represented in Mu-Lan-Shih and analyzing the aspect of self-realization in the animation "Mulan", the paper explicates the features of women`s subjectivity adapted in these two works. It finds the reality of women`s subjectivity by discussing the characters and themes related to the six motives, ① woman`s original function ② conscription and going-to-war-in-man`s-clothes ③ heroic exploits in the battle ④ declination of the offer of public office and homecoming ⑤ restoration of her femininity ⑥ responses of friends.
제왕절개술 환자에서 술후 통증치료를 위한 지속적 경막외 Morphine투여와 Morphin 혼합투여에 관한 연구
박경희 中央醫學社 1995 中央醫學 Vol.60 No.11
Epidural morphine and nalbuphine are commonly used for the postoperative pain control nowadays. We have evaluated the effect of continuous epidural morphine vs morphine combined with nalbuphine in 60 full term parturients. Sixty patients of ASA grade 1 to 2 scheduled to undergo elective Cesarian section were allocated randomly into three groups. Group A was given 0.25% pucaine 80 ml and 6 mg of morphine, group B and C as received with 0.12% pucaine 80 ml and 60 mg of morphine combined with nalbuphine 5 mg or 10 mg respectively. Pain score and side effect of each group were evaluated at 1, 2, 6, 12, 24, 40 hours after the administration of each drug via continuous epidural catcheter(Two day Baxter).In addition, analgesic duration time was checked. The results were as follows 1) Pain score Differences in analgesic effect at each time was significant between morphine group with nalbuphine group Group B and C combined administration of epidural morphine and nalbuphine) manifested significant lower pain score than group A. 2) Analgesic duration time. 3) Group B and C manifested more lasting analgesic effect than group A 4) Side effect of each group. Respiratory depression, pruritus, nausea vomiting, urinary retension were more frequent in group A than group B and C. but, there is no signifcant difference between group B and C.