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박경수,최영진,박재관,강교성,임동건,박재환,Park, Kyung-Su,Choi, Young-Jin,Park, Jae-Gwan,Kang, Gyo-Sung,Lim, Dong-Gun,Park, Jae-Hwan 한국재료학회 2007 한국재료학회지 Vol.17 No.9
The effect of oxygen in the synthesis of oxide nanowires by using carbothermal reduction process have been studied thermodynamically and kinetically. By using laboratory air, ZnO nanowires could be fabricated in the carbothermal reduction process and a metal oxidation process. As the processing pressure decreases, the diameter of the nanowires decreases and the oxygen vacancy increases. As the processing pressure increases, the oxygen vacancy decreases and the shape of the ZnO becomes plate-like.
Design, Syntheses, and Conformational Study of Angiogenesis Inhibitors
박경수,백동하,임동열,박상돈,김민영,박영선,김양미,Park, Gyeong Su,Baek, Dong Ha,Im, Dong Yeol,Park, Sang Don,Kim, Min Yeong,Park, Yeong Seon,Kim, Yang Mi Korean Chemical Society 2001 Bulletin of the Korean Chemical Society Vol.22 No.9
Since anti-angiogenesis could lead to the suppression of tumor growth, angiogenesis inhibitors have received particular attention for their therapeutic potential. In this study, two angiogenic inhibitors using the bioactive sequence from the kring le 5, AK1(KLYDY), AK2(KLWDF) were designed and synthesized. We have investigated their solution structures using NMR spectroscopy and their activities as angiogenesis inhibitors. AK2 has an intramolecular hydrogen bon d between the side chain amino proton of Lys1 and the carboxyl oxygen of Asp4 with a N ${\cdot}{\cdot}{\cdot}$O distance of $3.27\AA$, while AK1 shows more flexible structures than AK2. Indole ring in Trp is much bigger than the phenyl ring in Tyr and may have good face-to-edge interaction enforcing more rigid and constrained conformational features of AK2. Because of this relatively stable structure, Trp3 in AK2 may have better hydrophobic interaction with Phe5 than Tyr3 in AK1 if two adjacent aromatic groups are located in hydrophobic pocket of receptor. Since AK2 shows the similar anti-angiogenic activities to AK1, we are also able to confirm that the activity of AK1 is irrelevant to the Tyr phosphorylation. More rigid drug with higher activities can be provided by the mimetic approaches. For the further development of the angiogenesis inhibitors, these conformational studies on our lead peptides will be helpful in design of peptidomimetics.
공막 돌륭술 환자에서 피브리노겐-트롬빈 접착제를 사용한 결막 부착법의 유용성
박경수,김상우,우제문.Kyung Soo Park. MD. Sang Woo Kim. MD. PhD. Je Moon Woo. MD. PhD 대한안과학회 2013 대한안과학회지 Vol.54 No.12
Purpose: We investigated the efficacy of fibrin glue for conjunctival closure in scleral buckling operations.<br /> Methods: Thirty-seven eyes of 35 patients who underwent conjunctival closure for a scleral buckling operation with a minimum follow-up period of 3 months were evaluated. Postoperative discomfort (average score), presence of remnant adhesives, scleral buckle material infection, and wound dehiscence were evaluated prospectively in 35 eyes of 33 patients undergoing surgery with fibrin glue.<br /> Results: The eyes showed decreasing conjunctival injection and hemorrhage over time and near to full recovered without any treatment after 1 month. With time, the average discomfort score decreased significantly (p < 0.05) and wound dehiscence was found in only 1 eye. There was no adhesive remnant in any of the eyes.<br /> Conclusions: The use of fibrin glue for conjunctival closure in scleral buckling operations is excellent as a cosmetic and functional method. The glue can reduce postoperative discomfort and is especially useful as a method to replace conventional conjunctival sutures. <br /> J Korean Ophthalmol Soc 2013;54(12):1832-1837
박경수,정석희,Park, Kyoung-Su,Chung, Seok-Hee 척추신경추나의학회 2007 척추신경추나의학회지 Vol.2 No.1
Objectives : The aim of this study was to understand scale of lumbar spinal stenosis. Methods : Papers including questionnaires for assessment disability, fuction, activity limitation, or prticipation restriction in adult patients with low back pain or spinal stenosis were searched in the MEDLINE. Results and Conclusions : 1. VAS, VRS, NRS were recommended to the pain scale. 2.ODI and RMDQ were recommended to the function scale. 3. ODI, RMDQ, QBPDS, LBOS, MVAS, WDI commonly used to the fuction scale.
박경수,최정아,이은혜,Park, Kyung-Soo,Choi, Jeong-A,Lee, Eun-Hye 대한인간공학회 2005 大韓人間工學會誌 Vol.24 No.2
Human perceptional speed is different from its real speed. There is lack of research that the perceptional speed is different from real speed in 2-dimension, because most research of speed perception has concentrated on points and lines. This research investigates the effects of object size on speed perception. In this research, we used 2-D circular objects of the different size, 0.9, 1.8 and $3.6^{\circ}$. The objects moved 9.0, 13.5 and $18.0^{\circ}$ with three different speeds, 6.0, 9.0 and $18.0^{\circ}$/s. Six participants were exposed to the environment with standard scene(size: $1.8^{\circ}$, speed: $9.0^{\circ}$/s and travel distance: $13.5^{\circ}$). After the first scene, another scene in which the object had changed to different sizes, speeds and distances, was shown to the participants. A magnitude estimation method was used to construct a scale of the perceived speed level. The relationship between the perceived and the actual speed level was explained by Stevens's power law that the value was 0.978 with the exponent of 0.992. The size of object had an effect on the speed perception but travel distance was not. The perceptional speed of bigger object was lower than of smaller object. It showed that the degrees of perceptional speed decreased as size of object increased.
인간 섬유아세포에 대한 마이토마이신 C와 피르페니돈의 독성과 항섬유화효과
박경수,홍사민,이주카요코,김찬윤,성공제.Kyoung Soo Park. MD. Sa Min Hong. MD. Yoko Iizuka. MD. PhD. Chan Yun Kim. MD. Gong Je Seong. MD 대한안과학회 2014 대한안과학회지 Vol.55 No.7
<b>Purpose:</b> The cytotoxicities and anti-fibrotic effects of mitomycin C and pirfenidone on human dermal fibroblast were evaluated. <b>Methods:</b> Initially, 24-hour cell cultures were exposed to transforming growth factor (TGF)-β1, different concentrations of mitomycin C, and pirfenidone solutions in order to evaluate cytotoxicity. Expressions of fibronectin, collagen type 1, α smooth muscle, and β-actin were evaluated by real-time reverse transcription-polymerase chain reaction (RT-PCR) and western blot in mitomycin C solutions at concentrations of 4 μg/mL and 20 μg/mL, and in pirfenidone solutions at 250 μg/mL and 500 μg/mL. <b>Results:</b> In comparison to cell cultures exposed to TGF-β1 solutions, cytotoxicities were increased in solutions of mitomycin C at 4 μg/mL, 20 μg/mL, 40 μg/mL and pirfenidone at 500 μg/mL, 750 μg/mL, 1,000 μg/mL (<em>p</em> < 0.05, Mann Whitney U-test). The results of real-time RT-PCR show that expressions of fibronectin, collagen type 1, and α smooth muscle were significantly more decreased in all concentrations of mitomycin C and pirfenidone compared to those in TGF-β1 solution. In western blot analysis, expressions of fibronectin and α smooth muscle were decreased in all concentrations of mitomycin C and pirfenidone compared to TGF-β1 solution. <b>Conclusions:</b> Both drugs have cytotoxicities and anti-fibrotic effects, but pirfenidone was found to have less cytotoxicity and mitomycin C was found to have more anti-fibrotic effects when compared to each other. J Korean Ophthalmol Soc 2014;55(7):1077-1083
박경수,엄진섭,Park Kyoungsu,Eom Jinseob 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.5a
본 논문에서는 팔 길이 가변 마이켈슨 간섭계를 이용한 파장 잠금 구조를 새로이 제안하였다. 제안된 구조는 LD 드라이버, 마이켈슨 간섭계, ATC, APC, 신호처리부로 구성된다. 이 구조에서는 0.0005nm(=62.4MHz)이하의 정밀도로 파장 잠금이 가능하며, 마이켈슨 간섭계의 팔 길이가변성을 이용하여 주위 환경변화에 따른 문제점들에 쉽게 대처할 수 있다. In this paper, we propose a new wavelength locking structure which uses the Michelson interferometer equipped with a movable arm. The proposed one consists of LD driver, Michelson interferometer, automatic temperature controller, automatic power controller, and signal processor. This structure can provide the wavelength locking capability of a resolution below 0.0005nm(=62.4MHz) and cope easily with an external environment variation using movable arm of Michelson interferometer to give a good stability.
VDT작업에서의 근골격계 질환 예방을 위한 새로운 팔 지지대 제안
박경수,김상수,조일행,홍기범,Park, Gyeong-Su,Kim, Sang-Su,Jo, Il-Haeng,Hong, Gi-Beom 대한인간공학회 2006 大韓人間工學會誌 Vol.25 No.2
In spite of the rapid increase of computer use in our everyday life, not much effort is undertaken to take measures to prevent Musculoskeletal Disorders(MSDs). In this paper, we suggest a movable armrest which would lower the exposure to the MSDs, especially on the vicinity of arm. The aim of this study is to determine whether there are differences in wrist angle variations, forearm muscular loads, comfort and normal performance between the invented movable armrest and a conventional armrest when using a computer mouse. Eight experienced VDU workers performed a standardized simple task set which consists of 15 detailed tasks with each armrest. The wrist angle variations in the right arm were registered by electrogoniometer and the muscle activities in the shoulder, deltoid and two extensors in the forearm were also registered by electromyograph. The subjects rated perceived comfort while performing the tasks with each armrest. Working with the invented armrest, compared to general, gave significantly decreased wrist angle variations at most of the detailed tasks of both biaxial movements. Moreover, as the distance of targets increased, the difference of muscle activities in two different situations trend to be increasing. At the same time, in work with invented armrest, the subjects rated more comfort and they showed decreased normal performances in 8 detailed tasks which were mainly caused by macro moving time.