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민성욱 ( Seong Uk Min ),이갑석 ( Kap Sok Li ),원종현 ( Chong Hyun Won ),조소연 ( So Yun Cho ),허창훈 ( Chang Hun Huh ),김범준 ( Beom Joon Kim ),김명남 ( Myeung Nam Kim ),김성은 ( Sung Eun Kim ),김찬웅 ( Chan Woong Kim ),박하나 ( H 대한피부과학회 2007 대한피부과학회지 Vol.45 No.11
Background: Ramsay Hunt syndrome (herpes zoster oticus) is characterized by vesicles on the pinna, otalgia, facial nerve palsy and sensorineural hearing loss. It is not such a common dermatological disease like herpes zoster. However, reactivation of the latent varicella zoster virus causes facial palsy and therapeutic onset is one of the prognostic factors in Ramsay Hunt syndrome. Objective: The aim of this study was to elucidate the epidemiology, the clinical characteristics of Ramsay Hunt syndrome and prognosis according to therapeutic ways. Methods: The 84 cases diagnosed as Ramsay Hunt syndrome from January 2000 to July 2007 were assessed in regard to age, sex, clinical characteristics, electromyography (EMG) results, onset of neurological recovery according to medication and onset of rehabilitation therapy by review of medical records. Results: Ramsay Hunt syndrome consisted 4.7% (84 cases of 1787) of total herpes zoster patients. The ratio of male to female patients was 37:47. Frequency was slightly higher in female patients. The mean age was 62±14.7 and the age distribution was in the range of 26∼87 years. The most common clinical appearance was vesicular eruptions and facical nerve palsy including change in nasolabial fold and location of the lip (73.8%), followed by vesicular eruptions and vestibulocochlear symptoms like tinnitus and vertigo (16.7%), facial nerve palsy and vestibulocochlear symptoms appearing together (9.5%). EMG showed abnormal results in 67.9%. More than one kind of abnormality was commonly observed. The most common abnormal EMG result was fibrillation potential (42.2%), followed by positive sharp wave (31.3%), polyphasia (10.8%), high frequency discharge (8.4%), increased insertional activity (4.8%) and fasciculation (2.5%). There was no significant difference in onset of neurological recovery between acyclovir injections and oral famciclovir or valaciclovir treatment. The patients who had received physical therapy a week after the symptoms had developed, had a faster onset of recovery (2.8 week Vs 4.1 week, p<0.05). Conclusion: This study suggests that antiviral agents of a different kind may not affect recovery onset and earlier rehabilitation therapy seems to be effective in neurological recovery in Ramsay Hunt syndrome. (Korean J Dermatol 2007;45(11):1121∼1126)
김준형 ( Jun Hyung Kim ),민성욱 ( Seong Uk Min ),최유성 ( Yu Sung Choi ),서대헌 ( Dae Hun Suh ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.11
Infantile acne is a much less common disease than adolescent and postadolescent acne. It occurs in children approximately at 3 to 6 months of age. An 8 month-old male infant, accompanied by his mother, visited our clinic with a history of erythematous skin lesions on both cheeks, which started 5 months ago. Physical examination revealed closed comedones, several relatively well demarcated, erythematous papules, nodules and pustules. Inflammatory lesions left scars scattered over the face. For further evaluation of endocrinologic abnormalities or other systemic diseases, an additional abdominal ultrasound was done after a visit to the pediatrician. A skin biopsy revealed findings compatible with acne. Skin lesions were improved by treatment with oral and topical antibiotics, adapalene and isotretinoin. We report herein a case of infantile acne which has not been reported in Korean dermatological literature. (Korean J Dermatol 2007;45(11):1173∼1175)
Erlotinib (Tarceva(R)) 복용 후 생긴 여드름양 발진 및 조갑주위염
연제호 ( Je Ho Yeon ),민성욱 ( Seong Uk Min ),이동훈 ( Dong Hun Lee ),최유성 ( Yu Sung Choi ),서대헌 ( Dae Hun Suh ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.11
Erlotinib (Tarceva(R)) is a new anti-cancer agent which acts by inhibiting epidermal growth factor receptor (EGFR) signal transduction. It is currently used in the treatment of advanced stage non-small cell lung cancer and pancreatic cancer. We report a case of acneiform eruption and paronychia induced by erlotinib in a 69-year-old man. The patient visited our clinic with multiple erythematous papules and pustules on the face, periungual erythema and pus discharge, xerosis, fissures on the sole. He had taken erlotinib for the treatment of recurred lung cancer for 4 weeks. The skin lesions were partially improved with oral pyridoxine, corticosteroid and topical antibiotics. (Korean J Dermatol 2007;45(11):1180∼1182)
안와주위 부종과 박탈 피부염 소견을 보인 Imatinib Mesylate (Gleevec(TM))에 의한 약진
주영현 ( Young Hyun Joo ),민성욱 ( Seong Uk Min ),이동훈 ( Dong Hun Lee ),서대헌 ( Dae Hun Suh ) 대한피부과학회 2007 대한피부과학회지 Vol.45 No.2
STI571 (imatinib mesylate, Gleevec(TM)), a selective inhibitor of the bcr-abl, c-kit, platelet-derived growth factor receptor tyrosine kinases, is a new anticancer drug used for chronic myelogenous leukemia and gastrointestinal stromal tumors. Cutaneous adverse reactions of periorbital edema and exfoliative dermatitis related to STI571 are rare and there have been no previous reports in the Korean literature. We herein report a case of periorbital edema and exfoliative dermatitis due to STI571 and discuss the possible mechanism of periorbital edema related to STI571. (Korean J Dermatol 2007;45(2):194~196)
주기적 면역글로불린 정맥 투여로 호전된 청피반성 혈관염 2예
변희진 ( Hee Jin Byun ),박현선 ( Hyun Sun Park ),민성욱 ( Seong Uk Min ),신효승 ( Hyo Seung Shin ),이갑석 ( Kap Sok Li ),원종현 ( Chong Hyun Won ),조소연 ( So Yun Cho ) 대한피부과학회 2006 대한피부과학회지 Vol.44 No.10
Livedo vasculitis is a chronic dermatosis characterized by recurrent painful ulceration of the lower limbs, which heals to leave atrophie blanche. The precise pathophysiology is not known. Antiplatelet, anticoagulant, fibrinolytic therapies and anabolic steroids have been reported to be helpful in this syndrome. However, no consistent benefit has been demonstrated with any treatment modality. Recently, pulsed intravenous immunoglobulin therapy has been reported to be effective in some refractory cases. We herein report two cases of recalcitrant livedo vasculitis which were effectively treated with pulsed intravenous immunoglobulin therapy. These were the first trials carried out in Korea. (Korean J Dermatol 2006;44(10):1231~1234)
Klinefelter 증후군 남아에서 발생한 색소실조증
황은정 ( Eun Jung Hwang ),박경열 ( Gyeong Yul Park ),민성욱 ( Seong Uk Min ),조광현 ( Kwang Hyun Cho ) 대한피부과학회 2014 대한피부과학회지 Vol.52 No.9
Incontinentia pigmenti (IP) is an uncommon X-linked, dominantly inherited disorder due to a mutation in the NEMO(NF-κB essential modulator) gene on the X chromosome. IP mostly occurs in female infants, it is usually embryonic lethal in males. The mechanisms for survival of affected males are explained by the presence of an extra X chromosome (Klinefelter``s syndrome), hypomorphic mutations, and somatic mosaicism. We report here a rare case of incontinentia pigmenti in a 13-year-old boy with Klinefelter``s syndrome, NEMO gene mutation, and whorled, hyperkeratotic, hyperpigmented, linear lesions along the lines of Blaschko on the trunk and leg. (Korean J Dermatol 2014;52(9):642∼645)
김병윤 ( Byung Yoon Kim ),연제호 ( Je Ho Yeon ),민성욱 ( Seong Uk Min ),이동훈 ( Dong Hun Lee ),서대헌 ( Dae Hun Suh ) 대한피부과학회 2009 대한피부과학회지 Vol.47 No.4
Ectopic nail is characterized by growth of nail-like tissue in a location other than the nail bed. It is an extremely rare disorder that can be either congenital or acquired from incidents such as trauma. An 8-year old female presented with a complaint of a nail-like lesion on the dorsal surface around the center of the right fifth toe. It had been present for 3 years, while the patient continuously clipped it upon growth. The fifth toe was initially injured by a chair that had fallen on that toe 4 years prior to her visit. There was no associated bony deformity or other physical changes in the nail. A clinical diagnosis of ectopic nail was made and it was surgically excised under local anesthesia. The histopathological examination revealed a normal nail unit and there was no recurrence during the 6 month follow-up period. (Korean J Dermatol 2009;47(4):491~493)