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문기명,김대연,김성철,김인구,Moon, Ki-Myung,Kim, Dae-Yeon,Kim, Seong-Chul,Kim, In-Koo 대한소아외과학회 2004 소아외과 Vol.10 No.2
Intestinal obstruction secondary to intraabdominal adhesion is a well-known postoperative complication occurring after appendectomy. The aim of this study was to measure the incidence and clinical manifestations of mechanical intestinal obstruction after appendectomy for perforated appendicitis. We reviewed all of the children (age <16 years) who had been treated for appendicitis at Asan Medical Center between January 1996 and December 2001. Inclusion criterion included either gross or microscopic evidence of appendiceal perforation. Exclusion criteria were interval appendectomy, and patients immune compromised by chemotherapy. Associations of intestinal obstruction with age, sex, operation time, and use of peritoneal drains were analyzed. Four hundred and sixty two open appendectomies for appendicitis were performed at our department. One hundred and seventeen children were treated for perforated appendicitis (78 boys, 39 girls). The mean age was 8.9 years (range 1.5 to 14.8 years). There were no deaths. Eight patients were readmitted due to intestinal obstruction, but there was no readmission due to intestinal obstruction in patients with non-perforated appendicitis. The interval between appendectomy and intestinal obstruction varied from 12 days to 2 year 7 months. Four patients needed laparotomies. In three of four, only adhesiolysis was performed. One child needed small bowel resection combined with adhesiolysis. There was no significant association between age or sex and the development of intestinal obstruction. This was no association with operative time or use of peritoneal drain. Patients who required appendectomy for perforated appendicitis have a higher incidence of postoperative intestinal obstruction than those with nonperforated appendicitis. For the patients with perforated appendicitis, careful operative procedures as well as pre and postoperative managements are required to reduce adhesions and subsequent bowel obstruction.
남종길,문기명,박성우,정문기 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.4
We herein report a case of radical nephroureterectomy and replacement of the inferior vena cava (IVC) with ahuman cadaveric aortic graft for a patient with renal pelvis transitional cell carcinoma associated with IVC infiltration. In advanced disease, radical surgery is essential to achieve long-term survival. This case entails the use of another treatment option among the numerous options currently available for the management of patients with advanced renal cancer associated with IVC invasion.
최정규,문기명,정석윤,김지용,최성현,김다연,강송화,주종우,권상모 대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.2
Endothelial progenitor cells (EPCs) are known to play an important role in the repair of damagedblood vessels. We used an endothelial progenitor cell colony-forming assay (EPC-CFA) to determinewhether EPC numbers could be increased in healthy individuals through regular exercise training. The number of functional EPCs obtained from human peripheral blood-derived AC133 stem cells wasmeasured after a 28-day regular exercise training program. The number of total endothelial progenitorcell colony-forming units (EPC-CFU) was significantly increased compared to that in the control group(p=0.02, n=5). In addition, we observed a significant decrease in homocysteine levels followed by anincrease in the number of EPC-CFUs (p=0.04, n=5), indicating that the 28-day regular exercise trainingcould increase the number of EPC colonies and decrease homocysteine levels. Moreover, an inversecorrelation was observed between small-endothelial progenitor cell colony-forming units (small-EPCCFUs)and plasma homocysteine levels in healthy men (r=- 0.8125, p=0.047). We found that regularexercise training could increase the number of EPC-CFUs and decrease homocysteine levels, thusdecreasing the cardiovascular disease risk in men.