만성 간염에서 Interleukin-6의 간내발현

김성숙(Sung Sook Kim),김도영(Doe Young Kim),문일환(Il Whan Moon),변광호(Kwang Ho Pyun),최인표(In Pyo Choi) 대한소화기학회 1995 대한소화기학회지 Vol.27 No.4

N/A Rackground/Aims: Interleukin-6 (lL-6), also known as B cell stimulatory factor 2(BSF-2), induces the final maturation of B cells to antitxxiy-producing cells. IL-6 has many biologic properties including the immune and intlammatory responses. This study wos aimed to evaluate the role of local interleukin 6(IL-6) in the pathogenesis of chronic hepatitis. Methods; We examined the cellular site and grade of IL-6 staining in paraffin sections of the liver from 24 patients with liver disease, using immunohistochemistry with a polyclonal antitwdy. The patient. Were divided into two groups; Group A(n=l3) with high histologic uctivi1y consisted of CAH-type B(n=10) ond active cirrhosis(n=3), whilc Group B(n= l l) with low hi.itologic activity consisted of CPH-type B(n=4), inactive cirrhosis(n=2) and fatty liver(n=S). Results: There was no staining of IL-6 in normal liver tissue. Thv grade.I of IL-6 staining in Group A were three positive in seven cases (53.81o), two positive in five ca.ics(38.3%) and one positive in only one case(7.7%), while those in Group B were one positivc in three cases(27.3%) ancl trace in eight case.(72.7ln). IL-6 stained cells in chronic hepatitis were hepatocytcs, cspecially in the areu ot' piecemeol necrosi.I, bilc duct cel1., infiltrating inflammatory cells and endothelial cell.I. The score of histological activity index(HAJ), piecemeal necrosis and fibrasis and thc gradv. Of 1L-6 staining of Group A were ull significantly higher than those of Group B. The grade of IL-6 staining and HAI werc well correlated(r =0.74, p 0.0l), Conclusion: Locally produced IL-6 in the liver may contribute to the inflammatory process and immunological response in chronic hepatiti.. (Korean 3 Gastroenterol 1995;27:403-411)

사람 위 평활근 세포 내에서 카바콜에 의한 칼슘 농도 증가의 기전

문원(Won Moon),김영호(Young Ho Kim),박동일(Dong Il Park),이풍렬(Poong Lyul Rhee),김재준(Jae J . Kim),고광철(Kwang Cheol Koh),이종철(Jong Chul Rhee),최규완(Kyoo Wan Choi),강동묵(Tong Mook Kang) 대한내과학회 2001 대한내과학회지 Vol.60 No.5

N/A Background : The contraction of smooth muscle depends on an increase in the concentration of intracellular calcium ion and the source of this increase to various stimuli is different according to organs or species. Nevertheless, there have been only a few studies on human stomach smooth muscle. This study was designed to identify the source of the calcium utilized in the muscle contraction induced by carbachol, which is an important factor among various stimuli. Methods : After the administration of carbachol with various conditions in cultured human stomach smooth muscle cells, fura-2-acetoxymethyl ester was used to measure the increase in the intracellular calcium concentration. Results : (1) The carbachol-induced increase in the intracellular calcium concentration was not attenuated after removal of extracellular calcium. (2) Carbachol induced a small increase in the intracellular calcium concentration even after the depletion of intracellular calcium store. (3) Repeated histamine administration blocked the carbachol-induced increase in the intracellular calcium concentration in calcium-free extracellular solution. Conclusion : The main source of calcium utilized in human stomach smooth muscle contraction by carbachol is intracellular calcium store, particularly inositol triphosphate(IP3) - sensitive calcium stores. However, extracellular calcium also contributes to the carbachol-induced increase in the intracellular calcium concentration. (Korean J Med 60:432-438, 2001)

RDM(Real-time Digital Map)제작을 위한 관심영역 추출기법 사례 조사분석

문광일(Kwang-Il Moon),편무욱(Moo-Wook Pyeon),김강산(Kang-San Kim),김종화(Jong-Hwa Kim) 대한공간정보학회 2014 한국지형공간정보학회 학술대회 Vol.2014 No.5

본 연구는 3D 공간정보 분야의 Real-time Digital Map(RDM)에 구축에 필요한 3D 포인트 클라우드를 추출하는 영상정렬 기법에서 불필요한 영상간의 정합점을 제거할 수 있는 관심영역 추출 기법(Region of interest extraction techniques)에 대한 사례를 조사 및 분석하였다. 관심영역을 추출하기 위한 영상분할 기법은 경계선(edge)기반 기법과 영역(region)기반 기법이 있으며 경계선 기반 기법은 잡음에 민감하고 폐곡선 형태의 경계선을 얻기 어렵고 영역 기반 기법은 객체간의 세부적인 경계선을 명확하게 추출하기 어렵다는 문제점을 발견하였다. 이를 보완하기 위한 방법으로 영역인접 그래프를 이용한 병합이나 컬러 히스토그램 유사도를 이용한 병합, 크기 및 영역 관계를 이용한 병합 등을 통해 관심 영역을 추출하는 기법을 사용한다. 또한 기법들의 병합을 통해 영상 매칭 시 매칭정확도를 향상 시킬 수 있을 것으로 예상된다.

총담관암에서 담관 금속스텐트 삽관 후 발생한 십이지장-담관 누공 1예

문설경 ( Seol Kyung Moon ),정대영 ( Dae Young Cheung ),김지훈 ( Ji Hun Kim ),임은주 ( Eun Joo Im ),하직환 ( Jick Hwan Ha ),김진일 ( Jin Il Kim ),박수헌 ( Soo Heon Park ),김재광 ( Jae Kwang Kim ) 대한소화기학회 2008 대한소화기학회지 Vol.51 No.5

Biliary drainage in patients with malignant biliary obstruction relieves jaundice and prevents the development of cholangitis or hepatic failure from biliary obstruction. Therefore, this may result in better quality of life along with survival prolongation. Biliary stent placement is an effective and safe measure for biliary decompression and is preferred than bypass surgery in high risk patients. Entero-biliary perforation-communication is one of the rare complications of biliary stent. We herein report a case of duodeno-biliary perforation-communication in patient with distal cholangiocarcinoma who presented with duodenal ulcer and obstruction, occurring 4 years later from the metallic biliary stent insertion. Patient was managed with a pyloric metal stent and conservative care. (Korean J Gastroenterol 2008;51:314-318)

민중극의 새로운 형식실험 : 호르바트의 새로운 민중극으로의 발전과정

문광일 ( Kwang Il Moon ) 한국독일언어문학회 2008 독일언어문학 Vol.0 No.39

Die vorliegende Arbeit versucht, Odon von Horvaths fruhere Stucke in formexperimentellem Kontext zu betrachten und seine Werke in Bezug auf den Entwicklungsprozess zum neuen Volksstuck zu analysieren. Horvath versucht, eine neue Form des Volkstucks zu finden. Sein neues Volksstuck entsteht durch den experimentellen Ansatz, der in seinen fruheren Stucken zu sehen ist. Die Form dieses Entwicklungsprozesses kann man im neuen Volksstuck Horvaths deutlich nachvollziehen. Dabei kann man zum einen die Methode des Konstruktionsprinzips verfolgen, wobei Horvath den Akt als Konstruktionsmittel in den Dramen Bergbahn und Zur schonen Aussicht schon benutzt, Akt und Bild aber in Sladek oder die schwarze Armee mischt. Daruber hinaus arbeitet er in Rund um den Kongreß mit verzogerten Bildern. Zum anderen wechselt er zwischen Akt und verzogerten Bildern, oder wie im Beispiel Kasimir und Karoline(1931), wo er 117 Szenen ohne Pause hintereinander ablaufen lasst. Hier kann man Sprachveranderungen des Stuckes beobachten: Die Leitsprache in Bergbahn sind Dialekte des ostalpenlandischen Proletariats. In Zur schonen Aussicht wird anfangs Hochdeutsch verwendet, dass sich spater wieder in Umgangssprache verandert. Zum Schluss endet sie im Volksstuck im Bildungsjargon. Im Stuck Zur schonen Aussicht karikiert er die egoistischen Menschen, und er experimentiert gleichzeitig mit der Moglichkeit der Komodie. Im Stuck Sladek oder die schwarze Armee, dessen Untertitel “Historie” ist, kritisiert er einen zeittendenziosen Menschentyp und zeigt dabei die kranke Gesellschaft. Im Stuck Rund um den Kongreß, dessen Thema Prostiution ist, ubt er in Form einer Posse Gesellschaftskritik aus. In diesen Stucken kann man schon einen Keim der Volkstucke erkennen, den Horvath bald in seinen Volksstucken wiederholt und variiert. Veranderungen kann man auch in der Struktur des Stucks feststellen. Die Struktur der fruheren drei Dramen war eine Liniestruktur. Obwohl diese Strukturen in Rund um den Kongreß noch nicht ganz ausgewogen sind, werden sie spater in eine besondere Zyklus-Struktur gebracht. Wenn man diesen Veranderungsprozess in Hinsicht auf die Form sieht, konnen die vier Stucke von 1926-1929 als ein formexperimenteller Prozess zur Entwicklung zum Volksstuck gelten, und dadurch zur Reife gebracht werden. Hier angekommen, macht Horvath ein neues Formexperiment. Er versucht eine offene Form des Dramas. Spater geht er allmahlich weiter von der geschlossenen zur offenen Form uber. Durch diesen experimentellen Versuch konstruiert er seine eigene neue Form des Volksstucks.

금전과 도덕의 관계 - 문학적 답변의 한 예: 호르바트의 『전망 좋은 호텔』

문광일 ( Kwang Il Moon ) 한국독일어문학회 2013 독일어문학 Vol.61 No.-

Horvaths Werk Zur schonen Aussicht zeigt sehr gut, wie das Geld das Verhalten der Menschen und deren Moral verandert. In diesem Stuck finden wir die Heldin Christine, die die Realitat nicht exakt sieht oder sie zu sehen verweigert, weil sie von ihrer Fantasie besessen ist. Durch ihre Wahrnehmung konnen wir von ihren Bemuhungen erfahren, die Realitat positiv zu sehen. Diese Verzerrung der Realitat fuhrt zu wirklichen Demutigungen und Schamgefuhl. Nur das Geld, das sie spater von einer Verwandten erbt, kann sie von diesen Leiden retten. Die Manner, die Christine umgeben, verachten und misshandeln sie. Doch nachdem sie zu Geld kommt, verandert sich auch ihr Verhalten. Zwar sind die Manner verschieden, verhalten sich aber dem Geld gegenuber alle gleich. In diesem Sinne macht das Geld alle gleich und vereitelt ein moralisches Verhalten der Menschen. Auf der anderen Seite gibt es in diesem Stuck einige interessante komodiantische Techniken. Das Komodiantische, die Arten und Handlungen des Stucks im Stuck, wie sie bisher verwendet und eingesetzt wurden, hat verschiedene Funktionen. So verkehrt der Autor traditionelle Elemente der Komodie, um den Inhalt wirkungsvoll umzusetzen, wobei hier besonders interessant ist, dass die Technik des Umkehr-Musters sowohl im Motiv der Vererbung als auch des Traums erscheint.

화질개선 알고리즘들을 이용한 SIFT 정합점 증가 분석

문광일(Il-Kwang Moon),편무욱(Mu-Wook Pyeon),김종화(Jong-Hwa Kim),김강산(Kang-San Kim) 대한공간정보학회 2015 한국지형공간정보학회 학술대회 Vol.2015 No.5

Realtime Digital Map(RDM) 제작을 위한 Direct Linear Transformation(DLT) 위치 결정 기술 실험

문광일(Kwang-il Moon),편무욱(MuWook Pyeon),김종화(JongHwa Kim),문수정(Sujung Moon),김강산(KangSan Kim) 대한공간정보학회 2015 한국지형공간정보학회 학술대회 Vol.2015 No.9

KTX 개통에 따른 암환자의 일 대학병원 입원 이용 변화 GIS분석

문홍진 ( Hong Jin Moon ),이원재 ( Won Jae Lee ),최광일 ( Kwang Il Choi ) 대한보건협회 2013 대한보건연구 Vol.39 No.2

Objectives: This study analyzed how the operation of KTX influenced for the cancer inpatients on the use of a large education hospital in Seoul. It compared residences of inpatients of the hospital from March of 2003 to February of 2004 and from March of 2005 to February of 2006 to analyze the effect of KTX. Methods: Most of the researches used GIS were static, but this study expressed the change of inpatients and KTX stations on the space. Results: The results of the study showed that the number of inpatients of the hospital increased in the areas with KTX stations and the trend seemed to be continued. Especially, major cancer patients were increased sharply. Cancer patietns from Dague, Ulsan, and Dajeon, which had KTX stations, were increased a lot in the hospital. Conclusion: Hospitals need to change their management strategies as KTX influence the choice of hospitals of the patients. Large education hospitals need to concentrate on the high difficulty medical care and mid and small hospitals need to concentrate on the mid-low difficulty services. Besides, health care delivery system should be reoriented to induce hospitals to provide adequate services by their level of technologies. Small and medium size hospitals need to provide comprehensive care for patients with chronic diseases and health promotion services as health promoting hospitals do.

실내·외 조도에 따른 스테레오 CCTV 영상 정합점 수 변화

문광일(Moon, Kwang il),편무욱(Pyeon, Mu Wook),김종화(Kim, Jong Hwa),김강산(Kim, Kang San) 대한공간정보학회 2015 대한공간정보학회지 Vol.23 No.1

도시기반시설에 첨단 정보통신기술을 융합하여 언제 어디서나 자유롭게 서비스를 제공하고자 하는 U-City (Ubiquitous City)의 공간정보기술은 다양한 형태로 서비스 되고 있다. 그 중에서도 U-City에서 가장 많이 설치되어 있는 CCTV(Closed Circuit TV)의 스테레오 영상을 가지고 특징점(Key Point)을 선정하여 정합(Matching)하고 3차원 공간정보를 구축하는 연구가 진행되고 있다. 하지만 대부분 정합점을 추출하는데 사용된 데이터는 조도와 같은 외부 환경영향을 고려하지 않고 있다. 본 논문은 동일한 하드웨어에서 조도의 변화에 의해 영상의 질이 좌우되는 CCTV를 가지고 3차원 공간정보를 구축하는데 필요한 정합점이 조도에 따라 얼마나 변화 하는지 실험을 하였다. 조도에 따른 정합점 수의 분석 결과, 카메라의 조리개, 셔터속도, 감도를 고정하였을 때 3,000Lux까지 정합점 수가 조도에 비례하여 높아 졌으며, 물체와 배경의 경계가 뚜렷해졌다. 반대로 빛이 과도하게 들어 왔을 경우 화면이 밝아지며, 노이즈가 발생하고 사물과 사물의 경계가 없어져 특징점을 선정하기가 힘들었다. 본 논문에서 얻어진 결과를 이용하여 촬영할 경우 향상된 정합점을 가질 수 있을 것으로 기대된다. The Ubiquitous City (U-City) spatial information technology aimed to provide services freely anytime and anywhere by converging high-tech information & communication technology in urban infrastructure has been available in diverse patterns. In particular, there have been studies on the development of 3D spatial information after selecting and matching key points with stereo images from the many Closed Circuit TV (CCTV) in the U-City. However, the data mostly used in extracting matching points haven’t considered external environmental impacts such as illuminance. This study tested how much the matching points needed to construct 3D spatial information with the CCTV whose image quality is dependent upon changes in illuminance fluctuate under the same hardware performances. According to analysis on the number of matching points by illuminance, the number of matching points increased up to 3,000Lux in proportion to the illuminance when IRIS, shutter speed and ISO were fixed. In addition, a border between an object and background became more distinctive. When there was too much light, however, the page became brighter, and noise occurred. Furthermore, it was difficult to name key points because of the collapse of an inter-object border. It appears that if filmed with the study results, the number of matching points would increase.