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Single port laparoscopic myomectomy with modified suture technique using Hem-o-lock ligation clip
심민희,목지원,백이선,최현진,김태중,이정원,김병기,배덕수,최철훈 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: This study was to introduce a new approach of single-port laparoscopic myomectomy and present the operative outcomes. 방법: The inclusion criteria were symptomatic myoma measuring 10 cm or less and the number of myoma less than 3. The modified suture technique consists of continuous suture in a double layer, horizontal mattress suture with Hem-o-lock followed by “Baseball type suture”. 결과: Forty-two patients (76.4%) had single myoma. The most common type of the largest myoma was intramural (65.5%) and anteriorly located myoma (47.3%). The mean diameter of myoma was 6.8 ± 1.5 cm (range 5.0 – 9.9 cm), as measured by ultrasound. The most common symptoms were menorrhagia in 40% of patients followed by compression symptoms in 38.2%. The mean operative time and blood loss were 100.4 ± 41.1 minutes and 137.0 ± 116.9 ml, respectively. The mean hospital stay was 2.9 ± 0.6 days. No major complications occurred. Sixteen (29.1%) patients needed an additional port, and patients who were nulliparous and/or had a large myoma size needed an additional port more frequently (p=0.007, p=0.013, respectively). Two patients were pregnant after LM and they had a full-term delivery without side effects. 결론: SP-LM using modified suture technique is a feasible and effective in selected patients.
p53 gene mutations and amplification of c-erbB-2 in breast cancer
Yoon, Keun-young,Mok, Jee-Won,Lee, Min-hyuk,Park, Sung-sup,Park, Kyung-Sook 성신여자대학교 기초과학연구소 2001 基礎科學硏究誌 Vol.19 No.-
유방암은 종양억제 유전자 p53의 돌연변이 또는 기능 상실의 유전적인 요인과 종양유전자 c-erbB-2의 활성화에 의해 일어날 수 있으며, 한국 여성의 암발병율에서 3위를 차지하고 있다. 29명의 한국인 infiltrating ductal 유방암 환자를 대상으로 p53 유전자의 exons 2에서 11까지의 돌연변이를 PCR-Single Strand Conformation Polymorphism법과 직접염기서열분석법으로 분석하고, c-erbB-2의 증폭을 differential PCR로 확인하였다. 연구결과 20.6% (6예)의 p53 돌연변이가 나타났는데, 한개의 점돌연변이 (엑손 7: CD 248 CGG→ CAG)와 다섯개의 격자이동 돌연변이 (엑손 5: CD 181 -G, 엑손 6: CD 196 -G, 엑손 7· CD 234 -C, 엑손 8: CD 291 +A, 엑손 9: CD 316 +GG)로 다섯개의 격자이동 돌연변이가 많이 나타났다. 엑손 2-4 및 10-11에서는 돌연변이가 발견되지 않았다. c-erbB-2 증폭은 3예 (10%)에서 나타났으며, p53 돌연변이와 c-erbB-2 증폭은 유의한 상관관계를 보이지 않았다. 환자의 연령, 병기, 에스트로겐 수용체/프로게스테론 수용체, 종양의 크기, 폐경 및 림프절 전이도, p53 및 c-erbB-2와 관련하여 살펴보았으나 특이한 상관관계는 발견되지 않았다. p53 돌연변이 빈도와 분포는 일본, 미국, 프랑스등에서 보고된 결과와 유사하였으나, 돌연변이 양상은 점돌연변이가 대부분인 타 실험결과와는 달리 격자이동 돌연변이가 83%로 나타났다. 이로써, p53의 돌연변이는 지역이나 인종에 따라차이를 보이며, 유방암의 발병은 p53 종양억제 유전자의 체세포변이에 의함을 알 수 있었다.
Polymorphisms of the CYP2E1 in Koreans
Park, KyungSook,Mok, JeeWon 한국유전학회 2002 Genes & Genomics Vol.24 No.2
Cytochrome P450 2E1 (CYP2E1) is known to be a very important toxicological enzyme, particularly carcinogenesis, where there are interindividual variations of the CYP2E1 activities. To investigate the genetic variation in several regions of the CYP2E1 gene participating in the CYP2E1 expression, we analyzed one 5'-flanking region repeat polymorphism between -2178 to -1945, and five SNPs at the position -1293 G > C (PstI), -1053 C > T (RsaI) in 5'-flanking region, 1132 G > A (HhaI) in exon 2, 7632 T > A (DraI) in intron 6, and a single strand-conformational polymorphism at a position of 10023 G > A (V389I) of exon 8 from 323 Koreans. The CYP2E1*6, 6 VNTRs between -2178 to -1945, -1293*G and -1053*C in the 5'-flanking region were common alleles frequencies with of 79.3%, 77.2%, and 77.2%, respectively. The allele frequencies of the exons and introns regions at positions of 1132*G, 7632*T and 10023*G were 99.7%, 75.5% and 83.4%, respectively. There was no deviation detected in the Hardy-Weinberg Equilibrium. And PstI and RsaI polymorphisms in the 5'-flanking region were in complete linkage disequilibrium with each other. The VNTR/-1293/-1053/1132/7632/10023, 6/G/C/G/T/G (58.4%) in combination with the six types of CYP2El polymorphisms was dominant. Results of CYP2E1 polymorphisms showed that the frequencies of variants in the 5'-flanking region of CYP2E1 were higher than those in the exons. The allelic frequencies of CYP2E1 were ethnically different, variant alleles common among East Asians - including Koreans - but very rare among Caucasians