인체 폐암조직에서 Phospholipase C-γ1의 활성화 단백, AHNAK의 발현양상

류한영 ( Han Young Ryu ),하만준 ( Mahn Joon Ha ),배윤수 ( Yoon Su Bae ),이서구 ( Seo Goo Rhee ),오윤정 ( Yoon Jung Oh ),박준성 ( Chun Seong Park ),최소연 ( So Yeon Choi ),정성철 ( Seong Cheoll Cheong ),이선민 ( Sun Min Lee ),황성 대한결핵 및 호흡기학회 1999 Tuberculosis and Respiratory Diseases Vol.47 No.3

「謙菴玉淵二精舍十六景記(겸암옥연이정사십육경기)」에 나타난 하회16경의 경관특성

류한영 ( Han Young Ryu ),장태현 ( Tai Hyun Chang ),신상섭 ( Sang Sup Shin ) 한국전통조경학회 2004 한국전통조경학회지 Vol.22 No.3

울릉도에서의 화산과정과 발생 가능한 분출유형의 평가

황상구,정성욱,류한영,손영우,권태호,Hwang, Sang Koo,Jeong, Seong Wook,Ryu, Han Young,Son, Young Woo,Kwon, Tae Ho 대한자원환경지질학회 2020 자원환경지질 Vol.53 No.6

울릉도에서 화산층서는 도동현무암질암류, 울릉층군, 성인봉층군과 나리층군 등의 4개 층군으로 구분된다. 그 중에 화성쇄설암층은 도동현무암질암류에 협재하는 라필리응회암, 사동각력암 상부의 라필리응회암, 사태감응회암, 곰바위 용결응회암, 봉래분석층, 말잔등응회암, 나리분석층과 죽암분석층 등이 있다. 분출유형을 살펴보면 도동현무암질암류 내의 라필리응회암은 써쩨이언 분출에 의한 것이고 봉래분석층, 나리분석층과 죽암분석층은 소규모 스트롬볼리언 분출 혹은/및 저플리니언 분출에 의한 것이지만, 사태감응회암과 말잔등응회암은 대규모 플리니언 분출과 수증기플리니언 분출에 의한 것이다. 특히 말잔등응회암의 분출은 칼데라를 형성할 만큼 규모가 컸었으며, 한반도 동해안과 일본 열도까지도 영향을 미쳤을 것으로 분석된다. 아직도 살아있을 잠재성 높은 마그마는 조면안산암질과 포놀라이트질로 판단된다. 조면안산암질 마그마가 폭발한다면 아마도 스트롬볼리언 분출로 발생하여 폭발강도가 상당히 낮겠지만, 포놀라이트질 마그마가 터진다면 플리니언 분출로 폭발강도는 훨씬 더 커질 것이다. 그 분출이 높은 폭발강도를 가진다면, 단열의 발생빈도도 커질 것이고 그에 따라서 지하수의 유입으로 인해 수증기플리니언 분출로 쉽게 전환될 가능성도 있을 것이다. 이러한 대규모 분출은 한반도 동해안과 일본열도까지도 테프라를 확산시킬 수 있다. Volcanostratigraphy in Ulleung Island is divided into 4 stratigraphic groups: Dodong Basaltic Rocks, Ulleung Group, Seonginbong Group and NariGroup. The main pyroclastics in them includes lapilli tuff intercalated within the Dodong Basaltic Rocks, lapilli tuff at the top of Sadong Breccia, Sataegam Tuff, Gombawi Welded Tuff, Bongrae Scoria Deposits, Maljandeung Tuff, Nari Scoria Deposits and Jugam Scoria Deposits. Analysing eruption types, The lapilli tuff in the Dodong Basaltic Rocks is derived from Surtseyan eruption, and the Bongrae, Nari and Jugam Scoria Deposits are caused by Strombolian eruptions or/and sub-Plinion eruptions, but the Sataegam Tuff and Maljandeung Tuff are derived from Plinian and phreatoplinian eruptions. Among them the large-scaled eruptions. In particular, the eruptions of Maljandeung were large enough to result in caldera collapse, and had falled out tephras to the eastern Korean peninsula but even Japan Islands. The magma with high potential to be still alive is judged to be trachyandesitic and phonolitic in composition. If the trachyandesitic magma explodes, it will probably result in a strombolian eruption and have a fairly low explosivity, but if the phonolitic magma explodes, it will probably result in a plinian eruption and have a much higher explosivity. If the eruption had a high explosivity, there is a possibility that it could easily be converted into a phreatoplinian eruption due to the influx of groundwater by the easy generation of fractures. These large-scaled eruptions could fall out tephras to the eastern Korean peninsula but even Japan Islands.

Volcanic Processes of the Cretaceous Ignimbrites, Cheolwon Basin: Magmatic Processes of the Dongmakgol Tuff

황상구(Sang Koo Hwang),류한영(Han Young Ryu) 대한지질학회 2011 지질학회지 Vol.47 No.6

메치실린 내성 황색포도상구균 세균성 심내막염에 의한 패혈성 폐색전증

이기종 ( Ki Jong Lee ),김나영 ( Nha Young Kim ),김자선 ( Ja Seon Kim ),윤한결 ( Han Kyeol Yun ),오미정 ( Mi Jung Oh ),김도훈 ( Do Hoon Kim ),조상균 ( Sang Kyun Cho ),류한영 ( Han Young Ryu ),배영아 ( Young A Bae ),김대봉 ( Dae Bon 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.2

Septic pulmonary embolism is the process in which an infected thrombus becomes detached from its site of origin and lodges in a pulmonary artery, and is usually associated with infective endocarditis, especially right-sided, or infection-associated with indwelling catheters, peripheral septic thrombophlebitis, and periodontal diseases, etc. Here, we report a case of septic pulmonary embolism associated with tricuspid valve infective endocarditis. A 23-year-old female was admitted to our hospital, due to fever, sore throat, and myalgia. In her past medical history, she had undergone a surgical operation for closure of a ventricular septal defect, but was informed that the operation resulted in an incomplete closure. The initial chest radiograph demonstrated multiple rounded, parenchymal nodules in various sizes; several nodules had central lucency suggesting cavitations. Echocardiography demonstrated a large vegetation attached to the septal tricuspid valve leaflet, extending from right ventricular inflow tract to outflow tract. Computed tomography of thorax revealed bilateral peripheral nodules and wedge-shaped consolidation at various sizes, mostly accompanied by cavitations.

주요 폐절제술시 이환율과 사망률을 예견하는 위험인자의 평가

최호,이철주,소동문,김정태,홍준화,류한영,박재범,Choi, Ho,Lee, Cheol-Joo,Soh, Dong-Moon,Kim, Jung-Tae,Hong, Jun-Wha,Ryu, Han-Young,Park, Jae-Beom 대한흉부심장혈관외과학회 1999 Journal of Chest Surgery (J Chest Surg) Vol.32 No.6

배경: 폐암을 비롯한 각종 폐질환에 있어서 중요한 외과적 치료방법인 폐절제술시 일반적으로 수술전에 폐기능 검사 및 기타 임상적 평가를 시행하여 수술후에 이환율과 사망율에 영향을 주는 위험 인자를 확인하고 있으나 아직까지 가장 확실하고 정확한 단일 검사방법과 검사치에 대한 기준 설정에는 논란의 여지가 있다. 대상 및 방법: 본 연구는 1994년 6월부터 1998년 2월까지 3년 8개월 동안 아주대학교 병원 흉부외과학 교실에서 폐암, 기관지 확장증, 그리고 폐결핵 등으로 주요 폐 절제술을 시행받은 167명의 환자를 대상으로 25개의 수술전 또는 수술중 위험인자와 19개의 수술후 합병증을 분석하여 그 관련성을 연구하였다. 19개의 수술후 합병증은 사망율 및 호흡기, 순환기, 그리고 기타 합병증 네 가지로 분류하였고 수술전 또는 수술중 위험 인자와의 연관성을 확인하기 위하여 로지스틱 회귀분석과 $\chi$2검정을 사용하였다. 결과: 합병증을 예견하는 인자로 술후 예측 폐확산능백분율(ppoDLCO%)이 호흡기(p<0.009), 순환기(p<0.003), 전체 이환율(p<0.004)에 가장 유의한 영향을 주는 것으로 평가되었다. 결론: 폐기능 검사중 폐확산능(Diffusing Capacity for Carbon Monoxide, DLCO)이 일반적으로 사용되는 페활량측정법(Spirometry) 보다 술후 합병증을 예견하는데 있어서 통계학적으로 유의성있는 인자로 평가되었다. 따라서, 주요 폐절제술의 적응증이 되는 환자들은 폐확산능 검사를 통상적으로 시행하여 술전 정확한 평가에 의하여 유용한 치료의 지침으로 삼아야 될 것으로 판단된다. Background: Patients who are considered for major pulmonary resection are generally evaluated by spirometry and clinical assessment to predict morbidity and mortality. Despite this, none has yet proved to be a convenient and reliable estimate of risk. Material and Method: A retrospective analysis was performed in 167 patients who were diagnosed for lung cancer, bronchiectasis, pulmonary tuberculosis, and other benign pulmonary disease, and who underwent major lung resections. The relationship of 25 preoperative or postoperative variables to 19 postoperative events were classified into categories as operative mortality, pulmonary or cardiovascular morbidity, and other morbidity was assessed. Logistic regression analysis and $\chi$2 analysis were used to identify the relationship of the operative risk factors to the grouped postoperative complications. Result: The best single predictor of complications was the percent predicted postoperative diffusing capacity (pulmonary morbidity, p<0.009; cardiovascular morbidity, p<0.003: overall morbidity, p<0.004). Conclusion: The diffusing capacity of the lung for carbon monoxide was an important predictor of postoperative complications than the spirometry, and it usually should be a part of the evaluation of patients being considered for pulmonary resection.

외상성 기도 손상의 임상적 고찰

조현민 ( Hyun Min Cho ),김영진 ( Young Jin Kim ),류한영 ( Han Young Ryu ),황정주 ( Jung Joo Hwang ) 대한외상학회 2011 大韓外傷學會誌 Vol.24 No.1

Purpose: Traumatic airway injuries have high rates of mortality and morbidity. Thus, we evaluated the clinical results of trauma-related airway-injury patients. Methods: A clinical analysis was performed for patients with airway trauma who were admitted and treated at the Department of Thoracic and Cardiovascular Surgery, Konyang University Hospital from Dec. 2002 to Dec. 2009. Results: Sixteen patients were admitted and treated. Fourteen patients were male, and the ages of the patients ranged from 16 to 75 years. Six cases were penetrating injuries, 4 were traffic-accident injuries. 3 were fall injuries, and. 3 were other blunt trauma injuries. Anato- mic injuries included 14 trachea cases (87.5%), 1 Rt. main bronchus (6.25%), and 1 Lt. main bronchus cases (6.25%). Diagnosis was made by using computed tomography and bronchoscopy. Five patients were treated with an explothoracotomy, and 7 underwent neck exploration with primary repair. Three patients simply needed conservative management, and 1 patient was treated with a closed thoracostomy. The post-operative mortality rate was 6.25 % (1 patient). Conclusion: Airway trauma is dangerous and should be treated as an emergency, so a high index of suspicion is essential for rapid diagnosis and successful surgical intervention in patients with airway injuries. (J Korean Soc Traumatol 2011;24:7-11)

중증 다발성 늑골골절에 대한 조기 수술적 늑골고정술

황정주 ( Jung Joo Hwang ),김영진 ( Young Jin Kim ),류한영 ( Han Young Ryu ),조현민 ( Hyun Min Cho ) 대한외상학회 2011 大韓外傷學會誌 Vol.24 No.1

Purpose: A rib fracture secondary to blunt thoracic trauma continues to be an important injury with significant complications. Unfortunately, there are no definite treatment guidelines for severe multiple rib fractures. The purpose of this study was to evaluate the result of early operative stabilization and to find the risk factors of surgical fixation in patients with bilateral multiple rib fractures or flail segments. Methods: From December 2005 to December 2008, the medical records of all patients who underwent operative stabilization of ribs for severe multiple rib fractures were reviewed. We investigated patients` demographics, preoperative comorbidities, underlying lung disease, chest trauma, other associated injuries, number of surgical rib fixation, combined operations, perioperative ventilator support, and postoperative complications to find the factors affecting the mortality after surgical treatment. Results: The mean age of the 96 patients who underwent surgical stabilization for bilateral multiple rib fractures or flail segments was 56.7 years (range: 22 to 82 years), and the male-to-female ratio was 3.6:1. Among the 96 patients, 16 patients (16.7%) underwent reoperation under general or epidural anesthesia due to remaining fracture with severe displacement. The surgical mortality of severe multiple rib fractures was 8.3% (8/96), 7 of those 8 patients (87.5%) dying from acute respiratory distress syndrome or sepsis. And the other one patient expired from acute myocardial infarction. The risk factors affecting mortality were liver cirrhosis, chronic obstructive pulmonary disease, concomitant severe head or abdominal injuries, perioperative ventilator care, postoperative bleeding or pneumonia, and tracheostomy. However, age, number of fractured ribs, lung parenchymal injury, pulmonary contusion and combined operations were not significantly related to mortality. Conclusion: In the present study, surgical fixation of ribs could be carried out as a first-line therapeutic option for bilateral rib fractures or flail segments without significant complications if the risk factors associated with mortality were carefully considered. Furthermore, with a view of restoring pulmonary function, as well as chest wall configuration, early operative stabilization of the ribs is more helpful than conventional treatment for patients with severe multiple rib fractures. (J Korean Soc Traumatol 2011;24:12-17)

흉부외상 환자에 대한 전산화 단층촬영의 효용성

노환규,최호,김영진,김정태,소동문,류한영,이철주,Roh, Hwan-Kyu,Choi, Ho,Kim, Young-Jin,Kim, Jung-Tae,Soh, Dong-Moon,Ryu, Han-Young,Lee, Cheol-Joo 대한흉부심장혈관외과학회 1998 Journal of Chest Surgery (J Chest Surg) Vol.31 No.3

초기에 외상성 뇌병변의 진단에 국한되었던 단층 촬영은 전산화 단층 촬영기가 널리 보급됨에 따라 흉부, 복부 및 척추, 그리고 안면부나 골반부의 외상에 의한 병변의 진단에 널리 이용되고 있다. 본 연구는 1년간 응급실에 내원한 흉부외상 환자 중 흉부의 전산화 단층 촬영을 시행한 134명의 환자를 대 瓚막\ulcorner단순 흉부 엑스선 촬영의 결과와 단층 촬영 결과를 비교, 분석함으로 외상 환자에게 사용되고 있는 흉부 전산화 단층 촬영의 효용성을 알아보고자 하였다. 분석 결과 134명의 환자 중 45명은 단순 흉부 엑스선 촬영 소견이 정상인데 단층 촬영을 시행받은 환자였고, 이중 24명은 단층 촬영 결과 역시 정상 소견을 보였다. 단층 촬영의 기흉과, 혈흉을 포함한 늑막삼출에 대한 진단률을 100%라고 가정할 때 단순 흉부 엑스선 촬영의 기흉과 늑막 삼출의 진단률은 각각 46.2%, 62.9%로 낮은 진단율을 보였다. 전체 환자 중 흉관 삽관을 받은 환자는 63명이었는데 이중 45명(71.4%)이 단순 흉부 엑스선 촬영만으로 흉관 삽관을 결정한 환자여서 치료 방침의 결정에는 단순 촬영의 효용성이 다소 높았다. 따라서 본 연구에 흉부 외상에 대한 전산화 단층 촬영이 다소 남용되고 있음이 확인이 되었으나 단층 촬영은 소량의 기흉이나 종격동의 병변등, 임상적으로 중요하면서도 단순 촬영이 제공할 수 없는 병변의 진단에 결정적으로 유용하며 그 효용성 또한 높다고 할 수 있다. Computerized tomography(CT) is an effective technique in the initial evaluation of the abdomen and head following blunt trauma. To evaluate the efficacy of CT of the thorax, a retrospective study comparing early thoracic CT scanning with initial chest roentgenogram (CXR) was carried out on 134 patients with blunt trauma on the chest. Among 134 patients, 45 patients had normal initial chest roentgenogram and 24 patients showed normal CT findings. Sensitivities of diagnosing pneumothorax and pleural effusion by CXR were low (46.2 and 62.9% respectively), whereas 71.4%(45/63) of patients had thoracostomy only by CXR. Although sometimes abused, CT of the thorax is effective in the initial diagnosis.

철원분지 화성암류에 대한 SHRIMP 저어콘 연령측정의 결과와 해석

황상구(Sang Koo Hwang),안유미(Yu Mi An),류한영(Han Young Ryu),이기욱(Keewook Yi) 한국암석학회 2012 한국암석학회 학술발표회 논문집 Vol.2012 No.5