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Urine Protein Levels Predict Future Development of Cerebral Infarction in Koreans
류재홍,이상민,하은희 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.1
Purpose: Proteinuria is a clinical sign of adverse cardiovascular outcomes, including stroke. We aimed to assess the relationship between proteinuria and the occurrence of cerebral infarction. Materials and Methods: In total, 208854 Koreans who participated in the 2009 medical examination were followed up until 2013 using the database of the National Health Insurance Service. The results of urine dipstick tests were utilized to assess proteinuria as absent, 1+, 2+, or ≥3+. The International Classification of Diseases code 163 was used to document cerebral infarction. Results: Between 2009 and 2013, 2383 cases (1.14%) of cerebral infarction occurred during 912772.9 person-years of follow-up. Hazard ratios for incident cerebral infarction increased with inceasing amounts of urine protein from 1.53 (1.23–1.90) in group 2(1+), 1.67 (1.22–2.28) in group 3 (2+), and 2.66 (1.79–3.96) in group 4 (≥3+), compared to the reference group with little to no detectable urine protein (p<0.001, respectively). Conclusion: An increase in urine protein levels was significantly related to the risk of developing cerebral infarction. Our results suggest that proteinuria might be a potential risk factor for cerebral infarction and that urine dipstick test analysis may be clinically useful for predicting stroke.
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Clinical Significance of Non-Alcoholic Fatty Liver Disease as a Risk Factor for Prehypertension
류재홍,함우택,최중명,강민아,안소희,이종근,신호철,박성근 대한의학회 2014 Journal of Korean medical science Vol.29 No.7
Previous epidemiologic studies have shown the clinical association between non-alcoholicfatty liver disease (NAFLD) and cardiovascular disease (CVD). However, there is only limitedinformation about the effect of NAFLD on the development of hypertension. Accordingly,we investigated the clinical association between NAFLD and prehypertension. A prospectivecohort study was conducted on the 11,350 Korean men without prehypertension for 5 yr. The incidences of prehypertension were evaluated, and Cox proportional hazard model wasused to measure the hazard ratios (HRs) for the development of prehypertension accordingto the degree of NAFLD (normal, mild, moderate to severe). The incidence of prehypertensionincreased according to NAFLD states (normal: 55.5%, mild: 63.7%, moderate to severe:70.3%, P < 0.001). Even after adjusting for multiple covariates, the HRs (95% confidenceinterval) for prehypertension were higher in the mild group (1.18; 1.07-1.31) and moderateto severe group (1.62; 1.21-2.17), compared to normal group, respectively (P for trend< 0.001). The development of prehypertension is more potentially associated with themore progressive NAFLD than normal and milder state. These findings suggest the clinicalsignificance of NAFLD as one of risk factors for prehypertension.
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류재홍,하은희,김수근,유승호,이다운 대한의학회 2011 Journal of Korean medical science Vol.26 No.5
The aim of this study was to examine the association between serum apolipoprotein B (apoB) and the risk of coronary heart disease (CHD) using Framingham risk score (FRS) in healthy Korean men. A total of 13,523 men without medication history of diabetes and hypertension were enrolled in this study. The FRS is based on six coronary risk factors. FRS ≥ 10% was defined as more-than-a-moderate risk group and FRS ≥ 20% as high risk group, respectively. The logistic regression analyses were conducted. When quartile 1 (Q1)set as a reference, in unadjusted analyses, the Q2, Q3, Q4 of apoB level had increased odds ratio (OR) for the risk of CHD in both more-than-a-moderate risk and high risk group,respectively. After adjusting for confounding variables, multivariable-adjusted logistic regression analyses showed a strong relationship between the quartiles of apoB level and more-than-a-moderate risk and high risk group, respectively. These associations were attenuated, but still remained statistically significant. ApoB is found to be independently related to the risk of CHD using FRS in healthy Korean men, and the link between apoB and the risk of CHD is dose-depedent.
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DO 미터를 이용한 탐구중심 물 환경교육 프로그램 개발- 용존산소 측정 활동 -
류재홍,이두곤 한국환경교육학회 2006 環境 敎育 Vol.19 No.2
Inquiry has great value in environmental education(EE). Being able to see the world environmentally through 'inquiry-based environmental education' can be an important value and goal of EE. In this study, we intended to develop an EE program of measuring activity of dissolved oxygen(DO), based on the theory of 'inquiry-based EE'. Especially, we recognized the potential that DO meter can be used in 'inquiry-based EE', and we tried to develop a model of inquiry-based EE using DO meter. As a result of this research, we present specific models of inquiry-based EE about how to perform measuring activity of DO and how to use the DO meter in laboratories and streams from the perspective of inquiry of water environment.In the process of program development, we considered organization of the inquiry process, use of concept and knowledge, scientific inquiry and insightful inquiry, integration, sustainability, content components of 'Environmental Studies for EE', developmental level and in-
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사회네트워크 분석을 활용한 비즈니스 모델 지식구조 분석
류재홍,최진호 한국지식경영학회 2018 지식경영연구 Vol.19 No.2
Business environment is shifting from industrial economy to knowledge based economy. Enterprises go through numerous trials for successful management in changing environment. Along with trial tests, research area has been growing simultaneously. Unlike initial research which focused on basic concepts such as: form of business model and success points. Current research emphasizes on actualization of business that enterprises plan, which brought academic research with perplex form of knowledge structure. On the other hand, there is limitation in understanding business model systematically due to preceding research primarily centered on analyzing definition and case study. In order to analyze knowledge structure, this study utilized social network analysis based on “relationship”. For the analysis, 13,412 keywords were extracted from 36years worth of article or research related to business model stored in SCOPUS database. From the analysis, it was shown core research subject was INNOVATION and the number of co-authors has increased due to the academic diversity. Business model research is divided into five sub-categories (E-commerce, SMEs, sustainability, open-source, and e-book). Through cognitive map analysis on each of research characteristics of sub-category, it has shown that E-commerce, SMEs, sustainability, and open-source are core categories.
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