위암의 보조항암화학요법

류민희 ( Min Hee Ryu ),장대영 ( Dae Young Zang ) 대한내과학회 2012 대한내과학회지 Vol.83 No.3

Gastric cancer remains the second most common malignancy worldwide. Surgical resection with D2 lymph node dissection is the standard of care in localized gastric cancer. However about 40% of patients in East Asia and 70% of patients in Western countries experience recurrence after curative surgical resection of localized gastric cancer. Once recurrence occurs, the prognosis of patients is usually dismal, especially in case of distant metastases. Although many clinical trials of adjuvant treatment were conducted to reduce recurrence of gastric cancer after surgical resection, it was controversial until early 2000s whether adjuvant treatment could improve recurrence-free survival or overall survival in gastric cancer. In early 2000s, adjuvant chemoradiation became the standard of care in the US based on the results of SWOG 9008/INT 0116 trial, where only minor portion of patients underwent D2 lymph node dissection. However, adjuvant chemoradiation was considered not applicable to patients with gastric cancer in East Asia where D2 lymph node dissection is the standard surgical method. Recently, large scale phase III studies including ACTS-GC and CLASSIC trial were conducted in the East Asia. Based on those studies, adjuvant chemotherapy is currently accepted as standard treatment in gastric cancer in the East Asia.

REAL 분류상 B-미만성 대세포 림프종에서 조직학적 아형 분류의 임상적 의의

류민희 ( Min Hee Ryu ),김봉석 ( Bong Seog Kim ),김태원 ( Tae Won Kim ),박연희 ( Yeon Hee Park ),허주령 ( Joo Ryung Huh ),이승숙 ( Seung Sook Lee ),김철우 ( Chul Woo Kim ),류백렬 ( Baek Yeol Ryoo ),김노경 ( Noe Kyeong Kim ),이규형 대한내과학회 2003 대한내과학회지 Vol.65 No.1

목적 : REAL 분류상 B-미만성 대세포 림프종은 다양한 임상경과를 보이는 이질적인 림프종을 포함하고 있는데, 일부 연구에서는 B-미만성 대세포 림프종 중immunoblastic lymphoma (IBL)가 다른 조직아형에 비해 예후가 좋지 않음을 시사하고 있다. 본 연구에서는 B-미만성 대세포 림프종을 형태학적으로 IBL과 non-IBL로 세분화할 필요가 있는지 알아보고자 하였다. 방법 : 1989년부터 1995년까지 3개 병원에서 치료 받은 비호지 Background : Diffuse large B-cell lymphoma (DLBL) category in the REAL classification includes histologically heterogeneous subtypes in Working Formulation or Kiel classification. Some investigators insist that the prognosis of B-cell immunoblastic lympho

절제 가능한 국소 위암에서 수술 전 선행 항암화학요법

류민희(Min-Hee Ryu) 대한종양외과학회 2014 Korean Journal of Clinical Oncology Vol.10 No.1

In localized resectable stage II or III gastric cancer, D2 dissection has been accepted as the standard surgical method worldwide. The Adjuvant Chemotherapy Trial of TS-1 for Gastric Cancer and Capecitabine and Oxaliplatin Adjuvant Study in Stomach Cancer phase III trials have demonstrated that systemic adjuvant chemotherapy can significantly improve recurrence-free survival (RFS) and overall survival (OS) after D2 dissection with absolute survival benefit of 10% to 15% compared with surgery alone. Addition of radiation or intensification of adjuvant chemotherapy has been tried in localized resectable gastric cancer for further improvements of RFS and OS as well. However, addition of radiation after D2 dissection was proven to play no or only a minimal role at its best in reduction of loco-regional recurrences as well as distant metastases. The results of recent large-scale adjuvant trials suggest that more intensified adjuvant treatment including multiple chemotherapeutic agents would not likely induce a better result. For this reason, addition of neoadjuvant chemotherapy to current standard of care may be the only plausible strategy to improve long-term outcomes in localized resectable gastric cancer, and clinical trials of neoadjuvant chemotherapy are now ongoing in gastric cancer.

모바일 기기를 위한 H.264 인코더의 최적 매개변수의 결정

류민희(Ryu, Minhee),김형신(Kim, Hyung-Shin) 한국산학기술학회 2012 한국산학기술학회논문지 Vol.13 No.10

최근 스마트폰과 태블릿과 같은 소형 모바일 기기가 확산됨에 따라, 모바일 기기에서 동영상 촬영시 이용되 는 비디오 인코더의 성능 최적화의 필요성이 제기되고 있다. 본 논문에서는 모바일 기기를 대상으로 하는 H.264/AVC 기본 프로파일 비디오 인코더를 모바일 기기에 구현하고, 실험을 통해 H.264 인코더의 주요 제어 변수를 최적화하였 다. 실험으로는 인코더의 복잡도에 영향을 주는 것으로 알려진 라그랑지안 최적화, 하다마드 변환, 움직임 벡터 탐색 범위, I-프레임 주기, 참조 프레임 수를 다양하게 조합하여 변화시키면서 동영상의 화질, 비트율, 인코딩 시간, 움직임 추정 시간 그리고, 인코딩에 따라 보드에서 소모되는 전력을 측정하였다. 실험에서 측정된 데이터를 분석하여, 모바일 기기에서의 비디오 인코더에서 요구되는 조건을 만족할 수 있는 최적의 H.264/AVC 제어 변수를 위의 다섯 가지 기 능 모듈에 대해 결정하였다. As many mobile devices such as smart phones and tablets are widely spread, optimized mobile video encoder used during video recording application is needed. In this paper, we implemented H.264/AVC base profile video encoder on a mobile device and empirically optimized control parameters of the encoder. As the experiment, we more than 100 test cases were designed with varying Lagrangian optimization, Hadamard Transform, search range, I-frame period, and reference frames. During the experiment, we measured picture quality, bit-rate, encoding time, motion estimation time, and power consumption. From the result, we can determine optimal values for the H.264 control parameters.

뷰티체험관광 품질이 행동의도에 미치는 영향: 주관적 안녕감의 조절효과 중심으로

류민희 ( Minhee Ryu ),고정훈 ( Jeonghoon Ko ) 관광경영학회 2020 관광경영연구 Vol.100 No.-

This study assumes the effect of beauty experience tourism quality factors on behavioral intention, analyzes the relationship between the quality of beauty experience service and behavioral intention, and what experience factors are behavioral intentions including re-engagement intention and recommendation intention. We looked at the significant effect on. Through empirical analysis, it was confirmed that the quality factors of beauty experience tourism have a positive effect on behavioral intention. The effect between the service factor and the behavioral intention of the staff was the highest, followed by the effect of the experience facility environment factor and the behavioral intention. This study is expected to provide basic data required for specialization of beauty experience tourism and direction setting for market activation, and to present the direction of the tourism industry after the Corona 19 pandemic.

대퇴근막 이식과 전외측 대퇴 유리 피판을 이용한 난치성 경막 외 농양의 치료

박병찬,류민희,김태곤,이준호,Park, Byung-Chan,Ryu, Min-Hee,Kim, Tae-Gon,Lee, Jun-Ho 대한미세수술학회 2009 Archives of reconstructive microsurgery Vol.18 No.1

Purpose: Artificial dura maters are commonly used in cranioplasty, but sometimes they can result in serious postoperative infection. Once complications such as epidural abscess or chronic draining ulcer arise, they are very difficult to treat. In this case, reclosure of dura defect using artificial dura mater may give rise to recurrence of infection. We experienced a case of intractable epidural abscess caused by use of artificial dura. To avoid repeated infection, we decided to use autologous tissue for the coverage of dura and soft tissue defect. Therefore, autologous tensor fascia lata graft and anterolateral thigh free flap were harvested at the same donor site incision to cover composite defect on the scalp and dura mater. Methods: A 13 year old male patient, who underwent the decompression cranioplasty and duroplasty, suffered from the intractable infection lesion. Twice, the epidural abscess was removed, both times the infection recurred. And eventually dura mater was exposed through the infected open wound. Nine months after dura exposed, infected aritificial dura mater was removed and extensive debridement was performed. Through a surgical incision on donor thigh, first, tensor fascia lata graft was harvested in process of the anterolateral thigh flap elevation. After the fascia lata graft was fixed over the dural defect, the anterolateral thigh flap was used to fill the dead space as well as the scalp defect. Results: Postoperatively, no recurrent infection and cerebrospinal fluid leakage are observed for a year. After the surgery, on the first and second day, venous congestion of the flap was observed, this problem was solved by thrombectomy and vein reanastomosis. And partial necrosis of flap occurred, but completely healed as conservative treatment for two weeks. Conclusion: Using the autologous tensor fascia lata graft and anterolateral thigh flap, we could obtain satisfactory results as treatment for the intractable infection lesion after duroplasty. Autologous tensor fascia lata in conjunction with anterolateral thigh flap is useful method for covering composite defect of scalp and dura mater.

TinyOS 를 위한 실시간 유비쿼터스 센서 네트워크 성능 모니터링 시스템

조현우(Hyunwoo Joe),류민희(Minhui Ryu),홍민녀(Minnyo Hong),김형신(Hyungshin Kim) 한국정보과학회 2009 한국정보과학회 학술발표논문집 Vol.36 No.1

제한된 리소스 사용이 필요한 센서네트워크 시스템에서는 저전력이 가장 중요한 요소 중 하나이다. 하지만 센서네트워크는 하나의 센서노드만으로 동작되는 시스템이 아닌 많은 수의 센서노드들이 유기적으로 네트워크를 구성해 동작되는 시스템인 만큼 네트워크 성능 역시 중요한 요소이나 전력에 관한 연구나 전력 소모 측정에 대한 연구에 비해 네트워크 성능 측정 대해서는 많은 연구가 진행되어 있지 않다. 이에 본 논문에서는 실제 설치된 센서노드의 네트워크 성능을 모니터링 할 수 있도록 TinyOS 기반의 라이브러리 형태로 일반적인 네트워크 성능 평가 요소인 처리량(throughput), 지연율(latency), 패킷 손실(packet loss), CRC 에러를 위한 컴포넌트들을 구현하고, 실시간으로 호스트 컴퓨터에서 모니터링 할 수 있는 시스템을 개발 하였다.

대장암 예후인자의 다변량 분석

김동완 ( Dong Wan Kim ),류민희 ( Min Hee Ryu ),김태유 ( Tae You Kim ),허대석 ( Dae Seog Heo ),방영주 ( Yung Jue Bang ),박재갑 ( Jae Gahb Park ),김노경 ( Noe Kyeong Kim ) 대한내과학회 2003 대한내과학회지 Vol.64 No.3

목적 : 본 연구의 목적은 한국인 대장암 환자의 생존율에 영향을 미치는 예후인자를 분석하는 것이다. 방법 : 1990년 1월부터 1992년 12월 까지 조직학적으로 대장암 진단을 받은 406명의 환자를 대상으로 임상적, 병리학적, 실험실적 변수를 후향적으로 조사하였다. 생명표범을 이용하여 생존율을 구하였고, 로그-랭크법으로 단변량 분석을 통해 독립예후인자를 결정하였다. 결과 : 결장암의 5년 전체 생존율은 58.1%, 직장암의 5년 전체 생존율은 58% Background : It is the aim of this study to find out the prognostic factors in Korean colorectal cancer patients Methods : The analysis was performed on 406 patients diagnosed as colorectal cancer between Jan, 1990 and Dec. 1992. Survival rate was calcula

종양 표지 인자로서 혈장 Transforming Growth Factor-β1에 대한 연구

신훈,임창기,최인영,이두연,노동영,류민희,이효석,방영주,박종섭,진승원,Shin, Hoon,Lim, Chang Ki,Choi, In Young,Lee, Doo Yun,Noh, Dong Yong,Ryu, Min Hee,Lee, Hyo Suk,Bang, Yung Jue,Park, Jong Sup,Jin, Seung Won 대한면역학회 2001 Immune Network Vol.1 No.2

Background : Many investigators have found transforming growth factor-${\beta}1$ (TGF-${\beta}1$) to be elevated in tumors. Changes in responsiveness to TGF-${\beta}1$ have been linked to malignant transformation, tumor progression and tumor regression. Many malignant cell lines of epithelial or hematopoietic origin are refractory to the antiproliferative effects of TGF-${\beta}1$. However, a little is known about the association of TGF-${\beta}1$ with progression of malignant tumor. Methods : In this study, we measured the plasma level of TGF-${\beta}1$ in various cancer patients and evaluated the utility of plasma TGF-${\beta}1$ as a possible tumor marker. Plasma TGF-${\beta}1$ levels were measured using enzyme-linked immunosorbent assay in cancer patients and normal controls. Carcinoembryonic antigen (CEA) and alpha-fetoprotein (AFP) as tumor marker were compared with TGF-${\beta}1$ in the aspects of sensitivity and specificity. Results : The mean of plasma TGF-${\beta}1$ levels was $1.219{\pm}0.834ng/ml$ in normal controls, $5.491{\pm}3.598ng/ml$ in breast cancer, $12.670{\pm}10.386ng/ml$ in lung cancer, $5.747{\pm}3.228ng/ml$ in hepatocellular carcinoma and $10.854{\pm}7.996ng/ml$ in cervical cancer. In comparison with CEA and AFP, TGF-${\beta}1$ is more sensitive. Conclusion : We conclude that the high levels of TGF-${\beta}1$ are common in the plasma of cancer patients. These results suggest that the plasma TGF-${\beta}1$ level can be a potent tumor marker in various cancer patients.

HIV 음성 환자에서 형질모세포종의 세침흡인 세포소견 - 1예 보고 -

이향임,구현령,한은미,공경엽,서철원,류민희,강윤구,박찬정,허주령,Lee, Hyang-Im,Koo, Hyun-Ryung,Han, Eun-Mee,Gong, Gyung-Yub,Suh, Chul-Won,Ryu, Min-Hee,Kang, Yoon-Goo,Park, Chan-Jeong,Huh, Joo-Ryung The Korean Society for Cytopathology 2005 대한세포병리학회지 Vol.16 No.1

Plasmablastic lymphoma (PBL) is a recently described aggressive B-cell neoplasm, which usually manifests as a localized disease of the oral mucosa in individuals infected with human immunodeficiency virus (HIV). Recently we encountered a case of plasmablastic lymphoma manifesting in the left maxillary sinus and cervical lymph node of a previously healthy HIV-negative man, 48 years of age. we conducted a fine-needle aspiration smear of the cervical lymph node, and this was found to be highly cellular with numerous large cells exhibiting eccentrically positioned nuclei, prominent nucleoli, and moderate quantities of basophilic cytoplasm. A biopsy of the mass in the maxillary sinus evidenced diffuse growth of similar plasmablastic cells. These tumor cells were negative for the leukocyte common antigens, CD20, CD3, CD30, and EMA. However, the cells tested positive for CD79a and CD138/syndecan-1. The tumor cells also exhibited L-light-chain restriction. The Ki-67 proliferation index was measured at almost 100%. The patient was diagnosed with plasmablastic lymphoma. After three cycles of combination chemotherapy and radiotherapy, the patient went into complete remission, and currently remains in this state.