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Therapeutic Efficacy and Complications of Automated Peritoneal Dialyzer in Dogs with Renal Failure
권희정,최원진,이동국,데이비드탄,현창백 한국임상수의학회 2015 한국임상수의학회지 Vol.32 No.5
Peritoneal dialysis (PD) is a treatment for renal failure and acute poisoning, and uses the patient's peritoneum in the abdomen as a membrane across which fluids and dissolved substances are exchanged from the blood. In this study, we evaluated the therapeutic efficacy and complications of automated peritoneal dialyzer (APD) in dogs with renal failure. PD was performed in 10 dogs using a swan neck catheter (Neonatal, Coviden) and automatic APD. The efficacy for each dog was assessed by calculating urea reduction ratio (URR) and creatinine reduction ratio (CRR). Mean concentrations of pre-dialysis creatinine and blood urea (BUN) were 7.09 ± 3.84 and 145.8 ± 48.5, respectively. The mean number of peritoneal dialysis cycles applied was 6 ± 1 cycles. Peritoneal dialysis resulted in a significant decrease in BUN concentration in 7/10 dogs, while a significant decrease in creatinine concentration in 9/10 dogs. The mean of URR was higher than that of CRR (0.39 ± 0.16 vs 0.38 ± 0.13). The mean CRR and URR per dialysis cycles were 0.064 ± 0.023 and 0.065 ± 0.023, respectively. Complications found in this study were catheter occlusion, subcutaneous dialysate leakage, septic peritonitis, hypoalbuminemia and overhydration. This study found PD using a swan neck catheter and APD machine showed acceptable efficacy for successful peritoneal dialysis in dogs. However, close monitoring is required to minimize the risk of complication.
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Therapeutic Efficacy and Complications of Automated Peritoneal Dialyzer in Dogs with Renal Failure
권희정,최원진,이동국,데이비드 탄,현창백,Kwon, Heejung,Choi, Wonjin,Lee, Dong-Guk,Tan, David,Hyun, Changbaig The Korean Society of Veterinary Clinics 2015 한국임상수의학회지 Vol.7 No.2
Peritoneal dialysis (PD) is a treatment for renal failure and acute poisoning, and uses the patient's peritoneum in the abdomen as a membrane across which fluids and dissolved substances are exchanged from the blood. In this study, we evaluated the therapeutic efficacy and complications of automated peritoneal dialyzer (APD) in dogs with renal failure. PD was performed in 10 dogs using a swan neck catheter (Neonatal, Coviden) and automatic APD. The efficacy for each dog was assessed by calculating urea reduction ratio (URR) and creatinine reduction ratio (CRR). Mean concentrations of pre-dialysis creatinine and blood urea (BUN) were $7.09{\pm}3.84$ and $145.8{\pm}48.5$, respectively. The mean number of peritoneal dialysis cycles applied was $6{\pm}1$ cycles. Peritoneal dialysis resulted in a significant decrease in BUN concentration in 7/10 dogs, while a significant decrease in creatinine concentration in 9/10 dogs. The mean of URR was higher than that of CRR ($0.39{\pm}0.16$ vs $0.38{\pm}0.13$). The mean CRR and URR per dialysis cycles were $0.064{\pm}0.023$ and $0.065{\pm}0.023$, respectively. Complications found in this study were catheter occlusion, subcutaneous dialysate leakage, septic peritonitis, hypoalbuminemia and overhydration. This study found PD using a swan neck catheter and APD machine showed acceptable efficacy for successful peritoneal dialysis in dogs. However, close monitoring is required to minimize the risk of complication. 복막투석은 혈액에서부터 오는 체액과 노폐물을 교환하는 복강내의 막인 복막을 이용한 투석방법으로, 신부전과 중독증 환자에서의 치료법이다. 본 연구에서는 신부전증 개에서 자동투석기를 이용한 복막투석의 치료효율과 합병증에 대해 평가하였다. 10마리의 개를 대상으로 Swan neck 카테터(Neonatal, Coviden)와 자동 복막투석기를 사용하여 복막투석을 실시하였고, 그 효과는 요소감소율(urea reduction ratio)로 평가하였다. 평균 크레아틴닌 감소율과 평균 요소감소율은 $7.09{\pm}3.84$과 $145.8{\pm}48.5$였다. 평균 투석횟수는 $6{\pm}1$회 였다. 투석치료후 유의성 있는 요소의 감소가 7/10 개에서 관찰되었고, 유의성 있는 크레아틴의 감소가 9/10 개에서 관찰되었다. 요소의 감소율이 크레아틴 감소율보다 더 높게 관찰되었다. 1회 투석당 요소와 크레아틴닌의 감소율은 $0.064{\pm}0.023$과 $0.065{\pm}0.023$이 였다. 본 연구에서의 복막투석에 따른 합병증은 카테터 막힘, 투석액의 피하누출, 패혈성 복막염, 저알부민혈증, 과수화 등이었다. Swan neck 카테터와 자동 복막투석기를 이용한 복막투석은 임상에서 적용 가능하였으며 본 연구를 통하여 성공적인 복막투석의 가능성을 보여주었다. 하지만 합병증을 최소화하기 위해서는 주의 깊은 모니터링이 필요할 것으로 판단된다.
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