http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : 니시무라 요시카즈 (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
환경 방사선 생물학적 감시 지표로서 야생 등줄쥐의 방사선 감수성
김희선,니시무라 요시카즈,김종순,Kim, Hee-Sun,Nishimura, Y.,Kim, Chong-Soon 한국방사성폐기물학회 2006 방사성폐기물학회지 Vol.4 No.1
This study examined the possibility of using dark-striped field mice as a biological indicator for the environmental radio-surveillance. For this study, dark-striped field mice were caught from five areas of Kyonggi, Kyongsang, Chungchong and Cholla provinces. The external morphological characteristics and isoenzymic types of dark-striped field mice were studied after they were captured. Among the external morphological characteristics, the dark-brown coat, dark back stripe, head-to-tail length, tail length, and ear length matched the taxonomical characteristics of dark-striped field mice. The analyses on L-lactate dehydrogenase, aspartate aminotransferase, and malate dehydrogenese revealed that one species of dark-striped field mice, called Apodemus agrarius, was inhabitated throughout a wide range of Korea. On the other hand, the frequency of micronuclei in peripheral polychromatic erythrocytes to survived mice after irradiation also analyzed. The LD50/30 of A. cgrarius and ICR mice were approximately 5 Gy and 7.9Gy, respectively. The results of the study reveal that wild A. asrarius have a high potential as a biological monitoring system to determine the impact of radiation in areas such as those within the vicinity of nuclear power plants.
-
-
The Distribution of 14C-chitosan by Different Molecular Weight in Mice
Kim, Kwang-Yoon,Kim, Young-Ho,Kim, Hee-Kyung,Bom, Hee-Seung,Kim, Ji-Yeul,Roh, Young-Bok,Yoshikazu Nishimura 대한방사선 방어학회 1998 방사선방어학회지 Vol.23 No.2
키토산은 키틴의 탈아세틸화반응을 통해서 얻어진 유전적 동석이 없는 천연착화제로써 방사성동위원소 혹은 중금속 이온의 제거제 및 체내 흡수 억제제로 알려져 왔다. 본 연구에서는 분자량이 다른 C-14 chitosan을 정맥투여 한 후 C-14 chitosan 분자량별 마우스 체내 대사과정을 알아보고자 하였다. ICR계 웅성 마우스(8-10주령, 체중 30-35g)를 사용하였다. C-14 chitosan은 증류수로 희석한 다음, 꼬리정맥을 통해 정맥 투여하였다. C-14 chitosan 투여후 6시간, 1일, 3일, 7일째 마우스를 희생시켜 혈액, 간, 신장, 비장, 폐, 근육, 고환, 오줌을 채취하였으며, 각각의 β-방사능을 측정하여 상대농도를 구하였다. 대부분의 C-14 chitosan이 6시간째에 오줌을 통해 체외 배출되었고, 체내대사과정은 분자량이 서로 다름에도 불구하고 비슷하였다. 간, 신장, 비장등에서 높은 방사능을 나타내었다. 조직간의 상대농도는 6시간째에 증가하다가 서서히 감소함을 알 수 있었다. 결론적으로 정맥 투여한 키토산은 분자량에 상관없이 대부분 오줌을 통해 체외배출 되고, 체내 장기중의 대사과정은 비슷하게 나타났다. Chitosan is a nontoxic natural chealtor which was made by chitin, and reduced a contamination of radiostrontium in animals. In this experiment, A different molecular weight of C-14 chitosan was intravenously administered to mice, and then the distribution of C-14 chitosan in the body was observed. Male mice (8 to 10 weeks, body weight of 30 to 35g) of ICR strain were used. C-14 chitosan was diluted with saline and then given intravenously in mice. After the administration of C-14 chitosan, mice was sacrificed at the 6th hour, 1st, 3rd, 5th, and 7th day. Beta radioactivities in the blood, liver, kidney, liver, muscle, testis, and urine was measured using a liquid scintillation analyzer. Most of the C-14 chitosan was excreted through urine within 6 hours. Biodistribution of C-14 chitosan was similar despite the difference of molecular weight. Higher distributions of radioactivities were found in the liver, kidney, spleen. The relative concentration in tissue increased for the 6 hours and then decreased. In conclusion, most of C-14 chitosan was excreted through urine despite the difference of molecular weight and, low molecular weight of C-14 chitosan showed higher distribution than high molecular weight of C-14 chitosan in tissues.
-
임신 쥐에서 14C-chitosan 의 모체를 통한 태아로의 전이에 관한 연구
김영호(Young Ho Kim),범희승(Hee Seung Bom),김광윤(Kwang Yoon Kim),김희경(Hee Kyung Kim),김지열(Ji Yeul Kim),요시카즈 니시무라(Yoshikazu Nishimura) 한국키틴키토산학회 1999 한국키틴키토산학회지 Vol.4 No.4
N/A Chitosan is a nontoxic natural chealtor which was made by chitin, and reduced a contamination of radiostrontium in animals. And also, Chitosan was absorbed gastrointestinal tract and excreted into urine. But, there is no research whether chitosan, a natural polymer, can be transfered from mother to fetuses, The purpose of this study was to investigate to transfer from mother to fetus, in which oral administered C-14chitosan in pregnant rats. Wistar strain female rats bred at NIRS were used. They were mated ay 14 weeks of age(body weight of 250 to 300g) with males of about the same age. Mating was confirmed by presence of a vaginal plug and the day on which the plug was found was considered to be the first day of gestation. C-14 chitosan was diluted to 370 KBq/ml with distilled water, and was given oral(0.5 ml). After the administration of C-14 chitosan, At various time intervals following administration of each C-14 chitosan, the pregnant ternate and fetuses were killed by bleeding under ether anaesthesis and maternal tissues(liver, kidney, spleen, pancreas, heart, lung, blood and serum), and conceptuses(placenta, placenta membranacea, amnion, fetus-liver) were sampled. These samples were measured using a liquid scintillation counter after combusted by an oxidizer(Model 306Tri-Carb Packard). In case of pregnancy rats, Biodistribution of C-14 chitosan was similar despite the difference of gestation days. Higher distributions of radioactivities were found in the liver, kidney, spleen and lung. In case of conceptuses, The highest relative concentration were found in the late pregnancy period that were injected with the C-14 chitosan at 18 and 19 days of gestation(except for amnion).In conclusion, C-14 chitosan was transfered from mother to fetus.
eArticle연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
