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폐의 소세포암종에서 Synaptophysin, Neuron-SpecificEnolase, Chromogranin A, Neurofilarnent 항체들의 감수성에 대한연구
노종섭 ( Jong Sup Roh ),왕성수 ( Sung Su Wang ),이정아 ( Chung A Lee ),곽효일 ( Hyo Il Kwak ),윤기중 ( Ki Jung Yun ) 대한임상검사과학회 1998 대한임상검사과학회지(KJCLS) Vol.30 No.3
A variety of benign and malignant tumors may arise in the lung, but the bronchogenic carcinoma is majority. Among the brochogenic carcinomas, small cell carcinoma is a histologically distinctive type, and it is higly malignant and chemosensitive To evaluate of sensitivity of neuroendocrine markers such as synaptophysin, neuron-specific enolase(NSE), chrorrogranin A and neurofilament antibodies, we studied the small cell carcinoma of lung on the 32 paraffin embedded tissues. The sensitivities of synaptophysin, NSE, chrorrogranin A and neurofilarrent were ``irl.5%, 31.30/0, 25%, and l000~ respectively, Above result indicates that neurofilament and synaptophysin antibodies are good for diagnosis of small cell carcinoma of the lung.
자궁경부상피의 악성변화에서 비만세포가 간질세포의 α-Smooth Muscle Actin 발현에 미치는 영향
제갈승주,최영자,이광주,노종섭,Jekal, Seung-Joo,Choi, Young-Ja,Lee, Kwang-Joo,Roh, Jong-Sup 대한임상검사과학회 2007 대한임상검사과학회지(KJCLS) Vol.39 No.3
There is increasing evidence that stromal reaction in cancer has an important diagnostic and prognostic significance. The aim of our study is to analyze the relation between the increase in mast cell number and the expression CD34 and alpha-smooth muscle actin (${\alpha}$-SMA) in the stroma of cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC). We investigated a total of 29 CIN (1,2,3) and 21 SCC (microinvasive and invasive) specimens and compared the distribution of $CD34^+$ stromal cells, ${\alpha}-SMA^+$ cells, transforming growth factor-${\beta}1$ $(TGF-{\beta}1)^+$ cells, and the density of mast cells using immunohistochemistry with antibodies against CD34, ${\alpha}$-SMA, TGF-${\beta}1$, and c-Kit (CD117) respectively. Computerized image analysis was to evaluate the positive area (%) and density of the respective immunoreactive cells. In CIN $CD34^+$ cells were abundant in the stroma but no ${\alpha}-SMA^+$ cells were identified except the wall of blood vessels. $CD34^+$ cells were progressively decreased along the continuum from CIN 2 to microinvasive SCC and not observed in the stroma of invasive SCC. Whereas ${\alpha}-SMA^+$ cells were only observed in the stroma of microinvasive and invasive SCC. We found more intense TGF-${\beta}1$ expression in the increased mast cells in the stroma of invasive SCCs than that in the stroma of CIN. These results indicate that disappearance of $CD34^+$ stromal cells and appearance of ${\alpha}-SMA^+$ cells are associated with the stromal change of CIN to SCC and the transformation of $CD34^+$ stromal cells into ${\alpha}-SMA^+$ cells is mediated by TGF-${\beta}1$ secretions in the stromal mast cell of SCC.
자궁경부상피의 악성변화에서 비만세포가 간질세포의 α-Smooth Muscle Actin 발현에 미치는 영향
제갈승주 ( Seung Joo Jekal ),최영자 ( Young Ja Choi ),이광주 ( Kwang Joo Lee ),노종섭 ( Jong Sup Roh ) 대한임상검사과학회 2007 대한임상검사과학회지(KJCLS) Vol.39 No.3
There is increasing evidence that stromal reaction in cancer has an important diagnostic and prognostic significance. The aim of our study is to analyze the relation between the increase in mast cell number and the expression CD34 and alpha-smooth muscle actin (α-SMA) in the stroma of cervical intraepithelial neoplasia (CIN) and squamous cell carcinoma (SCC). We investigated a total of 29 CIN (1,2,3) and 21 SCC (microinvasive and invasive) specimens and compared the distribution of CD34+ stromal cells, α-SMA+ cells, transforming growth factor-β1 (TGF-β1)+ cells, and the density of mast cells using immunohistochemistry with antibodies against CD34, α-SMA, TGF-β1, and c-Kit (CD117) respectively. Computerized image analysis was to evaluate the positive area (%) and density of the respective immunoreactive cells. In CIN CD34+ cells were abundant in the stroma but no α-SMA+ cells were identified except the wall of blood vessels. CD34+ cells were progressively decreased along the continuum from CIN 2 to microinvasive SCC and not observed in the stroma of invasive SCC. Whereas α-SMA+ cells were only observed in the stroma of microinvasive and invasive SCC. We found more intense TGF-β1 expression in the increased mast cells in the stroma of invasive SCCs than that in the stroma of CIN. These results indicate that disappearance of CD34+ stromal cells and appearance of α-SMA+ cells are associated with the stromal change of CIN to SCC and the transformation of CD34+ stromal cells into α-SMA+ cells is mediated by TGF-β1 secretions in the stromal mast cell of SCC.
자궁경부의 편평상피내병소와 편평상피세포암종에서의 비만세포에 관한 연구
제갈승주 ( Seung Joo Jekal ),차현희 ( Hyun Hee Cha ),최영자 ( Young Ja Choi ),노종섭 ( Jong Sup Roh ),곽효일 ( Hyo Il Kwak ) 대한임상검사과학회 1999 대한임상검사과학회지(KJCLS) Vol.31 No.2
Mast cells have recently been found to be well correlated with the inhibition of invasiveness and metastasis in various cancer. This work aimed to investigate the number of mast cells and ratio of mast cell granulation in squamous intraepithelial lesions and squamous cell carcinoma of the cervix. Cervical biopsy specimens were divided into low grade squamous intraepithelial lesion(n=20), high grade squamous intraepithelial lesion(n=75) and squamous cell carcinoma(n=40) by The Bethesda System. The sections were cut from routinely formalin- f1xed and paraffin-embedded tissues and stained with 0.5% toluidine blue(pHO.5)-nuc1ear fast red. The mast cells were quantif1cated the numbers per square millimeter using a computerized image analysis system. Mean number of mast cells was signif1cantly higher in high grade squamous intraepithelial lesion than in low grade squamous intraepithelial lesion and signif1cantly lower in squamous cell carcinoma than in high grade squamous intraepithelial lesion(p<0.01). The percent of mast cell ganulation also was significantly higher in high grade squamous intraepithelial lesion than in low grade squamous intraepithelial lesion and significantly lower in squamous cell carcinoma than in high grade intraepithelial lesion (p<0.01). These results suggested that mast cell number and percent of mast cell granulation were to be correlated to the development from precancerous lesion to cervical cancerous lesion and may be useful as markers of cervical squamous cell carcinoma.