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이주용,노일환,박현석,원상철 제어로봇시스템학회 2009 제어로봇시스템학회 국내학술대회 논문집 Vol.2009 No.9
In hot finishing mill process of steel industry, the strip tension affects strongly the mass flow and the dimensional quality of the product. So the looper is installed between each roll stand to prevent sudden tension change. The strip tension is constructed by looper angle and the difference of strip velocity between neighbor roll stands. Therefore, the system is expressed by complex coupled system model, and the suitable control logic is required. Currently, there are many approaches for looper tension control, but a few of them is applied on real plant, because they are verified by only software simulation. However, it’s almost impossible to test the algorithms on real plant. So, in this study, the hardware simulator for looper tension control is developed to verify the various control algorithms.
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Antitumor Effect of Low-Dose of Rapamycin in a Transgenic Mouse Model of Liver Cancer
이형순,김준예,노원상,김명수,김혜령,주동진 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.11
Purpose: We investigate whether low-dose rapamycin is effective in preventing hepatocellular carcinoma (HCC) growth and treating HCC after tumor development in transgenic mice. Materials and Methods: We established transgenic mice with HCC induced by activated HrasG12V and p53 suppression. Trans genic mice were randomly assigned to five experimental groups: negative control, positive control, tacrolimus only, rapamycin only, and tacrolimus plus rapamycin. The mice were further divided into two groups according to time to commencement of im munosuppressant treatment: de novo treatment and post-tumor development. Results: In the de novo treatment group, marked suppression of tumor growth was observed in the rapamycin only group. In the post-tumor development group, the rapamycin only group displayed no significant suppression of tumor growth, compared to the positive control group. In T lymphocyte subset analysis, the numbers of CD4+effector T cells and CD4+ regulatory T cells were significantly lower in the positive control, tacrolimus only, and tacrolimus plus rapamycin groups than the negative control group. Immunohistochemical analysis revealed significantly higher expression of phosphorylated-mTOR, 4E-BP1, and S6K1 in the posi tive control group than in the rapamycin only group. Conclusion: Low-dose rapamycin might be effective to prevent HCC growth, but may be ineffective as a treatment option after HCC development.
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연속 압연기의 실시간 Hardware-In-the-Loop 시뮬레이터 개발
이규택,박정훈,구자후,노일환,원상철 제어로봇시스템학회 2011 제어로봇시스템학회 국내학술대회 논문집 Vol.2011 No.5
Because the rolling control technology depends on foreign mill maker, the leaking of rolling control information of POSCO’s characteristic steel is quite serious. And control technicians have problems of applying new control algorithm to real control system due to concerning rolling operation trouble. They also have difficulties of verification of new control logic without test bed instead of real rolling mills. In this paper, we introduced the development of real-time tandem rolling mills simulator for mill controller developers. To give solution to problems mentioned above, the hardware-in-the-loop typed simulator(HILS) including real controller (Siemens PLC) was developed.
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주혜림 ( Hye-lim Ju ),노원상 ( Simon Weonsang Ro ) 대한간암학회 2017 대한간암학회지 Vol.17 No.1
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. HCC develops in various causes - Viral hepatitis infection, toxins, or other liver conditions - by activation of oncogenes and/or inactivation of tumor suppressors. Understanding of signal pathways and protein-protein interactions critical in tumor development may lead to novel treatment strategy. To evaluate the progression of HCC and effects of potential therapies, various animal models have been established. Experimental models of HCC provide valuable tools to investigate the risk factors, new treatment modalities and biologic characteristics. Subcutaneous xenograft models have been widely used in the past. However, with the advancement of in vivo imaging technology, investigators are more concerned with the orthotopic models nowadays. Genetically engineered mouse models have greatly facilitated studies of gene function in HCC development. Lately, a novel approach for stable gene expression in mouse hepatocytes by hydrodynamic injection has been developed. Each model has its own advantages and disadvantages. Therefore, selecting the optimal models based on study objectives is necessary. In this review, we highlight both the frequently used mouse models and some emerging ones with emphasis on their merits or defects, and give advices for investigators to choose a ``best-fit`` animal model in HCC research. (J Liver Cancer 2017;17:1-14)
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