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김정선(Jung Sun Kim),정해영(Hae Young Chung),노영재(Young Jae Rho),이상록(Sang Rok Lee) 大韓藥學會 1992 약학회지 Vol.36 No.6
The treatment with gentamicin in the presence of pretreatment with bismuth nitrate significantly reduced blood urea nitrogen compared with given gentamicin alone. But the amelioration of gentamicin-induced nephrotoxicity by bismuth nitrate was abolished by pretreatment with indomethacin that is cyclooxygenase inhibitor, which significantly decreased renal glutathione S-transferase activity and thiobarbituric acid reactive substance compared with mice of given gentamicin and bismuth nitrate. On the other hand, treatment with bismuth nitrate significantly increased prostaglandin E2 production in rat kidney slice. These results suggest that bismuth nitrate might ameliorate the nephrotoxicity of gentamicin via prostaglandin E2 production.
Han, Suk Kyu,Rho, Young Jae,Lee, Jeong Hee 부산대학교 신약개발연구소 1992 藥學硏究誌 Vol.26 No.2
The local anesthetics procaine, tetracaine benoxinate, benzocaine, dyclonine, pramoxine, and proparacaine were found to quench the fluorescence of the probes N-octadecyl naphthyl-2-amine-6-sulfonic acid and 12-(n-anthroyloxy)stearic acid in the presence of liposomal membrane. The local anesthetics showed diversified abilities of quenching the fluorescence probes labeled into the phospholipid liposomal membranes, and their quenching abilities were quite different from their quenching abilities in the fluorescence probes in solution. This leads us to investigate the distribution profile of the local anesthetics in the liposomal membrane. The Stern-Volmer equation for fluorescence quenching was modified for the liposomal membrane system, and analysis of the quenching data employing the equation showed that the local anesthetic drugs locate mainly on the surface of the liposomal membrane. However, as the hydrophobicity of the local anesthetics increased, the more effectively they penetrate into the hydrocarbon interrior of the liposomal membrane.