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폐기능이 저하된 폐암환자에서 폐절제술후 합병중의 예측인자 평가에 관한 전향적 연구
박정웅 ( Jeong Woong Park ),정성환 ( Sung Whan Jeong ),남귀현 ( Gui Hyun Nam ),김호철 ( Ho Cheol Kim ),서지영 ( Gee Young Suh ),정만표 ( Man Pyo Chung ),김호중 ( Ho Joong Kim ),권오정 ( O Jung Kwon ),이종헌 ( Chong H. Rhee ) 대한결핵 및 호흡기학회 2000 Tuberculosis and Respiratory Diseases Vol.48 No.1
진행성 비소세포폐암 환자에서 Vinorelbine, Ifosfamide 복합화학요법
조은경(Eun Kyung Cho),홍순홍(Soon Hong Hong),방수미(Soo Mee Bang),이한경(Han Kyung Lee),박정웅(Jeong Woong Park),정성환(Seong Hwan Jeong),남귀현(Gui Hyun Nam),신동복(Dong Bok Shin),이재훈(Jae Hoon Lee) 대한내과학회 2001 대한내과학회지 Vol.60 No.1
N/A Background : Although cisplatin (CDDP)-based chemotherapy is currently considered to be the most active treatment for advanced non-small cell lung cancer (NSCLC), ultimate prognosis still remains poor. More effective cytotoxic agents are needed to improve outcom of these patients. We evaluated the efficacy and safty of combination chemotherapy with vinorelbine and ifosfamide in patients with advanced NSCLC. Methods : Thirty-three chemotherapy-nave patients with stage IIIB or IV NSCLC were treated with vinorelbine 25 mg/m2 on days 1 & 8 and ifosfamide 2 g/m2 on days 1, 2 & 3 with mesna every 3 weeks. Results : Among thirty evaluable patients who received the vinorelbine/ifosfamide combination chemotherapy, nine (30%) partial responses were observed. With median follow-up duration of 80weeks, the median response duration and overall survival durations were 23 weeks and 38 weeks respectively. World Health Organization grade 3 to 4 neutropenia and anemia occured in 5% and 4.3% respectively. Conclusion : Combination chemotherapy with vinorelbine and ifosfamide is an effective treatment for patients with advanced NSCLC with a manageable toxicity.(Korean J Med 60:70-76, 2001)
이상도,권오정,이춘택,조상헌,남귀현,한성구,심영수,김건열,한용철 대한내과학회 1990 대한내과학회지 Vol.38 No.3
It is well known that cigarette smoking induces chronic obstructive lung disease. Recently it has been noted that inflammatory changes of the small airways are the earliest lesions of chronic obstructive lung disease. Impairment of pulmonary function in teenage smokers, or in nonsmokers who are exposed chronically to cigarette smoke, is reported frequently, and after stopping cigarette smoking, restoration of pulmonary function is observed. Many studies are currently being carried out regarding pulmonary function tests for early detection of small airway disease. Different from chronic effect of cigarette smoking, increased resistance of central airways is reported as an acute effect of cigarette smoking, while others report increased resistance of small airways as an acute effect of cigarette smoking. There is many controversies about the major site of acute effect of cigarette smoking. Maximal expiratory flow volume curve, airway resistance, compliance(static and dynamic) and closing volume was measured in healthy medical students without present symptoms of pulmonary disease, with the object of comparison of the sensitivity of pulmonary function test items used for detection of small airway disease in young-age smokers, and to study about the acute effect of cigarette smoking. The results are as follows; 1) Mean age of smokers was 22.9±1.2(21~26) years and the mean of their smoking history was 4.2±1.2(3~7) pack-year. Mean age of nonsmokrs was 22.0±1. 0(21~23) years. 2) Compared to nonsmokers, CV/VC was significantly high(p<0.05) and C1.0/C0.0(Cdyn at repiration rate of 60/min/Cst) was significantly low(p<0.05) in smokers, while other pulmonary function test items showed no significant difference between smokers and and nosmokers. 3) Of 21 smokers, 12 persons(57%) showed significant decrease of Cdyn with an increase of respiration rate, while 2 persons(13%) showed abnormal MMF and other 2 showed abnormal CV/VC among 16 smokers who performed the tests and they all showed significant decrease of Cdyn with an increase of respiration rate. 4) Of 21 smokers, 13 persons(62%) had symptoms of cough or sputum, but there was no significant difference of pulmonary function tests between symptomatic and asymtomatic smokers. 5) After smoking, FEV1/FVC, MMF and PEFR were decreased significantly(p<0.05), and SRAW was increased significantly(p<0.005). 6) After smoking, the decrease of C1.0/C0.0 was significantly larger(p<0.05) in nonsmokers compared to smokers and increase of SRAW was somewhat larger in nonsmokers but without statistical significance.