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남궁경영,강명진,임홍목,김미성,고병성,안현택,이종률,김종옥 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.2
Metastasis of hepatocellular carcinoma occurs at a relatively late stage of the disease. Hematogenous and lymphatic metastases are the most common routes for dissemination of tumor cells. Hepatocellular carcinoma also extends into the adjacent portal vein and bile ducts. Since there is no peritoneum between the body of the gallbladder and the liver fossa, gallbladder cancer can easily cross the boundary. Gallbladder invasion of hepatocellular carcinoma, however, is quite rare. We report a case of hepatocellular-cholangiocarcinoma in a non-cirrhotic liver that invaded the gallbladder mimicking the gallbladder carcinoma complicated by cholecystitis and liver abscess. (Korean J Hepatol 2004;10:148-153)
남궁경영,강명진,임홍목,김미성,고병성,안현택,이종률,김종옥 대한간학회 2004 Clinical and Molecular Hepatology(대한간학회지) Vol.10 No.2
Metastasis of hepatocellular carcinoma occurs at a relatively late stage of the disease. Hematogenous and lymphatic metastases are the most common routes for dissemination of tumor cells. Hepatocellular carcinoma also extends into the adjacent portal vein and bile ducts. Since there is no peritoneum between the body of the gallbladder and the liver fossa, gallbladder cancer can easily cross the boundary. Gallbladder invasion of hepatocellular carcinoma, however, is quite rare. We report a case of hepatocellular- cholangiocarcinoma in a non-cirrhotic liver that invaded the gallbladder mimicking the gallbladder carcinoma complicated by cholecystitis and liver abscess.
NADPH Oxidase Mediates b-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures
최기오,남궁경영,황신애,김종근,배춘상 전남대학교 의과학연구소 2017 전남의대학술지 Vol.53 No.3
b-Amyloid peptide (Ab) is the main component of senile plaques in patients with Alzheimer's disease, and is known to be a main pathogenic factor of the disease. Recent evidence indicates that activation of NADPH oxidase (NOX) in microglia or astrocytes may be a source of Ab-induced reactive oxygen species (ROS). We investigated the role of neuronal NOX in Ab-induced neuronal death in mouse mixed cortical cultures. Cell death was assessed by measuring lactate dehydrogenase efflux to bathing media 24 or 48 hr after exposure to Ab25-35, a fragment of Ab with an equivalent neurotoxic effect. Ab25-35 induced neuronal death in concentration- and time- dependent manners with apoptotic features. Neuronal death was significantly attenuated, not only by anti-apoptotic drugs, such as z-VAD-fmk and cycloheximide, but also by antioxidants, such as trolox, ascorbic acid, and epigallocatethin gallate. We also demonstrated that treatment with 20 mM Ab25-35 increased fluorescent signals in mixed cortical cultures, but produced only weak signals in pure astrocyte cultures in the presence of 2’,7’-dichlorofluorescin diacetate (DCF-DA), an indicator for intracellular ROS. Increased DCF-DA fluorescence was markedly inhibited, not only by trolox, but also by selective NOX inhibitors, such as apocynin and AEBSF. Western blot analyses revealed that Ab25-35 increased the expression of gp91phox, a main subunit of NOX in cells. The above antioxidants, apocynin, and AEBSF significantly attenuated neuronal death induced by Ab25-35. Furthermore, the gp91phox-specific siRNA-based knockdown of NOX significantly inhibited neuronal death. These results suggest that activation of neuronal NOX is involved in Ab25-35-induced neuronal death.
담낭의 대세포 신경내분비암종에 의한 화농성 간농양 1예
강명진,남궁경영,임홍목,고병성,안현택,이종률,김종옥 대한내과학회 2004 대한내과학회지 Vol.66 No.2
저자들은 화농성 간농양을 항생제와 경피적 배액술로 치료 중 임상적 호전이 없고, 복부 전산화 단층촬영에서 담낭에 담석과 담낭벽의 비후가 관찰되어 담낭절제술과 배농을 위하여 외과적 수술을 시행한 바 담낭의 대새포 신경내분비세포암종을 조직학적 검사와 면역조직화학검사로 진단할 수 있었던 1예를 경험하여 문헌고찰과 함께 보고하는 바이다. Pyogenic liver abscess is a rare but highly lethal disease. The diagnosis and treatment of pyogenic liver abscess has been evolving owing to specific antibiotic therapy, ultrasonography, abdominal computed tomography with improved percutaneous and operative techniques. However, pyogenic liver abscess may present as a rapidly fatal outcome. These unfavorable results are mainly attributed to the increasing numbers of patients with malignant disease and biliary tract disease. Carcinoma of the gallbladder has remained an uniformly fatal neoplasm characterized by early metastasis and rapid fatal course. In early stage, the symptom is nonspecific and often mimics benign biliary tract disease. We experienced a case of the gallbladder carcinoma presenting with pyogenic liver abscess in a 78-year-old female patient. Surgical drainage and cholecystectomy were done. The microscopic finding of resected gallbladder revealed large cell neuroendocrine carcinoma of gallbladder.
췌장 미부에 발생한 췌장 내분비종양에 의한 위정맥류 출혈 1예
임홍목,강명진,남궁경영,고병성,안현택,이종률,한은미 대한내과학회 2003 대한내과학회지 Vol.65 No.4
저자들은 혈변, 흑색변을 주소로 내원한 27세 남자 환자에서 위내시경으로 고립성 위분문부정맥류에 의한 출혈이 있어 원인 질환 평가 등으로 췌장 종양에 의한 비정맥폐쇄에 의한다고 생각되어 외과적수술을 시행하여 비기능성 췌장 내분비종양에 의함을 확인한 증례를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Isolated obstruction of the splenic vein leads to segmental portal hypertension, which is mainly originated from pancreatic disease, such as chronic pancreatitis, pancreatic pseudocyst, pancreatic cancer. The clinical manifestation are devoid of ascites and encephalopathy, but presented with gastric variceal bleeding. We experienced 27-year-old male patient who complained or hematochezia and melena. After work-up with CT and angiography, we performed operation with the impression of pancreatic tumor associated with splenic vein occlusion. It resulted nonfunctioning pancreatic endocrine tumor. Ofter called islet cell tumor, pancreatic endocrine tumor has various names according to secreted hormones, such as inculinoma, Zollinger-Ellison syndrome and glucagonoma. It was classified as nonfunctioning tumor if there were any evidence of hormone secretin by radioimmunoassay and immunogistochemistry. Surgical excision and adjuvant medical therapy is the mainstay of therapy. We performed tumor resection and splenectomy for control of gastric variceal bleeding due to splenic vein occlusion.
춘계학술대회 : 포스터전시 ; B형 간염 보유와 동반된 자가면역성 간염 1예
안현택,강명진,남궁경영 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)
배경/목적: 자가 면역성 간염은 원인 미상의 지속적인 간세포염증과 섬유화를 보이는 질환으로 조직학적으로 경계면 간염, 고감마글로부린증, 자가항체 발현을 특징으로 하는 질환으로 만성 간염의 원인으로 감별해야 할 질환 중의 하나이다. 진단은 International AIH group에서 정한 기준에 따라 진단하게 된다. 이 질환은 유전적인 자가면역 경향이 있으며 환경적인 인자나 감염이 자가면역 과정을 유발한다고 추정되고 있으며 이에 관여된 바이러스로 C형