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페닐알킬 피페라진 유도체 합성과 α-Glucosidase 저해활성
우미희(Mi Hee Woo),이응석(Eung-Seok Lee),최란(Lan Choi),손경희(Kyung-Hee Sohn),김인규(In-Kyu Kim),황보경(Kyoung Hwangbo),이은영(Eunyoung Lee),손종근(Jong-Keun Son),나영화(Younghwa Na),장인혜(Inhye Chang) 大韓藥學會 2002 大韓藥學會 總會 및 學術大會 Vol.2002 No.2
As an effort to find a new scaffold for α-glucosidase inhibition, we have prepared total 11 phenylalkylated piperazine derivatives and tested their α-glucosidase inhibitory activities. Compounds 8 (IC50=2.73±0.075 mM) possessing two 3-methoxyphenethyl group on 1,4-position of piperazine showed comparable potency to acarbose used as reference. But other compounds were inactive to α-glucosidase. The result indicated that proper substituents on the piperazine can engender α-glucosidase inhibitory activities on the piperazine derivatives.