http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
신약의 기술이전 최적시기 결정 문제 – 바이오텍의 측면에서
나병수,김재영 한국지식경영학회 2020 지식경영연구 Vol.21 No.3
신약 개발과 관련하여 글로벌 판매망이 구축되지 않은 국내 바이오텍에게 가장 필요한 것은 신약의 기술이전과 관련된 의사 결정이다. 각 임상 단계별 성공 확률이 다르고, 어느 임상 단계에서 기술이전 계약을 하느냐에 따라서 총 계약금액과 로열티가 달라지게 된다. 이런 기술이전 계약의 특징과 바이오텍의 취약한 재무 구조 등으로 인하여, 바이오텍이빅파마에게 기술 이전을 하는 시기를 정하는 것은 매우 중요한 의사 결정 문제가 된다. 이 연구에서는 ‘신약의 기술이전최적시기 결정 문제’라는 연구모형을 제시하고, 의사결정트리 방법론으로 결과를 도출하였다. 사례 연구로, first-in-class 신약을 대상으로 FDA 글로벌 임상을 진행하고 있는 국내 바이오텍에 적용해 보았다. 타겟 질환의 시장 크기와 예상 시장 침투율은 알려져 있다고 가정하였을 때, 임상 1상이나 2상 이후에 기술이전을 하는 것이 이익을 최대화할 수 있는대안임을 알 수 있었다. 본 연구는 제약 분야 문제에 경영과학 방법론을 사용할 수 있는 개념적인 틀을 제시하여 신약기술이전에 대한 지식 및 연구의 기반이 될 수 있을 것으로 기대된다.
생산성 향상을 위한 수요 불확실성하의 듀얼 소싱에 관한 연구: 감자스낵시장 사례
나병수 ( Byungsoo Na ),김진민 ( Jinmin Kim ),이진표 ( Jinpyo Lee ) 한국생산성학회 2016 生産性論集 Vol.30 No.4
The demand for potato in potato snack industry has been gradually increased, but the supply of potato has hardly met such growing demand because of a limited domestic capacity of potato farming. Usually, domestic sourcing is used between June and November, and foreign sourcing from the United States or Australia is used in other periods. A foreign order should be placed prior to 1 year in order to purchase at a low price. However, it is hard to forecast domestic demand and domestic production. Hence, under such uncertainties of domestic demand and production, finding the optimal pre-order quantity is a very important issue in potato snack industry and the productivity of the company is seriously affected by its decision. This research defines the dual sourcing problem in potato snack industry and applies a stochastic programming approach to obtain an optimal pre-order quantity. We analyze five real-world cases according to the amount of domestic demand and supply. We compare the solution of the stochastic programming approach with the expected value solution. In all cases, the stochastic programming solution achieves 2% ~ 4% cost saving than the expected value solution. Its saving corresponds to about one million dollars. Furthermore, in the sensitivity analysis, we examine the change of optimal pre-order quantity and total cost when the late-order quantity increases. The result shows that as the late-order quantity increases, the optimal pre-order quantity should be increased. The contribution of this research is two fold. First, this is the first research to define the dual sourcing problem in potato snack industry using management science. In this research, it is expected to be useful for making decisions on sourcing in agricultural industry. Second, we apply the stochastic programming approach to solve this and our approach can contribute about 3% of cost saving. Although agricultural producers generally have a low operating margin, reduction of costs for raw materials will help to improve total productivity.
자연 용해된 급성 췌장염에 동반된 고립성 상장간막정맥 혈전증
나병수 ( Byung Soo Na ),전병민 ( Byung Min John ),김기범 ( Ki Bum Kim ),이제수 ( Je Soo Lee ),조현우 ( Hyun Woo Jo ),석창현 ( Chang Hyeon Seock ),김동휘 ( Dong Hui Kim ),이기성 ( Ki Sung Lee ) 대한소화기학회 2011 대한소화기학회지 Vol.57 No.1
Acute pancreatitis can result in many vascular complications in both artery and vein. Venous complication usually occurs as a form of splenic or portal vein thrombosis, and also can simultaneously occur in superior mesenteric vein as well. Rarely, isolated superior mesenteric vein thrombosis occurs as a venous complication. Although it is uncommon, mesenteric vein thrombosis is an important clinical entity because of the possibility of mesenteric ischemia and infarction of small bowel. The treatments of mesenteric venous thrombosis include anticoagulation therapy, transcatheter therapy and surgical intervention. We report a case of 45-yearold man who had acute pancreatitis with isolated superior mesenteric vein thrombosis, which was spontaneously dissolved with the resolution of underlying inflammation without anticoagulation or surgical intervention. (Korean J Gastroenterol 2011;57:38-41)
가토에서 Thiopental 과 Propofol의 피하주사에 따른 염증반응
오제환,나병수,이보령,박정원,정용훈,백종화,우영철,김진윤,박선규,구길회,오수원 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4
Background: Thiopental and propofol are the most widely used intravenous anesthetics as induction agents in general anesthesia. Thiopental is a very strong alkaline drug, and when it is extravasated, it can cause pain and skin necrosis. Propofol also can cause pain on injection in many populations. Therefore, we planed this study to compare inflammatory reactions of skin tissues after subdermal injections of thiopental and propofol in rabbits. Methods: Four rabbits were divided into 2 groups: Standard dose (S) group and double dose (D) group. In the S group, thiopental 0.4 ml and propofol 0.4 ml were injected subcutaneoudly on each side of the posterior proximal ear. In the D group, the dose was doubled to 0.8 ml of each drug and injection was done in the same manner. Skin tissue at the injection sites were excised after 1 day, 3 days, and 7 days. Then each skin tissue slide was examined under an optical microsccpe. Results: In the S group, the inflammatory reaction after the subdermal injection of 2.5% thiopental revealed a more progressed and more severe pattern than 1% propofol. In the D group, the inflammatory reaction after a subdermal injection of 2.5% thiopental revealed a more progressed and more severe pattern than 1% propofol at 3 days, but there was no significant difference in the degree of progression and severity between the 2 drugs at 7 days. Conclusions: When propofol is extravasated during continuous infusion for maintenance of anesthesia, it can cause distinct inflammatory reaction; though the inflammatory reaction is milder and the possibility of complications is lower than with thiopental. (Korean J Anesthesiol 2002; 43: 485~493)
정맥내 통증자가조절장치로 투여된 Fentanyl과 Ketorolac이 수술 후 오심 구토에 미치는 영향
신영근,나병수,박정원,우영철,김진윤,박선규 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.2-3
This study was performed to assess the effect of fentanyl and ketorolac in intravenous patient-controlled analgesia (IV-PCA) on postoperative nausea and vomiting. And we also evaluated the antiemetic effect of ondansetron. Ninety three patients who were undergoing elective operation of three departments (gynecology, GY; general surgery, GS; orthopedic surgery, OS) received enflurane anesthesia and IV-PCA. The IV-PCA device was filled with fentanyl 12-15 pg/kg, ketorolac 4-5 mg/kg and normal saline into total dose of 65 ml. After loading 5 ml of the above solution, the IV-PCA was started at a setting of 0.5 ml/h of basal infusion rate and 0.5 ml per demand, with 15 minutes lockout interval. Patients undergoing abdominal surgery were randomly allocated into ondansetron group and non-ondansetron group based on the addition of ondansetron 4 mg into the IV-PCA device. We assessed the incidence of nausea, vomiting by departments and ondansetron usage at operation day (OD), postoperative day 1 (POD1) and 2 (POD2). The incidence of nausea was 34%, 10.3% and 0% at OD in GY, GS and 0s respectively. There was no difference between ondansetron group and non-ondansetron group in the incidence of nausea and vomiting. The patients who received gynecological operation showed higher rate of postoperative nausea and vomiting at OD and PODI. Also, addition of ondansetron into IV-PCA with fentanyl and ketorolac did not reduce the incidence of postoperative nausea and vomiting in abdominal operation.
후천성면역결핍증 환자에서 발생한 아메바성 간농양과 흉막삼출 1예
김기범,나병수,이승훈,석창현,조현우,최원석,김명수 대한감염학회 2010 Infection and Chemotherapy Vol.42 No.5
Recent studies indicate that there is an increased risk of amebic liver abscess among those infected with HIV, which is associated with cell-mediated immunosuppression. Although Entamoeba histolytica infection is common among HIV infected patients,only a few cases of amebic liver abscess with bilateral pleural effusion have been reported. We present a case of a 44-year-old man who presented with fever and right lower quadrant abdominal pain. Amebic liver abscess with bilateral pleural effusion was confirmed by serologic test, clinical symptoms, and radiological findings. HIV infection was incidentally diagnosed during treatment. The possibility of the presence of amebic liver abscess should be considered in HIV infected patients with space-occupying lesions in the liver, and HIV screening should strongly be recommended in patients with amebic liver abscess.