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      • SCOPUSKCI등재

        Mycoplasma pneumoniae 폐렴 환아에서 급성기 및 회복기의 호산구 지표의 비교

        나규민,강은경,강희,박양,고영률,Nah, Kyu Min,Kang, Eun Kyeong,Kang, Hee,Park, Yang,Koh, Young Yull 대한소아청소년과학회 2002 Clinical and Experimental Pediatrics (CEP) Vol.45 No.10

        목 적: Mycoplasma pneumoniae 감염과 천식은 급성기에 호산구 지표의 증가가 관찰되며 두 질병간에 공통적인 병리기전이 작용하는 것으로 생각되고 있다. 호산구 지표는 천식의 질병경과를 반영하는 것으로 알려지고 있다. 이에 저자들은 Mycoplasma pneumoniae 폐렴의 임상경과에 따른 호산구 지표의 변화를 분석하는 연구를 시행하였다. 방 법 : 2000년 10월부터 2001년 8월까지 외래에서 진단된 Mycoplasma pneumoniae 폐렴 환자군 33명을 대상으로 급성기 및 회복기 말초혈액 TEC, 혈청 ECP를 측정하여 비교하였으며 이들을 다시 천명음양성군과 음성군으로 나누어 비교하였다. 또한, 급성기 Mycoplasma 항체가와 말초혈액 TEC, 급성기 Mycoplasma 항체가와 혈청 ECP 간의 상관관계를 분석하였다. 결 과 : 전체 33명의 환자군에서는 급성기 말초혈액 TEC, 혈청 ECP가 회복기 때보다 유의하게 높았으며(P=0.018, P=0.005) 천명음 양성군과 음성군간의 유의한 차이는 없었다. 천명음 양성군 내에서는 급성기 말초혈액 TEC, 혈청 ECP가 회복기에도 유의한 감소를 보이지 않았으나 천명음 음성군 내에서는 유의한 차이가 있었다(P=0.006, P=0.018). 급성기에 Mycoplasma 항체가와 말초혈액 TEC, Mycoplasma 항체가와 혈청 ECP 사이에는 각각 유의한 상관관계가 없었다. 결 론: Mycoplasma pneumoniae 폐렴에서 호산구 지표인 말초혈액 TEC와 혈청 ECP는 급성기에 증가하고 회복기에 감소하여 Mycoplasma pneumoniae 폐렴의 임상경과를 반영하며, 급성기에 천명음이 청진된 환아는 청진되지 않은 환아에 비해 회복기에 도 호산구성 염증이 지속되는 것으로 추정된다. Purpose : Several studies have shown that increases of eosinophil markers are common findings of asthma and Mycoplasma pneumoniae infection, and eosinophil markers reflect the clinical stage of asthma. The purpose of this study was to investigate the change of eosinophil markers according to the clinical stage of Mycoplasma pneumonia. Methods : The patient group consisted of 33 outpatient children with Mycoplasma pneumonia. Peripheral blood total eosinophil count(TEC) and serum eosinophilic cationic protein(ECP) level were measured at both acute and recovery stages and were compared between both stages. The patient group was subdivided into the wheezing(n=16) and the nonwheezing group(n=17), and the TECs and the ECPs of one group were compared with those of the other group. The correlation between Mycoplasma antibody titer and the eosinophil markers of acute stage were analyzed. Results : In the whole patient group, the TECs and the ECPs of the acute stage were significantly higher than those of the recovery stage(P=0.018, P=0.005), but there were no differences in the TEC and the ECP between the wheezing and the nonwheezing group. In the wheezing group, there were no significant differences in the TEC and the ECP between acute and recovery stages. There were no correlations between acute stage Mycoplasma antibody titer and the eosinophil markers. Conclusion : Eosinophil markers reflect the clinical stage of Mycoplasma pneumonia and eosinophilic inflammations may continue even after the acute stage in wheezing patients with Mycoplasma pneumonia.

      • KCI등재

        천식 및 알레르기성 비염 환아에서의 호기 일산화질소 농도 : 아토피 및 기도과민성과의 연관성

        나규민,박양,강은경,강희,고영률,이선화,백도명,Nah, Kyu Min,Park, Yang,Kang, Eun Kyeong,Kang, Hee,Koh, Young Yull,Lee, Sun Wha,Paek, Domyung 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.3

        목 적 : 호기 NO 농도는 비침습적인 하기도 염증의 지표로 주목받고 있으며 기도과민성과 아토피와의 관련성이 보고되고 있다. 이에 저자들은 만성천식 및 알레르기성 비염 환아에서 호기 NO 농도를 측정하고 기도과민성과 아토피 여부에 따른 차이를 분석하였다. 방 법 : 기관지 천식(n=55), 알레르기성 비염(n=17)으로 진단 된 환아 및 대조군(n=14)을 대상으로 2001년 1월부터 4월까지 호기 NO 농도를 측정하여 비교하였으며 다시 천식환아군은 아토피성(n=37) 및 비아토피성 천식군(n=18)으로 나누어 비교하였고 알레르기성 비염군은 기도과민성 유무에 따라 나누어 비교하였다(각각, n=7, n=10). 또한 천식군과 알레르기성 비염군을 대상으로 각각 피부 단자시험에서 양성항원 수 및 메타콜린 $PC_{20}$과 호기 NO 농도의 상관관계를 분석하였다. 결 과 : 호기 NO 농도는 천식군과 알레르기성 비염군이 대조군보다 유의하게 높았으며(P<0.01), 아토피성 천식군이 비아토피성 천식군보다, 비아토피성 천식군은 대조군보다 유의하게 높았다(P<0.01). 알레르기성 비염군은 기도과민성 유무에 따른 차이는 없었다(P=0.50). 천식군에서는 피부 단자시험에서 양성항원 수 및 메타콜린 $PC_{20}$과 호기 NO 농도간에 유의한 상관관계가 있었으나 (r=0.32, P=0.02; r=-0.38, P<0.01), 알레르기성 비염군에서는 유의한 상관관계가 없었다(r=0.42, P=0.09; r=-0.06, P=0.83). 결 론 : 호기 NO 농도는 천식환자에서 아토피에 의한 병태생리와 연관성이 있으며 기도과민성과 유의한 상관관계가 있다. 그러나 알레르기성 비염에서는 기도과민성 이외의 다른 인자가 호기 NO 농도와 관련성을 가질 것으로 추정되며 향후 이에 대한 연구가 필요하다. Purpose : A new airway inflammatory marker, exhaled nitric oxide(ENO) has been reported to correlate with bronchial hyperresponsiveness(BHR) and atopy. The purpose of this study was to analyze the relationship of ENO with BHR or atopy in patients with asthma and with allergic rhinitis. Methods : The subjects consisted of 55 children with asthma, 17 with allergic rhinitis, and 14 healthy controls. The asthma group was subdivided into the atopic asthma group(n=37) and the nonatopic asthma group(n=18) and the allergic rhinitis group into BHR group(n=7) and non-BHR group(n=10). All were investigated with spirometry and measurements of ENO concentration. The correlations between ENO concentration and both methacholine $PC_{20}$(provocative concentration causing a 20% decrease in forced expiratory volume in one second) and the number of allergen skin test positivity were analyzed. Results : ENO concentrations of both asthma and allergic rhinitis groups were significantly greater than that of control(P<0.01). ENO concentration of atopic asthma was significantly greater than that of nonatopic asthma(P<0.01). In allergic rhinitis, ENO concentration did not differ according to the presence or absence of BHR(P=0.50). ENO concentrations correlated significantly with the number of skin test positivity(r=0.32, P=0.02) or methacholine $PC_{20}$(r=-0.38, P<0.01) in asthma group, but not in the allergic rhinitis group(r=0.42, P=0.09; r=-0.06, P=0.83). Conclusion : In asthma patients, some pathogenetic mechanisms associated with atopy and BHR seem to influence ENO concentration. In allergic rhinitis patients, some factors other than BHR may be important in determining ENO concentration.

      • KCI등재

        대학 축구선수들의 여가활동 유형과 여가만족이 운동스트레스에 미치는 영향

        나규민(Na, Gyu-Min),김대훈(Kim, Dae-Hoon),오세이(Oh, Sei-Yi) 한국여가레크리에이션학회 2022 한국여가레크리에이션학회지 Vol.46 No.2

        The purpose of this study was to help university soccer players relieve sports stress through leisure satisfaction by efficiently utilizing their leisure time by identifying differences in leisure satisfaction and sports stress according to the types of leisure activities. In order to clarify this, the convenience sampling method was used for university soccer players registered in the Korea Football Association in 2021. The survey was conducted from September 4th to September 19th of 2021, and a total of 311 copies were used for data analysis. The following results were derived. First, significant differences were found in psychological leisure satisfaction, educational leisure satisfaction, physiological leisure satisfaction, and environment leisure satisfaction. Second, there were no significant differences in all leisure satisfaction sub-factors. Third, it was found that relaxational leisure satisfaction and physical leisure satisfaction had a significant effect on dissatisfaction with soccer skills, and environment leisure satisfaction was found to have a significant effect on restrict private life. As a result of this study, it is necessary to develop leisure education and leisure activity programs for university soccer players.

      • 음향신호 에너지 감소 메커니즘 기반 확률적 보일러 튜브 누설 위치 추정

        나규민(Kyumin Na),김형민(Hyeongmin Kim),이현찬(Hyeonchan Lee),윤병동(Byeng D. Youn) 대한기계학회 2020 대한기계학회 춘추학술대회 Vol.2020 No.12

        Estimation of leak location is important considering the labor cost of maintenance procedure and downtime cost in thermal power plant. The well-known approach, TDOA(Time difference of arrival) has lots of problem on practical situation such as limitation of leak signal extraction and numerically not solving issue. To solve these kinds of difficulties, we use probabilistic approach considering energy decaying effect of sound such as attenuation and geometric spreading. In addition, we use bayesian updating method to prevent bias error caused by unpredictable outsource energy variation such as soot-blowing. Finally, We validate our method with simulation data and acoustic emission sensor data of real power plant from installed BTLD(Boiler tube leak detection) system.

      • 굴삭기 스윙 기어박스의 고장 진단을 위한 주파수 에너지 불확실성 기반 진동 신호 데이터 증폭기법

        나규민(Kyumin Na),하종문(Jong Moon Ha),김건(Keon Kim),윤병동(Byeng D. Youn) 대한기계학회 2018 대한기계학회 춘추학술대회 Vol.2018 No.12

        This study was proposed for detecting the fault of swing gearbox in the excavator, and especially fault exists in sun gear component. To prevent the accident, it is necessary to monitor the health condition of a gearbox in the excavator. Generally, the excavator used in the industrial field have lots of noise related with not only sensor system but other component consisting the excavator. Additionally, it is hard to obtain the vibration signal due to the difficulty of installing the sensor system in the excavator in the industrial field. Therefore, the general machine learning algorithm for classifying the state of the gearbox have difficulty in learning the pattern induced by the fault because of the shortage of data. To get over this difficulty, we introduce the data augmentation techniques on frequency domain by considering the uncertainty of physical quantity. The proposed method is validated with the experiment, which shows the accuracy of several machine learning algorithm is higher with using the augmented data.

      • 굴삭기 기어박스 고장 진단을 위한 고장 정보 강화 전처리 이미지 기반 트랜스퍼 러닝

        나규민(Kyumin Na),박정호(Jungho Park),김윤한(Yunhan Kim),윤병동(Byeng D. Youn) 대한기계학회 2019 대한기계학회 춘추학술대회 Vol.2019 No.11

        Excavator swing reduction gearbox is major component to rotate whole body. Therefore, they are vulnerable to breakdown by teeth in gearbox because they transmit huge power with high efficiency. For many years ago, there are lots of approach to detect these kinds of fault diagnosis of gearbox using feature extraction method based on fault information. However, most of them shows the result under the lab-level environment, so they have robustness problem when they apply to real industrial field. Also, deep learning based approach also have problems that they do not produce the result under different environmental situation, but they just truncate the signal in same situation. Therefore, they did not considering reassembling problem, so it has high possibility for over-fitting. Therefore, in our research, we conjoin preprocessing approach to eliminate the noise effect due to different environment with transfer learning to solve non-linear hyperplane classification problem. We show that deep learning approach have weakness to over-fitting by comparing how much accuracy under the preprocessing could increase. We also use gradCAM and t-SNE result to briefly explain the result of our algorithm. Further research to make algorithm robust under different operating condition are also discussed.

      • 굴삭기 스윙 기어박스의 강건한 고장 감지를 위한 ARMED 필터의 오더 최적화

        나규민(Kyumin Na),김건(Keon Kim) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11

        This paper proposes the order parameter optimization technique of autoregressive minimum entropy deconvolution(ARMED). Traditionally, the best order is selected by Akaike information criterion(AIC) which is same as expected squared prediction error (ESPE). However, in practically, there are many cases that AIC value does not have minimum value and decreases monotonically. This is because residual signal could be disturbed by the other vibration source or noise even appropriate preprocessing. Therefore, AIC’s basic assumption could be violated and it does not work well. This paper proposes new order selection techniques based on health feature related with envelop frequency using Hilbert transform. The simulation and experimental result show that the selected order using these techniques make better performance in signal filtered by ARMED for differentiating normal and fault state than the order obtained by AIC.

      • KCI등재

        음악 기반한 과제지향 슬링운동 프로그램이 만성 뇌졸중 환자의 근수행력, 일상생활 기능 및 보행능력에 미치는 영향 : 단일사례연구

        임진구,나규민,박현주 한국신경근육물리치료학회(구 한국신경근육재활학회) 2019 한국신경근육재활학회지 Vol.9 No.1

        The purpose of this study is to examine how the task-oriented sling exercise based on rhythm affects patients with chronic stroke. We used a study with a single-subject design (A-B-A'). Two patients with chronic stroke participated in this study. Stretching/strengthening and task-oriented function exercises based on music using the sling were performed one hours per day for 8 times during intervention phase(B). Outcome measure included grip strength, range of motion(ROM), modified bathel index(MBI), berg balance scale(BBS), 10meter walk test(10MWT) and 6minute walk test(6MWT). After the intervention, the strength of grip strength, ROM, activities of daily living, balance and walking function of all patients was remarkably increased after the training, and these gains were positively maintained at 2-weeks follow-up phase. This result have shown that the task-oriented sling exercise basced on music might improve muscle performance, activities of daily living and gait function for patients with chronic stroke.

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