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제 1형 Trichorhinophalangeal 증후군
김형섭,심우영,허충림 ( Hyoung Seob Kim,Woo Young Sim,Choong Rim Haw ) 대한피부과학회 1997 대한피부과학회지 Vol.35 No.2
Trichorhinophalangeal syndrome(TRPS) was first described in 1966 by Giedion. It is a rare genetic disease and divided into two groups : TRPS type I and TRPS type II. TRPS type I is an autosomal dominant inherited disorder, defined by three characteristic findings : first, sparsely distributed brittle and slow-growing scalp hair, second, a bulbous pear-shaped nose with an elongated philtrum, third brachydactyla with angular deformities. The characteristic radiological features of the hands include cone shaped epiphysis of the proximal interphalangeal joints. Most TRPS type II is sporadic and shows multiple exosteosis, mental retardation and microcephaly in addition to the three chracteristic findings of TRPS type I . A 20-year-old female visited our department for the evaluation of her sparse, slow-growing scalp hair. She also had a bulbous pearshaped nose, ulnar deviated fingers and shortened both hallux. Some relatives of patients show similar symptoms of scalp hair. A Radiologic aly, histopathologic aly and chromosomal study were done, and we established the diagnosis, TRPS type I. (Kor J Dermatol 1997;35(2): 344-349)
α - MSH가 배양 정상 인체 멜라닌세포의 형태 , 생존 및 멜라닌화에 미치는 영향
김형섭 ( Hyoung Seob Kim ),이무형 ( Mu Hyoung Lee ) 대한피부과학회 1998 대한피부과학회지 Vol.36 No.2
Background: The effects of melanocyte stimulating hormone(MSH) on the integument of many species, including mammals, are well known. The significance of MSH as a physiological regulator of cutaneous pigmentation in humans is still controversial. Although the administration of MSH results in skin darkening, previous reports suggest that cultured human melanocytes are relatively unresponsive to this peptide. This may be related to the conditions under which the melanocytes were cultured. Objective: The purpose of this study was to investigate the effect of a -MSH on the morphological changes, survival, and melanization of cultured human melanocytes in a basal medium without any mitogen. Method: We examined the morphological changes, number and melanin contents of cultured human melanocytes in control(absence of a-MSH) and experimental groups(presence of 10-8 M, 10-7 M, and 10-6 M a -MSH). Results : 1. There were no significant morphological changes of cells between the control and experimental groups after 24, 48, and 72 hours' culture. The number and length of melanocyte dendrites showed no significant difference between the groups after 24, 48, and 72 hours' culture. 2. The number of melanocytes in the experimental groups(presence of 10-7 M, and 10-6 M a -MSH) were significantly higher than the number of melanocytes in control group after 72 hours culture(p<0.05). This effect of a-MSH was dose-related. 3. The melanin contents slightly increased in the experimental groups. The significant difference between the groups was showed in the presence of 10-8 M a-MSH. Conclusions : a -MSH has no effect on the morphology, but increases the survival of cultured human melanocytes and has a melanogenic effect. (Korean J Dermatol 1998;36(2): 280-285)
김광근(Kwang Keun Kim),김형섭(Hyoung Seob Kim) 관광경영학회 2001 관광경영연구 Vol.12 No.-
The primary purpose of this study is to analyze the effect of personal values and vacation styles, psychological variables for more understanding of vacation behavior by examining the factor structures of the two scales, Kahle`s LOV(1983) and Zins`s vacation styles(1998). The factor structure of LOV(Kahle, 1983), an instrument to measure personal values, is analyzed to be 8 items and 2 factors model. The factor analysis of vacation styles, measured by the scale used in Zins(1998) shows 18 items and 5 factors model. For the effect of the variables of Personal Values and vacation styles, intrinsic values have statistically significant connection with rest/safety, culture/spectacle, fun/entertainment and extrinsic values with rest/safety, familiarity/atmosphere, challenge/experience. Both intrinsic and extrinsic values are showed to be related to rest/safety.
스키장의 서비스스케이프가 고객만족과 행동의도에 미치는 영향
김형섭,장경수,이귀옥 대한경영학회 2003 大韓經營學會誌 Vol.16 No.6
The purpose of this study is to develop scale items to measure servicescape of ski resort, to measure servicescape of ski resort to use them, and to find out relationships among servicescape, customer satisfaction and Behavioral intentions. Hypotheses were developed from reviewing the existing literature and tested empirically. The survey, based on questionnaire, was conducted in ski resort. The data were analyzed using SPSS 10.0 and structural equation model by LISREL 8.51. As a result of factor analysis on servicescape of ski resort, 6 factors were extracted and titled "lift", "ski slope", "facilities layout", "safety facilities", "other facilities", and "ski equipments". The results of the study show that servicescape of ski resort has a positive relationship with customer satisfaction, but has not relationship with behavioral intention. The customer satisfaction has a positive influence on behavioral intentions.