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서방정으로부터의 약물 용출에 대한 고분자-약물 상호작용의 영향
김행자,이승진 한국약제학회 1996 Journal of Pharmaceutical Investigation Vol.26 No.2
To develop oral controlled release dosage forms, ionic interactions between polymers and drugs were evaluated. Hydroxypropylmethyl cellulose and carboxymethylene were used as model nonionic and ionic polymers, respectively. 5-fluorouracil, propranolol-HCl and sodium salicylate were selected as model nonionic, cationic and anionic, respectively. Polymer-drug mixtures were compressed into tablets and drug release kinetics from these tablets were determined. Drug release from the tablets made of the nonionic polymer was not affected by the charge of drugs, rather, was regulated by the solubility of drugs in different pH releasing media. However, drug release kinetics were significantly affected when drug-polymer ionic interactions exist. Enhanced drug release was observed from anionic drug-anionic polymer tablets due to ionic repulsion, whereas drug release was retarded in cationic drug-anionic polymer tablets owing to ionic attractive force. Therefore, the results suggested that the polymer-drug interactions are important factors in designing controlled release dosage forms.
김행자 고려대학교 의과대학 1985 고려대 의대 잡지 Vol.22 No.2
The purpose of this study was to identify the difference between complications and demographic data of the patients. The study was conducted from March 4 to May 31, 1985 at two artificial kidney rooms of K. medical center in Seoul. Data were gathered from 29 adult patients during 8 dialyses per one patient on frequency of complications, demographic data (age, sex, economic factors), change of hem3dialysis schedule, the situation of patients on hospitalization or outpatient and the extent of state-trait anxiety. In this study, the difference of frequency of complications according to each factor was identified by t-test. The measuring instrument of anxiety was State-Trait Anxiety Inventory(STAI) by Spielberger et al. and standardized STAI for Koreans by Kim et al. Results are as follows: 1. The hypothesis 1 that there would be significant dfference between demographic data and the frequency of complications on hemodialysis was partially supported. There were no significant differences in frequency of complications according to sex and age. But the patient group of patients with income showed a significantly lower incidence or complications than the group of patients without income(p<.05). 2. The hypothesis 2 that there would be significant difference between the group with change in dialysis schedule and the group without change was rejected. 3. The hypothesis 3 that there would be significant difference in frequency of complications between the situation of patients on hospitalization or outpatient was accepted. Namely, the situation of patients on hospitalization showed a significant higher frequency of complications than the situation of outpatient(p<.01). 4. The hypothesis 4 that there would be significant difference in frequency of complications according to the extent of anxiety was partially supported. The higher state-anxiety group was found to have higher incidence of complications than the lower state-anxiety group(p.<01) and the higher trait-anxiety group showed a trend to have higher incidence of complications than the lower trait-anxiety group. 5. In addition, other analysis showed that total frequencies of complications were 259 among total number of 232 hemodialysis. Therefore mean frequency of complications was 1.12 per hemodialysis. The ranking order and distribution of complications are as follows: pain/discomfort (19.31$), nausea/vomiting(14.29%), dizziness (13.90%), hypertention/hypotention (13.51%), headache(10.81%).
서방정으로부터의 약물 용출에 대한 고분자-약물 상호작용의 영향
김행자,이승진 梨花女子大學校 藥學硏究所 1997 藥學硏究論文集 Vol.- No.6
To develop oral controlled release dosage forms, ionic interactions between polymers and drugs were evaluated. Hydroxypropylmethyl cellulose and carboxymethylene were used as model nonionic and ionic polymers, respectively. 5-fluorouracil, propranolol-HCL and sodium salicylate were selected as model nonionic, cationic and anionic, respectively. Polymer-drug mixtures were compressed into tablets and drug release kinetics from these tablets were determined. Drug release from the tablets made of the nonionic polymer was not affected by the charge of drugs, rather, was regulated by the solubility of drugs in different pH releasing media. However, drug release kinetics were significantly affected when drug-polymer ionic interactions exist. Enhanced drug release was observed from anionic drug-anionic polymer tablets due to ionic repulsion. Whereas drug release was retarded in cationic drug-anionic polymer tablets owing to ionic attractive force. Therefore, the results suggested that the polymer-drug interactions are important factors in designing controlled release dosage forms.