신증후 출혈열 환자의 신장조직 병리소견 및 단핵구침윤에 대한 면역학적 성상에 관한 연구

김한선,원남희,백승룡 고려대학교 의과대학 1991 고려대 의대 잡지 Vol.28 No.1

Hemorrhagic fever with renal syndrome (HFRS ) has been recognized since 1913. Then it gained sudden fame, when during the Korean war, many soldiers around the 38th pararell fell into acute febrile hemorrhagic illness. It is characterized by generalized hemorrhage and renal failure. But any pathophysiologic mechanisms of HFRS have not been clearly established yet. To investigate the mechanism of heavy proteinuria (2-10gm/day) and tubulointerstitial nephritis in HFHS, pathologic analysis of 40 patients and immunohistochemical study on lymphocytic subpopulation in the renal biopsied tissue were performed. The results were as follows : 1. Two groups of 14 oliguric and 26 non-oliguric patients were studied. The serum creatinine levels were significantly different between the two groups at the levels of 13.37 ± 4.7mg/dl and 7.7 ±4.1mg/dl, respectively(P<0.01), but 24hr urine protein levels were 1859 ±1565mg /day in oliguric patients and 1799 ± 2219mg/day in non-oliguric patients which was not statistically different(p>0.05). 2. The pathologic findings were interstitial edema, tubular necrosis and mononuclear cell infiltration which were universally found in the all patients of HFRS but there was no histologic difference between the oliguric and non-oliguric patients. 3. In the immunofluorescent study on 20 cases of HFRS, there were 9 cases showing weak positive reaction for IgM, IgG, C3, Clq or C4 deposits in the mesangium or blood vessels and 9 cases displaying focal IgA or IgM, or C3, Clq or C4 deposits along the tubular basement membrane. The remaining 5 cases were entirely negative for all immunoglobulins. 4. Electronmicroscopic study showed focal irregularity with fusion of epithelial foot process without electron dense deposits. Also areas of desquamation of tubular epithelial cells, loss of brush border, and cellular swelling were observed. 5. In the lymphocyte subset study, T cell (UCHL1 positive)were predominantly present and they were mostly T-helper/inducer cells. With the above findings, it is strongly suggested that one of the mechanisms of renal functional and pathologic derangements in HFRS is induced by T-cells through cellular immunity.

강구조물 진단을 위한 누설자속 기반 강판 손상의 이미지화

김한선,김주원,유병준,김원규,박승희 한국구조물진단유지관리공학회 2019 한국구조물진단유지관리공학회 논문집 Vol.23 No.7

In this study, the magnetic flux leakage technique was applied to diagnose steel plate damage, imaging technique was applied through those signals. Steel plate specimens with different thicknesses were prepared for the imaging the magnetic flux leakage signal, and 6 different depths of damage were artificially processed at the same locations on each specimen. The sensor head consist hall sensor and magnetization yoke was fabricated to magnetize the steel plate specimen and measure the magnetic flux leakage signal. In order to remove the noise and increase the resolution of the image in the signal collected from the hall sensor, various of signal processing was performed. P-P value was analyzed for each channel to analyze the magnetic flux leakage signals measured from each damaged part. Based on the above processed signals and analysis, it was converted into heatmap image. Through this, it was possible to identify the damage on the steel plate at glance by imaging magnetic flux leakage signal. 본 연구에서는 강판 손상 진단을 위하여 누설자속 기법을 적용하고, 신호 기반으로 신호의 이미지화 기법에 대해 연구를 실시하였다. 누설자속 신호의 이미지화를 위해 다른 두께를 가지는 강판시편을 준비하였고, 각 시편에 똑같은 위치에 6가지 깊이의 손상을 인공적으로 가공하였다. 홀센서와 Yoke를 이용한 센서헤드를 제작하여 강판시편을 자화시킴과 동시에 누설자속 신호를 계측하였다. 센서로부터 수집된 자속신호의 노이즈 제거 및 이미지 해상도를 높이기 위하여 여러 신호처리 과정을 거쳤으며, 각 손상부로부터 계측된 누설자속 신호의 분석을 위해 각 채널별로 P-P value를 분석하였다. 위의 신호처리 및 분석을 바탕으로 누설자속 신호를 이미지로 변환시켰다. 이를 통해 누설자속 신호 기반 강판 손상의 이미지화로 손상을 한눈에 파악하는 것이 가능하였다.

췌장 및 십이지장의 외상성 손상에 관한 임상적 고찰

김한선,박응범 梨花女子大學校 醫科大學 醫科學硏究所 1983 EMJ (Ewha medical journal) Vol.6 No.2

12 injuries of the duodenum and pancreas were treated at Ewha Womans University Hospital From 1976 to 1982 and 10 of 12 cases were treated operatively. The result was as follows 1) 12 injuries were due to blunt(11) and Stab(1). 5 of the 11 cases of blunt trauma were due to road traffic accident. Other injuries were due to blow(3), fall(2) and kick(1). 2) There were 7 isolated duodenal injuries, 3 isolated pancreas injuries and 2 combined pancreaticoduodenal injuries. 3) Serum amylase determination preoperatively was done in all cases. 9 of 12 patients was elevated. 4) Associated and concomitant injuries were present in 7 patients including the following injuries organ : Stomach(3), Jejunum(2) and Retroperitoneal vessel(2). 5) Three main methods of treatment were used simple suture & drainage(4), simple suture and adjuctive operations(4). pancreaticoduodenetomy(2). 6) The postoperative complications were would infection, pancreatic fistula, duodenal leakage & fistula, pneumonia and sepsis. Among the complications, duodenal leakage and wound infections were most common ones. 7) 3 death occurred in these groups and the mortality was 30 percent. Th causes of death were sepsis and hypovolemia.

수술을 시행한 복강내 결핵

김한선,홍성기 대한소화기학회 1992 대한소화기학회지 Vol.24 No.5

This study included the clinical analysis of 60 cases of intraabdominal peritonitis, which were treated surgically at department of general Surgery in Seoul Red Cross hospital during 13 years from January, 1978 to December, 1990. The results of this study were as follows; 1) The peak incidence was third decades (30.0%) and the ratio of the male to the female was 1:1. 2) The frequent chief complaints were abdominal pain (81.7%), nausea & vomiting (43.3%) and abdominal mass (23.3%). 3) The frequent physical signs were abdominal tenderness (66.7%) and abdominal distension (46.7%). 4) The routine laboratory studies were little helpful for the diagnosis. 5) The routine chest films, 20 cases (33.3%), has the positive findings of pulmonary tuberculosis. 6) Postoperative complications were 17 cases (28.3%), The most common complications were wound complication in 8 cases and enterocutaneous firstula in 5 cases. 7) There was no mortality during the admission period.

명사초대석-나의 건강비결

김한선,Kim, Han-Seon 한국건강관리협회 1983 건강소식 Vol.7 No.4

인천공항의 친환경 전환을 통한 환경개선

김한선 한국서비스경영학회 2021 한국서비스경영학회 학술대회 Vol.2021 No.5

혼돈과 갈등 후의 성적 표출

김한선 중앙대학교 예술대학 회화학과 1979 卒業作品硏究報告書集 - 中央大學校 藝術大學 繪畵學科 Vol.1979 No.-

구부러진 거대 8자형 자기자극 코일을 이용한 대뇌운동피질 지도화

김한선,손수민,장민철,안상호,조윤우,조희경,장성호 대한근전도전기진단의학회 2010 대한근전도 전기진단의학회지 Vol.12 No.1

Objective: To investigate the characteristics of the motor cortex mapping using large and angled figure of eight stimulator in normal subjects. Methods: Twenty-four subjects without history of neurological diseases were recruited. The motor cortex mapping for abductor pollicis brevis muscle was performed with large(diameter: 80 mm) and angled(120°) figure of eight stimulator. Results: The optimum stimulation point were found at coordination(5.83, 0.67), (-5.50, 0.54). Excitation threshold was 75.83% of the maximum stimulus for right motor cortex and 76.25% for the left. Average latency was 20.36 msec for the right and 20.35 msec for the left, and average amplitude was 367 μV for the right and 451 μV for the left, respectively. Ipsilateral motor evoked potential was not found in any subjects. Conclusion : We conclude that transcranial magnetic stimulation using this large and angled figure of eight coil is useful for motor cortex mapping.

유한요소 해석을 이용한 PS 텐던 외부 자화용 센서 설계 및 검증

김한선 ( Kim Hansun ),문세범 ( Sebum Mun ),박승희 ( Park Seunghee ) 한국구조물진단유지관리공학회 2021 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.25 No.2

현재 공용중인 PSC I형 거더 교량의 경우 공용연수에 따라 노후화되어 안전등급이 지속적으로 낮아지고 있지만, 안전도의 핵심인 PSC 교량의 내부 PS 텐던의 긴장 응력은 거더 성능 관리에 있어 매우 중요한 요소이나 현재 시행하고 있는 정밀안전진단방법의 경우 정확한 정보를 파악하기 어려워 관리가 이루어지지 않는 실정이다. 따라서 본 연구에서는 유한요소 해석을 이용하여 외부 비접촉형 EM 센서를 검증하고, PS 텐던의 외부 자화를 위한 원거리 자기장 및 긴장 응력 계측용 센서를 설계하였다. 그 결과를 바탕으로 센서를 제작하였고, 양측 자화 코일의 거리는 I형 거더의 하부 두께를 고려하여 양측 자화 코일의 거리를 약 1.5[m]로 설정하였으며 유한요소 해석 결과를 토대로 외부자화 시스템을 설치하여 이를 검증하였다.

매립형 PZT센서를 활용한 콘크리트 구조물 강도 추정 기법

김한선(Kim, Hansun),홍채원(Hong, Chae Won),박승희(Park, Seunghee) 한국콘크리트학회 2023 한국콘크리트학회 학술대회 논문집 Vol.35 No.2