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가토에서 99.9% 에탄올을 이용한 화학적 담낭 경화법에 관한 연구
김학진,이광만,채권묵 圓光大學校 醫科學硏究所 1992 圓光醫科學 Vol.8 No.1-2
Chemical sclerosis of the gallbladder was attempted using 99.9% ethanol in 13 rabbits at laparotomy. This study was performed to observe the obliteration and fibrosis of the gallbladder after exposure to chemical sclerosant without operative cholecystectomy. The proximal cystic duct was occluded by vascular clamps, and then 99.9% ethanol was injected to the gallbladder, followed by aspiration of ethanol after 10min (4 rabbits), 20min (5 rabbits). Biopsies of the gallbladder were performed after 1 week and 2 weeks in 9 rabbits (twice for each rabbits), and after 3 weeks in remaining 4 rabbits. The gallbladder specimens were examined grossly and microscopically to observe the degree and extent of necrosis and fibrosis related to the ethanol-exposure time and the interval between the time of the ethanol-exposure and biopsy. The results were as follows. 1. Cystic duct occlusions were observed at 1 week after ethanol-exposure in all rabbits, and there were no gross changes of the liver and the common bile duct. 2. The specimen of the liver showed no remarkable microscopic change, and the titers of liver function test (AST, ALT and r-GTP) were in normal limit in all rabbits after ethanol-exposure. 3. Microscopic examination of the wall of the gallbladder after 1 week showed ischemic necrosis of entire layer in all rabbits, but inflammation or fibrosis was not observed. 4. After 2 weeks, the serosal layer of the gallbladder showed fibrosis with infiltration of fibroblasts in all rabbits, and the fibrosis was more progressed after 3 weeks with proliferating fibroblasts.