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Artemisia princeps Pampanini의 complete freund"s adjuvant 유발 관절염에 대한 개선 효과
김하림(Ha-Rim Kim),김솔(Sol Kim),김선영(Seon-Young Kim) 한국생명과학회 2021 생명과학회지 Vol.31 No.8
강화사자발쑥(Artemisia princeps Pampanini)은 항산화, 항염증 및 항균제와 같은 면역 기능 관련 질병에 널리 사용되는 약초이다. 이 연구에서 우리는 RAW 264.7 세포에서 AP 추출물의 항염증 효과를 조사하고 관련 메커니즘을 평가하였다. AP 추출물의 효과는 complete Freund’s adjuvant (CFA) 유도 관절염 및 lipopolysaccharide(LPS) 유도 마우스 모델에서도 평가되었다. RAW 264.7 세포에서 AP 추출물은 LPS에 의해 유도 된 산화질소(NO) 생성과 inducible NO synthase 및 cyclooxygenase-2 단백질 발현을 현저하게 억제했다. RAW 264.7 세포에서 LPS로 유도된 mitogen-activated protein kinase 와 nuclear factor-κB의 인산화 또한 AP 추출물에 의해 유의하게 억제되었다. AP 추출물의 경구 투여는 CFA 처리 마우스 그룹에 비해 발의 부종 및 비장 지수 증가를 억제하였다. 조직학적으로 CFA 처리 마우스 군에서는 cartilage와 synovium에서 염증 세포의 침윤이 증가한 반면 AP 추출물 투여군에서는 억제되었다. 더욱이, AP 추출물은 염증성 사이토카인으로 알려진 tumor necrosis factor-α 수준을 CFA 및 LPS 처리 마우스 모델에서 현저하게 감소시켰다. 결론적으로, AP 추출물의 항염증 및 항 관절염 효과는 in vitro 및 in vivo 모델 모두에서 확인되었으며, 이는 Artemisia princeps Pampanini가 관절염 치료의 후보 물질이 될 수 있음을 시사한다. Artemisia princeps Pampanini is an herbal medicine widely used to immune function-related diseases, such as anti-oxidative, anti-inflammatory, and antibacterial agents. In this study, we investigated the anti-inflammatory effects of AP extract and underlying mechanisms were evaluated in RAW 264.7 cells. The effects of AP extract were also studied in a complete Freund’s adjuvant (CFA)-induced arthritis and lipopolysaccharide (LPS)-induced inflammation mouse model. In RAW 264.7 cells, AP extracts significantly inhibited the LPS-induced nitric oxide (NO) production and inducible NO synthase and cyclooxygenase-2 protein expression. The LPS-induced phosphorylation of mitogen-activated protein kinases and nuclear factor-κB was also significantly blocked by AP extract in RAW 264.7 cells. Oral administration of AP extract suppressed the increase in mouse paw edema and spleen index compared to CFA-treated mice group. Histologically, the infiltration of inflammatory cells was increased in cartilage and synovium in the CFA-treated mouse group, whereas it was suppressed in the AP extract-administered group. Furthermore, AP extract treatment significantly reduced the inflammatory cytokine, tumor necrosis factor-α, levels in CFA and LPS-treated mouse. In conclusion, the anti-inflammatory and anti-arthritis effect of AP extract was confirmed in both in vitro and in vivo models, suggesting that Artemisia princeps Pampanini may be a candidate material for arthritis treatment.
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할로잉 운동 시 시각적 피드백 방법에 따른 복근 두께에 미치는 영향 비교
김하림 ( Ha-rim Kim ),손호희 ( Ho-hee Son ) 대한물리의학회 2021 대한물리의학회지 Vol.16 No.3
PURPOSE: Selective strengthening of the transverse abdominis muscle (TrA) during abdominal hollowing makes an important contribution to the stability and control of the spine. This study examined the effects of abdominal hollowing exercise (AHE) according to the visual feedback method on the external oblique, internal oblique, and transverse abdominis muscles. METHODS: Twenty healthy subjects were assigned randomly to an AHE with visual feedback from real-time ultrasound image (group A, n = 10), AHE with visual feedback with pressure biofeedback unit (group B, n = 10). Both groups underwent 20 min of AHE with visual feedback once daily, five days/week for two weeks. The changes in the muscle thickness of the TrA, internal oblique abdominal muscle (IO), and external oblique abdominal muscle (EO) were measured by ultrasonography. RESULTS: The thickness of TrA was changed significantly in both groups (p < .05). However, the lowest minimal detectable changes were achieved in Group A. The thickness of the IO and EO muscles in group A was changed significantly, but there were no significant changes in group B. CONCLUSION: Both visual feedback methods were effective for strengthening the TrA muscles selectively. Nevertheless, AHE with visual feedback using real-time ultrasound images may be more useful in trA muscle contraction.
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金河林(Kim, Ha Rim) 중국근현대사학회 2018 중국근현대사연구 Vol.78 No.-
The article aimed to focus on the significance of the discourse of controlled economy that had been popular over the intellectual milieu of China in 1930s. The article pursued to overview the intellectual trend in that period, in particular, investigate various moments and points for its emergence within the context of the perception of modernization. In 1930s the world encountered a great deal of demand for the reformation of capitalism, which was closely connected to the formation and the spread of the discourse of controlled economy in China. The contrast between the crisis of the Great Depression by the United States of America and the celebration of the Five-year plan by the Soviet Union defined the characteristic of the discourse of controlled economy in China as contemporary reaction. The foundation of the Nanjing Government strongly involved in the formation of the discourse. The political circumstances since introduction of the government and the outbreak of the Manchurian Affair further complicated the discourse. The Principle of People’s Livelihood, a prototype of the Chinese non-capitalist modernization, played a significant role for the discourse of controlled economy to broaden its ideological scope by its being converged with the discourse, and the practice of Principle itself also became expanded and deepened by it. The article particularly emphasized that the discourse of controlled economy enabled related discussions for a subjective pathway to the modernization of China grounded upon the periodic circumstance of 1930s. Here, I argued that the implication for the discourse of controlled economy lay in the fact that it sparked the alteration of the discourse of modernization itself. Such qualitative change in perception further conditioned the intellectual trend in 1940s along with non-capitalist scope. There are three connected clues in terms of the acceptance to the discourse of controlled economy: First, the socialist perspective in Chinese intellectual milieu was rather gradually underscored via the structure of the discourse of controlled economy. Second, there had been formed a wide agreement with mixed economy as a result of subjective acceptance of the discourse. Three, there occurred politico-intellectual divergence according to the subjects, and accelerated the political changes in 1940s. The discourse of controlled economy in China not only reveal the intellectual significance of 1930s, but it also allow us to glimpse the characteristic of the Chinese Revolution in the twentieth century. More studies on the topic are anticipated.
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방향족 무수물 기반의 에폭시 변성 아크릴레이트 바인더 합성 및 SiO₂ 레지스트 제조에 관한 연구
김하림(Ha-Rim Kim),김도현(Do-Hyun Kim),김영운(Young-Woon Kim),이운영(Woon-Young Lee),배진영(Jin-Young Bae) 한국고분자학회 2018 폴리머 Vol.42 No.4
본 연구에서는 유기 절연막에 적용 가능한 새로운 광경화 에폭시 변성 아크릴레이트의 합성 및 그 특성에 대해 살펴보았다. 우선 다양한 에폭시 변성 아크릴레이트를 합성하기 위하여 산 무수물과 하이드록시 아크릴 단량체의 조합에 의해 diesteric acid(DA) 유도체를 반응시켰다. 합성된 diesteric acid(DA)에 에폭시 화합물인 글리시딜 메타아크릴레이트(glycidyl methacrylate)를 반응시켜 광경화 타입의 에폭시 변성 아크릴레이트를 합성하였다. 그리고 실리카 분산액인 NANOBYK-3650과의 호환성을 살펴보았다. 사용한 단량체의 구조에 기인하여 실리카와 최적의 바인더를 선정하고 이를 고투과율·저유전 실리카 레지스트에 적용시키고자 배합을 하여 유기 절연막을 제조하였다. 실리카 함량에 따른 투과율, 패턴성, 열 안정성 그리고 전기적 특성(유전 상수)을 확인하였다. In this study noble UV-curable epoxy modified acrylates binder was designed and synthesized to apply an organic insulating film. Firstly, diesteric acid (DA) derivatives were prepared from anhydrides and hydroxy acrylates to synthesize epoxy modified acrylates. UV-curable epoxy modified acrylates were prepared from synthesized diesteric acid (DA) and epoxy chemicals, glycidyl methacrylate (GMA). The miscibility with silica millbase ‘NANOBYK-3650’ was investigated. Appropriate binder with silica was chosen by considering the monomer chemical structure. To obtain an organic insulating film with high transmittance and low k silica resist, optimum composition of UV-curable epoxy modified acrylates was also formulated. Transmittance, patternability, and electrical properties (dielectric constant) was measured.
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