간질환자의 유발인자에 관한 뇌파학적 고찰

金杓漢,李丙允 고려대학교 의과대학 1981 고려대 의대 잡지 Vol.18 No.1

This clinical study was made to investigate the relation between precipitating factors and E.E.G. findings of 1,038 epileptics who were diagnosed as idiopathic epilepsy at the Korea University Hospital, from Jan. 1968 until Dec. 1972. The results were as follows. 1. Among 1,038 cases of the idiopathic epileptics, 23.9% (248 cases) of them had precipitating factors. 2. Their most frequent precipitating factors were insomnia-fatigue (6.5%) followed by emotional stress (5.5%), sleep (2.9%), alcohol (2.2%), menstruation-pregnancy(1.8%), fever(1.6%),photogenic stimulation (1.0%), overeating (0.7%), somatogenic stimulation (0.5%), excessive exercise (0.4%), audiogenic stimulation (0.4%), reading (0.3%), sudden movement (0.2%) in that order. 3. In the first decade of both sex, the frequency of precipitating factors were in the order of sleep (male 36.4%, female 30.0%), fever(male 18.2%, female 25.0%), photogenic stimulation (male 13.6%, female 10.0%). In the second decade of both sex, insomnia-fatigue (male 32.6%, female 31.0%), emotional stress (male 21.7%, female 21.4%) were the most frequent. In the third decade, the frequency of precipitating factors were insomnia-fatigue (39.4%), emotional stress (33.3%) in male and emotional stress (30.8%), menstruation pregnancy (27.0%) in female in that order. Alcohol was the most frequent precipitating factor in fourth (36.0%) and fifth (61.5%) decade in male. 4. The frequency of precipitating factors were insomnia-fatigue emotional stress in grand mal, jacksonian, focal, and adversive type and emotional stress (34.5%), sleep (17.2%) in psychomotor type in that order. Photogenic stimulation were the most frequent in petit mal (33.3%) and myoclonic type (25.0%). 5. The group with precipitating factors was more predominant in abnormal E.E.G. patterns than in group without precipitating factor. (156:112) 6. The most frequent precipitating factors were in the order of insomnia-fatigue, emotional stress in the epileptics with slow wave and spike-wave patterns. Insomnia-fatigue (44.4%) was the most frequent in the epileptics with isolated spike and emotional stress (37.5%) in the epileptics with 3 c/s spike and wave patterns. 7. Generalized extension was more predominant in the abnormal E.E.G. patterns than localized or focalized extension. 8. The most frequent precipitating factors were insomia-fatigue, emotional stress, sleep in the cases of abnormal E.E.G. of central, parietal region and fever (40.0%), emotional stress (30.0%), photogenic stimulation (20.0%) in the cases of abnormal E.E.G. of occipital and menstruation-pregnancy (21.4%), alcohol (21.4%) in the cases of abnormal E.E.G. of temporal region in the order.

精神疾患 患者의 幻覺에 對한 臨床的 考察

金杓漢 고려대학교 의과대학 1974 고려대학교 의과대학 잡지 Vol.11 No.1

强迫神經症患者의 臨床的 考察

金杓漢 大韓神經精神醫學會 1974 신경정신의학 Vol.13 No.3

In this clinical study, it was intended to reveal the distribution of subtypes and their educational level, socioedonomic status, marital status, occupation, parent histories, premorbid personality, ages of onset, precipitating factors, and symptomatology of obsessive compulsive patients in Korea. The subjects in the study were 62 cases of obscessive compulsive neurosis who were diagnosed at the Department of Neuropsychiatry, Woo Suk Hospital, Korea University, Medical College from Jan, 1968 to June,1974. These 62 cases of the obsessive-compulsive neurotics were classified into three subtypes, which were 20 cases of mixed type. The results were as follows; 1. The obscessive-compulsive neurotics occupied 2.2% of all neurotic patients. 2. As to the sex distribution, it was revealed that male occupied 62.9% and female occupied 37.1% of all patients. 3. Their mean age of initial visit to our department was 27.5 years old. 4. Educational background revealed that 71.7% of the patients had higher educational level. 5. Socio-economic status revealed that 87.1% of the patients belonged to upper class. 6. As to the marital status, unmarried cases occupied 64.5% of the patients. 7. According to the occupational distribution, among the male patients, student showed highest rete of 48.7%, and among the female patients, housewife showed the highest rate of 52.5%. 8. Parent histories revealed that 66.1% of the patients had obsessional character trait and some kind of neuroses and psychoses in their parents. Among these parents 46.8% of them had obsessional character traits and 4.8% of them had obsessive compulsive neurosis and 11.3% of them had other kind of neurosis and 3.2% of them had psychosis. 9. As to the premorbid personality, obsessive compulsive personality was most frequent one which occupied 75.8% of the patients. 10. As to the age of onset, 32.3% of total patients had their inital symptoms at the ages between 16 and 20. 11. As to the precipitationg factors, 45.2% of total patients had clear precipitating factors. 12. In all obsessive compulsive neurotic patients, the more frequent symptoms were cleaning ritual, emotional obsession, "making sure" routine, obsessive related phenomena in phobia, and exaggeration of minutiae in daily routine in this order. According to each subtypes, the patients with emotional obsession occupied highest rate of 40. 71% of total obsessions, the patients with "making sure" routine occupied 34.4% of total compulsions. The patients with obsessive related phenomena in phobia occupied highest rate of 26.4% of all mixed type.

精神疾患 患者의 幻覺에 對한 臨床的 考察

金杓漢 고려대학교 의과대학 1974 고려대 의대 잡지 Vol.11 No.1

The clinical studies were made on the 294 hallucinating patients which were interviewed and confirmed by the process of treatment at Neuropsychiatry Department of Woo Sok Hospital, Korea University, Medical College from Jan. 1968 to Dec. 1972. The results obtained are as follows: 1. According to the clinical categories, in the cases of schizophrenia 32.7% of them, in the cases of affective psychosis 9.5% of them, in the cases of organic brain syndrome 5.2% of them, in the cases of other psychosis 3.3% of them and in the cases of psychoneurosis 0.3% of them revealed hallucinations respectively. 2. As to the forms of hallucinations according the clinical diagnosis it was revealed that auditory hallucination occupied 70.7% of all the hallucinations, and 81.8% of schizophrenic patients showed auditory hallucinations while 47.4% of organic brain syndrome patients exhibited visual hallucinations. 3. The mean age of hallucinating patients was 31.6 years old. 4. According to the occupational distribution among the male patients student showed the highest rate of 25.9% and among the female patients housewife showed the highest rate of 50.7%. 5. As to the religious distribution non-religious group showed highest rate of hallucinations. 6. Among all of the hallucinating patients 77.9% of them had delusional ideas, and int he cases of having auditory hallucinations 88.9% of them showed delusional ideas while in the cases of having visual hallucinations 33.3% of them showed delusional ideas. 7. As to the nature of auditory hallucinations 95.0% of them were unpleasant ones. About 50.0% of auditory hallucinations occupied accusatory natures. 8. The contents of visual hallucinations in organic brain syndrome showed that impersonal materials occupied the highest rate of 54.5% while in the schizophrenic cases devil occupied 29.4%. 9. As to the object of auditory hallucinations. the voices of coming from unknown person occupied the highest rate of 29.3%.

여성에서의 성욕항진증 2례

김표한,이세종,신동균 大韓神經精神醫學會 1974 신경정신의학 Vol.13 No.3

Two cases of nymphomania were presented and psychodynamic factors of them were elucidated. The first case, widowed 3 years before and age of 72, showed no organic basis of nymphomania but in the study of her life-long pattern of sexual adjustment it was found that her personality is typical hysterical one and fixated to the mother object choice. The second case, widowed 15 years before and age of 76, had life long pattern of obsessive compulsive adjustment and supposed to be frigid in her marital life. After being widowed 10 years and death of her eldest son, who had unhappy marital life, while taking care of her grandchildren, she suddenly developed the impulsion of decapitating her grandchildren and sexual impulse toward her son in low and male relatives. This incesteous impulse supposed to be the results of her weakening of repressing power to the sexual impulse. According to Thoinot and Weyese's classification, the first case belong to the active type of nymphomania and the second case to the platonic one.

라포나이트-X(X = Eu, Tb) 형광체의 합성 및 열적 안정성과 발광특성 연구

김표라,손동민,이한나,김유혁,Kim, Pyo-Ra,Son, Dong-Min,Lee, Han-Na,Kim, You-Hyuk 한국결정성장학회 2009 韓國結晶成長學會誌 Vol.19 No.4

본 연구에서는 라포나이트의 발광 기능성을 부여하기 위하여 수용액에서 라포나이트의 층간에 존재하는 Na 이온을 Eu 및 Tb 이온으로 치환하여 동결 건조 후 소성하여 라포나이트-X(X=Eu, Tb) 형광체를 제조하였다. 합성된 형광체의 열적 안정성을 조사하기 위하여 여러 온도에서 소성하여 XRD로 결정구조를 분석한 후 형광체가 $600^{\circ}C$까지 안정하고 $700^{\circ}C$ 이후에는 새로운 결정상이 형성됨을 확인할 수 있었다. 합성된 형광체의 발광 특성은 UV 및 VUV 여기 광원하에서 조사하였으며 적색 및 녹색 발광 특성은 $300^{\circ}C$와 $500^{\circ}C$에서 각각 $Eu^{3+}$와 $Tb^{3+}$에 기인하는 발광 피이크로 확인 할 수 있었다. In order to give emission functionality for laponite the laponite-X (x = Eu, Tb) phosphors were prepared by calcination of cryogels which were prepared through Na ion exchange reaction with Eu and Tb ions. Thermal stability and emission properties of new laponite-X (X = Eu, Tb) phosphors were investigated by X-ray diffractormeter and UV/VUV spectrofluorometer. The phosphors were stable around up to $600^{\circ}C$ and new crystalline phases were observed at $700^{\circ}C$. Red and green emissions of phosphors under UV/VUV excitation were also identified at $300^{\circ}C$ and $500^{\circ}C$ as emission peaks of $Eu^{3+}$ and $Tb^{3+}$, respectively.

柳宗元〈永싸|八記〉와 歐陽修〈醒쳤亨記〉의 創作心境및 主題• 風格比較

金杓 대한중국학회 1988 중국학 Vol.4 No.-

히스테리 신경증 환자에 관한 임상적 고찰

김수일,김표한,송수식 대한적십자사 1979 적십자병원지 Vol.6 No.1

분자유전학을 통한 정신분열증의 이해

이민수,김표한,Lee, Min-Soo,Kim, Pyo-Han 대한생물정신의학회 1996 생물정신의학 Vol.3 No.1

Molecular genetic approaches contribute to the understanding of the underlying genetic mechanism for schizophrenia. Currently genetic evidence rests on molecular genetic methods. However, the result are contradictory and somewhat confusing due to genetic heterogeneity, incomplete penetrance, misspecification of genetic model. It is expected that molecular genetics could provide key answers to the genetic cause of schizophrenia. The purpose of this article is to call attention of the readers to heterogeneity, linkage, association, basic molecular genetic methods and genetic markers and to the need far further research. It is the author's hope thai continuous research on the molecular genetics con provide clinicians with better understanding of the schizophrenia.

세로토닌 재흡수억제제의 약리학과 임상적용

이민수,김표한,Lee, Min-Soo,Kim, Pyo-Han 대한생물정신의학회 1995 생물정신의학 Vol.2 No.2

1) Paroxetine이 5-HT흡수에 가장 강력하고, 선택적이었으며, 그 다음이 fluvoxamine, sertraline, fluoxetine순이었고, sertraline은 다른 SSRIs와는 달리 NE보다 DA억제작용이 더 강했다. 2) Paroxetine이 muscarinic cholinergic 수용체에 대한 친화력이 다소 높았을 뿐, 전반적으로 SSRIs는 histamine $H_1$과 ${\alpha}_1$에 대한 친화력은 약했다. 3) Paroxetine은 ${\beta}$-adrenoceptor와 cyclic AMP에 영향을 미치지 않는 반면, sertraline은 ${\beta}$-adrenoceptor와 cyclic AMP의 감소를 가져왔다. 4) SSRIs의 생체이용율은 대략 50%이었으며, 투약후 2~8시간 사이에 최고혈중농도에 도달하였으며, 특히 sertraline은 음식물과 같이 복용시 혈장의 concentration time curve와 최고 농도를 증가시켰다. 5) Sertraline은 혈중농도가 용량에 비례하였으며, 모든 SSRIs는 비교적 큰 용량분포를 보이고, 높은 비율로 혈장 단백질과 결합되어 있었다. 6) Fluoxetine 대사물의 5-HT 억제 작용이 제일 강했다. 그러나 paroxetine, fluoxetine, sertraline 대사물은 강도는 서로 다르지만 간의 isoenzyme IID6를 억제하며, 그 중에서 paroxetine의 억제작용이 제일 강력하다. 7) Sertraline은 TCAs나 haloperidol과 병합사용시 TCAs나 haloperidol의 혈중농도의 유의한 변화가 없었으며, MAOI A형인 moclobemide와 비교적 안전하게 병용 치료할 수 있다. 8) SSRIs는 TCAs와 비교해볼 때 치료효과는 유사하였으나 fluvoxamine은 자살사고에, paroxetine은 우울중에서 나타나는 불안과 운동성 초조증에 효과적이다. 9) 급성 우울증 삽화시 현저한 효과를 보인 후 적어도 4개월 이상의 유지치료기간이 필요하다. 10) SSRIs는 위장관계통의 부작용이 가장 많았고, 부작용은 일반적으로 분복한 경우가 적었다. In comparison with tricyclic antidepressants(TCAs), one of the most interesting characteristics of selective serotonin reuptake inhibitors(SSRIs) is its structural differences, reveals different pharmacological properties. The applications at the moment are most effective in clinical applications to depression. The limited result of the research to date on the various applications of SSRIs has not revealed the total potential and applicability of SSRIs. Therefore, attending physicians utilizing SSRIs do not know the full capabilities of the drug on patients and what the patients may reap in terms of benefit from its curing elements. Physicians must first try to understand the full potential of SSRIs and its potential applications for it to be effective on patients. recently, it has been determined that SSRIs and other drugs when administered together may be more effective in the healing process because SSRIs complements and aids in the enhancement and effect of the other drugs. This article is written to give attention to the reader of the pharmacological properties and the clinical use of SSRIs. It is the authors's hope that continuous research on the particular aspects of SSRIs can aid the clinicians in the use of this SSRIs.