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Scopolamine Hydrobromide 및 $\ell$-Hyoscyamine의 생체이용성에 미치는 위산도의 영향
김창영,함성호,한상수,손동환,고건일,김재백,Kim, C. Y.,Ham, S. H.,Han, S. S.,Sohn, D. H.,Ko, G. I.,Kim, J. B. 한국임상약학회 1993 한국임상약학회지 Vol.3 No.2
The effects of gastric acidity on the bioavailability of scopolamine hydrobromide and ${\ell}$-hyoscya-mine were studied in rabbits. Each drug was administered orally at dose of 0.2mg/kg to gastric acidity controlled rabbits. The plasma concentration of scopolamine and ${\ell}$-hyoscyamine were determined by selected ion monitoring in GC/MSCScopolamine; m/Z= 138, ${\ell}$-Hyoscyamine; m/z= 124). Rabbits with hypoacidity showed significantly higher Cp and AVC than rabbits with hyperacidity after oral administration of each drug. From the results of this experiment, it is desirable that dosage regimen of dose of scopolamine and hyoscyamine should be adjusted when the drugs should be administered with antacids in clinical practice.
김창영,이의중,이성우,김수진,한갑수,Kim, Chang Yeong,Lee, Eui Jung,Lee, Sung Woo,Kim, Su Jin,Han, Kap Su 대한임상독성학회 2018 대한임상독성학회지 Vol.16 No.1
Purpose: On November 15, 2012, sales of OTC (Over-The-Counter) drugs began at convenience stores, which changed the accessibility of some drugs. As a result, the exposure and access patterns of these drugs could have changed. In this study, we reviewed the changes in the characteristics of drug poisoning patients because of the reposition of nonprescription drugs according to the revised Pharmaceutical Affairs Act. Methods: A retrospective study was conducted to evaluate changes in characteristics of drug poisoning patients between 2008 and 2016. A registry was developed by an emergency medical center in a local tertiary teaching hospital, and patients who visited the center were enrolled in this registry. We compared two periods, from 2008 to 2012 (Pre OTC) and from 2013 to 2016 (Post OTC), for type of intoxicant, time from poisoning to visiting the emergency center, intention, psychiatric history, previous suicidal attempt, alcohol status, and emergency room outcomes. The primary outcome was the number of patients who took acetaminophen and NSAIDs (nonsteroidal anti-inflammatory drugs). Secondary outcomes were ICU admission rate, mortality rate, and number of patients who visited the ER when the pharmacy was closed after taking acetaminophen and NSAIDs (nonsteroidal anti-inflammatory drugs). Results: Among 1,564 patients, 945 and 619 patients visited the emergency room during pre and post OTC periods. The number of patients with acetaminophen and NSAIDs poisoning decreased from 9.2% to 6.1% (p=0.016). The ICU admission rate and mortality rate in the emergency room did not show significant results in the relevant patient groups, and so was the number of patients visiting ER when the pharmacy was closed taking acetaminophen and NSAIDs. Conclusion: Despite the sales of nonprescription drugs at convenience stores, the number of acetaminophen and NSAIDs poisoning patients decreased.
MOST 네트워크에서 비동기 데이터 전송의 신뢰성 향상 알고리즘 구현
김창영,박유현,전영준,유윤식,Kim, Chang-Young,Park, Yoo-Hyun,Jeon, Young-Joon,Yu, Yun-Sik 한국정보통신학회 2012 한국정보통신학회논문지 Vol.16 No.12
MOST(Media Oriented Systems Transports)Network는 차량용 멀티미디어 기기를 위한 통신 프로토콜로서 높은 대역폭과 신뢰성을 보장하는 차량용 네트워크이다. 그러나 기존의 MOST 디바이스는 데이터 제어나 전송을 위해 내부 버스 통신방식인 I2C나 I2S통신 방식만을 사용하여 왔으나, MOST 네트워크의 대역폭이 늘어나고 하나의 디바이스 내에 여러 장치들이 추가되면서 더 넓은 대역폭의 통신방식이 필요하게 되었다. 따라서 본 연구에서는 MediaLB 통신을 사용하여 비동기 데이터 전송 시 효율성 향상 방법을 제시하고, MOST 네트워크에서 비동기 데이터 전송 시에 발생할 수 있는 데이터 신뢰성 문제를 해결하기 위하여 비동기 데이터 영역의 데이터 형태를 개선하여 전송 데이터의 신뢰성을 향상할 수 있는 알고리즘을 제안하고자 한다. MOST(Media Oriented Systems Transport) is a network protocol for vehicle multimedia, where it guarantees large bandwidth and reliability. However, previous MOST device utilized I2C or I2S communication method to data manage or transfer, Bandwidth of MOST have increased and additional equipments are added to one device, requiring a larger form of bandwidth communication method. Therefore, this research suggests of the methods in improving the efficiency of asynchronous data transfer, and suggest an algorithm, which will improve the reliability.
김창영,최치규,Hyun Seung Kim,R. Navamathavan,Seung Hyun Kim 한국물리학회 2007 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.50 No.4
SiOC(-H) films were deposited with and without ultraviolet irradiation on p-Si(100) substrate by using plasma-enhanced chemical-vapor deposition (PECVD) with dimethyldimethoxysilane (DMDMS) and oxygen precursors. The DMDMS/O2 flow rate ratio was varied from 10 to 100 % to investigate its effect on the properties of the films. Various species in the DMDMS/O2 plasma were identified using optical emission spectroscopy (OES). The deposition rate increased with increasing oxygen flow rate, and precursor molecules were dissociated due to the activation of oxygen radicals. The chemical structure was characterized by using Fourier transform infrared spectroscopy (FTIR) in the absorbance mode. These measurements show that more C and H were incorporated into the O-Si-O network. As more carbon atoms were incorporated into the SiOC(-H) film with increasing DMDMS flow rate ratio, the dielectric constant was reduced due to introduction of more Si-C related bonds in the film.
NMEA2000 프로토콜을 적용한 선박 모니터링 시스템 설계 및 구현
김창영,이임건,Kim, Chang Young,Lee, Imgeun 한국정보통신학회 2015 한국정보통신학회논문지 Vol.19 No.2
최근 선박용 전자, 통신 장비들이 다양하고 복잡해짐에 따라 새로운 통신 프로토콜을 적용하기 위한 많은 연구가 진행되고 있다. 그중에서도 CAN(Controller Area Network)통신 프로토콜을 기반으로 하는 NMEA(National Marine Electronics Association)2000 프로토콜은 대표적인 차세대 선박용 프로토콜로 표준화와 더불어 선박에 적용되고 있다. NMEA2000은 선박에서 사용되는 다양한 데이터들을 다른 전자장비로 통신하기 위한 표준으로 네트워크 관리를 위한 서버가 필요 없는 멀티마스터의 실시간 제어 네트워크이다. 본 연구에서는 NMEA 2000 기반의 선박 센서용 프로토콜 변환 알고리즘의 구현과 NMEA2000/CAN/Ethernet/RS232 등의 데이터 포맷 변환 및 NMEA2000 기반 전용 케이블을 고려한 아날로그 데이터 모듈의 개발을 목표로 한다. 본 연구에서 NMEA2000 핵심 기술의 개발과 적용으로 다양한 통신 프로토콜을 지원함으로써 사용자 기반의 데이터 모니터링 시스템을 설계하고 구현하였다. Recently, due to the variety and complexity of marine electronics communication devices, much research has been done to adopt the novel communication protocol. Among them, NMEA2000 protocol, is adopted as standardized protocol to the next generation ship. In this paper, we design and implement the conversion algorithm for sensor protocol based on NMEA2000, and analog data module which convert data format between NMEA2000, CAN, Ethernet, RS232. The present study was designed to implement user-based data monitoring system by supporting various communication protocols through the development and application of key technologies through NMEA2000.
김창영,최기용,Kim, Chang-Young,Choi, Ki-Yong 항공우주시스템공학회 2011 항공우주시스템공학회지 Vol.5 No.1
In this report US and Korea civil and military simulator certification system is researched, and a plan for improvement is proposed. Korean simulator certification system should adopt FAA's system and improve upon it. Certification criteria should have a basis on FAA certification criteria and add military operation characteristics selectively. Flight test data, used as comparison criteria in certification, should be acquired in package during aircraft development or overseas acquisition. The establishment of certification system is expected to improve external credibility and improve competitiveness in overseas market.