장비정도관리에 Calibrator[I-125] Set 적용

김지나,안재석,원우재,Kim, Ji-Na,An, Jae-seok,Won, Woo-Jae 대한핵의학기술학회 2015 핵의학 기술 Vol.19 No.2

Purpose Lately, in accordance with the increasing interest about Healthcare accreditation program and International laboratory accreditation scheme, requirements about the instrument quality management are gradually taking shape. In nuclear medicine In vitro laboratory, the most typical instruments are multi detector gamma counter and automatic dispensing system. Each laboratory continue with the quality control adequate for circumstances. The purpose of this study is to application and establish the new Calibrator[I-125]Set which is efficient at standardization of equipment quality management. Materials and Methods Deviation between detectors were measured with 12 solid samples of the Calibrator[I-125]Set. their activities differ from each other by less than 1%. Multi detector gamma counters are GAMMA-10;Shinjin medics. Inc, Goyansi, Korea(Gamma counter A), SR300;Stratec biomedical systems AG, Gewerbestr, Germany(Gamma counter B) and COBRA II; Packard Instrument Co. Inc, Meriden, USA(Gamma counter C). Evaluation of two automatic dispensing system used A, B liquid tracer of the Calibrator[I-125]Set. After dispensing and counting, calculated using the ratio of the measured value and proposed value. We used solution A for 20, 25ul and solution B for 50, 100ul. Method of data analysis and reference range was provided by kit documentation. Furthermore, we could calculate our counter efficiency indirectly. Results The CV(%) of measured values by Gamma counter A, B, C are 0.34, 0.70, 1.30. Calculated value are 1.05314, 2.10419, 4.08485. Provided reference range is less than 3. A dispensing system's calculated values are 0.986, 0.989, 1.023, 1.017 and B are 0.874, 0.725, 1.021, 0.904. Provided reference range is from 0.95 to 1.05. Also, counter's efficiency are 74.18, 72.79, 74.32% at counter A, B, C and efficiency of the one detector counter is 79.26%. Conclusion If using this Calibrator[I-125]Set after verifying whether quality assurance, is applicable to equipment quality management on behalf of the role of gold standard.

건조조건이 다른 무채말랭이 및 무채말랭이 볶음의 품질특성

김지나,박영희,노윤영,김영,강민숙,Kim, Ji-Na,Park, Young-Hee,Noh, Yun-Young,Kim, Young,Kang, Min-Sook 한국식품조리과학회 2015 한국식품조리과학회지 Vol.31 No.5

This study investigated changes in the chemical properties and antioxidant activity of dried shredded radish (Raphanus sativus L.). Shredded radishes with a thickness of either 3.5 mm or 7.0 mm were dried using hot air at $45^{\circ}C$ or were sun dried. The degree of browning for the 3.5 mm sun dried radish, the 7.0 mm sun dried radish, the 3.5 mm hot air dried radish and the 7.0 mm hot air dried radish was 0.12, 0.14, 0.04 and 0.04, respectively. The DPPH radical scavenging activity (EDA%) of the hot air dried radish had a higher value than the sun dried radish. In contrast, the ABTS values of the sun dried radishes were higher than the hot air dried radishes. The total polyphenol content of the 7.0 mm and 3.5 mm hot air dried radishes reached high values of 15.99 and 11.62 mg/g, respectively. The total polyphenol contents of the 7.0 mm and 3.5 mm sun dried radishes were 9.63 and 6.77 mg/g, respectively. In sensory evaluation of the stir-fry dried shredded radishes, the 7.0 mm hot air dried sample scored the highest in terms of smell, color, gloss and overall preference. In conclusion, hot air drying ($45^{\circ}C$) and a thickness of 7.0 mm were found to be the optimal conditions for dried shredded radish and stir-fried dried shredded radish products.

한식을 기반으로 한 수출전략형 할랄 레토르트 편의식의 해외 소비자 요구도 및 기호도 조사

김지나,이근종,박현지,이현민,신원선,Kim, Ji-Na,Lee, Kun Jong,Park, Hyun-Ji,Lee, Hyeon Min,Shin, Weon-Sun 한국식품조리과학회 2018 한국식품조리과학회지 Vol.34 No.3

Purpose: The objective of this study was to develop export strategic home meal replacement (HMR) recipes for Halal retort food certification by analysis of manufacturing practices for certified Halal retort food processes. Methods: Selected retort foods in Halal meeting were prepared in laboratories. The frequency of consumer preference was examined. For this, an export strategic menu was surveyed and analyzed using a questionnaire. Based on the results of the first survey in Korea, a second survey was conducted for the sensory evaluation of Halal retort foods in Kuala Lumpur, Malaysia. The results of the second survey were analyzed by the response methods. In order to achieve the objective of this study, a consumer panel was formed and operated. We investigated developing Halal retort foods based on appearance, fragrance, saltiness, sweetness, texture, harmony of ingredients, off-flavor, and overall acceptability of Kimchi-pilaff (KP), Bulgogi-pilaf (BP), and Dolsot-pilaf (DP), which are commonly used in Korean style foods. Results: In the Malaysia survey results (9 scoring test), they preferred KP (7.1score) compared to BP (6.43 score) and DP (6.39 score) (p<0.001). In each category, KP showed high score compared to BP and DP samples.; appearance (KP 6.64 score, BP 6.45, DP 6.04 score), fragrance (KP 7.10 score, BP 6.20, DP 6.16 score), saltiness (KP 7.20, BP 6.35 score, DP 5.97 score), sweetness (KP 6.77, BP 6.28 score, DP 6.0score), harmony (KP 7.13 score, BP 6.47 score, DP 6.39 score), and off taste (KP 3.40, BP 3.69, DP 6.9 score). The study results show an export strategic developing menu as follows: First, export strategic menu development was conducted for BP and KP. ${\chi}^2$-test of general factor (gender, age, religion) was conducted. There was no difference. Conclusion: KP was a major retort food and has similar potential power or can be developed as an export strategic Halal food. Furthermore, we were developed foods through many expert meetings. So, we need to develop more HMR recipes.

간호현장속의 파트너와 라이벌

김지나,Kim, Ji-Na 대한간호협회 2007 대한간호 Vol.46 No.2

선의의 맞수, 이화여대 간호대학 73학번-고성희.장혜령

김지나,Kim, Ji-Na 대한간호협회 2007 대한간호 Vol.46 No.2

Thyrogen 투여 후 측정된 Thyroglobulin 농도변화

김지나,안재석,원우재,Kim, Ji-Na,An, Jae-seok,Won, Woo-Jae 대한핵의학기술학회 2018 핵의학 기술 Vol.22 No.1

Purpose Assessment of Serum Thyroglobulin (sTg) value in total thyroidectomy patients having an ablation dose of radioactive iodine indicates remaining cancer or metastasis. Especially, sTg in patients on withdrawal thyroxine or thyrogen administration for radioiodine ablation is an important indicator to determine the direction of further treatment and prognosis. Current guidelines suggest measurement of sTg is performed at 72 hours after the last injection of thyrogen. and assumes that sTg reaches maximum serum levels at that time. The purpose of this study is to evaluate the variation of sTg measured after thyrogen administration. Materials and Methods We compared with sTg performed at 24hours(D0) and 72hours(D2) after the last injection of thyrogen. We reviewed D0 and D2 from 276 patients were divided them into three groups according to ablation dose of radioactive iodine, 5mCi(A group), 30~80mCi(B group) and 100~200mCi(C group). We used T-test for comparison between D0 and D2. sTg was measured in serum using immunoradiometric assay (Tg-plus RIA; BRAHMS, Berlin, Germany). Results There is no critical variation between D0 and D2 in A group(n=100)(P=0.32), The case of increase(D2>D0) is 45, no change(D2=D0) is 23, decrease(D2<D0) is 32. The biggest increase is the 3.0 ng/mL from 2.9 to 5.9 in A group. In B group(n=155, 30mCi:154, 80mCi:1), the difference is meaningful(P<0.05) and D2>D0 is 91, D2=D0 is 28, D2<D0 is 36. The biggest increase is 2.6 ng/mL from 3.5 to 6.1. In C group(n=21, 100mCi:19, 200mCi:2), D2>D0 is 19, D2=D0 is 2. The biggest increase is 143.6 ng/mL from 98.4 to 242. Conclusion There was a significant difference in the group over 30mCi. and the case of D2>D0 is 45%, 58.7%, 90.5% for each group. therefore, D2 increased as the dose of radioactive iodine increased. Furthermore, the most sTg values of D0 and D2 are variation under 2.0 ng/mL, so reproducibility as well as sensitivity of sTg will be important at values below 2ng/mL.

건강, 행복, 평화를 주는 뇌호흡과 뇌체조

김지나,Kim, Ji-Na 대한간호협회 2007 대한간호 Vol.46 No.1

하루에도 몇 번씩 간호사는 촉각을 곤두세우며 생활한다. 상사, 동료, 환자들과 함께하며 마음이 상할 때도 있고 자기 자신을 다그치며 스트레스를 떠안을 때도 있다. 마음을 다치면 몸도 상한다. 스트레스는 각종 신경성 증상을 유발하며 나아가 심각한 질병을 불러오기 때문에 그때그때 마음을 다스리는 편이 좋다. 마음에 평화를 주는 뇌호흡과 뇌체조로 건강을 유지하는, 서울아산병원 신경외과 병동의 김연희 수간호사에게 스트레스를 풀어주는 효과적인 동작을 배워보았다.

Thyroglobulin 검사 시 재검선별 및 결과보고절차마련

김지나,박광서,원우재,Kim, Ji-Na,Park, Kwang-Seo,Won, Woo-Jae 대한핵의학기술학회 2014 핵의학 기술 Vol.18 No.1

Purpose: Serum thyroglobulin (Tg) determination has been reported to be a sensitive indicator of persistent or recurrent differentiated thyroid cancer (DTC) after total thyroidetectomy. In patients free of metastasese and recurrences after a complete thyroidectomy and radioiodine removal for DTC, the Tg is usually <1 ng/mL or can no longer be detected even with TSH stimulation. Therefore, report in low Tg levels and selecting criteria for retest is very important. The purpose of this study was to establish selecting criteria for retest which is efficient at reliability improvement and Turn around time (TAT). Materials and Methods: Sera from 137 patients with DTC were divided into two groups as first(<1.0 ng/mL or >4.0 ng/mL) and second(1.0-4.0 ng/mL). In case of group(<1.0 ng/mL) is in patient free of metastases and recurrences, >4.0 ng/ml is low coefficient of variation (CV%) at internal quality control and good linearity at standard curve. Therefore first group began with Delta/Panic check (D/P) and second group surveyed with the latest results. In that the latest results were <1.0 ng/ml, we checked the thyroxin withdrawal. Finally selected specimen retested with raw specimen. Results: In first group, we was able to reduce the retest rate(30.8% to 7.7%). and In second group, 40% to 5%. The total retest rate was 7.3%. Conclusion: If using the selecting criteria for retest, is helpful to accuracy and quickness of the result report.

검사별 radioimmunoassay시약 조사 및 비교실험

김지나,안재석,전영우,윤상혁,김윤철,Kim, Ji-Na,An, Jae-seok,Jeon, Young-woo,Yoon, Sang-hyuk,Kim, Yoon-cheol 대한핵의학기술학회 2021 핵의학 기술 Vol.25 No.1

Purpose If a new test is introduced or reagents are changed in the laboratory of a medical institution, the characteristics of the test should be analyzed according to the procedure and the assessment of reagents should be made. However, several necessary conditions must be met to perform all required comparative evaluations, first enough samples should be prepared for each test, and secondly, various reagents applicable to the comparative evaluations must be supplied. Even if enough comparative evaluations have been done, there is a limit to the fact that the data variation for the new reagent represents the overall patient data variation, The fact puts a burden on the laboratory to the change the reagent. Due to these various difficulties, reagent changes in the laboratory are limited. In order to introduce a competitive bid, the institute conducted a full investigation of Radioimmunoassay(RIA) reagents for each test and established the range of reagents available in the laboratory through comparative evaluations. We wanted to share this process. Materials and Methods There are 20 items of tests conducted in our laboratory except for consignment tests. For each test, RIA reagents that can be used were fully investigated with the reference to external quality control report. and the manuals for each reagent were obtained. Each reagent was checked for the manual to check the test method, Incubation time, sample volume needed for the test. After that, the primary selection was made according to whether it was available in this laboratory. The primary selected reagents were supplied with 2kits based on 100tests, and the data correlation test, sensitivity measurement, recovery rate measurement, and dilution test were conducted. The secondary selection was performed according to the results of the comparative evaluation. The reagents that passed the primary and secondary selections were submitted to the competitive bidding list. In the case of reagent is designated as a singular, we submitted a explanatory statement with the data obtained during the primary and secondary selection processes. Results Excluded from the primary selection was the case where TAT was expected to be delayed at the moment, and it was impossible to apply to our equipment due to the large volume of reagents used during the test. In the primary selection, there were five items which only one reagent was available.(squamous cell carcinoma Ag(SCC Ag), β-human chorionic gonadotropin(β-HCG), vitamin B12, folate, free testosterone), two reagents were available(CA19-9, CA125, CA72-4, ferritin, thyroglobulin antibody(TG Ab), microsomal antibody(Mic Ab), thyroid stimulating hormone-receptor-antibody(TSH-R-Ab), calcitonin), three reagents were available (triiodothyronine(T3), Tree T3, Free T4, TSH, intact parathyroid hormone(intact PTH)) and four reagents were available are carcinoembryonic antigen(CEA), TG. In the secondary selection, there were eight items which only one reagent was available.(ferritin, TG, CA19-9, SCC, β-HCG, vitaminB12, folate, free testosterone), two reagents were available(TG Ab, Mic Ab, TSH-R-Ab, CA125, CA72-4, intact PTH, calcitonin), three reagents were available(T3, Tree T3, Free T4, TSH, CEA). Reasons excluded from the secondary selection were the lack of reagent supply for comparative evaluations, the problems with data reproducibility, and the inability to accept data variations. The most problematic part of comparative evaluations was sample collection. It didn't matter if the number of samples requested was large and the capacity needed for the test was small. It was difficult to collect various concentration samples in the case of a small number of tests(100 cases per month or less), and it was difficult to conduct a recovery rate test in the case of a relatively large volume of samples required for a single test(more than 100 uL). In addition, the lack of dilution solution or standard zero material for sensitivit [목 적] 의료기관의 핵의학 검사실에서 신규검사를 도입하거나 사용하던 시약을 변경하게 되는 경우 절차에 따라 검사의 특성이 분석되고 시약에 대한 평가가 이루어져야 한다. 그러나 요구되어지는 비교실험을 모두 수행하기 위해서는 몇 가지 필요한 조건이 충족되어야 하는데, 첫째 각 검사별로 수행하기에 충분한 검체량이 준비되어야하며, 둘째 비교실험에 적용 가능한 다양한 시약의 공급이 가능해야한다. 충분한 비교실험이 이루어졌다고 하더라도 변경된 시약에 의한 데이터 변동이 전체 환자데이터 변동을 의미하는 것에는 한계가 있으므로 검사실에서 시약이 변경되는 것에 대한 부담이 있다. 이러한 다양한 어려움으로 검사실에서의 시약변경은 제한적으로 이루어지고 있다. 본원에서는 원할한 경쟁 입찰을 도입하기 위하여 검사별로 radioimmunoassay(RIA)시약을 전수조사하고 비교실험을 통해 검사실에서 사용가능한 시약범위를 설정하였다. 이 과정을 공유하고자 하였다. [대상 및 방법] 본원 핵의학 검체 검사실에서 시행하고 있는 검사는 위탁검사를 제외하고 총 20종목이다. 각각의 검사별로 외부정도관리와 기관간 정도관리 결과보고서를 참고로 사용가능한 RIA시약을 전수 조사하였고, 각 시약에 대한 메뉴얼을 확보하였다. 각각의 시약마다 메뉴얼을 확인하여 검사 방법과 incubation시간, 검사 시 필요한 검체량, 시약량 등을 확인하여 본 검사실에서 사용가능한지 여부에 따라 시약 1차 선정을 하였다. 1차 선정된 시약을 100 test기준으로 2 kit씩 공급받아 데이터 상관성시험, 민감도, 회수율, 희석시험을 진행하였고, 비교실험 결과에 따라 시약을 2차 선정하였다. 1, 2차 선정을 통과한 시약을 경쟁 입찰리스트로 제출하였다. 검사 시약을 단수로 지정할 경우에는 1차, 2차 선정 과정에서 얻은 자료로 단수지정 사유서를 작성하였다. [결 과] 각각의 시약마다 매뉴얼을 확인하여 시약 1차 선정에서 제외되는 경우는 각 검사의 현재 Turn Around Time(TAT)보다 길어지는 경우와 검사 시 사용 시약량이 많아 장비사용이 불가능한 경우였다. 1차 선정에서 사용가능한 시약이 1개인 경우는 5종목 squamous cell carcinoma antigen(SCC Ag), 𝛽-human chorionic gonadotropin(𝛽-HCG), vitamin B12, folate, free testosterone 이었고, 2개인 경우는 8종목 (CA19-9, CA125, CA72-4, ferritin, thyroglobulin antibody(TG Ab), microsomal antibody(Mic Ab), thyroid stimulating hormone-receptor-antibody(TSH-R-Ab), calcitonin), 3개인 경우는 5종목(triiodothyronine(T3), Free T3, Free T4, TSH, intact parathyroid hormone(intact PTH)), 4개인 경우는 2종목(carcinoembryonic antigen(CEA), TG)이었다. 2차 최종 선정결과 사용가능한 시약이 3개인 것은 T3, Free T3, Free T4, TSH, CEA, 2개인 것은 TG Ab, Mic Ab, TSH-R-Ab, CA125, CA72-4, intact PTH, calcitonin이었다. 단수 지정된 종목은 ferritin, TG, CA19-9, SCC, 𝛽-HCG, vitamin B12, folate, free testosterone이었다. 2차 선정에서 제외된 사유에는 비교실험을 위한 시약공급이 안된 경우와 데이터 재현성에 문제가 있었던 경우, 데이터 변동에 대한 수용이 불가능하다고 판단되는 경우였다. 비교실험 시 가장 문제가 되는 부분은 검체 수집이었다. 검사건수가 많고 검사 시 필요한 검체량이 적은 경우에는 문제가 되지 않았지만, 검사건수가 적은 경우(월 100건 이하)에는 다양한 농도 검체를 수집하기가 어려웠으며, 한번 검사 시 필요한 검체량이 상대적으로 많은 경우(100 uL이상)에는 회수율시험을 진행하기가 어려웠다

12주간 발레프로그램이 초등 저학년 여학생의 건강체력과 자세에 미치는 영향

김지나 ( Ji Na Kim ),오덕자 ( Deuk Ja Oh ) 대한무용학회 2021 대한무용학회논문집 Vol.79 No.4

The purpose of this study is to verify the effect on the Health-related physical fitness (muscular strength, flexibility, muscular endurance, cardiorespiratory endurance, and body composition), posture, and stress coping of elementary school lower grade girls. A total of 30 subjects(EG n=15, CG n=15) was collected with a 60-minute ballet exercise program for 12 weeks. For analysis, two-way ANOVA was conducted to analyze interactions effects, the main effect, and the simple main effect. Results are 12 weeks ballet exercise program has effected positively of the flexibility and muscular endurance. At ASIS height showed an effect between groups. The right knee had a positive effect on pre and post-test. In the posterior posture, the 7th cervical vertebras, PSIS were positive on pre and post-test. The difference between groups of the right and left ear holes in the lateral posture. The left pelvic inclination has effected significantly differences in the pre and post-test of the experimental group. In the foot pressure, the right and left sides of the total foot pressure had positive effects on the balance on pre and post-test.