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김주동,육정환,김용만,최원용,김용진,임정택,오성태,김병식,Kim Joo Dong,Yook Jeong Hwan,Kim Yong Man,Choi Won Yong,Kim Yong Jin,Lim Jung Taek,Oh Sung Tae,Kim Byung Sik 대한위암학회 2004 대한위암학회지 Vol.4 No.2
Purpose: A Krukenberg tumor is an ovarian tumor of a signet-ring cell type. This tumor arises more commonly in young women, and the prognosis is poor. The primary focus of this tumor is often found at gastrointestinal malignancy, especially gastric cancer. We tried to identify the clinical characteristics of this tumor, and in that regard, this report might be helpful. Materials and Methods: We reviewed the 61 patients with Krukenberg tumors, who had been diagnosed at our hospital from 1994 to 2002, and retrospectively analyzed the clinical features. Results: The age distribution ranged from 15 to 59 years, and the mean age was 41 years. The most common symptom was a lower abdominal mass ($46\%$). Fourty-two cases ($77\%$) showed bilateral ovarian involvement, and the size of this tumor was variable, but in 24 cases ($4\%$) the size was $5\∼10$ cm for the largest diameter. Among 54 cases, 40 cases had ascites, and the volume of ascites was variable. The median survival of the 61 patients was 10 months, and Krukenberg tumor developed 19.7 months after the primary operation. The median survival durations of recurrence patterns were 20 months for the Krukenberg tumor alone, and 7 months for the Krukenberg tumor with peritoneal seeding. Conclusion: In young women treated with a gastrectomy, especially one for an advanced tumor, closed observation with abdominal ultrasonography or computed tomography to detect a Krukenberg tumor is recommended. The patient with a Krukenberg tumor alone has a better prognosis than one with a Krukenberg tumor combined peritoneal seeding. We will have to consider more progressive treatment for the patient with a Krukenberg tumor alone.
가상플랜트 기반의 최적설계 기술을 활용한 공기분리장치 설계 최적화
김주동(Joo-Dong Kim),최신범(Shin-Beom Choi),최재붕(Jae-Boong Choi),이홍철(Hong-Chul Lee),황인주(In-Ju Hwang) 대한설비공학회 2010 대한설비공학회 학술발표대회논문집 Vol.2010 No.6
Recently, plant design review by employing virtual plant is an important issue in the field of plant engineering. Especially, many researches for compactness and modularization were performed to reduce time, cost and space. So, the aim of this paper is development of design optimization techniques based on virtual plant for small-sized cryogenic plant such as ASU(Air Separation Unit). To do this, design optimized modules such as scale up/down, piping generation and navigator are developed by employing XVL(eXtensible Virtual world description Language). Finally, the availability of these modules is determined to apply the LNG(Liquefied Natural Gas) plant management system based on RAMS(Reliability, Availability, Maintainability and Safety) called as LPMS-RAMS. This result will be used to develop the web-based LPMS-RAMS.
강준모(Junmo Kang),김형근(Hyeongkeun Kim),박영철(Young Chul Park),김주동(Joo Dong Kim),최성(Sung Choi),홍병희(Byung Hee Hong),김영진(Young-Jin Kim),최재붕(Jae-Boong Choi) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11
We demonstrate the application of graphene coated heat pipe, showing high thermal transfer and corrosion resistant by water environment. The graphene coating layer was directly synthesized on both the inside and the outside of Cu pipe using chemical vapor deposition (CVD) method. The surface properties of Cu pipe exposed to water were investigated by optical and Raman spectroscopy. The heat transfer property of Cu pipe was tested by using hot water flows, showing improved heat transfer effect on the graphene coated heat pipe. This suggested that the graphene coated heat pipe would be very useful for the corrosion resistant coating and high thermal conductive material.
Roles of Src-family kinase isoforms, Lyn, Fyn, Fgr, and c-Src on degranulation in RBL-2H3 mast cells
이준호,문세환,고나영,김지완,김도균,김주동,허억,최완수,Lee, Jun-Ho,Mun, Se-Hwan,Ko, Na-Young,Kim, Jie-Wan,Kim, Do-Kyun,Kim, Joo-Dong,Her, Erk,Choi, Wahn-Soo Korean Society of Life Science 2007 생명과학회지 Vol.17 No.3
흰쥐유래의 비만세포인 RBL-2H3 세포는 다양한 Src-family kinase를 발현한다. 현재까지의 연구결과에 의하면 비만세포의 초기 활성화에 Lyn kinase가 중요한 역할을 한다고 알려져 왔다. 그러나 그 세포에서 발현되는 다양한 다른 Src-family kinase의 역할은 불분명하다. 본 연구에서는 비만세포에서 다양한 Src-family kinase가 세포내 다른 곳에서 다양하게 발현되고 있다는 사실을 RT-PCR, immunoblotting 그리고 confocal microscopy 기법을 이용하여 증명하였다. 그 결과 Lyn 및 Fgr kinase는 세포막에 위치하고 c-Src 및 Yes kinase는 세포 내 과립에 존재하는 것을 알 수 있었다. 모든 Src-family kinase를 클로닝하고 과발현하여 탈과립 대한 영향을 평가하였다. 그 결과 fyn과 Fgr kinase는 비만세포에서 항원 유도의 탈과립을 증가시켰으며 반면 Lyn kinsae는 탈과립을 억제시키는 것을 확인할 수 있었다. 이러한 결과는 비만세포 초기 신호전달계에서 Fgr가 중요한 역할을 할 가능성을 제시한다. The rat RBL-2H3 mast cells contain various Src-family kinases. Previous reports with this cell line indicated that Lyn activation is an important initial signaling for the activation of the cells. However, the role and location of other Src-family kinase isoforms which are expressed in the cells are not clear. In this study, we now show that isoforms of Src-family kinases, Lyn, fyn, Fgr, c-Src, and Yes are differentially expressed and located differently in the cells as indicated by RT-PCR, immunoblotting analysis, and confocal microscopy. Lyn and Fgr were located on plasma membrane but on the other hand c-Src and Yes were located on intracellular organelle. All of Src-family kinases were cloned and overexpressed for investigating the roles of the isoforms. Overexpression of Fyn and Fgr, not Lyn and c-Src, stimulated Ag-induced degranulation in the cells. Our findings strongly suggest for the first time that each of Src-family kinase isoform can regulate differentially $Fc{\varepsilon}RI$-mediated signaling in RBL-2H3 mast cells.
API RP 581 코드 기반의 LNG 플랜트 전용 정량적 위험도 평가 프로그램 개발
이정민(Jung-Min Lee),최신범(Shin-Beom Choi),김주동(Joo-Dong Kim),최재붕(Jae-Boong Choi),황인주(In-Ju Hwang),최송천(Song-Chun Choi) 대한설비공학회 2011 대한설비공학회 학술발표대회논문집 Vol.2011 No.7
The aim of this paper is to develop the quantitative RBI program for LNG plant based on API RP(Recommended Practice) 581 code. To achieve this goal, API RP code is reviewed to make the algorithm and structure for RBI program. And the web-based quantitative RBI is developed as the interim result of LNG-RBI program. This result will be useful to develop another RBI program related to qualitative RBI and semi-quantitative RBI. Finally, these RBI programs will be combined as the LNG-RBI program.