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구강 편평 상피 암종에서 TGF-β1과 MMP-2의 발현과 경부 임파절 전이 간의 상관 관계에 관한 연구
김좌영(Jwa-Young Kim),Horatiu Rotaru,김성곤(Seong-Gon Kim) 대한구강악안면외과학회 2007 대한구강악안면외과학회지 Vol.33 No.3
Several matrix metalloproteinases (MMPs) have been shown to play an important role in the invasion and metastasis of oral squamous cell carcinoma(OSCC). The members of the TGF-βsignaling pathway are being considered as predictive biomarkers for progressive tumorigenesis and molecular targets for the prevention and the treatment of cancer and metastasis. The aim of the present study was to find the clinical significance of the expression of TGF-β1 and MMP-2 related to the regional lymph node metastasis in OSCC. This study included 76 cases of primary OSCC, of which 42 cases showed regional lymph node metastases. Immunohistochemistry was used for the localization of protein. The relation between the expression of each protein and clinical variables was statistically evaluated. In results, the expression of TGF-β1 both main mass with lymph node metastasis and without lymph node metastasis was found not to be statistically significant (p>0.05). The expression of MMP-2 was found to be statistically significant related to regional lymph node metastasis (p<0.05). When compared the expression in the metastatic lymph node, TGF-β1 was significantly highly expressed than MMP-2 (p<0.05). In conclusion, the expression of MMP-2 was significantly elevated in patients with lymph node metastasis as compared to the patients without lymph node metastasis, which could be useful in predicting the risk of lymph node metastasis in OSCC.
구개열을 동반한 저한성 외배엽형성이상 환자의 악교정수술을 포함한 치료
김좌영(Jwa-Young Kim),박인영(In-Young Park),송윤정(Yun-Jung Song) 대한치과의사협회 2019 대한치과의사협회지 Vol.57 No.2
Ectodermal dysplasia is a genetic disorder in which various clinical manifestations involve two or more of the differentiated tissues of the ectoderm. Facial deformity, which is frequently associated with ectodermal dysplasia, appears in the form of cleft lip or cleft palate, especially in the middle facial area.Cleft and tooth defects result in decreased alveolar bone development.This leads to severe skeletal incongruity. Facial features include frontal protrusion, malar bone hypoplasia, flat nose, mandibular prominence and long lower facial height. This clinical report presents treatment including orthognathic surgery of a patient with Hypohidrotic Ectodermal dysplasia with cleft palate.
박영욱(Young-Wook Park),이석근(Suk-Keun Lee),권광준(Kwang-Jun Kwon),김성곤(Seong-Gon Kim),팽준영(Jun-Young Paeng),황대석(Dae-Seok Hwang),김좌영(Jwa-Young Kim) 대한구순구개열학회 2020 대한구순구개열학회지 Vol.23 No.1
Objective: The cleft lip and/or palate is the most common congenital anomaly with a high incidence within developing or low-income countries. To overcome the disease burden, humanitarian international missions are essential. In mission operation, patients never underwent any type of preoperative hospital care. Moreover, lots of patients past appropriate time of surgery. Therefore, we investigated primary palatoplasties in mission environments with regard to patients’ age and operation modality. Materials and Methods: The subjects included 106 patients who wanted palatoplasty during cleft missions in Vietnam. Medical records and peri-operative clinical photographs were analyzed retrospectively. Results: Primary palatoplasty was performed at the age of 72.5 months on average. Clinically, incomplete cleft palate was 61.3%. Main surgical technique was V-Y push-back operation with intravelar veloplasty (68%). Additional surgical procedures were pedicled buccal fat pad (33%) and vomer flap (16%). Postoperatively, no motality and any transfusion was not performed. Until 1 month after palatoplasty, fistula rate was 3.8%. Conclusion: For management of untreated cleft palate, which past the appropriate time of palatoplasty, pedicled buccal fat pad could be a reliable additional procedure to decrease postoperative fistula rate.
은 나노 연고가 측두하악관절낭염의 환자의 치료에 미치는 영향에 관한 연구
채창훈(Chang-Hoon Chae),김좌영(Jwa-Young Kim),김미자(Mi-Ja Kim),정훈(Hoon Chung),김승호(Seung-Ho Kim),오현우(Hyun-Woo Oh),김영남(Young-Nam Kim),김영일(Young-Il Kim),양병호(Byung-Ho Yang),김성곤(Seong-Gon Kim) 대한구강악안면외과학회 2006 대한구강악안면외과학회지 Vol.32 No.3
The silver nanocrystalline is widely used for biological field because of its biocompatibility and anti-microbial effect. The objective of this study was to evaluate the therapeutic efficacy of the silver nanocrystalline ointment on the temporomandibular joint (TMJ) capsulitis. Total 39 patients were included in this study and all patients were received single topical application of the silver nanocrystalline ointment (group A, n=30) or placebo ointment (group B, n=19). Measured variables were maximum mouth opening (MMO), visual analog scale (VAS) for pain, and VAS for function. In results, we could not assess any therapeutic efficacy of single application in the chronic TMJ capsulitis (p〉0.05). However, the single application of silver nanocrystalline ointment showed significant improvement in MMO and VAS for pain compared to placebo effect in the acute TMJ capsulitis(p〈0.05). We could not find any complications related to ointment application in both groups. In conclusion, the single application of silver nanocrystalline ointment was effective in improving patient’s symptom in acute TMJ capsulitis without any noticing complications.
토끼 두개골 결손부에서 전기 방사된 나노실크-수산화인회석 복합체를 이용한 골재생 효과에 대한 연구
계준영,김성곤,김민근,권광준,박영욱,김좌영,이민정,박영환,Kye, Jun-Young,Kim, Seong-Gon,Kim, Min-Keun,Kwon, Kwang-Jun,Park, Young-Wook,Kim, Jwa-Young,Lee, Min-Jung,Park, Young-Hwan 대한악안면성형재건외과학회 2010 Maxillofacial Plastic Reconstructive Surgery Vol.32 No.4
Purpose: The objective of the present study was to determine the capability of electrospun silk fibroin as a biomaterial template for bone formation when mixed with nano-hydoxyapatite in vivo. Materials and Methods: Ten New Zealand white rabbits were used for this study and bilateral round shaped defects were formed in the parietal bone (diameter: 8.0 mm). The electrospun silk fibroin was coated by nano-hydroxyapatite and grafted into the right parietal bone (experimental group). The left side (control group) did not receive a graft. The animals were sacrificed at 6 weeks and 12 weeks, humanly. The microcomputerized tomogram (${\mu}CT$) was taken for each specimen. Subsequently, they were undergone decalcification and stained for the histological analysis. Results: The average value of all measured variables was higher in the experimental group than in the control at 6 weeks after the operation. BMC in the experimental group at 6 weeks after operation was $48.94{\pm}19.25$ and that in the control was $26.17{\pm}16.40$ (P = 0.027). BMD in the experimental group at 6 weeks after operation was $324.59{\pm}165.24$ and that in the control was $173.03{\pm}120.30$ (P = 0.044). TMC in the experimental group at 6 weeks after operation was $19.50{\pm}6.00$ and that in the control was $10.52{\pm}6.20$ (P = 0.011). TMD in the experimental group at 6 weeks after operation was $508.88{\pm}297.57$ and that in the control was $273.54{\pm}175.91$ (P = 0.06). Gross image of both groups showed higher calcification area at 12 weeks than them in 6 weeks. The average value of ${\mu}CT$ analysis was higher at 12 weeks than that in 6 weeks in both groups. BMC in the experimental group at 12 weeks after operation was $51.21{\pm}8.81$ and that in the control was $33.47{\pm}11.13$ (P = 0.010). BMD in the experimental group at 12 weeks after operation was $323.39{\pm}21.54$ and that in the control was $197.75{\pm}76.23$ (P = 0.012). TMC in the experimental group at 12 weeks after operation was $21.44{\pm}5.30$ and that in the control was $13.31{\pm}4.17$ (P = 0.008). TMD in the experimental group at 12 weeks after operation was $524.47{\pm}19.37$ and that in the control was $299.60{\pm}136.20$ (P = 0.016). Conclusion: The rabbit calvarial defect could be successfully repaired by electrospun silk nano-fiber combined with nano-hydroxyapatite.
Panorama, CT를 이용한 상악동내 중격의 임상적 연구
정진원,송경호,이슬기,김좌영,양병은,김성곤,송상훈,Jung, Jin-Won,Song, Kyoung-Ho,Lee, Seul-Ki,Kim, Jwa-Young,Yang, Byoung-Eun,Kim, Sung-Gon,Song, Sang-Hun 대한구강악안면외과학회 2008 대한구강악안면외과학회지 Vol.34 No.3
Purpose: The aim of this study was to examine the incidence, location and morphology of antral septa using radiographic exam.(Panorama, CT) in the dentate/non-atrophic and edentulous/atrophic maxillary segments. Material & methods: 232 sinuses were subdivided into two groups(group1 : 175 sinuses were classified as complete & partial dentate maxillary segments, group2 : 57 sinuses were classified as complete edentulous maxillary segments) and were investigated for the incidence, location and morphology of maxillary sinus septa. Results: A total of 80 septa were observed in 232 maxillary sinuses, which corresponded to 30.65% of the sinuses(71 of 232). 67.5% of the total septa was observed in the complete & partial dentate groups, but 32.5% of the total septa was observed in the complete edentulous group. Upon analysis of the anatomical location of the septa, it was seen that 14 septa(17.5%) were located in the P1 area, 15 septa(18.7%) were located in the P2 area, 19 septa(23.8%) were located in the M1 area and 32 septa(40%) were located in the M2 area & dista area of M2. we found 45 septa in the apical lesion of teeth, Group 1. However the remaining 9 septa were found in the edentulous area. Conclusion: CT is a better method than panoramic radiography for detecting the presence of the maxillary sinus septa. Maxillary sinus septa are more commonly detected in complete edentulous maxillary segments than in complete & partial dentate maxillary segments. Also maxillary sinus septa are more commonly detected posteriorly than anteriorly.
송경호,이슬기,정재안,신진업,김좌영,송상훈,양병은,최영준,김성곤,Song, Kyung-Ho,Lee, Seul-Ki,Chung, Jae-An,Shin, Jin-Eob,Kim, Jwa-Young,Song, Sang-Hoon,Yang, Byoung-Eun,Choi, Young-Jun,Kim, Seong-Gon 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.6
Typical surgical methods for the treatment of mandibular fractures include intermaxillary-fixation (IMF) for obtaining temporary intraoperative occlusion. Traditionally IMF has been achieved with arch-bars or interdental eyelet wiring. However, these techniques are time-consuming procedures, can produce periodontal damage, and are not well tolerated by the patient even under local anesthesia. Moreover, daily maintenance of oral hygiene is difficult for patients with an arch bar. Recently, intermaxillary fixation using intraoral skeletal anchorage screws (SAS) has been introduced for the treatment of mandibular fractures. This method solves the problems above, but they have the potential for tooth damage, screw fractures and intraoperative occlusal instability. In this study, patients with mandiblular fractures were divided into three groups. Group 1 was treated by IMF using archbars(both maxilla and mandible), Group 2 was treated with SAS(maxilla) and arch-bar (mandible), Group 3 was treated with SAS(both maxilla and mandible). The aim of this study was to evaluate the influence of the different IMF methods on periodontal tissue health and intraoperative occlusal rehabilitation about each groups, and to discuss the most favorable IMF method.