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새로운 백금 착체(II) 화합물의 흰쥐 혈장에서 대사체 확인
김종환,조요나,노영수,서성훈,정지창,장성구,이규홍,이주한,이경태,Kim, Jong-Whan,Jo, Yo-Na,Rho, Young-Soo,Seo, Seong-Hoon,Jung, Jee-Chang,Chang, Sung-Goo,Lee, Kyoe-Heung,Lee, Joo-Han,Lee, Kyung-Tae 한국약제학회 1998 Journal of Pharmaceutical Investigation Vol.28 No.3
KHPC-002 $[(trans-l-diaminocyclohexane-bis-l,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ and $KHPC-006[(cis-diaminocyclohexane-bis-1,2(diphenylphosphinoethane)platinum)\;{\cdot}2NO_3]$ were synthesized as candidates for third platinum antitumor agent. Before their pharmacokinetic study, we optimized the analytical condition with HPLC and identified the major metabolites in the rat plasma. HPLC analysis by $C_{18}$ reverse-phase column showed that standard peak of both compounds appeared rapidly at around 1 minutes, whereas metabolites of KHPC-002 and KHPC-006 which were extracted from plasma after single I.V. administration in rats or incubation for 24 hr at $37^{\circ}C$ showed retention time of $10{\sim}11$ minutes. These metabolites were identified as the major compound by Matrix Associated Laser Deposition/Ionization (MALDI), which only lose the 2 molecules of $NO_3$. Based on these results, we suggest that the major metabolites of KHPC-002 and KHPC-006 were [trans-l-diamino-cyclohexane-bis-l,2(diphenylphosphinoethane)platinum] and [cis-diaminocyclohexane-bis-l.2(diphenylphosphinoethane)platinum], respectively.
김종환,박준렬,최계근,Kim, Jong-Hwan,Park, Jun-Ryeol,Choe, Gye-Geun 대한전자공학회 1985 전자공학회지 Vol.22 No.3
Pad'e-Type 근사화법을 이용하여 새로운 기준모델 적응 제어계를 설계하였다. 공정의 파라미터를 모르는 상태에서 제어계를 설계하여 이로부터 제어목적을 만족시키는 등가 방정식을 유도하여 이조건을 만족시키는 파라미터를 반복적으로 추정하였다. 이결과 추정할 공정의 파라미터 갯수를 줄이는 효과를 얻을 수 있다. 기존의 방법과 새로운 방법을 컴퓨터 시뮬레이tus으로 나타내었다. A Novel design of MRAC for achieving independent tracking and regulation objectives by applying Pad e-Type approximation in the controller parameter estimation is presented. The design of the controller is done with the unknown plant parameters from the first. The result of the design is a simple control scheme with the reduction of estimation para-meters. The performance of rho proprosed contiol structure in tracking and regulation is compared with the other method by computer simulation.
삼기층(三紀層) 퇴적암(堆積岩) 중(中) 비석(沸石)의 산출상태(産出狀態)
김종환,문희수,Kim, Jong-hwan,Moon, Hee-Soo 대한자원환경지질학회 1978 자원환경지질 Vol.11 No.2
Of more than 30 varieties of zeolite group minerals, 7 varieties, mordenite, clinoptilolite, natrolite laumontite, stilbite, stellerite and chabazite are identified in Korea, whereas mordenite and clinoptilolite occur in Miocene sediments of small Yonil tertiary basin, east coast of Korea. The basin consists of three separate groups of sediments called Janggi, Gampo and Haseo, which are not correlated stratigraphyically yet. Zeolite occurs alternating with montmorillonite layers in Nuldaeri, Yongdongri and Haseori tuffs of Jahanggi, Gampo and Haseo Groups respectively. Zeolite was formed by diagenesis. of acidic volcanic tuffs.
온도저하에 따른 SF<sub>6</sub>의 상전이 및 절연특성
김종환,최은혁,박광서,윤대희,김이국,이광식,Kim, Jong-Whan,Choi, Eun-Hyuck,Park, Kwang-Seo,Yoon, Dae-Hee,Kim, Lee-Kook,Lee, Kwang-Sik 한국조명전기설비학회 2005 조명·전기설비학회논문지 Vol.19 No.8
고본 연구는 모의 GIS내 절연특성을 $SF_6$ Gas의 온도의 변화($+30{\sim}-40[^{\circ}C]$)에 따른 절연특성을 구명하였다. 절연 특성은 기체상태의 Paschen's law 적용구간, 기체와 액체 공존상태의 절연파괴전압이 대세적으로 높고, 편차가 심한 구간과 챔버 내부가 저밀도 $SF_6$와 잔류공기의 혼합체로 이루어지는 극히 낮은 압력상태로 되어 절여파괴 전압이 크게 낮아지는 구간으로 구분되었다. 또한 본 실험에서 액체 $SF_6$가 기체 $SF_6$보다 절연특성이 우수함을 확인하였다. 상전이와 절연특성을 구명함으로서 각종 고온초전도 및 극저온 응용 설비의 절연설계의 기초 자료로 제공하고자 한다. In this paper, insulations characteristics by temperature changes($+30{\sim}-40[^{\circ}C]$) of $SF_6$ gas in the experimental chamber were studied. From this result, The breakdown characteristics classify the vapor stage of $SF_6$ according the Paschen's law, the gas & liquid coexisted stage of voltage value increases & much deviation and the VB low stage as the interior of chamber gets filled with mixture of $SF_6$ that are not liquefacted and remaining air which couldn't be ventilated. In addition the ability of insulation of liquid $SF_6$ was higher than that of the highly pressurized $SF_6$ gas. In this research, we want to provide the base data on designing insulation of high-temperature superconductor and the cryogenic equipments by investigating the insulation characteristics of $SF_6$.
김종환,고승희,배재성,Kim, Jonghwan,Ko, Seughee,Bae, Jaesung,Hwang, Jaihyuk 항공우주시스템공학회 2012 항공우주시스템공학회지 Vol.6 No.4
The morphing flap wing has different structure unliked general wing structure. The actuated chord length of the morphing flap was more longer than conventional wing flap. In this reason, morphing flap wing structure was important to bending moment by aerodynamic lift force. In this study, through the fluid-structure interaction using computational fluid dynamics and structure finite element analysis to apply that the morphing flap wing's static aeroelastic stability analysis.
AIDP 환자(患者)의 한양방(韓洋方) 치료(治療) 1례(例)
김종환,박상욱,장자원,신우진,홍현우,김지윤,최인선,황원덕,Kim Jong-Hwan,Park Sang-Wook,Jang Ja-Won,Sin Woo-Jin,Hong Hyun-Woo,Kim Ji-Yun,Choi In-Sun,Hwang Won-Duek 대한한방내과학회 2003 大韓韓方內科學會誌 Vol.24 No.4
Introduction: Guillain-Barre syndrome(GBS) is defined as a recognizable clinical entity that is characterized by rapidly evolving symmetric limb weakness, a loss of tendon reflexes, absent or mild sensory signs, and variable autonomic dysfunctions. Recently there is an opinion that Acute Inflammatory Demyelinating Polyradiculoneuropathy'(AIDP) is more effective than 'GBS' for the symptoms. These symptoms are applicable to rheumatic arthritis(痺), flaccid paralysis of limb(?) caused by wind, cold and dampness(風, 寒, 濕) from an oriental medical view point. On this, we reported one case that diagnosed as 'complex of rheumatic arthritis(痺) and flaccid paralysis of limb(?)' at our oriental medical hospital. Result: we considered these symptoms as 'complex of rheumatic arthritis(痺), flaccid paralysis of limb(?)'. In accordance with the result, we treated the patient with Chung-Sang Tong-Jung On-Ha(淸上通中溫下). We concluded that external factors such as wind, cold and dampness(風, 寒, 濕) and internal factors like vital energy's disharmony(生氣不調和) affected the patient.
몬테칼로 시뮬레이션 기반의 다수 지상 연성표적에 대한 최적 조준점 산출
김종환,안남수,Kim, Jong-Hwan,Ahn, Nam-Su 한국시뮬레이션학회 2020 한국시뮬레이션학회 논문지 Vol.29 No.1
본 논문은 드론봇 전투체계를 운용하여 전투전단의 적 보병부대 위치정보를 수집하였을 시, 지휘관이 요구하는 적 부대 피해수준을 충족하면서 적 보병부대를 신속하고 정확하게 타격하기 위하여, 보유한 화력체계의 살상범위를 기초로 최적의 사격발수 및 조준점 위치를 실시간 자동으로 산출하는 인공지능 알고리즘 연구이다. 이를 위해, 100m×200m 크기의 야지 전장환경에서 증강된 소대급 규모의 적 보병부대를 임의로 전개 및 모의하고, 약 15m의 살상범위를 갖는 가상의 화력체계에 대한 모델링을 수행하였으며, 각개 적병사의 무피해/경상 및 중상/사망 등의 피해유형 및 임무수행 가능여부를 모의하기 위하여 연성표적의 피해효과에 적용되는 칼튼피해함수를 적용하고 전장의 불확실성을 모의하기 위하여 몬테칼로 시뮬레이션을 수행하였다. 또한, 지휘관 의도에 부합된 적부대의 피해수준을 달성하기 위하여, 반복적인 모의 및 비지도학습의 k-mean clustering 기법을 적용하여 최적의 사격발수 및 조준점 위치를 0.4초 이내로 산출하였다. 본 연구에서 제안하는 방법은 드론봇 전투체계를 운용하는 대대급 규모의 전투부대에서 '탐지-결심-타격' 의사결정시간의 단축에 기여할 것으로 판단된다. This paper presents a real-time autonomous computation of shot numbers and aiming points against multiple soft targets on grounds by applying an unsupervised learning, k-mean clustering and Monte carlo simulation. For this computation, a 100 × 200 square meters size of virtual battlefield is created where an augmented enemy infantry platoon unit attacks, defences, and is scatted, and a virtual weapon with a lethal range of 15m is modeled. In order to determine damage types of the enemy unit: no damage, light wound, heavy wound and death, Monte carlo simulation is performed to apply the Carlton damage function for the damage effect of the soft targets. In addition, in order to achieve the damage effectiveness of the enemy units in line with the commander's intention, the optimal shot numbers and aiming point locations are calculated in less than 0.4 seconds by applying the k-mean clustering and repetitive Monte carlo simulation. It is hoped that this study will help to develop a system that reduces the decision time for 'detection-decision-shoot' process in battalion-scaled combat units operating Dronebot combat system.
재귀적 베이시안 필터를 적용한 소화기탄의 충돌속도 추정 연구
김종환,조성식,Kim, Jong-Hwan,Jo, Seungsik 한국군사과학기술학회 2016 한국군사과학기술학회지 Vol.19 No.2
This paper presents a strike velocity estimation using the recursive Bayesian filter that operates both correction and prediction models to probabilistically remove noises of sensors and accurately estimate the strike velocity during the real-time experiments. Four different types of bullets such as 5.56 mm M193, 7.62 mm M80, 5.45 mm 7N10 and 7.62 mm MSC were used to validate the proposed method. Compared to the existing method, the proposed method statistically results in higher stability of the strike velocity estimation as well as its reliability for the ballistic limit velocity computation.