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김정구(JK Kim),라건영(KY Rha) 대한산부인과학회 1979 Obstetrics & Gynecology Science Vol.22 No.9
The purpose of the present study is to see whether the determination of amniotic fluid creatinine concentration has a clinical usefulness in prediction fetal lmaturity, and factors by which it is influenced. Creatinine concentration in the paired amniotic fluid and maternal serum was measured by Technicon autoanalyzer Ⅱ in the 73 normal pregnant women, 24 preeclamptic women, and 7 women delivered S.G.A.I.(Small for Gestational Age Infant) between 23 to 43 gestational weeks. The results were as follows : 1) The mean amniotic fluid and maternal serum creatinine concentration and the mean AF/MS ratio(amniotic fluid/maternal serum creatinine ratio) in preeclampsia were significantly higher than those in the normal pregnancy. 2) The mean amniotic fluid creatinine concentration in S.G.A.I. was lower tahn that in the normal pregnancy, and this has stastically borderline significance(0.05)
정상 및 비정상임신에서 양수내 β-endorphin에 관한 연구
김정구(JK Kim),문신용(SY Moon),이진용(JY Lee),장윤석(YS Chang) 대한산부인과학회 1988 Obstetrics & Gynecology Science Vol.31 No.12
분만중 양수내 B-endrophin 치의 변화, 태아곤란증이 양수내 B-endrophin 치에 미치는 영향 및 정상임신과 비정상임신에서 모체혈장 및 양수내 B-endrophin 치의 유무를 알아보고자 정 상임부 44명, 선택적 제왕절개술이 시행된 임부 12명, 태아곤란증으로 응급제왕절개술이 시 행된 임부 8명, 저체중아 임부 10명, 조기진통이 합병된 임부 10명으로부터 채취한 총 124개 의 모체혈장 또는 양수에서 방사면역측정법을 이용하여 B-endrophin을 측정하여 다음과 같 은 결론은 얻었다. 1. 양수내 B-endrophin 치는 분만의 진행에 따라 유의한 변화를 하지 않았다. 2. 태아곤란증의 경우 평균 양수내 B-endrophin 치는 정상태아에서의 것보다 유의하게 높았 다. 3. 저체중아임부, 조기진통이 합병된 임부의 평균양수내 B-endrophin 치는 정상임부의 것보 다 각각 유의하게 높앗으나 평균 모체혈장 B-endrophin 치는 유의한 차이가 없었다. 4. 모체혈장 B-endrophin 치와 양수내 B-endrophin 치 사이에는 유의한 상관관계가 없었다. This study was undertaken to determine change in Immunoreactive B-endrophin activity in amniotic fluid during normal labor and effect of fetal stress upon the levels of this peptide in amniotic fluid. Immunoreactive B-endrophin levels were measured by radioimmunoassay in a total of 124 maternal plasma and/or amniotic fluid samples obtained from 44 normal pregnant women, from 20 patients with pregnancy complicated by premature labor or intrauterine growth retardation (IUGR) and from 20 patients who underwent elective or emergency cesarean section. The results were as follows; 1. There were no significantly difference in the mean levels of Immunoreactive B-endrophin in the amniotic fluid at each stage of labor. 2. The mean amniotic fluid Immunoreactive B-endrophin level in patients with IUGR or premature labor was significantly higher than that in normal pregnant women. 3. There was a apparent relationsphi between fetal distress and Immunoreactive B-endrophin level in the amniotic fluid. 4. No significantly correlation was found between amniotic fluid and maternal plasma Immunoreactive B-endrophin levels.
가토난관의 미세수술을 이용한 봉합술후 생식능력 및 난관의 형태학적연구
김정구(JK Kim),장윤석(YS Chang) 대한산부인과학회 1984 Obstetrics & Gynecology Science Vol.27 No.13
The purpose of this study was to investigate the impact of a microsurgical anastomosis not only upon fertility but also ovulatory function as correlated with the production of corpora lutea and the morphologic characteristics and reconstructed isthmus, using 13 rabbits that were subjected to microsurgical transection and anastomosis of right isthmus. Left unoperated oviducts served as controls. The results side, the postoperative tubal patency rate was 90% and pregnancy rate 80%. 2. the mean nidation index was 58.78 on the operated side and 80.80 on the control side. This difference was not statistically significant. 3. There was no significant difference in the mean number of corpora lutea between the operated side and control side. 4. The mucosa of the anastomosis area couldnot be distinguished from that of the nonsutured area and no lack of continuity was found. 5. Collagen accumulation in the muscularis as demonstrated by trichome staining was associated with relatively decreased tubal function.
불임부부, 정상임신 및 처녀의 혈청내정자불동화항체와 정자응집항체에 관한 연구
김정구(JK Kim),문신용(SY Moon),이진용(JY Lee),장윤석(YS Chang) 대한산부인과학회 1986 Obstetrics & Gynecology Science Vol.29 No.8
정상임신, 처녀와 부임부부(원인불명부임증과 기질적불임증환자)에서의 혈청정자응집항체 및 정자부동화항체의 빈도를 비교하고 불임부부에서 이들 각각의 혈청정자항체와 성교후검사, 자연유산력, 불임기간과의 상호관계를 알아보고자 서울대학교병원 산부인과 불임상담실에 내원한 불임부부 109쌍과 정상임신 30명, 처녀 10명을 대상으로 TAT 및 SIT를 사용하여 1 : 32역가의 혈청정자응집항체와 1 : 4역가의 정자부동화 항체를 측정하여 다음과 같은 결과를 얻었다 1 정상임신, 처녀의 혈청내 두가지 정자항체 모두 발견되지 않았다 2 불임부부의 여성측에서 혈청정자부동화항체, 정자응집항체의 양성율은 각각 6 4%, 11 0%이었고 남성측의 7 8&에서 두가지 항체 모두 양성이었다 3 원방성불임증과 책발성불임증부부, 원인불명불음증과 기질적불임증부부사이에 혈청정자부동화항체, 정자응집항체의 빈도는 각각 유의한 차이가 없었다 4 불임부부의 양측에 두가지 혈청정자항체 모두 성교후검사와 유의한 상관관계가 없었다 5 혈청정자항체의 존재여부에 따른 자연유산력의 차의는 없었다 6 원인불명불임증의 경우 적어도 한가지 검사이상에서 양성인 부부의 평균불임기간은 음성인 부부에서보다 길었다 The possible causative role of immunologic factors in infertility is still the subject of investigation Sperm immobilizing antibodies and sperm agglutinating antibodies were assayed in sera of 109 infertile couples and 2 control groups (30 normal pregnant women and 10 virgins) by means of sperm immobilization test and tray agglutination test Both sperm antibodies were not detected in sera from control groups Sperm immobilizing antibodies and sperm agglutinationg antibodies were respectively present in sera of 6 4% and 11 0% of infertile women and 2 8%, and 2 8% of male partners The frequency of both sperm antibodies in sera of couples with organic infertility was not significantly different from the results in couples with unexplained infertility The presence of sperm immobilizing antibodies or sperm agglutinating antibodies in female or male sera didn`t show any significant correlation with the results of postcoital test There was no statistically significant correlation between a history of spontaneous abortion and the result of circulating sperm antibody test The couples with circulating sperm agglutinating antibodies and/or sperm immobilizing antibodies had a longer mean duration of infertility compared to the antibody negative couples in unexplained infertility
미세술을 이용한 가토난관의 협부절제술후 생식력 및 합부의 전자현미경적 관찰
김정구(JK Kim),장윤석(YS Chang) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.7
The present study was undertaken to examine the effect of microsurgical resection not only upon fertility but also ovarian ovulatory function as correlated wih the productin of corpora lutea and relationship between electron microscopic fnding of the anstomosis region and fertility 12 rabbits were subjected to microsurgical resection of 1.5cm segments of right isthmus. Left tube was left intact as a control The results were as follows: 1. The pregnancy rate on the operated side was 80% 2. There was no signifcant difference in the mean nidation index and the mean number of corpora lutea between the two sides. 3. The scanning electron microscopic examination of the anastomosis region revealed a normal complement of ciliated and secretory cells and minimal disruption ot the normal mucosal fold pattern 4. No relationship was found between the presence of narrow transverse cleft at the anstomosis region and the fertiltiy of than animal 5. There was no relationship apparent between the cilia agglutination at the anastomosis region and the nidation index of that animal We concluded that resection of 1.5cm segments of rabbit isthmus doesn;t affect fertility and ovarian function
김정구(JK Kim),김용봉(YB Kim),정홍(H Jung),신면우(MW Shin) 대한산부인과학회 1981 Obstetrics & Gynecology Science Vol.24 No.2
저자들은 서울대학교 산부인과에서 자궁경부암 1예를 경험하였기에 간략한 문헌고찰과 아울 러 증례를 보고하였다. Adenosquamous Cell carcinoma is generally called as adenocarcinoma associated with malignant-appearing squamous epithelium. It has more serious prognosis than either pure squamous cell carcinoma or adenocarcinoma. A case of Adenosquamous Cell carcinoma of cervix is presented with brief review of literature.
Mayer-Rokitansky-Kuster-Hauser 증후군 3예의 치험
김정구(JK Kim),임선재(SJ Lim),이양우(YW Lee),오보훈(BH Oh),이효표(HP Lee),라건영(KY Rha) 대한산부인과학회 1979 Obstetrics & Gynecology Science Vol.22 No.6
저자들은 최근 서울대학교 의과대학 부속병원 산부인과학교실에서 M.R.K.H. 증후군 3례를 치험하였기에 문헌적 고찰과 함께 증례보고를 하는 바이다. The Mayer-Rokitansky-Kuster-Hauser syndrom refers to the clinical entity consisting of: normal female secondary sex characteristics, normal external genitalia, congenital absence of the vagina, a rudimentary uterus in the form of bilateral noncanaliculated muscular buds, and normal tubes and ovaries with normal cytogenetic and endocrine evaluation. Three cases of Mayer-Rokitansky-Kuster-Hauser syndrome were presented and the literature was reviewed briefly.
정상 및 클로이펜 과배란유도 월경주기에서의 혈청 B-endorphin 치의 동태에 관한 연구
김정구(JK Kim),문신용(SY Moon),이진용(JY Lee),장윤석(YS Chang) 대한산부인과학회 1988 Obstetrics & Gynecology Science Vol.31 No.9
월경주기에 따른 혈청 B-endorphin치의 동태와 혈청 17 B-endorphin치와 혈청 B-endorphin 치의 상호관계를 알아보고자 정상월경주기군 12명과 클로미펜 과배란유도 월경주기군 8군 총 20명에서 혈청 B-endorphin과 17 B-endorphin을 방사면역법을 이용하여 측정하여 다음과 같은 결론은 얻었다. 1. 정상월경주기군에서 혈청 B-endorphin치는 배란전 제 2일에 유의한 변화를 보이기 시작 하여 배란전 제 1일에 최대치에 도달후 서서히 감소하였다. 2. 클로미펜 과배란유도 월경주기군에서는 난자흡인 제 3일전에 혈청 B-endorphin치의 작은 정점이 있었으나 유의한 변화는 없었다. 3. 정상월경주기군과 클로미펜 과배란유도 월경주기군에서 혈청 B-endorphin치는 17 B-endorphin치와 유의한 상관관계가 없었다. The aim of this study was to examine change in serum B-endorphin level in the human menstrual cycles and their relationship to serum 17 B-endorphin levels. Daily suerm B-endorphin levels in conjunction with 17 B-endorphin were measured during the normal menstrual cycle in healthy control subjects(n=8) and the clomiphene-hyperstimulated ovulatory menstraul cycle in in vitro fertilization candidates (n=12). The results were as follows. 1. In the normal menstrual cycle the mean serum B-endorphin level began to change significantly on 2 day before ovulation reached its maximum on 1 day before ovulation and then declined slowly. 2. In the clomiphene-hyperstimulated ovulatory menstraul cycle there was a small peak of the mean serum B-endorphin level on 3 days before aspiration of oocyte but no significantly change was found 3. There was no significantly correlation between serum B-endorphin and 17 B-endorphin levles.
무배란성 불임증환자에서 Human Menopausal Gonadotropin 치료중 임신주기에서의 배란전 혈청 17-B estradiol변화 양상에 관한연구
김정구(JK Kim),윤병구(BK Yoon),신창재(CJ Shin),문신용(SY Moon),이진용(JY Lee),장윤석(YS Chang) 대한산부인과학회 1989 Obstetrics & Gynecology Science Vol.32 No.11
서울대학교병원 산부인과에 내원한 무배란성 불임환자 47명을 대상으로 HMG로 배란을 유 도한 67치료 주기에서 배란주위 혈청 E2치 동태 및 최대 난포크기에 따른 임신율과 단태임 신과 다태임신에서 배란전 혈청 E2치 동태를 비교 검토한 결과 다음과 같은 결론은 얻었다. 1. HCG투여일의 혈청 E2치가 500 pg/ml이상인 고반응군의 경우, 제 0일부다 제 +1일의 혈 청 E2치가 상승하는 치료군에서 감소하는 치료군보다 임신율이 유의하게 높았다. 저반응군 의 경우 임신예는 없었다. 2. 제 0일의 최대난포 직경이 14mm이하인 경우 15mm이상인 경우보다 임신율이 현저히 낮 았다. 3. 제 0일의 혈청 E2치는 임신군과 비임신군에서 차이가 없었으나 난소 과작극 증후군의 경 우 현저히 상승하였다. 4. 다태임신의 경우 단태임신보다 제 -4일과 제 -3일의 혈청 E2치가 상대적으로 높은 경향 을 보였으나 통계적 유의성은 없었다. Forty-seven patients with anovulatory infertility were treated with Human Menopausal Gonadotropin to induce ovulation . Sixty-seven treatment cycles were analyzed to evaluate the effect of preovulatory serum estradiol patten on conception, and to compare pregnancy rate according to the size of maximal follicular diameter and preovulatory serum estradiol levels between single and multiple pregnancy. 1. In high responder with serum estradiol greater than 500pg/ml on day , pregnancy rate was higher in ascending group than in descending group . In low responder, there was no case of conception. 2. pregnancy rate was significantly lower in the treatment group with dominant follicle diameter not more than 14mm than in that not less than 15mm 3. serum estradiol level on day 0 was comparable between pregnancy and nonpregnancy group , but significantly higher in hyperstimulated group than in the other group . 4. There was a tendency that serum estradiol levels on day -4 and day -3 were higher in multiple pregnancy group than in single pregnancy group with no statistical significantly.
정상임부, 자간전증의 임부 및 신생아에서의 혈청면역복합체에 관한 연구
김정구(JK Kim),박준우(JW Park),윤보현(BH Yoon),김승욱(SW Kim) 대한산부인과학회 1985 Obstetrics & Gynecology Science Vol.28 No.12
Circulating immune complexes were measured using the polyethylene glycol (PEG) precipitation assay in 29 normal nonpregnant women 108 normal pregnant women 18 preeclamptic pregnant women and 20 normal newborn infants The results were as follows: 1. In normal pregnant women there was no significant change in levels of circulating immune complexes complexes during pregnancy Also there was no significant difference in the mean levels of circulating immune complexes between normal pregnant and nonpregnant women 2. Taking into account a upper level (mean + 2. S.D.) in the nonpregnant state more preeclamptic pregnant women(8/18) than normal pregnant women in third trimester (7/47) showed levels beyond this point 3. The mean level of circulating immune complexes in normal newborn infants was about 1/4 of that in paried normal pregnant women