주사 항암제 최소수가 적용 전산 프로그램 개발

김재송,안지현,고종희,김경희 한국의료QA학회 2009 가을학술대회 Vol.2009 No.2

집중조명 : 부산 영도구 ; 영도구의 전통문화와 새로운 문화와의 연계

김재송 한국지방행정연구원 2000 지방포럼 Vol.5 No.-

Vinblastine Sulfate가 Mouse 간세포내 소기관에 미치는 영향에 관한 연구

김재송,정호삼,이규식 한양대학교 의과대학 1988 한양의대 학술지 Vol.8 No.1

Vinblastine sulfate, isolated from the vinca, has been widly used in the therapy of Hodgkin's disease, breast cancer, neuroblastoma and choriocarcinoma. Vinblastine sulfate not only inhibits the formation of microtubule but also destructs preformed microtubule so that crystal bodies are formed in the cell by vinblastine sulfate treatment. Therefore vinblastine sulfate inhibits so profoundly the mitosis and transport of methbolites, the degenerative changes are occurred. Based on above mentioned, the author undertook the present study to pursue the effect of vinblastine sulfate on the cytoplasmic organelles of the hepatocytes. Albino mice, ICR strain, weighing 20 gm were used as experimental animals. The experimental animals were killed 4 days after administration of 12 mg/kg of vinblastine sulfate. The specimens obtained from the anterior lobe of the liver were prefixed in Millonig's solution and post-fixed in th 1% osmic acid. And then specimens were embedded in the Epon 812, stained with uranyl acetate and lead citrate, and observed with JEM 100B electron microscope. The results were as follows: 1. The cisternae of the rough endoplasmic reticulum were dilated, sacculated and irregularly arranged, and membrane bound ribosomes were detached. 2. Golgi complex was hypetrophied, and its forming face and maturing face were nt identified. 3. Some mitochondria were hypetrophied and their crest and double membranes were disappeared. 4. Numerous autophagic vacuoles, multivesicular bodies and lysosomes were observed. 5. Numerous lipid droplets wer also observed. Consequently, it is suggested that vinblastine sulfate would induce a deenerative changes in the cytoplamic organelles of the hepatocytes in mice.

손위형제 또는 자매가 있는 소아에서 Palivizumab 투여 여부에 따른 임상적 효과 분석

김진여,박지은,정민재,김재송,김수현,손은선 한국병원약사회 2018 病院藥師會誌 Vol.35 No.4

Background : Palivizumab is an intravenous monoclonal antibody which is used in the prevention of respiratory syncytial virus (RSV) infection. It is currently recommended for infants who are at high-risk for RSV infections due to preterm birth or other medical conditions such as congenital heart disease. Palivizumab is a humanized monoclonal antibody directed against an epitope in the antigenic site A of the protein F of RSV particles. Palivizumab is given once a month via intramuscular (IM) injection throughout the duration of the RSV season. Since palivizumab is known to have preventive effects against RSV infection for children with older siblings, the insurance coverage for palivizumab was expanded in October 2016. Methods : The electronic medical records of children under 2 years old who have older siblings who visited or were admitted to the Severance Hospital from October 2015 to May 2016 and from October 2016 to May 2017 were reviewed retrospectively. The data were then divided into two groups depending on the pilivizumab administration. Results : A total of 67 patients were enrolled in this study. The effectiveness in the reduction of hospitalization was statistically significant (p=0.009). Palivizumab decreased respiratory symptoms such as cough, rhinorrhea, and fever in patients with older siblings (p 0.05). Conclusions : In this study, palivizumab administration was effective in preventing RSV infection in infants with older siblings. Expanding palivizumab-prophylaxis administration to infants with older siblings may be effective in the prevention of upper respiratory infections.

연구발표 초록 ( 에너지 / 환경 (Ⅳ) ) : CaSO4 · ( ½ ) H2O / CaSO4 열화학 반응을 이용한 열저장에 관한 연구

김재송(Jae Song Kim),류희욱(Hee Wook Ryu),김상돈(Sang Done Kim) 한국화학공학회 1991 추계학술발표회 Vol.- No.-

Effect of a Functional SEBS Triblock Elastomer on Morphology in PA / PC Blend (Ⅱ)

이창형,고재송,김조웅,이영무,최형기 한국공업화학회 1998 한국공업화학회 연구논문 초록집 Vol.1994 No.1

호스피스 케어가 말기암환자 가족들의 죽음에 대한 인식 변화에 미치는 영향

계광원,김재송,원주희,이성옥,이채영,조성훈,박윤미,윤영미,이명숙,주선미,Gye Gwang-Won,Kim Jae-Song,Won Ju-Hui,Lee Seong-Ok,Lee Chae-Yeong,Jo Seong-Hun,Park Yun-Mi,Yun Yeong-Mi,Lee Myeong-Suk,Ju Seon-Mi 한국호스피스협회 2005 호스피스 학술지 Vol.5 No.2

The objective of this research is to provide the basic material for effective hospice care by analyzing the recognition of families who have terminally ill patients over death. To do so, this research is designed to investigate the general tendency toward death and changes after hospice care. To analyse the initial status of the recognition about the death, questionnaires were provided to the families of the terminally ill patients who were taken hospice care from June 1st, 2005 to September 10th, 2005 at Saemmul Hospice. The same questionnaires were distributed to research some changes of the recognition of the death after 3 weeks. As the Data Analysis Methodology, SPSS v.10.0 statistics program were utilized. The summary of this research is as follows. First, by gender, it is analyzed that women have more fear than men in terms of incompetence sense after death. By religion, Christians have less fear than other religious people in terms of fear toward after death and general sense of death. Second, those who experienced deaths of close family members, relatives, friends for the past 3 years have more fear toward the moment of death than those who did not experience it. Third, statistically valid difference was found in terms of fear toward the moment of death, fear toward incompetence, fear toward after death, and fear toward death before and after the hospice care was taken. Based on the result of this research, terminally ill patients' families facing death have shown significant differences on fear and incompetence before and after hospice care was offered. It is necessary that the hospice care should be settled more professionally by expanding the opportunities of hospice care and institutionalizing the system. In addition, hospice activities which are focused on providing hope after death and facing death with dignity and peace should be expanded increasingly as the family members who experienced deaths showed higher degree of fear and powerlessness and Christians have less fear toward death with the help of biblical influence. It is also required that hospice care specialized in recognizing the importance of terminal cancer patients and their families at the same time.

¹³¹I-RoseBengal 肝走査所見의 診斷的 意義

高昌俊,金在松,李哉昇,金炳洗,尹德鎭 金原出版 1979 小兒科 Vol.20 No.8

노인의 Medication Error 및 고찰

황계자,김재송,박제은,안지현,김미현,손은선,이아연,석현주,박순배 한국병원약사회 2003 병원약사회지 Vol.20 No.2

환자의 치료를 돕기 위해 약사의 일을 하고 있는 우리의 소임을 다시 한번 되새기며 약사로서 이러한 오류가 발생했을 때 자기를 질책 및 처벌하거나 혹은 은폐하여 오류에 대한 불법행위나 죄를 완화하려는 시도 보다는, 약사의 직업윤리차원에서 발견 즉시 보고하여 그 즉시 대처한다면 큰 사고로 확대되는 것을 방지할 수 있다. 또한 그러한 오류의 재발을 방지하기 위해서 오류 사례에 대한 공지 및 약사 교육 등의 노력이 필요하다고 하겠다. 그리고 일반적으로 노인환자는 본인이 복용하는 약물의 이름을 잘 모르고 언제부터 처방 받았는지 무슨 목적으로 복용하는지도 모르고 여러 가지 약물을 복용하는 경우가 많으므로, 환자에 대한 약물 교육을 일반 환자보다 더욱 철저히 하여, 미국의 경우처럼 환자에게 복약상담을 하고 복용방법에 대한 환자의 이해 정도를 확인하며, 환자 가족까지도 교육시킬 수 있는 복약상담이 노인환자에서는 요구된다. 이러한 철저한 복약상담을 국가 정책적 차원으로 장려하거나 수가 책정 등의 노력을 보여줘야 하겠다. 더 나아가 error에 대한 개인적 또는 의료인 각 집단적인 관심보다는 미국의 경우처럼 국가적 차원의 error 방지에 대한 대책 마련도 필요할 것이다. 인터넷 검색 기술이 날로 발전하여 환자 및 그 보호자들의 의료지식이 나날이 증가하고 있고 이러한 해박한 지식을 바탕으로 환자들의 권리주장도 높아지고 있다. 이러한 환경변화에 의해 의료소송도 점차 증가하고 있고, 소송 시 지불액의 단위도 점점 커지고 있는 현 상황에서 투약오류에 의한 소송도 앞으로 늘어갈 것으로 예측된다. 따라서 이러한 투약사고를 미연에 방지할 수 있는 체계적인 관리지침을 개발하여 병원 약사가 숙지할 수 있도록 하는 것도 매우 중요한 작업이고, 관리지침에 맞추어 약사의 지속적인 교육과 바코드 시스템 도입 등 조제 환경의 개발 및 미국과 같은 오류 예방 시스템의 개발도 필요하다. 또한 장기적인 안목에서 병동환자를 위한 약사의 병동 임상활동 등도 오류 예방책으로 도입할 수 있을 것이다.

Analysis of Prescriptions Not Recommended for Concomitant Use

이경아,김재송,손은선,권경희 한국병원약사회 2019 병원약사회지 Vol.36 No.2

In accordance with the drug utilization review program developed in 2004, a single general hospital of 2,400 beds instituted prescription control of the drug combinations to avoid (DCA) in 2006. However, in order to treat certain patients, it is necessary to use some of these drugs together. Therefore, this study was conducted for the purpose of guiding safe drug use by analyzing prescriptions, monitoring rates, and the incidence of personal injury for DCA selectively allowed by the hospital’s Committee of‘ Medication Management and Use’. This study was conducted on patients administered DCA during a hospitalization period from August 1, 2016, to July 31, 2017, in a single general hospital in Korea. Prescription status, monitoring status, and the occurrence of drug interactions were reviewed in the medical records retrospectively. As a result, among the DCA designated by the MFDS (Korea Ministry of Food and Drug Safety), 306 cases of 17 combinations were used during the one-year study period. Of the total prescriptions, followup monitoring occurred in 110 cases (35.9%) and there were 42 (13.7%) adverse drug events (ADE). However, since 176 cases (57.5%) were not monitored, ADEs were not identified in those patients. In addition, the DCA prescription rate for children and the elderly, who have a high probability for ADEs, was 38.2% (117 cases) and 12.1% (37 cases), respectively, and accounted for 50.3% of all cases. Prescribing DCA is highly likely to cause harm to patients. Although it should be accompanied by follow- up monitoring, a low monitoring rate was observed in this study. Therefore, additional measures are needed, such as follow-up by the pharmacist. In particular, it is necessary to concentrate on children and the elderly. This study has significance, not only in its analysis of DCA prescriptions but also for post-management, which offers a basis for safer drug use.