http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
간암 환자에서 혈청 인터루킨 - 6 측정의 임상적 유용성
홍요한(Yo Han Hong),박중원(Joong Won Park),차영주(Young Joo Cha),김미경(Mi Kyung Kim),김형준(Hyung Joon Kim),도재혁(Jae Hyuk Do),김재규(Jae Gyu Kim),유병철(Byung Chul Yoo),박실무(Sill Moo Park) 대한소화기학회 2002 대한소화기학회지 Vol.39 No.5
Background/Aims: Interleukin-6 (IL-6) has been reported as a mediator of growth control in several human neoplasms, including cholangiocellular carcinomas (CCC). The clinical utility of the serum IL- 6 was evaluated for patients with primary and metastatic liver cancer regarding to differential diagnosis of liver cancers. Methods: Clinical characteristics and serum level of IL-6 were examined in 50 patients [ 13, CCC; 21, hepatocellular carcinomas (HCC) ; 16, metastatic adenocarcinomas (MAC) ] , using an enzyme linked immunosorbent assay (ELISA) and immunohistochemistry specific for IL-6. Results: Hyperbilirubinemia was observed more frequently in the patients than in the patients with HCC or MAC. The elevation of serum IL-6 level was detected in all the CCC patients, 13 HCC patients, and 8 MAC patients. However, 6 healthy controls did not show it. Mean level of serum IL-6 was significantly higher in the patients with CCC ( 263.8 pg/mL) than in the patients with HCC ( 21.8 pg/mL) and MAC ( 6.8 pg/mL) ( p=0.0185). Serum level of IL-6 was correlated with tumor burden in the patients with CCC (r= 0.57, p=0.042). IL-6 expression was more frequently observed in CCC and HCC specimens than in MAC specimens by immunohistochemical study (p= 0.0136). Conclusions: A high serum level of IL-6 marks CCC patients and correlates with tumor burden. The immunohistochemical study of IL-6 may distinguish CCC from MAC. ( Korean J Gastroenterol 2002; 39: 362-369)