흰쥐에서 Vitamin A 의 장기 투여가 혈중 및 간조직의 각종 지질 분획에 미치는 영향

김인주(In Joo Kim),손재경(Jae Kyung Sohn),정상립(Sang Lip Chung),김정철(Jung Chul Kim),정태호(Tae Ho Chung) 대한피부과학회 1986 大韓皮膚科學會誌 Vol.24 No.6

This study was carried out to determine the effect of long term administration of vitamin A on the changes of lipids in liver tissue and serum in rat. The animals were fed with control diet(200 ug/day) and high vitimin A diet(2, 000 ug/day) for 24 weeks. Vitamin A contents of liver in high vitamin A fed rats were increased linearly accordance with duration of the vitamin A administration, but levels of serum vitamin A showed unremarkable changes during the experimental period. Contents of cholesterol and triglycerides of vitarnin A fed rats were significantly higher than those of controls. Levels of HDL-triglycerides in v:itamin A fed rats were significantly higher than those of control rats during experimental period, while levels of HDL-cholesterol and HDL-phospholipids showed unremarkable changes during experimental period. Levels of individual cholesteryl esters showed undremarkable changes during experimental period in both animal groups.

당뇨병과 흡연 : 당뇨병환자에서 흡연과 심혈관질환

김인주 ( In Joo Kim ) 대한당뇨병학회 2009 임상당뇨병 Vol.10 No.2

항공사 스케쥴링과 네트워크에 관한 연구

김인주 ( In Joo Kim ) 한국항공대학교 경영연구소 2006 경영연구 Vol.13 No.1

애니메이션 장면화에 관한 연구

김인주 ( In Joo Kim ) 사단법인 한국교수불자연합회 2009 한국교수불자연합학회지 Vol.15 No.1

Animation은 라틴어 ``anima``에서 그 어원을 찾아 볼 수 있다. 이것은 생명, 영혼 정신을 의미하는 것으로 즉 움직임이 없는 사물에다 생명을 불어넣어 움직임을 준다는 뜻이다. 그리고 애니메이션이란 낱장의 그림 또는 이동 및 동작을 한 프레임(frame)씩 촬영하여 움직임이 있는 것처럼 보이게 하는 것을 말한다. 각 프레임(frame)에 담겨진 이미지들의 형태나 색채, 속 도등의 개별적 요소들이 다양한 방법으로 조작 표현 될 수 있다는 것이 실사영화와 가장 뚜렷이 구별되는 특징이라고 할 수 있다. 프레임(frame)은 애니메이션 제작 과정상 기본 단위로 자신이 의도하는 표현성에 의존하는 의식적인 장면화(framing)작업을 하게 된다. 이 글에서는 게슈탈트(Gestalt)이론을 기초로 루돌프 아른 하임의 열 가지 요소들을 개념화하고, 각각의 요소가 표현된 기존의 애니메이션 프레임을 분석할 것이다. 따라서 장면 화 과정을 거친 애니메이션 제작을 통한 장면화(framing) 작업에 기본이 될 수 있는 이론적인 도움을 찾고자 한다. Animation has perched and been developed as a part of industry or artistry. Animation of the pioneer days exceeded a level which used an extremely partial and special sight effect. It became an important mean to present more positively by manipulating the all visual elements seen on the screen. Indebted to technical development recently, a manufacture process is digitalized and the methods are diversified, too. A set of frames which has an image of producer`s, intention comes to life as animation when constructed, connected and transformed. Basic unit of animation production is a frame. Instead of catching characteristics of things simply in order to characterize them, the framing work will be operated consciously as oneself is intending. Therefore, the purpose of this study is to find theoretical assistance which may be fundamental part in framing of animation. I will attempt to analyze shape-quality framing of animation based on Gestalt theory. I intend to analogize further the systematic aspect of framing in animation and to make framing of animation that is visually communicable-possible to assist in actual production of animation, with visual communication.

항공사 스케쥴링과 네트워크에 관한 연구

김인주(In Joo Kim) 한국항공대학교 경영연구소 2006 산업과 경영 Vol.13 No.1

객실서비스의 물리적 환경이 엔터테인먼트 만족에 미치는 영향

김인주 ( In Joo Kim ) 한국산학경영학회 2008 산학경영연구 Vol.21 No.2

항공기내의 엔터테인먼트는 항공기를 여행의 단순공간이동 차원이 아닌 문화적 공간으로 승화시키는 결정적 요소로 작용한다. 동시에 항공사간 여행 상품 자체를 차별화하는 도구로써 고객들의 재구매 및 구전을 가능케 하는 새로운 도구로 자리매김하고 있다. 연구에서는 기내 엔터테인먼트에 대해 살펴보고 이의 만족에 미치는 영향을 물리적 환경과 엔터테인먼트 상품 즉 콘텐츠로 구분하여 기내 엔터테인먼트 만족과 이후의 재구매와 구전에 이르는 과정을 분석하였다. 연구 결과를 요약하면 다음과 같다. 첫째, 불리적 환경에 대한 긍정적 관점은 기내 엔터테인먼트 만족에 모두 유의한 영향을 미치는 것으로 나타났다. 이중 물리적 환경의 레이아웃 즉 편의성은 물리적 환경에 있어서 가장 중요한 요인으로 나타났으며, 분위기와 디자인은 중요도가 비슷하게 나타났다. 둘째, 제공된 엔터테인먼트 콘텐츠는 기내 엔터테인먼트 만족에 유의한 정의 영향이 나타났다. 셋째, 기내 엔터테인먼트 만족은 긍정적 구전과 재구매에 모두 유의한 영향을 가지고 있다고 나타났으며, 특히 재구매보다 구전에 대한 설명력이 매우 높음을 나타내고 있다. 실증 분석을 통하여 기내 물리적 환경이 기내 엔터테인먼트에 만족에 미치는 영향을 살펴본바, 기내 엔터테인먼트도 기내라는 한정된 공간에서 제공 되어지는 공간적 시간적 제약을 제외하고는 여타 엔터테인먼트 산업과 마찬가지로 다양한 물리적 환경에 의해 고객 만족이 결정되는 것을 확인할 수 있었다. In this study, specific review for the recent trend both in technical parts and the contents of IFE will be revealed. At the same time, how the passenger`s satisfaction on IFE will lead to make an intention of repurchase and create the transmission of positive feed backs on the concerned airline has been thoroughly studied. In order to do the above, 250 air traveling passengers has participated the survey and 235 survey forms has been analyzed by Multiple Regression Analysis. According to the analysis, the physical environmental improvement in aircraft system helps to increase the satisfaction degree on IFE. The convenience is revealed as the most effective factor in the satisfaction degree on IFE while the atmosphere and design is regarded as the similarly important factor. The contents of IFE are obviously affecting the satisfaction degree in positive side. Consequently, the customers` satisfaction on IFE positively affects to the repurchase intention especially to the transmission of the feed back.

혈당지수의 재조명

김인주 ( In Joo Kim ) 대한당뇨병학회 2009 Diabetes and Metabolism Journal Vol.33 No.4

The implementation of effective dietary strategies is important for diabetes management. Dietary carbohydrate is the main factor determining blood sugar level, especially in the postprandial period. Carbohydrate-rich diets can have deleterious effects on glycemic control in diabetic patients and may play an important role in the development of cardiovascular diseases. Low glycemic diets have been reported to have beneficial effects for diabetes control and cardiovascular risk factors. However, according to the American Diabetes Association recommendations for medical nutrition therapy, monitoring carbohydrate intake, whether by carbohydrate counting, exchange, or experience-based estimation, remains a key strategy for achieving glycemic control, with the use of the glycemic index and glycemic load recommended only as an auxiliary method that may provide a modest additional benefit for glycemic control over the effects observed when total carbohydrate is considered alone. Recently, an increasing amount of clinical evidence supports the efficacy of low glycemic diets for the management of diabetes. The development of practical methods to apply the glycemic index and glycemic load to the management of diabetes in clinical settings is warranted. (Korean Diabetes J 33:261-266, 2009)

인슐린 비의존형 당뇨병환자의 사망원인에 대한 고찰

김종훈(Jong Hoon Kim),최익수(Ik Soo Choi),김천환(Cheon Whan Kim),구호성(Ho Seong Ku),손성표(Seong Pyo Son),이광재(Kwang Jaw Lee),정철호(Cheol Ho Jeong),최신영(Shin Young Choi),김인주(In Joo Kim),김용기(Yong Ki Kim),강도영(Do Young Ka 대한내과학회 1996 대한내과학회지 Vol.50 No.4

N/A Objectives: The morbidity and mortality of diabetes mellitus have increased with the improvement of our economy. To these days, there is no report on the cause of death associated with NIDDM in Korea, but it has been generally accepted that infection may be the leading cause of death in NIDDM patients. But recently, with the improvement of infection control technique and the clinical application of new effective antibiotics, it is suspected that the death due to infection is decreasing. And, due to improvement of skill of diabetic control, the life expectancy of the diabetics has been increased. So, we hypothesized that macrovascular diseases complicated with Diabetes Mellitus may play central role in death of diabetics, resembling in developed country. In this study, we try to confirm this hypothesis. Methods: We analysed the cause of death of 149 NIDDM patients on the basis of death certificates from major hospitals in Pusan, Korea. We compared the major cause of death such as cardiovascular disorder and infection with those of general population on the basis of the 1992's statistical mortality analysis. Results: 1) In the decreased 149 Non-insulin dependent diabetics, death from cerebrovascular disease was 24.8% (37/149), infection was 24.2% (36/149), ischemic heart disease was 12.8% (12/149), congestive heart failure was 9.4% (14/149). Death due to diabetic metabolic complications, liver disease, malignant tumor and renal failure were 6.0%, 5.4%, 4.7% and 3.3% respectively. 2) When we compared the major cause of death of non-insulin-dependent diabetic patients with that of general population by observed to expected death ratio(O/E ratio), infection was 7.8, congestive heart failure was 4.1, ischemic heart diease and cerebrovascular disease were 3.3 and 1.4 respectively. 3) When cerebrovascular disease, ischemic heart disease and congestive heart failure were defined together as cardiovascular disorder, O/E ratio was 2.0, and this is lower than that of infection. Conclusion: The large vessel disease is the most common cause of death in patients with non-insulin-dependent diabetes mellitus in Pusan, Korea. So, not only strict glycemic control, but detecting the risk factors related to large vessel disease and its control is important. This type of management may influence the diabetic's life expectancy ultimately, Generally, infection has been thought to be decreasing in recent years but, it is still one of the major cause of death in Korea. We have to detect infection early and treat it actively in non-insulin-dependent diabetic population.

분화성갑상선암에서 최초 고용량 방사성요오드 치료시 혈청 갑상선글로불린 수치 변화의 의의

남현열 ( Hyun Yeol Nam ),김인주 ( In Joo Kim ),김용기 ( Yong Ki Kim ),김성장 ( Seong Jang Kim ),전성민 ( Sung Min Jun ),김범수 ( Bum Soo Kim ) 대한핵의학회 2009 핵의학 분자영상 Vol.43 No.4

목적: 이 연구에서는 고용량 방사성요오드 치료 시행 전, 각각 rhTSH 전처치를 시행한 환자군(rhTSH군)과 갑상선호르몬 투여 중단 시행한 환자군(THW군)에서 방사성요오드 투여 후 단기 혈청 갑상선글로불린(Tg) 상승 정도가 성공적인 잔여갑상선 제거(RRA)를 예측할 수 있는지, 그리고 두 군 사이에서 동등한 잔여갑상선 제거 효과를 보이는지 알아보았다. 대상 및 방법: 분화성갑상선암으로 수술 후 방사성요오드 치료를 받은 환자들 중, rhTSH군은 2003년 1월에서 2006년 12월까지 39명, THW 군은 2005년 1월에서 2005년 6월까지 46명을 대상으로 후향적으로 평가하였다. 이들은 방사성요오드 투여하는 날, 방사성요오드 투여 후 9일째 되는 날 및 6개월에서 12개월 사이에 시행한 추적 검사에서 갑상선기능검사를 시행하였다. 결과: 85명 중 64명에서 성공적인 RRA를 보였다. rhTSH 군에서는 27명, THW 군에서는 37명에서 RRA 성공을 보였고 이 두 군의 결과는 유의한 차이를 보이지 않았다(p=0.347). rhTSH군 및 THW군에서 TgD9/TgD0은 RRA 성공군에서 실패군보다 유의하게 높은 값을 보였다(p=0.03, p=0.04). TgD0와 TgD9/TgD0의 절단값을 결합하였을 경우, TgD0가 5.28이하이면서 TgD9/TgD0이 4.37 초과인 경우 96.7%(29/30)의 RRA 성공률을 보였고, rhTSH군과 THW군에서도 각각 92.9%(13/14)와 100%(16/16)의 높은 RRA 성공률을 나타냈다. 로지스틱 회귀분석에서는 오직 TgD0만 성공적인 RRA와 유의한 연관성을 보였다(p=0.001). 결론: THW군 뿐 아니라 rhTSH군에서도 RRA를 위한 고용량 방사성요오드 치료 도중의 혈청 갑상선글로불린의 변화 양상으로 향후 성공적인 RRA를 예측할 수 있다. Purpose: The purpose of this study was to evaluate if short-term serum thyroglobulin (Tg) elevation after radioiodine administration can predict successful radioiodine remnant ablation (RRA) and whether comparable RRA effectiveness is exhibited between a group administered with recombinant human thyrotropin (rhTSH) and a group experiencing thyroid hormone withdrawal (THW), in preparation for RRA. Materials and Methods: A retrospective chart review was performed on 39 patients in the rhTSH group and 46 patients in the THW group. They were treated for differentiated thyroid carcinoma by total or near total thyroidectomy, and referred for RRA between 2003 and 2006 (the rhTSH group) and between January and June of 2006 (the THW group). They were assessed for serum Tg levels just before I-131 administration (TgD0), reassessed 9 days later (TgD9), and again 6-12 months later. Results: RRA was successful in 64 (37 from the THW group and 27 from the rhTSH group) of the total 85 patients. The success rates of RRA had no statistically significant differences between the two groups. In both groups, TgD9/TgD0 values were significantly higher in the RRA success group (the rhTSH group; P=0.03, the THW group; P=0.04). By combining cutoff values of TgD0 and TgD9/TgD0, the successful RRA value was determined to be 96.7% (29/30) with TgD0≤5.28 ng/mL and TgD9/TgD0>4.37 in both groups (the rhTSH group; 100% (16/16), the THW group; 92.9% (13/14)). Using logistic multivariate analysis, only TgD0 was independently associated with successful RRA. Conclusion: We may predict successful ablation by evaluating short-term serum Tg elevation after I-131 administration for RRA, in both rhTSH and THW patients. (Nucl Med Mol Imaging 2009;43(4):294-300)

Statin 치료시 LDL 콜레스테롤의 직접 측정값과 계산값의 비교

김현진 ( Hyeon Jin Kim ),석지혜 ( Ji Hye Suk ),강지현 ( Ji Hyun Kang ),권혁용 ( Hyuk Yong Kwon ),황치성 ( Chi Sung Hwang ),김명준 ( Myoung Joon Kim ),김미경 ( Mi Kyung Kim ),김태익 ( Tae Ik Kim ),김인주 ( In Joo Kim ) 대한내과학회 2010 대한내과학회지 Vol.79 No.3

Background/Aims: Lowering low-density lipoprotein cholesterol (LDL-C) is the primary target for the prevention of cardiovascular disease. Previous studies have shown that estimated LDL-C levels calculated using Friedewald`s formula (FLDL-C) are closely correlated with directly measured LDL-C levels (DLDL-C). However, because statins not only reduce LDL-C, but also alter the levels of parameters used to calculate FLDL-C (i.e., total cholesterol, triglycerides, and high-density lipoprotein cholesterol), whether calculated LDL-C levels remain a reliable estimate of actual levels after statin treatment is unclear. Methods: Subjects included 985 patients at high risk of cardiovascular disease who had taken statins for more than 6 months. FLDL-C data were compared to DLDL-C data. Results: A strong correlation was observed between DLDL-C and FLDL-C data (R2=0.879). However, the absolute values for FLDL-C and DLDL-C differed significantly according to a paired t-test, and 42.3% of patients showed a difference of greater than 10% between these two values. Among patients with diabetes, the percentage of patients deemed to have achieved target LDL-C levels differed significantly according to the method of LDL-C determination (p=0.007). Conclusions: FLDL-C and DLDL-C data remained well correlated after statin treatment, although the absolute values differed significantly according to the LDL-C determination method. Furthermore, the percentage of subjects deemed to achieve target LDL-C levels differed significantly according to the method of determination among patients with diabetes. (Korean J Med 79:277-284, 2010)