A Case of Giant Osteoma Located across the Parietal and Temporal Bones

김이혁 대한이비인후과학회 부산,울산,경남 지부회 2020 임상이비인후과 Vol.31 No.2

Osteoma often develops in the skull and facial bones, most frequently in the paranasal sinuses, but rarely develops in the temporal bone. Temporal osteoma is most commonly seen in the external auditory meatus, followed by in the mastoid process. Although temporal osteoma can vary in size, it does not exceed 3 cm in most cases. In this case, a 64-year-old woman presented with a left-sided skull mass located behind the auricle that had grown gradually in size over the past 40 years. The mass was a giant osteoma exceeding 3 cm in diameter (maximum diameter, 3.2 cm) located across the upper mastoid process, posterior temporal squama, parietomastoid suture, asterion, and inferior parietal bone. The lesion was successfully removed surgically. We report this case and review the related literature.

하비갑개에 발생한 혈관평활근종 1예

김이혁,윤성재,이유정,김정수 대한비과학회 2008 Journal of rhinology Vol.15 No.1

Vascular leiomyoma (Angiomyoma) is a benign tumor composed of smooth muscle cell and vascular endothelium. Most of them occur at the skin of the lower leg. Cases of vascular leiomyomas developing in the nasal cavity and paranasal sinuses are extremely rare. Most common symptoms are nasal obstruction, epistaxis and nasal pain but none are specific for diagnosis. Complete surgical excision is the treatment of choice and was used in all cases reported. Local recurrence rate is very low. We experienced a case of vascular leiomyoma in the inferior turbinate of a 70-year-old woman who complained of intermittent epistaxis. The tumor was successfully removed via an endoscopic approach. It displayed the characteristic histological findings of abundant thick-walled blood vessels blending with proliferative smooth muscle tissue. Vascular leiomyoma (Angiomyoma) is a benign tumor composed of smooth muscle cell and vascular endothelium. Most of them occur at the skin of the lower leg. Cases of vascular leiomyomas developing in the nasal cavity and paranasal sinuses are extremely rare. Most common symptoms are nasal obstruction, epistaxis and nasal pain but none are specific for diagnosis. Complete surgical excision is the treatment of choice and was used in all cases reported. Local recurrence rate is very low. We experienced a case of vascular leiomyoma in the inferior turbinate of a 70-year-old woman who complained of intermittent epistaxis. The tumor was successfully removed via an endoscopic approach. It displayed the characteristic histological findings of abundant thick-walled blood vessels blending with proliferative smooth muscle tissue.

A Case of Intratympanic Membrance Congenital Cholesteatoma

김이혁 대한이비인후과학회 2012 대한이비인후과학회지 두경부외과학 Vol.55 No.3

Intratympanic membrane congenital cholesteatoma (ITMCC) is extremely rare in patients without previous trauma or surgery of the ear. There are multiple theories to the pathogenesis of middle ear congenital cholesteatoma but none are applicable for ITMCC. When the size of ITMCC is small, there are usually no ear symptoms. However, surgery is needed early, as in any other type of cholesteatoma, because early treatment before middle ear involvement enables enucleation without the need for other procedures such as myringoplasty. We report an incidental finding of a small pearl at the umbo in a 2-year-old boy. The cholesteatoma involved only the outer epidermic layer of the tympanic membrane (TM). A transcanal approach was performed and the cholesteatoma was enucleated from TM.

Clinical Features of Otomycosis Co-occurring with Chronic Otitis Media and the Causative Fungi Yee-Hyuk

김이혁 대한의진균학회 2018 대한의진균학회지 Vol.23 No.4

Background: Otomycosis is a fungal infection that comprises 7~10% of outer ear infections. Although the occurrence is higher in humid climates, relatively few studies have investigated otomycosis occurrences in humid environments. While recurrent chronic otitis media discharge in the ear creates a milieu in which otomycosis is likely to occur, investigations of otomycosis co-occurring with chronic otitis media have been rare. Objective: To examine the characteristics of patients with otomycosis co-occurring with chronic otitis media and identify causative fungi. Methods: The study included 60 patients with chronic otitis media who presented typical otomycosis findings in the outer ear canal and the presence of fungi. Patients were treated in the department of otolaryngology, Daegu Catholic University Medical Center, between July 2011 and June 2018. Results: The mean patient age was 57.77 years, and our study included 20 men and 40 women (p =0.010). The lesion was on the right in 39 patients and on the left in 21 (p =0.020). Ear discharge was the most common chief complaint at diagnosis. Of the 54 patients over age 19, 10 had diabetes (18.5%). Aspergillus was causative in 29 patients and Candida in 31. Aspergillus niger was identified in 15 patients, Aspergillus sp. in 14, Candida parapsilosis in 12, Candida sp. in six, and Candida albicans in five. Conclusion: Otomycosis and chronic otitis media co-occurrences increase with age. The Aspergillus and Candida genera were similar in proportion. A. niger was the most common Aspergillus species, while C. parapsilosis was the most common Candida.

호산구성 중이염을 동반한 알레르기성 진균성 부비동염 1예

김이혁,고재진,손호진,신승헌 대한이비인후과학회 부산,울산,경남 지부회 2012 임상이비인후과 Vol.23 No.2

Eosinophilic otitis media (EOM) is a middle ear disease with extremely viscous mucoid effusion containing numerous eosinophils associated with allergic rhinitis and bronchial asthma. EOM is extremely unresponsive to conventional treatment for the common type of otitis media. EOM patients have the deterioration of the bone conduction hearing level, due to the inflammatory mediators released from inflammatory cells could enter the inner ear. One of the most effective treatments for esoinophilic inflammation is the administration of a steroid. Although EOM is commonly associated with nasal polyps, their relation to allergic fungal sinusitis is not reported. Hence we report a case of EOM proceeded with allergic fungal sinusitis with a review of literature.

자동차 도장 물성과 그에 따른 시험 방법

김이혁 한국분석과학회 2018 학술대회논문집 Vol.2018 No.11

글짓기 능력을 신장시키는 단계적인 지도 연구 ( 실제 )

김이혁 ( I Hyeok Kim ) 한국어교육학회 1966 국어교육 Vol.- No.12

Alternaria Induces Production of Thymic Stromal Lymphopoietin in Nasal Fibroblasts Through Toll-like Receptor 2

신승헌,김이혁,진효승,강승현 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.1

Purpose: Chronic rhinosinusitis with nasal polyps is a chronic inflammatory disease with markedly increased eosinophils, Th2-type lymphocytes, fibroblasts, and goblet cells. Fungi are commonly associated with airway inflammatory diseases, and thymic stromal lymphopoietin (TSLP) is important in the development of Th2 inflammatory responses. The aim of this study was to investigate the interaction between airborne fungi and nasal fibroblasts in TSLP mRNA and protein expression. Methods: Inferior turbinate and nasal polyp fibroblasts were stimulated with Alternaria and Aspergillus, respectively, for 48 hours, and TSLP mRNA and protein expressions were measured. The reverse transcriptase polymerase chain reaction was performed for the Toll-like receptor (TLR) mRNA expression of the nasal fibroblasts. To determine the role of TLR in the induction of TSLP, the fibroblasts were transfected with siRNA against TLR2 and TLR5. Results: Alternaria induced TSLP mRNA and protein expression in both inferior turbinate and nasal polyp fibroblasts. The nasal polyp fibroblasts responded more strongly to the fungi. TLR2 and TLR5 mRNA expressions were significantly increased with fungal stimulation and TSLP production was significantly inhibited by siRNA against TLR2. Conclusions: The results of this study show that TSLP expression could be induced in nasal fibroblasts by exposure to Alternaria and that TLR2 may be involved in the process. The promotion of TSLP production in nasal fibroblasts by airborne fungi may facilitate the development or exacerbation of Th2-type nasal inflammation, especially in CRS with nasal polyps.

봉독에 의한 말초혈액단핵구의 증식 및 활성화 억제

신승헌,김이혁,예미경,박관규 대한비과학회 2011 Journal of rhinology Vol.18 No.2

Background and Objectives:Bee venom (BV) has been used as a traditional medicine to treat a variety of diseases, and the anti-inflammatory, antinociceptive, and anticancer activity of BV has been studied over the past few years. This study was designed to investigate the effects of BV on the production of cytokines by peripheral blood mononuclear cells (PBMCs) and on the proliferation of these cells. In addition, we investigated the potential cytotoxic effects of BV on PBMCs. Materials and Methods:PBMCs from healthy human volunteers were stimulated with 5 μg/mL phytohaemagglutinin (PHA) and 10 μg/mL lipopolysaccharide (LPS) in the presence of different concentrations of BV. The cytotoxic effects of BV were measured using an aqueous cell proliferation assay kit and the supernatants were analyzed using an enzyme-linked immunosorbent assay. Tumor necrosis factor-α (TNF-α), interleukin-5 (IL-5), and interferon-γ (INF-γ) levels were measured to determine the activation status of PBMCs. Result:Although BV alone did not have a cytotoxic effect on PBMCs, PHA- and LPS-induced cytokine production was significantly inhibited by BV. TNF-α and INF-γ production was inhibited by a lower concentration (0.5-1 μg/mL) of BV than IL-5 (6 μg/mL). Conclusion:BV seems to be relatively safe as a modulator of cytokine production by PBMCs. These experimental data suggest that BV could be used to treat immunologic and inflammatory diseases.

개방형 유양돌기절제술 후 조기에 발생한 미로 누공 1예

최성용,김이혁 대한평형의학회 2016 Research in Vestibular Science Vol.15 No.3

Labyrinthine fistula refers to a condition caused by an abnormal connection between the inner ear and surrounding structures. Most cases of that occur as a result of a complication brought about by cholesteatoma. It may also be generated by long repeated infections of a mastoid cavity that has been exposed to the outside after canal wall down mastoidectomy (CWDM). The infection is usually repeated for several years or decades after surgery. Therefore, labyrinthine fistula after CWDM is known as a late complication. In this case, labyrinthine fistula occurred in two months after surgery due to postoperative infection. Although cholesteatoma was removed after CWDM and the horizontal semicircular canal (HSCC) was not damaged during the operation, this labyrinthine fistula was thought to develop very early after surgery. Two months after surgery, the patient complained of dizziness, we identified the opened bony labyrinth and damaged endosteum of the HSCC in the patient.Res Vestib Sci 2016;15(3):89-93