산욕기에 발생한 뇌교출혈로 인한 마비성 사시 환자 치험 1례

김유경,김우성,강세영,심국진,윤지원,백동기,이종덕,원진희,이상관,김홍준,Kim, Yu-Kyung,Kim, Woo-Sung,Kang, Sei-Young,Sim, Kuk-Jin,Yoon, Ji-Won,Baek, Dong-Gi,Lee, Jong-Deok,Won, Jin-Hee,Lee, Sang-Kwan,Kim, Hong-Joon 대한한방내과학회 2004 大韓韓方內科學會誌 Vol.25 No.3

Pregnancy related stroke is significant because it has dire impact on both mother and the fetus. Pregnant or puerperal women are reported to have about 13-fold more risk of stroke compared to non-pregnant women. Pregnancy-related stroke must be differentiated from stroke in elderly patients, because it is different in pathophysiological etiologies and recurrence rates and also diagnostic and therapeutic methods may affect the fetal health status. Because the VI cranial nerve manages lateral rectus muscles, it' s palsy causes sudden onset of double vision. The eyes turn medially. In this article, one case of paralytic strabismus resulting from pontine hematoma during puerperium is reported. It was treated with herb medicine and acupuncture. Symptoms improved. This case is submitted with a brief overview of related lit.

클리펠-트레노네이증후군 환자에서 발생한 재발척수병

김유경,엄영인,주인수,Kim, Yue Kyung,Eom, Young In,Joo, In Soo 대한임상신경생리학회 2015 Annals of Clinical Neurophysiology Vol.17 No.2

Klippel-Trenaunay syndrome (KTS) is a rare congenital malformation syndrome involving blood and lymph vessels, which is characterized by triad of cutaneous hemangioma, venous varicosities, and overgrowth of the affected limbs. Because vascular malformation in KTS can be located anywhere except the face and brain, the clinical presentation could be extremely variable. But there are only rare case reports that KTS is associated with spinal cord lesion. We report a case of recurrent myelopathy in a patient with KTS.

윤작이 감자 수량, 토양 화학성 및 미생물 활성에 미치는 영향

김유경,강호준,양상호,오한준,이신찬,강성근,김형신,Kim, Yu-Kyoung,Kang, Ho-Jun,Yang, Sang-Ho,Oh, Han-Jun,Lee, Shin-Chan,Kang, Seong-Keun,Kim, Hyoung-Sin 한국유기농업학회 2012 韓國有機農業學會誌 Vol.20 No.4

The objective of this study was to determine crop rotation effects on potato yield, soil chemical and microbiological properties from a short-term field experiment from 2010 to 2011 in Jeju Island, Korea. Potato cropping systems included continuous and rotation sequences of soybean (Glycine max(L.) Merr.), barley (Hordeum vulgare var. hexastichon), rapeseed (Brassica napus L.) and broccoli (Brassica oleracea var. italica). Crop rotations increased the yields of potato from 31% to 52% compared with continuous potato. Marketable yield of potato was highest under soybean plus rapeseed rotation by $20.97MT\;ha^{-1}$ and lowest under continuous cropping by $11.95MT\;ha^{-1}$. The incidence and severity of scab disease was significantly lower in tubers from crop rotation with soybean plus barley. Differences in marketable tuber yields among rotations were associated with potato scab disease. Especially, incidence and severity of potato scab were strongly correlated with soil pH, exchangeable calcium, and bacteria population of the soil. Crop rotations significantly increased soil pH, available phosphate, exchangeable K and Ca, especially in crop rotations with soybean plus barley or rapeseed. Soil microbial biomass C of crop rotations with soybean plus barley or rapeseed, was also significantly higher compared with monoculture. In conclusion, crop rotation may decrease the incidence of soil-born pathogen by increasing soil chemical properties and soil microbial biomass. Overall, potato crop productivity was generally maintained in rotations that contained soybean plus barley or rapeseed but declined under continuous cropping system. 본 시험은 윤작처리가 감자의 상품수량과 토양 화학성 및 미생물 활성에 미치는 영향을 평가하고 알맞은 작부체계를 확립하기 위하여 시험을 수행하였다. 작부체계내 콩과 보리를 도입하여 2년 2기작으로 감자를 윤작하였을 경우 총수량과 상품수량은 대조구인 연작구 대비 각각 31% 및 53% 정도 증가하였으며, 콩과 유채를 도입하여 2년 2기작으로 감자를 윤작하였을 경우 총수량과 상품수량은 각각 57% 및 75% 정도 증가하였다. 그리고 감자의 상품수량에 미치는 요인간 상관관계를 분석한 결과 상품수량은 토양미생물 활성, 특히 Biomass C 및 세균 밀도가 높을수록 증가하였고, 토양 pH, 유효인산, 치환성 칼슘함량이 높을수록 세균 밀도가 증가하였다. 따라서 윤작을 통해서 토양 화학성을 개량하고 미생물 밀도 및 활성을 증가시키면, 토양병 발생을 억제하고 감자의 생산성을 높일 수 있을 것으로 판단된다.

객체지향 설계의 특성을 고려한 품질 평가 메트릭스

김유경,박재년,Kim, Yu-Kyung,Park, Jai-Nyun 한국정보처리학회 2000 정보처리논문지 Vol.7 No.2

지금까지의 객체지향 메트릭스에 대한 연구는 단순히 품질의 일부 요소만을 다루고 있으며, 대부분의 메트릭스는 클래스 사이의 관계 정보만을 기반으로 제안되어 왔다. 이로써 객체지향 설계의 특성을 충분히 반영하지 못하고 있다. 또한 기존의 객체지향 메트릭스는 각 메트릭의 계산 결과를 평가하기 위하여 제한값(threshold)을 제공하고 있으며, 형식적으로 정의되지 않은 것이 대부분이다. 이들의 문제점은 계산 과정이 복잡하여 쉽게 적용할 수 없고 프로젝트의 성격이나 소프트웨어의 특성에 따라 제한 값이 달라질 수 있다는 것이다. 이에 본 논문에서는 객체지향 설계의 특성인 크기, 복잡도, 결합도 및 응집도를 고려하여 설계의 품질을 평가하기 위한 메트릭 집합을 제시한다. 제시된 메트릭 집합은 평균값에 대한 비율(proportion)을 사용하여 평균값을 상회하는 클래스 및 설계 요소들을 쉽게 파악할 수 있도록 하였다. 이것은 설계 품질을 저하시키고 있는 클래스를 찾아내어 평균값에 근접한 수준을 h다시 설계할 수 있도록 함으로써, 구현하는 동안 직면하는 설계 결점을 개발 초기에 발견할 수 있도록 하였다. 본 논문에서 정의한 메트릭 집합은 측정원칙에 의하여 분석적으로 평가된다. 그 결과로서 메트릭에 대하여 요구되는 성질의 대부분을 만족하고 있음을 알 수 있다. 도한 플랫폼과 무관하게 사용할 수 있도록 웹 브라우저 및 자바 애플릿으로 개발되어 분산 인트라넷 환경을 지원하는 평가 도구 ASSOD(ASsessment System of Object oriented Design)를 설계한다. There are many researches about metrics to measure a quality of Object-Oriented(OO) software. However, most of them have only discussed a concept or properties of metrics, and have not shown the detailed procedure for measuring them. They also define a measurement indicator as a threshold, but it has been influenced on a project size or application domains. In this paper, we propose metrics based on characteristics of OO design such as size, complexity, coupling and cohesion, and use a propotion to an average as the measurement indicator. It is easy to classify classes which have a result above the average, and to predict classes which reduced the quality of OO design. They will be modified to hold the average. Proposed metrics are analytically evaluated by Weyuker's nine properties. They are satisfied with seven properties except two properties co not apply to OO metrics. Also, we design a quality assessment system, ASSOD(ASsessment System of Object oriented Design), to measure the quality of the OO design independent of the platform.

식품 섭취와 인지기능장애와의 관계: 체계적 문헌고찰 및 메타분석

김유경,김경희,Kim, Yoo-Gyeong,Kim, Kyung-Hee 한국식생활문화학회 2020 韓國食生活文化學會誌 Vol.35 No.6

This systematic review and meta-analysis aimed to determine whether food intake is effective in preventing diseases related to cognitive impairment. We searched English databases namely MEDLINE, PubMed and ScienceDirect from 2000 to May 2020, and Korean databases namely RISS, KISS, and DBPIA from 1990 to May 2020. We divided the data into 15 groups using the food group classification of the Korean Nutrition Society (KNS). The effect size (Cohen's d) was estimated using a random-effect model, and a 95% confidence interval was calculated for each study. We included 17 cross-sectional studies and 7 cohort studies which involved 45,115 participants. As a result of analyzing the subgroups in the Asian population of both sexes, it was observed that grain intake has a protective effect against cognitive impairment. For females, pulses and fish also have a protective role against cognitive impairment. In the case of seaweed, a negative relationship was found with a moderate protective effect against cognitive impairment (Cohen's d:-0.533, 95% CI: -0.939, -0.126; p=0.010) in Korean studies. Dairy products are associated with an increased risk of cognitive impairment in the American and European population but drinking alcohol is associated with a lower impairment risk. These results provide a basis for formulating the dietary guidelines for preventing dementia for each country.

디지털식 진화론과 현대기업

김유경,Kim, Yu-Gyeong 한국정보통신집흥협회 1999 정보화사회 Vol.133 No.-

Complete genome of the multidrug-resistant Escherichia coli strain KBN10P04869 isolated from a patient with acute myeloid leukemia

김유경,이원길,송경은,Kim, Yu Kyung,Lee, Won Kil,Song, Kyung Eun The Microbiological Society of Korea 2018 미생물학회지 Vol.54 No.4

저자들은 최근 급성골수성백혈병 환자로부터 다제내성대장균 균주 KBN10P04869를 분리했다. 균주는 4,457개의 단백질 코딩 유전자, 88개의 운반 RNA, 22개의 리보솜 RNA를 포함하는 5,104,264 염기쌍으로 구성되고, $^{bla}CMY-2$, $^{bla}TEM-1$, $^{bla}CTX-M-15$, $^{bla}NDM-5$, $^{bla}OXA-18$를 포함한 다제내성유전자를 가지고 있다. 저자들은 이 균주의 총유전체를 보고하는 바이다. Recently, we isolated a multidrug-resistant Escherichia coli strain KBN10P04869 from a patient with acute myeloid leukemia. We report the complete genome of this strain which consists of 5,104,264 bp with 4,457 protein-coding genes, 88 tRNAs, and 22 rRNAs, and the co-occurrence of multidrug- resistant genes including $^{bla}CMY-2$, $^{bla}TEM-1$, $^{bla}CTX-M-15$, $^{bla}NDM-5$, and $^{bla}OXA-18$.

Denosumab (Prolia^®)의 투여 간격 및 칼슘·비타민 D 복합제제 처방 여부에 따른 임상적 결과 평가

김유경,김정현,도현정,정영미,이정화,이주연,김은경,Kim, Youkyeong,Kim, Junghyun,Doh, Hyunjeong,Jeong, Young Mi,Lee, Jeonghwa,Lee, Ju-Yeun,Lee, Euni 한국임상약학회 2022 한국임상약학회지 Vol.32 No.3

Background: Denosumab (Prolia®) is administered every 6 months for osteoporosis treatment. Co-administration of calcium and vitamin D is required to minimize hypocalcemia risk. We evaluated clinical outcomes based on the administration interval of denosumab and co-prescription with calcium-vitamin D combination products. Methods: A retrospective study was conducted using electronic medical records from 668 patients who started denosumab therapy between January 1 and December 31, 2018, at Seoul National University Bundang Hospital. Clinical outcomes, as measured by changes in T-score, were evaluated by the intervals and concurrent prescriptions with calcium-vitamin D combination products. Results: Of the 668 patients, 333 patients met the eligibility criteria. These patients were divided into two groups based on appropriateness of the administration interval: "Appropriate" (304 patients, 91.3%) and "Inappropriate" (29 patients, 8.3%). T-score changes were significantly higher in the "Appropriate" than in the "Inappropriate" group (0.30±0.44 vs. 0.13±0.37, p=0.048). At the beginning of the treatment, 221 patients (66.4%) were prescribed calcium-vitamin D combination products, but the changes in T-scores were not significantly different by the prescription status of the product (0.29±0.46 vs. 0.28±0.38, p=0.919). Conclusion: T-scores were significantly improved in patients with appropriate administration intervals. No significant changes in T-scores were observed by the prescription status with calcium-vitamin D combination products. For optimal treatment outcomes, prescribers should encourage adherence to the approved prescription information on dosage and administration, and pharmacists should provide medication counseling for patients.

"섬세한 여성과학인 파워 국가 기술 발전 디딤돌" - 정명희

김유경,Kim, Yu-Gyeong 한국과학기술단체총연합회 2003 과학과 기술 Vol.36 No.1

광합성세균 Rhodopseudomonas palustis 분리 및 IAA와 Carotenoid 생성에 관한 연구

김유경,조영윤,강호준,김정선,양성년,좌창숙,Kim, Yu-Kyoung,Cho, Young-Yun,Kang, Ho-Jun,Kim, Jung-Sun,Yang, Sung-Nyun,Jwa, Chang-sook 한국유기농업학회 2017 韓國有機農業學會誌 Vol.25 No.4

본 연구에서는 제주도 한라산 중산간 습지대 28개소에서 IAA 및 carotenoid 생성능이 우수한 광합성 세균 1종을 최종 선발하였으며, 16S rRNA 염기서열 분석과 생리학적 특성을 조사한 결과 Rhodopseudomonas palustris JK-1 균주로 동정하였다. JK-1 균주의 최적배양조건을 선발하기 위하여 pH, 온도, 빛 및 통기 등을 포함한 여러 가지 요인들이 균주의 생장과 IAA 및 carotenoid 등 광합성색소 생성에 미치는 영향을 조사하였다. 시험결과 JK-1 균주는 명/혐기조건에서 균생장, IAA 및 광합성색소 생성이 양호하였으며 암/혐기조건에서 균생장, IAA 및 광합성색소 형성이 모두 크게 억제되었다. 명/혐기조건에서 균생장, IAA 및 carotenoid 등 광합성색소의 생산을 위한 최적 pH, 온도 및 배양회전속도는 각각 7, $30^{\circ}C$, 150 rpm, 9, $30^{\circ}C$ 및 150 rpm, 그리고 6, $25^{\circ}C$ 및 50 rpm이었다. 그리고 명/호기조건(0.5~1 vvm)에서는 명/혐기조건(0 vvm)보다 균생장 및 IAA 합성이 양호하였으나 광합성색소 형성은 크게 억제되었다. 따라서 최적배양조건은 명/혐기조건에서 pH 7, 온도 $30^{\circ}C$ 및 회전속도 100 rpm을 선발하였으며, IAA 합성을 유도한 배양액을 생육촉진 효과검증에 이용하였다. 시험결과 R. palustris JK-1 균주를 열무에 3% (v/v) 처리 시 지상부 및 지하부 건물중이 무처리 및 배지처리구 대비 각각 20~58% 및 40-28% 증가하였다. The JK-1 isolate which was the best producer of indole-3-acetic acid and carotenoid among the 388 strains isolated from 28 wetlands in Jeju, was identified to be Rhodopseudomonas palustirs belongs to a typical group of non sulfur purple bacteria based on 16S sRNA sequencing. This study investigated the effect of different cultural conditions of pH, temperature, agitation, light and aeration on growth, IAA and carotenoid production of photosynthetic bacterium JK-1 for optimization of IAA and carotenoid production. It was found that growth, IAA, carotenoid, and bacteriochlorophyll production with light (3,000~3,500 Lux) and agitation (100 rpm) showed better results than those with dark/static or dark/agitation (100 rpm) in anaerobic conditions. The optimal pH, temperature and agitation speed for cell growth were 7, $30^{\circ}C$, 150 rpm, for IAA production were 9, $30^{\circ}C$, 150rpm and for carotenoid production were 6, $25^{\circ}C$, 50 rpm, cultured for 72 h under anaerobic light, respectively. The growth and IAA production were high in aerobic culture compared with anaerocic culture, whereas carotenoid and bacteriochlorophyll content were decreased extremely in aerobic condition (0.5~1 vvm). Subsequently, the optimal culture conditions for JK-1 were selected with pH 7, $30^{\circ}C$ and 100 rpm under anaerobic light and the effect on plant growth was tested by pot assay. Inoculation of JK-1 with 3% (v/v) level caused increase in shoot and root dry weigh that varied from 20%~58% to 40%~28% in young radish in camparison to uninoculated treatment at 50 days of growth. The study suggests that the JK-1 isolate may serve as efficient biofertilizer inoculants to promote plant growth.